ATA427975A - Verfahren zur herstellung von neuen 8-thiomethylergolinen - Google Patents

Verfahren zur herstellung von neuen 8-thiomethylergolinen

Info

Publication number
ATA427975A
ATA427975A AT427975A AT427975A ATA427975A AT A427975 A ATA427975 A AT A427975A AT 427975 A AT427975 A AT 427975A AT 427975 A AT427975 A AT 427975A AT A427975 A ATA427975 A AT A427975A
Authority
AT
Austria
Prior art keywords
thiomethyler
golines
manufacturing new
manufacturing
new
Prior art date
Application number
AT427975A
Other languages
English (en)
Other versions
AT344333B (de
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ATA427975A publication Critical patent/ATA427975A/de
Application granted granted Critical
Publication of AT344333B publication Critical patent/AT344333B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT427975A 1974-06-06 1975-06-05 Verfahren zur herstellung von neuen 8-thiomethylergolinen AT344333B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US477136A US3901894A (en) 1974-06-06 1974-06-06 8-thiomethylergolines

Publications (2)

Publication Number Publication Date
ATA427975A true ATA427975A (de) 1977-11-15
AT344333B AT344333B (de) 1978-07-10

Family

ID=23894677

Family Applications (1)

Application Number Title Priority Date Filing Date
AT427975A AT344333B (de) 1974-06-06 1975-06-05 Verfahren zur herstellung von neuen 8-thiomethylergolinen

Country Status (27)

Country Link
US (1) US3901894A (de)
JP (1) JPS582946B2 (de)
AR (1) AR210736A1 (de)
AT (1) AT344333B (de)
AU (1) AU507574B2 (de)
BE (1) BE829887A (de)
BG (1) BG24812A3 (de)
CA (1) CA1071623A (de)
CH (1) CH617196A5 (de)
CS (1) CS199591B2 (de)
DD (1) DD120438A5 (de)
DE (1) DE2524575A1 (de)
DK (1) DK144160C (de)
ES (1) ES438313A1 (de)
FR (1) FR2273542A1 (de)
GB (1) GB1505296A (de)
HU (1) HU173590B (de)
IE (1) IE41474B1 (de)
IL (1) IL47424A (de)
NL (1) NL180911C (de)
PH (1) PH10992A (de)
PL (1) PL95738B1 (de)
RO (1) RO77543A (de)
SE (1) SE420095B (de)
SU (1) SU613724A3 (de)
YU (1) YU145575A (de)
ZA (1) ZA753638B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147789A (en) * 1974-03-14 1979-04-03 Sandoz Ltd. 6-Methyl-8-thiomethyl-ergolene derivatives
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
JPS5283894A (en) * 1976-01-01 1977-07-13 Lilly Co Eli 88thiomethyl ergoline
GB1549829A (en) * 1976-05-26 1979-08-08 Farmaceutici Italia 10'-methoxy-1',6'-dimethylergoline-8'-beta-methyl-amino(or thio)-pyrazines
IT1192260B (it) * 1977-07-05 1988-03-31 Simes Derivati di ergoline-2-tioeteri e loro solfossidi
US4180582A (en) * 1978-02-08 1979-12-25 Eli Lilly And Company 6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4202979A (en) * 1979-01-11 1980-05-13 Eli Lilly And Company 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
FR2526797A1 (fr) * 1982-05-12 1983-11-18 Roussel Uclaf Nouveaux derives de l'acide 9-oxalysergique, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
CH649998A5 (de) * 1982-08-09 1985-06-28 Sandoz Ag Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff.
GB8427536D0 (en) * 1984-10-31 1984-12-05 Lilly Industries Ltd Ergoline derivatives
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
FR2589734B1 (fr) * 1985-11-13 1988-09-02 Roussel Uclaf Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
CN101481405A (zh) * 2001-06-08 2009-07-15 研究及应用科学协会股份有限公司 生长激素释放抑制因子-多巴胺嵌合类似物
WO2003078432A2 (en) * 2002-03-15 2003-09-25 Antibioticos S.P.A. Process for the synthesis of pergolide
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
CN104768565B (zh) 2012-11-01 2017-04-26 益普生制药股份有限公司 促生长素抑制素类似物及其二聚体
DK3197429T3 (da) 2014-09-25 2024-08-26 Boehringer Ingelheim Vetmedica Gmbh Kombinationsbehandling med sglt2-hæmmere og dopaminagonister til forebyggelse af metaboliske lidelser af dyr i hestefamilien
US20190374534A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507248A (de) * 1967-03-16 1971-05-15 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von D-6-Methylergolin(I)ylessigsäure
DE1935556A1 (de) * 1969-07-12 1971-01-21 Hoechst Ag Verfahren zur Herstellung von Lysergol
JPS5012398A (de) * 1973-06-08 1975-02-07

Also Published As

Publication number Publication date
IL47424A (en) 1979-11-30
DK144160B (da) 1981-12-28
DK144160C (da) 1982-06-07
IL47424A0 (en) 1975-08-31
DK249975A (da) 1975-12-07
ZA753638B (en) 1977-01-26
RO77543A (ro) 1982-02-26
SE420095B (sv) 1981-09-14
AT344333B (de) 1978-07-10
BG24812A3 (en) 1978-05-12
JPS50160300A (de) 1975-12-25
BE829887A (fr) 1975-12-05
ES438313A1 (es) 1977-05-16
AU507574B2 (en) 1980-02-21
SU613724A3 (ru) 1978-06-30
US3901894A (en) 1975-08-26
CA1071623A (en) 1980-02-12
CS199591B2 (en) 1980-07-31
FR2273542B1 (de) 1978-10-06
JPS582946B2 (ja) 1983-01-19
PH10992A (en) 1977-10-20
AR210736A1 (es) 1977-09-15
SE7506327L (sv) 1975-12-08
CH617196A5 (de) 1980-05-14
DE2524575A1 (de) 1975-12-18
NL180911C (nl) 1987-05-18
GB1505296A (en) 1978-03-30
NL7506584A (nl) 1975-12-09
DD120438A5 (de) 1976-06-12
AU8182775A (en) 1976-12-09
FR2273542A1 (fr) 1976-01-02
IE41474L (en) 1975-12-06
HU173590B (hu) 1979-06-28
IE41474B1 (en) 1980-01-16
YU145575A (en) 1982-02-28
NL180911B (nl) 1986-12-16
PL95738B1 (pl) 1977-11-30

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee