ATA388376A - Verfahren zur herstellung einer neuen kristallinen form von flunisolid - Google Patents

Verfahren zur herstellung einer neuen kristallinen form von flunisolid

Info

Publication number: ATA388376A
Authority: AT; Austria
Prior art keywords: benzenesulphonamides; salts; novel; preparation; novel benzenesulphonamides
Prior art date: 1975-05-27

Application number

AT388376A

Other languages

English (en)

Other versions

AT357702B (de

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-05-27

Filing date

1976-05-26

Publication date

1979-12-15

1976-05-26 Application filed by Syntex Inc filed Critical Syntex Inc

1979-12-15 Publication of ATA388376A publication Critical patent/ATA388376A/de

1980-07-25 Application granted granted Critical

1980-07-25 Publication of AT357702B publication Critical patent/AT357702B/de

Links

KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

AT388376A 1975-05-27 1976-05-26 Verfahren zur herstellung einer neuen kristallinen form von flunisolid AT357702B (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58130075A	1975-05-27	1975-05-27
US58130175A	1975-05-27	1975-05-27

Publications (2)

Publication Number	Publication Date
ATA388376A true ATA388376A (de)	1979-12-15
AT357702B AT357702B (de)	1980-07-25

Family

ID=27078279

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT388376A AT357702B (de)	1975-05-27	1976-05-26	Verfahren zur herstellung einer neuen kristallinen form von flunisolid

Country Status (15)

Country	Link
JP (1)	JPS51144719A (de)
AT (1)	AT357702B (de)
AU (1)	AU506080B2 (de)
CA (1)	CA1075228A (de)
DE (2)	DE2661037C2 (de)
ES (1)	ES448220A1 (de)
FR (1)	FR2361900A1 (de)
GB (1)	GB1525181A (de)
HK (1)	HK8580A (de)
IL (1)	IL49652A (de)
MX (1)	MX3864E (de)
MY (1)	MY8000275A (de)
NL (1)	NL191234C (de)
NZ (1)	NZ180946A (de)
SE (1)	SE421426B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ193778A (en) *	1979-05-21	1982-03-16	Syntex Corp	Preparing a crystalline form of flunisolide
ATE3774T1 (de) *	1980-05-02	1983-06-15	Schering Corporation	Beclomethason-ester-solvate, verfahren zu ihrer herstellung und herstellung einer formulierung.
GB2127689B (en) *	1982-10-05	1986-07-09	Sandoz Ltd	Calcitonin inhalation compositions
US4782047A (en) *	1986-05-22	1988-11-01	Syntex Pharmaceuticals International Ltd.	Aqueous steroid formulations for nasal administration
US5707634A (en) *	1988-10-05	1998-01-13	Pharmacia & Upjohn Company	Finely divided solid crystalline powders via precipitation into an anti-solvent
EP0437451B1 (de) *	1988-10-05	1993-06-09	The Upjohn Company	Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel
DE4003272A1 (de)	1990-02-03	1991-08-08	Boehringer Ingelheim Kg	Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
IL122752A (en) *	1995-06-27	2001-07-24	Boehringer Ingelheim Kg	Stable preparations for creating propellant-free sprays
DE19653969A1 (de) *	1996-12-20	1998-06-25	Boehringer Ingelheim Kg	Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
US20010031244A1 (en)	1997-06-13	2001-10-18	Chiesi Farmaceutici S.P.A.	Pharmaceutical aerosol composition
DZ2947A1 (fr)	1998-11-25	2004-03-15	Chiesi Farma Spa	Inhalateur à compteur de dose sous pression.
US6715485B1 (en) *	1999-03-03	2004-04-06	Optinose As	Nasal delivery device
IT1313553B1 (it) *	1999-07-23	2002-09-09	Chiesi Farma Spa	Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317846B1 (it)	2000-02-22	2003-07-15	Chiesi Farma Spa	Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
AU5070100A (en)	2000-05-22	2001-12-03	Chiesi Farma Spa	Stable pharmaceutical solution formulations for pressurised metered dose inhalers
EP1273292B1 (de)	2001-07-02	2004-05-26	CHIESI FARMACEUTICI S.p.A.	Optimierte Tobramycin-Formulierung zur Aerosolbildung
JP4632687B2 (ja) *	2003-04-25	2011-02-16	ロート製薬株式会社	点鼻剤
JP5238779B2 (ja) *	2003-04-25	2013-07-17	ロート製薬株式会社	点鼻剤
EP1595531A1 (de)	2004-05-13	2005-11-16	CHIESI FARMACEUTICI S.p.A.	Stabile Arzneimittellösung für Druckdosierinhalatoren
CN105188758A (zh) *	2013-03-15	2015-12-23	梅迪奇斯医药公司	氟尼缩松的局部组合物及治疗方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3126375A (en)		1964-03-24		Chioacyl
GB933868A (en) *	1958-12-08	1963-08-14	American Cyanamid Co	Process for fluorinating steroids
US3282791A (en)	1965-08-17	1966-11-01	Merck & Co Inc	Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) *	1968-07-19	1971-07-13	Syntex Corp	Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
FR2038105A1 (fr) *	1969-04-01	1971-01-08	Syntex Corp	Composition anti-inflammatoire locale et son mode d'utilisation
GB1429184A (en) *	1972-04-20	1976-03-24	Allen & Hanburys Ltd	Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (de)	1973-06-23	1986-07-31	Schering AG, 1000 Berlin und 4709 Bergkamen	Verwendung von Kortikoid-Wirkstoffen zur Inhalationstherapie
US3934013A (en)	1975-02-21	1976-01-20	Syntex (U.S.A.) Inc.	Pharmaceutical composition

1976
- 1976-05-14 MX MX76234U patent/MX3864E/es unknown
- 1976-05-25 SE SE7605927A patent/SE421426B/xx not_active IP Right Cessation
- 1976-05-25 IL IL49652A patent/IL49652A/xx unknown
- 1976-05-25 ES ES448220A patent/ES448220A1/es not_active Expired
- 1976-05-25 CA CA253,267A patent/CA1075228A/en not_active Expired
- 1976-05-25 NZ NZ180946A patent/NZ180946A/xx unknown
- 1976-05-26 AU AU14301/76A patent/AU506080B2/en not_active Expired
- 1976-05-26 JP JP51061032A patent/JPS51144719A/ja active Granted
- 1976-05-26 NL NL7605699A patent/NL191234C/xx not_active IP Right Cessation
- 1976-05-26 GB GB21936/76A patent/GB1525181A/en not_active Expired
- 1976-05-26 AT AT388376A patent/AT357702B/de not_active IP Right Cessation
- 1976-05-26 FR FR7616040A patent/FR2361900A1/fr active Granted
- 1976-06-03 DE DE2661037A patent/DE2661037C2/de not_active Expired
- 1976-06-03 DE DE2624924A patent/DE2624924C2/de not_active Expired
1980
- 1980-03-06 HK HK85/80A patent/HK8580A/xx unknown
- 1980-12-30 MY MY275/80A patent/MY8000275A/xx unknown

Also Published As

Publication number	Publication date
NZ180946A (en)	1978-07-28
DE2661037C2 (de)	1989-04-06
DE2624924A1 (de)	1977-12-15
JPS51144719A (en)	1976-12-13
HK8580A (en)	1980-03-14
NL191234C (nl)	1995-04-03
MX3864E (es)	1981-08-26
FR2361900A1 (fr)	1978-03-17
NL7605699A (nl)	1976-11-30
JPS6247880B2 (de)	1987-10-09
NL191234B (nl)	1994-11-01
SE421426B (sv)	1981-12-21
DE2624924C2 (de)	1986-11-27
CA1075228A (en)	1980-04-08
ES448220A1 (es)	1977-11-01
IL49652A (en)	1979-05-31
AU506080B2 (en)	1979-12-13
AU1430176A (en)	1977-12-01
FR2361900B1 (de)	1979-04-13
AT357702B (de)	1980-07-25
SE7605927L (sv)	1976-11-28
IL49652A0 (en)	1976-07-30
MY8000275A (en)	1980-12-31
GB1525181A (en)	1978-09-20

Legal Events

Date	Code	Title	Description
1990-08-15	ELJ	Ceased due to non-payment of the annual fee
1998-10-15	ELA	Expired due to lapse of time

Publication	Publication Date	Title
GB1547802A (en)	1979-06-27	Process for the preparation of poly-phenyleneterephthalamide
PT65486B (en)	1978-03-24	Process for the preparation of carbonil-substituted 1-sulfonylbenzimidazoles
GB1517423A (en)	1978-07-12	Process for the preparation of diaryl-carbonates
ATA388376A (de)	1979-12-15	Verfahren zur herstellung einer neuen kristallinen form von flunisolid
IL50503A (en)	1980-12-31	Substituted 2-aminopyrimidin-4-ones and pyrimidine-4-thiones and process for their preparation
GR60835B (en)	1978-08-31	Preparation process of delta15-steroids
GB1539403A (en)	1979-01-31	Process for the preparation of polyamines
GR60435B (en)	1978-05-26	Preparation process of acylamino-derivatives
PT64878B (en)	1977-07-22	Process for the preparation of new indolylalkylpiperidines
PT65910A (en)	1976-12-01	Process for the preparation of asymmetrical bis-carbamoyl
PT65255B (en)	1977-12-06	Process for the preparation of 11-desoxy-16-aryloxy-w-tetranorprostaglandins
YU39275B (en)	1984-10-31	Process for the preparation of propargyl-2-phenylamino-imidazolines-(2)
CH608786A5 (en)	1979-01-31	Process for the preparation of acetoacetylarylamides
GB1534077A (en)	1978-11-29	Process for the preparation of 5-acetoacetylamino-benzimidazolone
GR60849B (en)	1978-08-31	Preparation process of l-pyroglutamyl-l-prolinamide
GB1552658A (en)	1979-09-19	Process for the preparation of s substituted phosphorodichloridothiolates
GB1554310A (en)	1979-10-17	Process for the preparation of 5-oxo-hexanoic acid and derivatives thereof
GB1520330A (en)	1978-08-09	Process for the preparation of phospholene-1-oxides or su-lphides
PT65624A (en)	1976-10-01	Process of preparation of 4-hydroxymethyl-2-pyrrolidinone
PT65120A (en)	1976-06-01	Process for the preparation of novel diureide derivatives
ZA763221B (en)	1977-05-25	Process for the preparation of 3-bromobenzalidehyde
PT65821A (en)	1976-12-01	Process for the preparation of novel d-homosteroids
GR59793B (en)	1978-02-28	Preparation process of n-alkenyl-2-aminomethyl-pyrrolidines
PT65357B (en)	1978-01-09	Process for the preparation of gamma-pyrones
PT65176B (en)	1977-11-18	Process for the preparation of 6-aminomethylated 3-oxygenated cholest-5-enes