ATA191078A - Verfahren zur herstellung von neuen n-substi- tuierten derivaten der 4,6-di(aminoglycosyl)-1, 3-diaminocyclitole sisomicin, verdamicin, tobramycin, der kanamycine, der gentamicine a, b, b, b1, c1, c1a, c2, c2a, c2b, x2, der anti- biotika g-418, 66-40 b, 66-40 d, ji-20 a, ji-20 a, ji-20 b und g-52 sowie deren 5-epi-, 5-epi-amino-5-desoxy- und 5-epiazido-5-desoxy- derivaten und der mutamicine 1,2,4,5 und 6 - Google Patents

Verfahren zur herstellung von neuen n-substi- tuierten derivaten der 4,6-di(aminoglycosyl)-1, 3-diaminocyclitole sisomicin, verdamicin, tobramycin, der kanamycine, der gentamicine a, b, b, b1, c1, c1a, c2, c2a, c2b, x2, der anti- biotika g-418, 66-40 b, 66-40 d, ji-20 a, ji-20 a, ji-20 b und g-52 sowie deren 5-epi-, 5-epi-amino-5-desoxy- und 5-epiazido-5-desoxy- derivaten und der mutamicine 1,2,4,5 und 6

Info

Publication number: ATA191078A
Authority: AT; Austria
Prior art keywords: epi; deoxy; derivatives; mutamicins; epiazido
Prior art date: 1977-03-19

Application number

AT191078A

Other languages

English (en)

Other versions

AT356816B (de

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-19

Filing date

1978-03-17

Publication date

1979-10-15

1978-03-17 Application filed by Bayer Ag filed Critical Bayer Ag

1979-10-15 Publication of ATA191078A publication Critical patent/ATA191078A/de

1980-05-27 Application granted granted Critical

1980-05-27 Publication of AT356816B publication Critical patent/AT356816B/de

Links

YQGZDAPJXRYYLX-UHFFFAOYSA-N 2-[4,6-diamino-3-[3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(C(O)C(O)C(CN)O2)N)C(N)CC1N YQGZDAPJXRYYLX-UHFFFAOYSA-N 0.000 title 2
XUSXOPRDIDWMFO-CTMSJIKGSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-[(1s)-1-aminoethyl]-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(O2)[C@H](C)N)N)[C@@H](N)C[C@H]1N XUSXOPRDIDWMFO-CTMSJIKGSA-N 0.000 title 1
229930182566 Gentamicin Natural products 0.000 title 1
URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 title 1
229930192786 Sisomicin Natural products 0.000 title 1
XUSXOPRDIDWMFO-UHFFFAOYSA-N Verdamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(O2)C(C)N)N)C(N)CC1N XUSXOPRDIDWMFO-UHFFFAOYSA-N 0.000 title 1
239000003242 anti bacterial agent Substances 0.000 title 1
229940088710 antibiotic agent Drugs 0.000 title 1
CEAZRRDELHUEMR-UHFFFAOYSA-N gentamicin Chemical compound O1C(C(C)NC)CCC(N)C1OC1C(O)C(OC2C(C(NC)C(C)(O)CO2)O)C(N)CC1N CEAZRRDELHUEMR-UHFFFAOYSA-N 0.000 title 1
229960005456 sisomicin Drugs 0.000 title 1
URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 title 1
229960000707 tobramycin Drugs 0.000 title 1
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Fodder In General (AREA)

AT191078A 1977-03-19 1978-03-17 Verfahren zur herstellung von neuen n-substi- tuierten derivaten der 4,6-di(aminoglycosyl)-1, 3-diaminocyclitole sisomicin, verdamicin, tobramycin, der kanamycine, der gentamicine a, b, b1, c1, c1a, c2, c2a, c2b, x2, der anti- biotika g-418, 66-40 b, 66-40 d, ji-20 a, ji-2- b und g-52 sowie deren 5-epi-, 5-epi-amino-5-desoxy- und 5-epiazido-5-desoxy- derivaten und der mutamicine 1,2,4,5 und 6 AT356816B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19772712160 DE2712160A1 (de)	1977-03-19	1977-03-19	Pseudotrisaccharide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
ATA191078A true ATA191078A (de)	1979-10-15
AT356816B AT356816B (de)	1980-05-27

Family

ID=6004119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT191078A AT356816B (de)	1977-03-19	1978-03-17	Verfahren zur herstellung von neuen n-substi- tuierten derivaten der 4,6-di(aminoglycosyl)-1, 3-diaminocyclitole sisomicin, verdamicin, tobramycin, der kanamycine, der gentamicine a, b, b1, c1, c1a, c2, c2a, c2b, x2, der anti- biotika g-418, 66-40 b, 66-40 d, ji-20 a, ji-2- b und g-52 sowie deren 5-epi-, 5-epi-amino-5-desoxy- und 5-epiazido-5-desoxy- derivaten und der mutamicine 1,2,4,5 und 6

Country Status (11)

Country	Link
US (1)	US4199572A (de)
JP (1)	JPS53116349A (de)
AT (1)	AT356816B (de)
AU (1)	AU3426378A (de)
BE (1)	BE865015A (de)
DE (1)	DE2712160A1 (de)
ES (1)	ES467964A1 (de)
FR (1)	FR2383963A1 (de)
GB (1)	GB1584138A (de)
IT (1)	IT7821336A0 (de)
NL (1)	NL7802892A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4282350A (en) *	1977-08-05	1981-08-04	Schering Corporation	Selective 3"-N-acylation of 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols
JPS5461151A (en) *	1977-10-25	1979-05-17	Shionogi & Co Ltd	Novel aminoglycoside derivative
DE2832268A1 (de) *	1978-07-22	1980-01-31	Bayer Ag	Pseudotrisaccharide
DE2936120A1 (de) *	1978-09-14	1980-03-27	Sandoz Ag	Neue aminoglykoside, deren herstellung und deren verwendung als antimikrobielle mittel
DE2924659A1 (de) *	1979-06-19	1981-01-22	Bayer Ag	Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel
US4493831A (en) *	1982-10-25	1985-01-15	Fujisawa Pharmaceutical Co., Ltd.	Aminoglycoside derivatives
ZA867785B (en) *	1985-10-15	1988-05-25	Schering Corp	Process for preparing netilmicin
US5268168A (en) *	1990-02-19	1993-12-07	Sakai Engineering Co., Ltd.	Antibacterial and deodorant processing agent and processing method using same
JP2717894B2 (ja) *	1990-10-11	1998-02-25	富士写真フイルム株式会社	ハロゲン化銀写真感光材料
JP2811268B2 (ja) *	1992-10-16	1998-10-15	富士写真フイルム株式会社	ハロゲン化銀カラー写真感光材料用の安定液、リンス液及びそれを用いた処理方法
RU2180559C1 (ru) *	2001-04-18	2002-03-20	Федеральное государственное учреждение Всероссийский научно-исследовательский институт защиты животных	Препарат для лечения мастита у животных
RU2180558C1 (ru) *	2001-04-18	2002-03-20	Федеральное государственное учреждение Всероссийский научно-исследовательский институт защиты животных	Препарат для лечения мастита у животных
RU2352326C1 (ru) *	2007-09-03	2009-04-20	Государственное научное учреждение Краснодарский научно-исследовательский ветеринарный институт Российской академии сельскохозяйственных наук	Средство для лечения мастита у коров
CN101868472B (zh)	2007-11-21	2013-05-29	尔察祯有限公司	抗菌性氨基糖苷类似物
WO2010132768A1 (en)	2009-05-15	2010-11-18	Achaogen, Inc.	Antibacterial derivatives of sisomicin
WO2010132757A2 (en)	2009-05-15	2010-11-18	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010132765A2 (en)	2009-05-15	2010-11-18	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010132760A1 (en)	2009-05-15	2010-11-18	Achaogen, Inc.	Antibacterial derivatives of tobramycin
WO2010132759A1 (en)	2009-05-15	2010-11-18	Achaogen, Inc.	Antibacterial derivatives of dibekacin
US9238670B2 (en) *	2013-03-15	2016-01-19	The Board Of Trustees Of The Leland Stanford Junior University	Aminoglycoside antibiotics with reduced ototoxicity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3920628A (en) *	1972-10-24	1975-11-18	Schering Corp	2{41 -Deoxyaminoglycosides and 2{41 -epi-amino-3{41 -desamino derivatives thereof, methods for their manufacture and novel intermediates useful therein
LU70223A1 (de) *	1973-06-05	1976-04-13
US4002742A (en) *	1974-03-19	1977-01-11	Schering Corporation	1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor
US4062947A (en) *	1975-11-04	1977-12-13	Schering Corporation	Di-N-alkylaminoglycosides, methods for their manufacture and novel intermediates useful therein, method for their use as antibacterial agents and pharmaceutical compositions useful therefor
US4002608A (en) *	1975-11-04	1977-01-11	Schering Corporation	1-N-alkyl-aminoglycoside-XK-88 derivatives and methods for their manufacture
US4085208A (en) *	1976-06-21	1978-04-18	Schering Corporation	Process for preparing 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 1-epimers and 1-N-alkyl derivatives produced thereby; methods for the use of the 1-epimer derivatives as antibacterial agents and compositions useful therefor

1977
- 1977-03-19 DE DE19772712160 patent/DE2712160A1/de not_active Withdrawn
1978
- 1978-02-24 US US05/881,263 patent/US4199572A/en not_active Expired - Lifetime
- 1978-03-14 GB GB10043/78A patent/GB1584138A/en not_active Expired
- 1978-03-16 NL NL7802892A patent/NL7802892A/xx not_active Application Discontinuation
- 1978-03-17 IT IT7821336A patent/IT7821336A0/it unknown
- 1978-03-17 JP JP3001278A patent/JPS53116349A/ja active Pending
- 1978-03-17 AU AU34263/78A patent/AU3426378A/en active Pending
- 1978-03-17 AT AT191078A patent/AT356816B/de not_active IP Right Cessation
- 1978-03-17 BE BE186028A patent/BE865015A/xx unknown
- 1978-03-17 FR FR7807791A patent/FR2383963A1/fr active Granted
- 1978-03-17 ES ES467964A patent/ES467964A1/es not_active Expired

Also Published As

Publication number	Publication date
AT356816B (de)	1980-05-27
AU3426378A (en)	1979-09-20
FR2383963A1 (fr)	1978-10-13
DE2712160A1 (de)	1978-09-28
FR2383963B1 (de)	1980-06-13
NL7802892A (nl)	1978-09-21
GB1584138A (en)	1981-02-04
IT7821336A0 (it)	1978-03-17
US4199572A (en)	1980-04-22
ES467964A1 (es)	1978-11-16
BE865015A (fr)	1978-09-18
JPS53116349A (en)	1978-10-11

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Legal Events

Date	Code	Title	Description
1983-07-15	ELJ	Ceased due to non-payment of the annual fee