ATA23983A - METHOD FOR PRODUCING NEW SUBSTITUTED N-ARYL UREAS - Google Patents

METHOD FOR PRODUCING NEW SUBSTITUTED N-ARYL UREAS

Info

Publication number
ATA23983A
ATA23983A AT0023983A AT23983A ATA23983A AT A23983 A ATA23983 A AT A23983A AT 0023983 A AT0023983 A AT 0023983A AT 23983 A AT23983 A AT 23983A AT A23983 A ATA23983 A AT A23983A
Authority
AT
Austria
Prior art keywords
producing new
new substituted
aryl ureas
ureas
aryl
Prior art date
Application number
AT0023983A
Other languages
German (de)
Other versions
AT391313B (en
Inventor
Vern Gordon Devries
Elwood Eugene Largis
Ransom Brown Conrow
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ATA23983A publication Critical patent/ATA23983A/en
Application granted granted Critical
Publication of AT391313B publication Critical patent/AT391313B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
AT0023983A 1982-01-26 1983-01-25 METHOD FOR PRODUCING NEW SUBSTITUTED N-ARYL UREAS AT391313B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas

Publications (2)

Publication Number Publication Date
ATA23983A true ATA23983A (en) 1990-03-15
AT391313B AT391313B (en) 1990-09-25

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0023983A AT391313B (en) 1982-01-26 1983-01-25 METHOD FOR PRODUCING NEW SUBSTITUTED N-ARYL UREAS

Country Status (20)

Country Link
KR (1) KR890001808B1 (en)
AT (1) AT391313B (en)
AU (1) AU562699B2 (en)
CH (1) CH654571A5 (en)
DE (1) DE3247581A1 (en)
DK (1) DK160869C (en)
ES (2) ES519246A0 (en)
FI (1) FI85013C (en)
FR (1) FR2521134B1 (en)
GB (1) GB2113684B (en)
GR (1) GR77186B (en)
HU (1) HU200746B (en)
IE (1) IE54683B1 (en)
IL (1) IL67417A (en)
IT (1) IT1203647B (en)
NL (1) NL8300269A (en)
NO (1) NO158417C (en)
PL (1) PL143836B1 (en)
PT (1) PT76138A (en)
SE (1) SE462653B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
DE68911203T2 (en) * 1988-03-30 1994-04-14 Warner Lambert Co N - [[(2,6-disubstituted) phenyl] N'-arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents.
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
WO1991011994A1 (en) * 1990-02-14 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
HUT67475A (en) * 1992-07-20 1995-04-28 Eisai Co Ltd Benzene derivatives and pharmaceutical compositions containing them as active components
JP2003524574A (en) * 1997-08-05 2003-08-19 ノボ ノルディスク アクティーゼルスカブ 2,5- and 3,5-disubstituted aniline derivatives, their preparation and use
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
JP2001501979A (en) * 1998-01-21 2001-02-13 ザイモジェネティクス，インコーポレイティド Dialkyl ureas as mimetics of calcitonin.
AU2008275595B2 (en) * 2007-07-10 2013-11-14 Amgen Inc. Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL212631A (en) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (en) * 1979-07-14 1981-01-29 Bayer Ag USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS

Also Published As

Publication number Publication date
IL67417A (en) 1989-10-31
DK28683D0 (en) 1983-01-25
DK160869C (en) 1991-10-14
GB2113684A (en) 1983-08-10
ES8505943A1 (en) 1985-07-01
NL8300269A (en) 1983-08-16
SE8300370L (en) 1983-07-27
ES8406422A1 (en) 1984-08-01
FI830247A0 (en) 1983-01-25
SE8300370D0 (en) 1983-01-25
FR2521134B1 (en) 1987-01-09
FI85013C (en) 1992-02-25
ES531508A0 (en) 1985-07-01
HU200746B (en) 1990-08-28
IE830146L (en) 1983-07-26
SE462653B (en) 1990-08-06
PL240284A1 (en) 1985-01-02
FR2521134A1 (en) 1983-08-12
IT1203647B (en) 1989-02-15
AT391313B (en) 1990-09-25
GR77186B (en) 1984-09-11
NO158417B (en) 1988-05-30
NO158417C (en) 1988-09-07
DK160869B (en) 1991-04-29
FI830247L (en) 1983-07-27
AU1068183A (en) 1983-08-04
FI85013B (en) 1991-11-15
NO830238L (en) 1983-07-27
AU562699B2 (en) 1987-06-18
PL143836B1 (en) 1988-03-31
DK28683A (en) 1983-07-27
IE54683B1 (en) 1990-01-03
ES519246A0 (en) 1984-08-01
CH654571A5 (en) 1986-02-28
DE3247581A1 (en) 1983-08-04
IT8347605A0 (en) 1983-01-25
KR840002773A (en) 1984-07-16
GB8301863D0 (en) 1983-02-23
GB2113684B (en) 1985-12-18
PT76138A (en) 1983-02-01
KR890001808B1 (en) 1989-05-23

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
ELJ Ceased due to non-payment of the annual fee