AT83392B - Process for the preparation of therapeutically usable bismuth-iodine-alkali solutions. - Google Patents
Process for the preparation of therapeutically usable bismuth-iodine-alkali solutions.Info
- Publication number
- AT83392B AT83392B AT83392DA AT83392B AT 83392 B AT83392 B AT 83392B AT 83392D A AT83392D A AT 83392DA AT 83392 B AT83392 B AT 83392B
- Authority
- AT
- Austria
- Prior art keywords
- bismuth
- iodine
- preparation
- solutions
- therapeutically usable
- Prior art date
Links
- 239000003513 alkali Substances 0.000 title claims description 9
- DRFWMCAJOWTPKC-UHFFFAOYSA-K [Bi](I)(I)I.[I] Chemical compound [Bi](I)(I)I.[I] DRFWMCAJOWTPKC-UHFFFAOYSA-K 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 2
- CBIXFXPGRXJEAJ-UHFFFAOYSA-N [I].[Bi] Chemical compound [I].[Bi] CBIXFXPGRXJEAJ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 239000011630 iodine Substances 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- KOECRLKKXSXCPB-UHFFFAOYSA-K triiodobismuthane Chemical compound I[Bi](I)I KOECRLKKXSXCPB-UHFFFAOYSA-K 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Darstellung von therapeutisch verwendbaren Wismut-Jodalkalilösungen.
Nach vorliegender Erfindung sollen Wismutjodid-Jodalkalidoppelsalze bzw. ihre Komponenten in eine für pharmazeutische Zwecke verwendbare Lösung übergeführt werden. Dies geschieht in der Weise, dass man Jodalkali und geeignete Säuren in solchem Verhältnis dem Wismutjodid bzw. seinen Doppelsalzen zufügt, dass Eiweiss, Gelatine u. dgl. durch die entstehenden Lösungen nicht gefällt werden.
Hierdurch unterscheiden sich die nach vorliegendem Verfahren hergestellten Lösungen grundsätzlich von den für analytische Zwecke benutzten Wismutjodalkalilösungen, wie z. B. dem Dragendorffschen und'Manginischen Reagens usw., welche Eiweiss und Gelatine u. dgl. fällen. Für therapeutische Zwecke können die letzteren Lösungen schon aus diesem Grunde nicht in Frage kommen, ganz abgesehen davon, dass ihr hoher Säuregehalt eine solche Verwendung ausschliesst.
Die nach vorliegendem Verfahren hergestellten Lösungen zeichnen sich durch eine hohe keimtötend Kraft und erhebliche Tiefenwirkung aus. Bringt man diese Lösungen auf affizierte Schleimhäute, so dringen sie tief in diese ein und erreichen somit auch die in deren Buchten und Kanälen sitzenden Krankheitskeime.
Zur Herstellung solcher Lösungen verfährt man beispielsweise wie folgt : i. 0. 5 Teile Wismutjodidjodnatrium (Kahlbaum), 7. 5 Teile Natriumjodid und 0. 1 Teil Weinsäure werden in 500 Cflta Wasser gelöst.
2. Man bringt 2 Teile Wismutjodid, 78 Teile Jodkalium und 3. 5 Teile Glykolsäure durch 5000 Teile Wasser in Lösung.
An Stelle der genannten Doppelverbindung können auch andere Wismutjodid-Jodalkalidoppelsalze bzw. deren Komponenten Verwendung finden und an Stelle von Weinsäure und Glykolsäure können andere geeignete Säuren, wie z. B. Essigsäure, Zitronensäure, Milchsäure, Jodwasserstoffsäure usw. benutzt werden.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the preparation of therapeutically usable bismuth-iodine-alkali solutions.
According to the present invention, bismuth iodide-iodine alkali double salts or their components are to be converted into a solution which can be used for pharmaceutical purposes. This is done in such a way that iodine alkali and suitable acids are added to the bismuth iodide or its double salts in such a ratio that protein, gelatin and the like. Like. Are not precipitated by the resulting solutions.
As a result, the solutions produced by the present process differ fundamentally from the bismuth iodine alkali solutions used for analytical purposes, such as. B. the Dragendorffschen und'Manginischen reagent, etc., which egg white and gelatin u. the like. For this reason alone, the latter solutions cannot be considered for therapeutic purposes, quite apart from the fact that their high acid content precludes such use.
The solutions produced according to the present process are characterized by a high germicidal power and considerable depth of effect. If you apply these solutions to affected mucous membranes, they penetrate deeply into them and thus also reach the germs that are located in their bays and channels.
To produce such solutions, one proceeds, for example, as follows: i. 0.5 parts of bismuth iodide iodine (Kahlbaum), 7. 5 parts of sodium iodide and 0.1 part of tartaric acid are dissolved in 500 Cflta of water.
2. 2 parts of bismuth iodide, 78 parts of potassium iodide and 3. 5 parts of glycolic acid are dissolved in 5000 parts of water.
Instead of the double compound mentioned, other bismuth iodide-iodine alkali double salts or their components can be used and instead of tartaric acid and glycolic acid, other suitable acids, such as. B. acetic acid, citric acid, lactic acid, hydriodic acid, etc. can be used.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE83392X | 1915-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT83392B true AT83392B (en) | 1921-03-25 |
Family
ID=5640049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83392D AT83392B (en) | 1915-09-21 | 1916-09-16 | Process for the preparation of therapeutically usable bismuth-iodine-alkali solutions. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT83392B (en) |
-
1916
- 1916-09-16 AT AT83392D patent/AT83392B/en active
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