AT77318B - Process for the production of durable, easily disintegrating tablets from acetylsalicylic acid lithium. - Google Patents
Process for the production of durable, easily disintegrating tablets from acetylsalicylic acid lithium.Info
- Publication number
- AT77318B AT77318B AT77318DA AT77318B AT 77318 B AT77318 B AT 77318B AT 77318D A AT77318D A AT 77318DA AT 77318 B AT77318 B AT 77318B
- Authority
- AT
- Austria
- Prior art keywords
- acetylsalicylic acid
- acid lithium
- durable
- production
- disintegrating tablets
- Prior art date
Links
- MVIGXHUGRATYCI-UHFFFAOYSA-N 2-acetyloxybenzoic acid;lithium Chemical compound [Li].CC(=O)OC1=CC=CC=C1C(O)=O MVIGXHUGRATYCI-UHFFFAOYSA-N 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 238000000034 method Methods 0.000 title description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 210000002837 heart atrium Anatomy 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 3
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000004554 water soluble tablet Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Herstellung haltbarer, leicht zerfallender Tabletten aus azetyl8alizylaaurem
Lithium.
EMI1.1
wenige Monate dauerndem Lagern sich in Wasser kaun) noch auflösen, es sei denn. dass man sie wieder fein pulvert, was für den Verbraucher natürlich unbequem ist.
Die üblichen Tablettensprengmittel, wie Stärke, Tragant. Agar-Agar usw. haben, ganz abgesehen davon, dass sie nicht kiar wasserliislich sind, nicht die Wirkung, die Tabletten aus azetylsalizylsaurem Lithium leichter zerfallbar zu machen, ebensowenig wasserlösliche
EMI1.2
Es wurde nun gefunden, dass leicht zerfallende, nicht nachhärtende Tableten gewonnen werden können, wenn man dem Lithiumsatz einen geringen Zusatz von Alkalikarbonaten giht. Am brauchbarsten orwies sich Natriumbikarbonat. von dem schon fünf Prozent genügen, um Tahletten zu erhalten, die nicht naehhärten und auch bei monate.
EMI1.3
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the production of durable, easily disintegrating tablets from acetyl-alicylaic acid
Lithium.
EMI1.1
A few months storage in water can still dissolve, unless. that they are finely powdered again, which is of course inconvenient for the consumer.
The usual disintegrants such as starch, tragacanth. Apart from the fact that they are not completely water-soluble, agar-agar etc. do not have the effect of making tablets made of lithium acetylsalicylic acid more easily disintegratable, and neither do water-soluble tablets
EMI1.2
It has now been found that easily disintegrating, non-post-hardening tablets can be obtained if the lithium charge is given a small addition of alkali metal carbonates. Sodium bicarbonate proved to be the most useful. Five percent of that is enough to get tahlettes that don't harden and even for months.
EMI1.3
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT77318T | 1917-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT77318B true AT77318B (en) | 1919-07-25 |
Family
ID=3598928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT77318D AT77318B (en) | 1917-03-04 | 1917-03-04 | Process for the production of durable, easily disintegrating tablets from acetylsalicylic acid lithium. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT77318B (en) |
-
1917
- 1917-03-04 AT AT77318D patent/AT77318B/en active
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