ATA500478A - Verfahren zur herstellung von neuen derivaten des daunorubicins - Google Patents

Verfahren zur herstellung von neuen derivaten des daunorubicins

Info

Publication number: ATA500478A
Authority: AT; Austria
Prior art keywords: derivs; daunorubicin; low toxicity; phosphoryl; oxy
Prior art date: 1977-07-11

Application number

AT500478A

Other languages

English (en)

Other versions

AT359191B (de

Original Assignee

Rhone Poulenc Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-07-11

Filing date

1978-07-11

Publication date

1980-03-15

1978-07-11 Application filed by Rhone Poulenc Ind filed Critical Rhone Poulenc Ind

1980-03-15 Publication of ATA500478A publication Critical patent/ATA500478A/de

1980-10-27 Application granted granted Critical

1980-10-27 Publication of AT359191B publication Critical patent/AT359191B/de

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
229960000975 daunorubicin Drugs 0.000 title abstract 2
231100000053 low toxicity Toxicity 0.000 title abstract 2
KQRWYZDETCDVGB-TZSSRYMLSA-N (7s,9s)-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-9-(2-bromoacetyl)-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CBr)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 KQRWYZDETCDVGB-TZSSRYMLSA-N 0.000 abstract 2
PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
239000004254 Ammonium phosphate Substances 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910000148 ammonium phosphate Inorganic materials 0.000 abstract 1
235000019289 ammonium phosphates Nutrition 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT500478A 1977-07-11 1978-07-11 Verfahren zur herstellung von neuen derivaten des daunorubicins AT359191B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7721272A FR2397425A1 (fr)	1977-07-11	1977-07-11	Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent

Publications (2)

Publication Number	Publication Date
ATA500478A true ATA500478A (de)	1980-03-15
AT359191B AT359191B (de)	1980-10-27

Family

ID=9193210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT500478A AT359191B (de)	1977-07-11	1978-07-11	Verfahren zur herstellung von neuen derivaten des daunorubicins

Country Status (11)

Country	Link
US (1)	US4185111A (de)
JP (1)	JPS5419959A (de)
AT (1)	AT359191B (de)
AU (1)	AU3791178A (de)
BE (1)	BE868888A (de)
DE (1)	DE2830488A1 (de)
FR (1)	FR2397425A1 (de)
GB (1)	GB2001987A (de)
IT (1)	IT1096695B (de)
NL (1)	NL7807215A (de)
ZA (1)	ZA783939B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8519452D0 (en) *	1985-08-02	1985-09-11	Erba Farmitalia	Injectable solutions
US5212291A (en) *	1986-10-23	1993-05-18	American Cyanamid Company	Anthracycline derivatives as solubilized pro-drugs
US5716990A (en) *	1987-03-09	1998-02-10	Cancer Research Campaign Technology Limited	Drug delivery systems
NZ225599A (en)	1987-08-04	1991-09-25	Bristol Myers Co	Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
US4904768A (en) *	1987-08-04	1990-02-27	Bristol-Myers Company	Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4975278A (en) *	1988-02-26	1990-12-04	Bristol-Myers Company	Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5632990A (en) *	1988-04-22	1997-05-27	Cancer Research Campaign Tech. Ltd.	Treatment for tumors comprising conjugated antibody A5B7 and a prodrug
US4874779A (en) *	1988-06-29	1989-10-17	Bristol-Myers Company	Mitomycin phosphate derivatives
EP3336093B1 (de) *	2015-08-10	2023-11-01	Stella Chemifa Corporation	Phosphorsäurediestersalz, herstellungsverfahren dafür, wasserfreier elektrolyt für ein energiespeicherelement sowie energiespeicherelement

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4012448A (en) *	1976-01-15	1977-03-15	Stanford Research Institute	Synthesis of adriamycin and 7,9-epiadriamycin

1977
- 1977-07-11 FR FR7721272A patent/FR2397425A1/fr active Granted
1978
- 1978-07-03 NL NL7807215A patent/NL7807215A/xx not_active Application Discontinuation
- 1978-07-10 ZA ZA00783939A patent/ZA783939B/xx unknown
- 1978-07-10 JP JP8312378A patent/JPS5419959A/ja active Pending
- 1978-07-10 GB GB7829342A patent/GB2001987A/en active Pending
- 1978-07-10 AU AU37911/78A patent/AU3791178A/en active Pending
- 1978-07-10 US US05/923,448 patent/US4185111A/en not_active Expired - Lifetime
- 1978-07-10 BE BE189197A patent/BE868888A/xx unknown
- 1978-07-11 DE DE19782830488 patent/DE2830488A1/de not_active Withdrawn
- 1978-07-11 AT AT500478A patent/AT359191B/de not_active IP Right Cessation
- 1978-07-11 IT IT25559/78A patent/IT1096695B/it active

Also Published As

Publication number	Publication date
DE2830488A1 (de)	1979-01-25
IT1096695B (it)	1985-08-26
NL7807215A (nl)	1979-01-15
IT7825559A0 (it)	1978-07-11
FR2397425A1 (fr)	1979-02-09
ZA783939B (en)	1979-07-25
JPS5419959A (en)	1979-02-15
AU3791178A (en)	1980-01-17
US4185111A (en)	1980-01-22
GB2001987A (en)	1979-02-14
AT359191B (de)	1980-10-27
FR2397425B1 (de)	1980-02-01
BE868888A (fr)	1979-01-10

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Legal Events

Date	Code	Title	Description
1981-12-15	ELJ	Ceased due to non-payment of the annual fee