AT90273B - Process for the production of long-lasting serum and lymph preparations. - Google Patents
Process for the production of long-lasting serum and lymph preparations.Info
- Publication number
- AT90273B AT90273B AT90273DA AT90273B AT 90273 B AT90273 B AT 90273B AT 90273D A AT90273D A AT 90273DA AT 90273 B AT90273 B AT 90273B
- Authority
- AT
- Austria
- Prior art keywords
- lymph
- preparations
- production
- long
- serum
- Prior art date
Links
- 210000002751 lymph Anatomy 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 5
- 210000002966 serum Anatomy 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 3
- 230000005923 long-lasting effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000999 acridine dye Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229940083538 smallpox vaccine Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
<Desc/Clms Page number 1>
VerfahrenzurHerstellunghaltbarerSerum-undLyisphepräparate.
Die Haltbarmachung von Heilseren und Lymphen wurde bisher durch Zusatz von Phenolen oder Glycerin angestrebt.
Es wurde nun gefunden, dass dieses Ziel durch Zugabe geringer Mengen VOR Akridinfarbstoffen,
EMI1.1
servierende bzw. desinfizierende Kraft der Akridinfarbstoffe ist eine weit höhere als die der genannten Substanzen, die Wirksamkeit der Seren und Lymphen wird durch sie in keinerlei Weise beeinträchtigt und ausserdem sind bei Anwendung dieser Farbstoffe schädliche Nebenwirkungen ausgeschlossen, da sie im Gegensatz zu den Phenolen ungiftig sind. Wie durch ausgedehnte Untersuchungen festgestellt wurde. sind Akridinfarbstoffe als prophylaktische Wunddesinfektionsmittel ausserordentlich wirksam, daher ist ihre Anwesenheit in der Lymphe von grösster Bedeutung für die Verhütung sekundärer Wundinfektionen (Impfschäden).
Beispiel : Zur Darstellung von Pockenimpfstoff wird der Kälberrohstoff mit der drei-bis fünffachen Menge sterilisierter l%iger Lösung von 3#6-Diamino-10-methylakridiniumchlorid (Neutraltrypaflavin) vermischt und in üblicher Weise weiterverarbeitet.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the preparation of durable serum and lyisphe preparations.
The preservation of healing serums and lymphs was previously aimed at by adding phenols or glycerine.
It has now been found that this goal can be achieved by adding small amounts BEFORE acridine dyes,
EMI1.1
The serving or disinfecting power of the acridine dyes is much higher than that of the substances mentioned, the effectiveness of the serums and lymphs is not impaired by them in any way and, in addition, harmful side effects are excluded when using these dyes, as they are non-toxic in contrast to the phenols . As established by extensive research. Acridine dyes are extremely effective as prophylactic wound disinfectants, so their presence in the lymph is of great importance for the prevention of secondary wound infections (vaccine damage).
Example: To produce the smallpox vaccine, the calf raw material is mixed with three to five times the amount of sterilized 1% solution of 3 # 6-diamino-10-methylacridinium chloride (neutral trypaflavin) and processed further in the usual way.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT90273T | 1920-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT90273B true AT90273B (en) | 1922-12-11 |
Family
ID=3610558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90273D AT90273B (en) | 1920-11-02 | 1920-11-02 | Process for the production of long-lasting serum and lymph preparations. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT90273B (en) |
-
1920
- 1920-11-02 AT AT90273D patent/AT90273B/en active
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