ATA107397A - Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons - Google Patents
Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklonsInfo
- Publication number
- ATA107397A ATA107397A AT107397A AT107397A ATA107397A AT A107397 A ATA107397 A AT A107397A AT 107397 A AT107397 A AT 107397A AT 107397 A AT107397 A AT 107397A AT A107397 A ATA107397 A AT A107397A
- Authority
- AT
- Austria
- Prior art keywords
- cell clone
- serum
- protein
- obtaining
- free medium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| US09/100,253 US6100061A (en) | 1997-06-20 | 1998-06-19 | Recombinant cell clone having increased stability in serum- and protein-free medium and a method of recovering the stable cell clone and the production of recombinant proteins by using a stable cell clone |
| US09/324,612 US6475725B1 (en) | 1997-06-20 | 1999-06-02 | Recombinant cell clones having increased stability and methods of making and using the same |
| US10/170,661 US6936441B2 (en) | 1997-06-20 | 2002-06-12 | Recombinant cell clones having increased stability and methods of making and using the same |
| US11/123,362 US7094574B2 (en) | 1997-06-20 | 2005-05-06 | Recombinant cell clones having increased stability and methods of making and using the same |
| US11/482,504 US20070161079A1 (en) | 1997-06-20 | 2006-07-07 | Recombinant cell clones having increased stability and methods of making and using the same |
| US12/488,441 US20090258391A1 (en) | 1997-06-20 | 2009-06-19 | Recombinant cell clones having increased stability and methods of making and using same |
| US12/488,465 US8080414B2 (en) | 1997-06-20 | 2009-06-19 | Recombinant cell clones having increased stability and methods of making and using the same |
| US12/778,776 US8084251B2 (en) | 1997-06-20 | 2010-05-12 | Recombinant cell clones having increased stability and methods of making and using the same |
| US12/848,897 US8084252B2 (en) | 1997-06-20 | 2010-08-02 | Recombinant cell clones having increased stability and methods of making and using the same |
| US12/986,111 US8329465B2 (en) | 1997-06-20 | 2011-01-06 | Recombinant cell clones having increased stability and methods of making and using the same |
| US14/567,942 USRE46745E1 (en) | 1997-06-20 | 2014-12-11 | Recombinant cell clones having increased stability and methods of making and using the same |
| US15/203,558 USRE46860E1 (en) | 1997-06-20 | 2016-07-06 | Recombinant cell clones having increased stability and methods of making and using the same |
| US15/203,550 USRE46897E1 (en) | 1997-06-20 | 2016-07-06 | Recombinant cell clones having increased stability and methods of making and using the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA107397A true ATA107397A (de) | 2000-06-15 |
| AT407255B AT407255B (de) | 2001-02-26 |
Family
ID=3506017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0107397A AT407255B (de) | 1997-06-20 | 1997-06-20 | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US6100061A (de) |
| AT (1) | AT407255B (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| AU4330597A (en) * | 1996-08-30 | 1998-03-19 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
| US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| US6747003B1 (en) * | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| CA2739933A1 (en) * | 2000-02-11 | 2001-08-16 | Bayer Healthcare Llc | Factor vii or viia-like molecules |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7812132B2 (en) * | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| US20040185534A1 (en) * | 2000-10-02 | 2004-09-23 | Knudsen Ida Molgaard | Industrial-scale serum-free production of recombinant proteins in mammalian cells |
| US20040185535A1 (en) * | 2003-03-21 | 2004-09-23 | Giles Wilson | Industrial-scale serum-free production of recombinant FVII in mammalian cells |
| BR0114373A (pt) * | 2000-10-02 | 2004-02-17 | Novo Nordisk As | Célula hospedeira eucariótica, métodos para a produção de fvii e de fviia ou de suas variantes, de uma proteìna dependente de vitamina k e de uma célula hospedeira eucariótica produtora de fvii ou de seu análogo, vetor recombinante, fvii e fviia recombinante ou suas variantes, e, proteìna dependente de vitamina k recombinante |
| US7445924B2 (en) * | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| EP1434857B1 (de) * | 2001-10-02 | 2007-08-01 | Novo Nordisk Health Care AG | Verfahren zur herstelllung rekombinanter proteine in eukaryontischen zellen |
| US6830917B2 (en) | 2001-12-10 | 2004-12-14 | Baxter Healthcare S.A. | Method of isolation and purification of trypsin from pronase protease and use thereof |
| US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| US6825027B2 (en) | 2001-12-10 | 2004-11-30 | Baxter Healthcare S.A. | Method of production of purified hepatitis a virus particles and vaccine preparation |
| WO2003093465A1 (en) * | 2002-04-30 | 2003-11-13 | Maxygen Holdings Ltd. | FACTOR VII OR VIIa POLYPEPTIDE VARIANTS |
| JP3916516B2 (ja) * | 2002-06-10 | 2007-05-16 | 独立行政法人科学技術振興機構 | 硬組織−軟組織界面再生用足場材料 |
| EP2287288B1 (de) | 2002-07-09 | 2012-11-07 | Baxter International Inc. | Tierproteinfreies Zellkulturmedium |
| ES2305514T5 (es) | 2002-09-05 | 2019-06-14 | Bavarian Nordic As | Método para la amplificación de un poxvirus en condiciones exentas de suero |
| CA2840692A1 (en) * | 2002-09-30 | 2004-04-08 | Bayer Healthcare Llc | Fvii or fviia variants having increased clotting activity |
| CU23097A1 (es) * | 2002-10-23 | 2005-11-18 | Centro Inmunologia Molecular | Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método |
| CA2519873C (en) * | 2003-03-20 | 2012-12-18 | Maxygen Holdings Ltd. | Fvii or fviia variants |
| RU2373282C2 (ru) * | 2003-06-19 | 2009-11-20 | Байер Хелткэр Ллк | ВАРИАНТЫ ДОМЕНА GLA ФАКТОРА VII ИЛИ VIIa |
| JP4874806B2 (ja) | 2003-12-01 | 2012-02-15 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 液体因子vii組成物のウイルス濾過 |
| EP1697505A1 (de) * | 2003-12-23 | 2006-09-06 | Schering Corporation | Methoden zur herstellung von a549 zelllinien, die in serumfreiem medium in suspensionskultur stabil sind |
| KR20070008645A (ko) * | 2004-05-04 | 2007-01-17 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 폴리펩티드의 o-연결된 단백당형 및 그들의 제조 방법 |
| KR20070101226A (ko) * | 2004-09-07 | 2007-10-16 | 아케믹스 코포레이션 | 앱타머의 약화학 |
| EP1789096A4 (de) | 2004-09-07 | 2009-07-08 | Archemix Corp | Aptamere für den von-willebrand-faktor und ihre verwendung als therapeutika für thrombotische erkrankungen |
| US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| EP1851305B1 (de) * | 2005-02-11 | 2012-01-18 | Novo Nordisk Health Care AG | Herstellung eines proteins in serumfreier zellkultur, die ein proteinhydrolysat aus pflanzen enthält |
| US20070231895A1 (en) * | 2005-11-02 | 2007-10-04 | Lee Gene W | Methods for adapting mammalian cells |
| ES2474573T3 (es) * | 2006-01-04 | 2014-07-09 | Baxter International Inc | Medio de cultivo celular sin oligop�ptidos |
| EP2423307A1 (de) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modifizierte Gerinnungsfaktor-IV-Polypeptide und deren Verwendung bei der Behandlung |
| CA2683317C (en) * | 2007-04-26 | 2014-12-16 | Bayer Healthcare Llc | Stabilization of liquid solutions of recombinant protein for frozen storage |
| WO2008150495A2 (en) * | 2007-06-01 | 2008-12-11 | Archemix Corp. | Vwf aptamer formulations and methods for use |
| SG187397A1 (en) | 2007-12-27 | 2013-02-28 | Baxter Int | Cell culture processes |
| CA2716801A1 (en) * | 2008-03-12 | 2009-09-17 | Wyeth Llc | Methods for identifying cells suitable for large-scale production of recombinant proteins |
| PT2356247E (pt) | 2008-11-12 | 2015-10-26 | Baxalta Inc | Método de produção de fator vii isento de soro e de insulina |
| CN104962539B (zh) | 2009-07-31 | 2019-09-17 | 百深公司 | 用于adamts蛋白表达的细胞培养基 |
| PL4218797T3 (pl) | 2009-09-21 | 2025-02-10 | Takeda Pharmaceutical Company Limited | Stabilizowane płynne i liofilizowane preparaty adamts13 |
| WO2012006594A1 (en) | 2010-07-08 | 2012-01-12 | Baxter International Inc. | Method of producing recombinant adamts13 in cell culture |
| JP2013535981A (ja) | 2010-08-20 | 2013-09-19 | ワイス・エルエルシー | 成長因子不含適合細胞の細胞培養 |
| US20120076779A1 (en) | 2010-09-17 | 2012-03-29 | Baxter Healthcare S.A. | STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL ph |
| TWI557135B (zh) | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| US9534037B2 (en) | 2011-08-02 | 2017-01-03 | Baxalta GmbH | Systems and methods to increase protein yield from recombinant manufacturing processes |
| HUE056073T2 (hu) | 2013-03-15 | 2022-01-28 | Genzyme Corp | Magas denzitású sejtbanki tárolási eljárások |
| AU2013202965B2 (en) | 2013-03-15 | 2016-07-21 | Takeda Pharmaceutical Company Limited | Improved method for producing factor h from a plasma precipitation fraction |
| US9700486B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| JP6190205B2 (ja) * | 2013-08-08 | 2017-08-30 | 極東製薬工業株式会社 | 無タンパク質・無脂質培地馴化細胞株、その製造方法及び培地 |
| JP6195191B2 (ja) * | 2013-08-08 | 2017-09-13 | 極東製薬工業株式会社 | 無タンパク質・無脂質培地馴化細胞株を用いた組換えタンパク質の製造方法 |
| US20160100570A1 (en) | 2014-09-18 | 2016-04-14 | Genzyme Corporation | Ultra-high density cell banking methods |
| US20230203469A1 (en) | 2020-04-02 | 2023-06-29 | Takeda Pharmaceutical Company Limited | Adamts13 variant, compositions, and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4978616A (en) * | 1985-02-28 | 1990-12-18 | Verax Corporation | Fluidized cell cultivation process |
| EP0531562A1 (de) * | 1991-09-11 | 1993-03-17 | Doerr, Hans-Wilhelm, Prof. Dr. med. | Kultivierung von Säugetierzellen |
| CA2205015C (en) * | 1994-11-10 | 2003-04-08 | Otfried Kistner | Method for producing biologicals in protein-free culture |
| WO1996026266A1 (en) * | 1995-02-23 | 1996-08-29 | Quest International B.V. | Peptides for tissue and cell culture media |
| AUPN442295A0 (en) * | 1995-07-26 | 1995-08-17 | Commonwealth Scientific And Industrial Research Organisation | Regulated autocrine growth of mammalian cells |
-
1997
- 1997-06-20 AT AT0107397A patent/AT407255B/de not_active IP Right Cessation
-
1998
- 1998-06-19 US US09/100,253 patent/US6100061A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AT407255B (de) | 2001-02-26 |
| US6100061A (en) | 2000-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK07 | Expiry |
Effective date: 20170620 |