ATA202886A - Verfahren zur herstellung eines kristallinen dimethylformamidsolvats der 7-((d)-2-amino2-(4-hydroxyphenyl)-acetamido)-3-((z)-1propenyl)-ceph-3-em-4-carbons|ure - Google Patents

Verfahren zur herstellung eines kristallinen dimethylformamidsolvats der 7-((d)-2-amino2-(4-hydroxyphenyl)-acetamido)-3-((z)-1propenyl)-ceph-3-em-4-carbons|ure

Info

Publication number
ATA202886A
ATA202886A AT0202886A AT202886A ATA202886A AT A202886 A ATA202886 A AT A202886A AT 0202886 A AT0202886 A AT 0202886A AT 202886 A AT202886 A AT 202886A AT A202886 A ATA202886 A AT A202886A
Authority
AT
Austria
Prior art keywords
1propenyl
amino2
ceph
acetamido
ure
Prior art date
Application number
AT0202886A
Other languages
English (en)
Other versions
AT389876B (de
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ATA202886A publication Critical patent/ATA202886A/de
Application granted granted Critical
Publication of AT389876B publication Critical patent/AT389876B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT0202886A 1985-07-29 1986-07-28 Verfahren zur herstellung eines kristallinen dimethylformamidsolvats der 7-((d)-2-amino2-(4-hydroxyphenyl)-acetamido)-3-((z)-1propenyl)-ceph-3-em-4-carbons|ure AT389876B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/759,805 US4694079A (en) 1985-07-29 1985-07-29 3-propenyl cephalosporin solvates

Publications (2)

Publication Number Publication Date
ATA202886A true ATA202886A (de) 1989-07-15
AT389876B AT389876B (de) 1990-02-12

Family

ID=25057020

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0202886A AT389876B (de) 1985-07-29 1986-07-28 Verfahren zur herstellung eines kristallinen dimethylformamidsolvats der 7-((d)-2-amino2-(4-hydroxyphenyl)-acetamido)-3-((z)-1propenyl)-ceph-3-em-4-carbons|ure

Country Status (17)

Country Link
US (1) US4694079A (de)
KR (1) KR930004014B1 (de)
CN (1) CN1015263B (de)
AR (1) AR243530A1 (de)
AT (1) AT389876B (de)
CA (1) CA1262345A (de)
CS (1) CS258143B2 (de)
DD (1) DD248594A5 (de)
EG (1) EG18112A (de)
ES (1) ES2001338A6 (de)
FI (1) FI84269C (de)
GR (1) GR861988B (de)
HU (1) HU195224B (de)
NO (1) NO167461C (de)
PT (1) PT83074B (de)
SU (1) SU1414317A3 (de)
YU (1) YU45350B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128336A (en) * 1988-03-23 1992-07-07 Eli Lilly And Company 3-(substituted)-1-carba(dethia)-3-cephems
DK0630380T3 (da) * 1992-02-05 2001-12-10 Biochemie Gmbh Fremgangsmåde til rensning af et 3-cephem-4-carboxylsyrederivat
AT399876B (de) * 1992-02-05 1995-08-25 Biochemie Gmbh Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
PT102061B (pt) * 1997-10-08 2000-06-30 J K Ind Ltd Processo de preparacao de um antibiotico cefalosporina geralmente activo-cefixime
WO2001023393A1 (en) * 1999-09-30 2001-04-05 Otsuka Kagaku Kabushiki Kaisha 3-cephem derivative crystal and method for preparing the same
KR100408430B1 (ko) * 2001-04-18 2003-12-06 한미약품 주식회사 3-(ｚ)-프로페닐 세펨 화합물의 선택적인 제조 방법
US6903211B2 (en) * 2002-10-30 2005-06-07 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of 3-propenyl cephalosporin DMF solvate
US7230097B2 (en) * 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
WO2004110399A2 (en) * 2003-06-19 2004-12-23 Ranbaxy Laboratories Limited Solvates of cefprozil
KR100576336B1 (ko) * 2003-10-30 2006-05-03 씨제이 주식회사 세팔로스포린 유도체의 제조방법
US20070072945A1 (en) * 2004-03-31 2007-03-29 Pohoreski Anton Sulphur-containing oils for controlling plant pathogens and stimulating nutrient uptake
ES2338335T3 (es) 2004-11-01 2010-05-06 Hetero Drugs Limited Nuevo procedimiento de preparacion de intermedio cefprozilo.
CN101058584B (zh) * 2007-05-23 2010-05-26 上海骏捷生化科技有限公司 一种制备头孢丙烯母核7-氨基-3-丙烯基头孢烷酸的方法
CN103524533B (zh) * 2013-10-10 2016-01-27 珠海金鸿药业股份有限公司 一种头孢丙烯化合物、其分散片、干混悬剂及制备方法
CN108017658B (zh) * 2017-12-26 2020-06-16 山东裕欣药业有限公司 一种头孢丙烯的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985741A (en) * 1972-09-15 1976-10-12 Bristol-Myers Company Production of p-hydroxycephalexin
EP0113568B1 (de) * 1982-12-27 1990-04-04 Eli Lilly And Company Zwischenverbindungen für die Herstellung von Ceftazidin und Verfahren zu ihrer Herstellung
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins

Also Published As

Publication number Publication date
PT83074A (en) 1986-08-01
GR861988B (en) 1986-12-22
CN86105568A (zh) 1987-04-01
KR930004014B1 (ko) 1993-05-19
YU131086A (en) 1987-10-31
HUT41799A (en) 1987-05-28
YU45350B (en) 1992-05-28
AR243530A1 (es) 1993-08-31
NO862970L (no) 1987-01-30
NO167461C (no) 1991-11-06
DD248594A5 (de) 1987-08-12
NO862970D0 (no) 1986-07-24
SU1414317A3 (ru) 1988-07-30
FI84269B (fi) 1991-07-31
CS258143B2 (en) 1988-07-15
NO167461B (no) 1991-07-29
ES2001338A6 (es) 1988-05-16
PT83074B (pt) 1989-06-30
FI863066A0 (fi) 1986-07-25
CS561386A2 (en) 1987-09-17
EG18112A (en) 1992-08-30
CA1262345A (en) 1989-10-17
AT389876B (de) 1990-02-12
CN1015263B (zh) 1992-01-01
KR870001216A (ko) 1987-03-12
FI863066L (fi) 1987-01-30
US4694079A (en) 1987-09-15
FI84269C (fi) 1991-11-11
HU195224B (en) 1988-04-28

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Legal Events

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ELA Expired due to lapse of time