ATA269187A - Neue tricyclische lactame - Google Patents

Neue tricyclische lactame

Info

Publication number
ATA269187A
ATA269187A AT0269187A AT269187A ATA269187A AT A269187 A ATA269187 A AT A269187A AT 0269187 A AT0269187 A AT 0269187A AT 269187 A AT269187 A AT 269187A AT A269187 A ATA269187 A AT A269187A
Authority
AT
Austria
Prior art keywords
lactame
new tricyclic
tricyclic
new
tricyclic lactame
Prior art date
Application number
AT0269187A
Other languages
English (en)
Other versions
AT398425B (de
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA000539111A priority Critical patent/CA1337654C/en
Priority to ZA874107A priority patent/ZA874107B/xx
Priority to AR87307816A priority patent/AR247213A1/es
Priority to AU74022/87A priority patent/AU601433B2/en
Priority to EP87108410A priority patent/EP0249223B1/de
Priority to KR1019870005908A priority patent/KR950014572B1/ko
Priority to IE154787A priority patent/IE61476B1/en
Priority to ES87108410T priority patent/ES2044870T3/es
Priority to DK300487A priority patent/DK170840B1/da
Priority to JP62145419A priority patent/JP2542213B2/ja
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Priority to AT0269187A priority patent/AT398425B/de
Priority to US07/352,675 priority patent/US4973585A/en
Priority to GR930400057T priority patent/GR3006802T3/el
Publication of ATA269187A publication Critical patent/ATA269187A/de
Application granted granted Critical
Publication of AT398425B publication Critical patent/AT398425B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
AT0269187A 1986-06-13 1987-10-12 Neue tricyclische lactame AT398425B (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA000539111A CA1337654C (en) 1986-06-13 1987-06-08 Fused tricyclic lactams as antihypertensive agents
ZA874107A ZA874107B (de) 1986-06-13 1987-06-08
AR87307816A AR247213A1 (es) 1986-06-13 1987-06-09 Preparacion de acido 7-¡(1-carboxi-3-fenilpropil)amino¿-3,4,6,7,8,12b-octahidro-6-oxopirido ¡2,1-a¿ o hexahidro-6-oxo-1h(1,4-tiazino¡3,4-a¿¡2¿-benzazepin-4-carboxilico, agentes hipertensivos.
AU74022/87A AU601433B2 (en) 1986-06-13 1987-06-09 Novel antihypertensive agent
KR1019870005908A KR950014572B1 (ko) 1986-06-13 1987-06-11 융합된 트리사이클릭 락탐 및 이의 제조방법
IE154787A IE61476B1 (en) 1986-06-13 1987-06-11 Novel antihypertensive agent
EP87108410A EP0249223B1 (de) 1986-06-13 1987-06-11 Antihypertensives Mittel
ES87108410T ES2044870T3 (es) 1986-06-13 1987-06-11 Un procedimiento para la preparacion de nuevos agentes antihipertensivos.
DK300487A DK170840B1 (da) 1986-06-13 1987-06-12 Tricycliske lactamer indeholdende en benzazepingruppe, lægemiddel indeholdende sådanne lactamer samt anvendelse deraf til fremstilling af et lægemiddel til behandling af hypertension
JP62145419A JP2542213B2 (ja) 1986-06-13 1987-06-12 抗高血圧剤として有用な新規化合物とその製法
AT0269187A AT398425B (de) 1986-06-13 1987-10-12 Neue tricyclische lactame
US07/352,675 US4973585A (en) 1986-06-13 1989-05-10 Tricyclic lactams active as antihypertensive agents
GR930400057T GR3006802T3 (de) 1986-06-13 1993-01-14

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87375486A 1986-06-13 1986-06-13
AT0269187A AT398425B (de) 1986-06-13 1987-10-12 Neue tricyclische lactame

Publications (2)

Publication Number Publication Date
ATA269187A true ATA269187A (de) 1994-04-15
AT398425B AT398425B (de) 1994-12-27

Family

ID=25598925

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0269187A AT398425B (de) 1986-06-13 1987-10-12 Neue tricyclische lactame

Country Status (12)

Country Link
EP (1) EP0249223B1 (de)
JP (1) JP2542213B2 (de)
KR (1) KR950014572B1 (de)
AR (1) AR247213A1 (de)
AT (1) AT398425B (de)
AU (1) AU601433B2 (de)
CA (1) CA1337654C (de)
DK (1) DK170840B1 (de)
ES (1) ES2044870T3 (de)
GR (1) GR3006802T3 (de)
IE (1) IE61476B1 (de)
ZA (1) ZA874107B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DK0492369T3 (da) * 1990-12-21 1997-10-13 Merrell Pharma Inc Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
ATE155143T1 (de) * 1991-09-27 1997-07-15 Merrell Pharma Inc 2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
ATE182892T1 (de) * 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
PT669936E (pt) * 1992-10-30 2001-04-30 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
NZ275939A (en) * 1993-11-19 1997-04-24 Merrell Pharma Inc Preparation of (s)-1-[2(s)-(1,3-dihydro-1,3-dioxoisoindol-2-yl)-1-oxo-3-phenylpropyl ]-1,2,3,4-tetrahydropyridine-2-carboxylic acid methyl ester
JP3596778B2 (ja) * 1994-02-14 2004-12-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類
JP3561753B2 (ja) * 1994-02-14 2004-09-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類
PT750631E (pt) * 1994-02-14 2000-07-31 Merrell Pharma Inc Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
CA2183313C (en) * 1994-02-14 2001-01-02 Gary A. Flynn Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
ATE246927T1 (de) * 1994-03-24 2003-08-15 Merrell Pharma Inc Cholesterin senkende mercaptoacetylamiddisulfidderivate
PT751783E (pt) * 1994-03-24 2000-05-31 Merrell Pharma Inc Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
CN1241924C (zh) * 1994-12-21 2006-02-15 阿温蒂斯药物公司 制备脑啡肽酶与血管紧张素转化酶抑制剂中间体的新方法及其中间体
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
EP0166357A3 (de) * 1984-06-26 1988-10-26 Merck & Co. Inc. Kondensierte Benzo-Laktame und deren pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
AU7402287A (en) 1987-12-17
EP0249223A2 (de) 1987-12-16
CA1337654C (en) 1995-11-28
AR247213A1 (es) 1994-11-30
IE871547L (en) 1987-12-13
AU601433B2 (en) 1990-09-13
DK300487A (da) 1987-12-14
GR3006802T3 (de) 1993-06-30
JP2542213B2 (ja) 1996-10-09
KR880000399A (ko) 1988-03-25
AT398425B (de) 1994-12-27
EP0249223A3 (en) 1989-01-25
EP0249223B1 (de) 1992-10-14
IE61476B1 (en) 1994-11-02
ZA874107B (de) 1987-12-09
DK300487D0 (da) 1987-06-12
ES2044870T3 (es) 1994-01-16
KR950014572B1 (ko) 1995-12-08
JPS62298591A (ja) 1987-12-25
DK170840B1 (da) 1996-02-05

Similar Documents

Publication Publication Date Title
DK624887A (da) Tricycliske ketoner
BR8702474A (pt) Conjunto de sobre-tampa
DK628087D0 (da) Diazepinderivater
PT85102A (de) Neue komplexverbindungen
DK662687A (da) Anvendelse af tricycliske carbazoloner
DK10087D0 (da) Praeparat
DK244488D0 (da) Efterskummende praeparat
DK255787D0 (da) Praeparat
DK477287D0 (da) Tricycliske forbindelser
BR8703802A (pt) Conjunto seccionador
DK8188D0 (da) Veterinaert praeparat
IS1456B6 (is) Þríhringja ketónar
FR2604609B3 (fr) Bavoir
DK30788A (da) Co-vaccinationspraeparat
ATA103088A (de) Neue chinolinthioaether
BR8704164A (pt) Grupo pistao-biela de tipo aperfeicoado
ATA313787A (de) Neue prostacycline
KR880004244U (ko) 다색 배턴
SE8603131D0 (sv) Tricyclic compounds
KR880009302U (ko) 간이 의자의 골조
PT83101B (de) Neue cycloaliphatische ketoamine
BR8603397A (pt) Multicor
ATA313887A (de) Neue prostacycline
SE8600796D0 (sv) Sesambeslaget
ATA265587A (de) Neue 9-deazaguanine

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee