ATA147080A - Verfahren zur herstellung von 1-mercaptoacylderivaten von oxo-prolin und ihren salzen mit basen - Google Patents

Verfahren zur herstellung von 1-mercaptoacylderivaten von oxo-prolin und ihren salzen mit basen

Info

Publication number
ATA147080A
ATA147080A AT0147080A AT147080A ATA147080A AT A147080 A ATA147080 A AT A147080A AT 0147080 A AT0147080 A AT 0147080A AT 147080 A AT147080 A AT 147080A AT A147080 A ATA147080 A AT A147080A
Authority
AT
Austria
Prior art keywords
prolin
oxo
bases
salts
producing
Prior art date
Application number
AT0147080A
Other languages
English (en)
Other versions
AT371436B (de
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Priority claimed from BE0/199891A external-priority patent/BE882366A/fr
Publication of ATA147080A publication Critical patent/ATA147080A/de
Application granted granted Critical
Publication of AT371436B publication Critical patent/AT371436B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT0147080A 1980-03-21 1980-03-18 Verfahren zur herstellung von neuen 1-mercaptoacyl-derivaten von oxo-prolin und ihren salzen mit basen AT371436B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE0/199891A BE882366A (fr) 1980-03-21 1980-03-21 Derives mercaptoacyles de la proline et de l'acide pipecolique a fonction cetonique, leur preparation et leur utilisation

Publications (2)

Publication Number Publication Date
ATA147080A true ATA147080A (de) 1982-11-15
AT371436B AT371436B (de) 1983-06-27

Family

ID=3843313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0147080A AT371436B (de) 1980-03-21 1980-03-18 Verfahren zur herstellung von neuen 1-mercaptoacyl-derivaten von oxo-prolin und ihren salzen mit basen

Country Status (9)

Country Link
JP (1) JPS56133261A (de)
AT (1) AT371436B (de)
CH (1) CH645619A5 (de)
DE (1) DE3009684A1 (de)
FR (1) FR2478632A1 (de)
GB (1) GB2070586A (de)
NL (1) NL8001599A (de)
PT (1) PT70988A (de)
SE (1) SE431331B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1258853A (en) * 1982-04-30 1989-08-29 Rudiger D. Haugwitz Substituted 4-phenoxy prolines
JP2007262017A (ja) * 2006-03-29 2007-10-11 Ajinomoto Co Inc ピペコリン酸含有抗糖尿病組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
JPS55147257A (en) * 1979-05-04 1980-11-17 Ono Pharmaceut Co Ltd Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component

Also Published As

Publication number Publication date
NL8001599A (nl) 1981-10-16
JPH0140827B2 (de) 1989-08-31
SE8001620L (sv) 1981-08-30
SE431331B (sv) 1984-01-30
JPS56133261A (en) 1981-10-19
DE3009684A1 (de) 1981-09-24
FR2478632B1 (de) 1983-08-26
CH645619A5 (en) 1984-10-15
FR2478632A1 (fr) 1981-09-25
AT371436B (de) 1983-06-27
PT70988A (en) 1980-09-16
GB2070586A (en) 1981-09-09

Similar Documents

Publication Publication Date Title
AT371815B (de) Verfahren zur herstellung von 7-hydroxycumarinderivaten und ihren salzen
AT381934B (de) Verfahren zur herstellung von neuen indolderivaten und ihren salzen
AT375639B (de) Verfahren zur herstellung von neuen carbazolyl-(4)-oxy-propanolamin-derivaten und ihren salzen
DD129651A5 (de) Verfahren zur herstellung von carboxyalkylacylaminosaeuren und ihren salzen mit basen
AT372087B (de) Verfahren zur herstellung von pyrimidonen und ihren salzen
ATA143781A (de) Verfahren zur herstellung von neuen diaminopyridinen und ihren salzen
AT358597B (de) Verfahren zur herstellung von neuen dihydro- uracilen und ihren salzen
AT377974B (de) Verfahren zur herstellung von neuen aromatischen carbonsaeuren und ihren salzen
ATA487977A (de) Verfahren zur herstellung von neuen thieno- pyridinderivaten und ihren salzen
AT370407B (de) Verfahren zur herstellung von neuen 9-aminoalkyfluorenen und ihren salzen
AT363619B (de) Verfahren zur herstellung von 2,6-diaminonebularinen und ihren salzen
AT359486B (de) Verfahren zur herstellung von neuen thiophen- derivaten und ihren salzen
AT359060B (de) Verfahren zur herstellung von neuen benz-acyl- benzimidazol-2-derivaten und ihren salzen
AT363948B (de) Verfahren zur herstellung von neuen heterocyclopyrimidinen und ihren salzen
AT374468B (de) Verfahren zur herstellung von neuen substituierten chinazolinen und ihren salzen
AT374470B (de) Verfahren zur herstellung von neuen piperazinderivaten und ihren salzen
AT371436B (de) Verfahren zur herstellung von neuen 1-mercaptoacyl-derivaten von oxo-prolin und ihren salzen mit basen
AT387016B (de) Verfahren zur herstellung von basischen oximaethern und ihren salzen
AT379377B (de) Verfahren zur herstellung von hydroxyaminderivaten und ihren salzen
AT382866B (de) Verfahren zur herstellung von benzylalkoholderivaten und ihren salzen
AT355015B (de) Verfahren zur herstellung von imidazolderivaten und ihren salzen
AT373256B (de) Verfahren zur herstellung von neuen benzocycloheptapyridinen und ihren salzen
AT364377B (de) Verfahren zur herstellung von neuen n-mercaptoalkanoyl-4-aminocarbonyloxyprolinen und ihren salzen
ATA246081A (de) Verfahren zur herstellung von phenylaethanolaminen und ihren salzen
ATA55081A (de) Verfahren zur herstellung von 3-amino-beta-lactam-1-sulfonsaeuren und ihren salzen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties