ATA505579A - Verfahren zur herstellung von neuen a-alkylimidazolderivaten und deren salzen - Google Patents

Verfahren zur herstellung von neuen a-alkylimidazolderivaten und deren salzen

Info

Publication number: ATA505579A
Authority: AT; Austria
Prior art keywords: alkyl; anticonvulsants; phenyl; aroyl; aryl
Prior art date: 1978-07-26

Application number

AT0505579A

Other languages

English (en)

Other versions

AT374188B (de

Original Assignee

Recordati Chem Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-07-26

Filing date

1979-07-23

Publication date

1983-08-15

1979-07-23 Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm

1983-08-15 Publication of ATA505579A publication Critical patent/ATA505579A/de

1984-03-26 Application granted granted Critical

1984-03-26 Publication of AT374188B publication Critical patent/AT374188B/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 8
-1 aryl-hydroxyalkyl imidazole Chemical compound 0.000 title abstract 5
229940125681 anticonvulsant agent Drugs 0.000 title abstract 3
239000001961 anticonvulsive agent Substances 0.000 title abstract 3
231100000053 low toxicity Toxicity 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
101100386311 Arabidopsis thaliana DAPB3 gene Proteins 0.000 abstract 1
101150076189 CRR1 gene Proteins 0.000 abstract 1
241000699670 Mus sp. Species 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04F—FINISHING WORK ON BUILDINGS, e.g. STAIRS, FLOORS
- E04F11/00—Stairways, ramps, or like structures; Balustrades; Handrails
- E04F11/18—Balustrades; Handrails
- E04F11/181—Balustrades
- E04F11/1851—Filling panels, e.g. concrete, sheet metal panels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Architecture (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Civil Engineering (AREA)
Structural Engineering (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT0505579A 1978-07-26 1979-07-23 Verfahren zur herstellung von neuen a-alkylimidazolderivaten und deren salzen AT374188B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT26094/78A IT1097314B (it)	1978-07-26	1978-07-26	Derivati dell'imidazolo ad attivita' anticonvulsivante

Publications (2)

Publication Number	Publication Date
ATA505579A true ATA505579A (de)	1983-08-15
AT374188B AT374188B (de)	1984-03-26

Family

ID=11218623

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0505579A AT374188B (de)	1978-07-26	1979-07-23	Verfahren zur herstellung von neuen a-alkylimidazolderivaten und deren salzen

Country Status (29)

Country	Link
US (1)	US4275071A (de)
JP (1)	JPS6036426B2 (de)
AR (1)	AR221734A1 (de)
AT (1)	AT374188B (de)
AU (1)	AU528564B2 (de)
CA (1)	CA1116611A (de)
CH (1)	CH640837A5 (de)
DD (1)	DD144408A5 (de)
DE (1)	DE2929777A1 (de)
DK (1)	DK303079A (de)
EG (1)	EG14301A (de)
ES (1)	ES482782A1 (de)
FI (1)	FI73668C (de)
FR (1)	FR2434154A1 (de)
GB (1)	GB2030563B (de)
GR (1)	GR69643B (de)
HU (1)	HU184669B (de)
IE (1)	IE48368B1 (de)
IL (1)	IL57849A (de)
IT (1)	IT1097314B (de)
NL (1)	NL7905630A (de)
NO (1)	NO155490C (de)
NZ (1)	NZ191044A (de)
PH (1)	PH19846A (de)
PT (1)	PT69928A (de)
SE (1)	SE445640B (de)
SU (1)	SU865125A3 (de)
YU (1)	YU177879A (de)
ZA (1)	ZA793808B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE339165B (de) *	1969-04-22	1971-09-27	Calor & Sjoegren Ab
US4277486A (en) *	1979-03-09	1981-07-07	Syntex (U.S.A.) Inc.	1-[(Substituted-naphthyl)ethyl]-imidazole derivatives
US4293561A (en) *	1979-03-09	1981-10-06	Syntex (U.S.A.) Inc.	1-(Naphthyl-n-propyl)imidazole derivatives
GB2069481B (en) *	1980-02-13	1983-07-27	Farmos Oy	Substituted imidazole derivatives
CA1156661A (en) *	1980-02-25	1983-11-08	Hoffmann-La Roche Limited	Phenoxy-aminopropanol derivatives
EP0158741A3 (de) *	1980-11-19	1986-02-12	Imperial Chemical Industries Plc	Zwischenprodukte für fungizide Triazol- und Imidazolverbindungen
DE3121676A1 (de) *	1981-06-01	1982-12-16	Hoechst Ag, 6000 Frankfurt	"1,1-diaryl-2-azolyl-aethane, ihre herstellung, ihre verwendung und diese verbindungen enthaltende praeparationen"
DE3307218A1 (de) *	1983-03-02	1984-09-06	Bayer Ag, 5090 Leverkusen	Substituierte diazolylalkyl-carbinole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
US4590063A (en) *	1983-06-24	1986-05-20	Adria Laboratories, Inc.	Anticonvulsants
US4540814A (en) *	1983-06-24	1985-09-10	Adria Laboratories, Inc.	1,4-Dimethoxy naphthalenecarboxamide anticonvulsants
US4581370A (en) *	1983-07-12	1986-04-08	Schering A.G.	Antiarrhythmic imidazoliums
US4533670A (en) *	1983-09-21	1985-08-06	Eli Lilly And Company	Anti-convulsant fluorenylalkylimidazole derivatives, compositions, and method of use
DE3501370A1 (de) *	1985-01-17	1986-07-17	Bayer Ag, 5090 Leverkusen	1-aryl-2,2-dialkyl-2-(1,2,4-triazol-1-yl)-ethanole
JPS62103068A (ja) *	1985-09-23	1987-05-13	ヘキスト・アクチエンゲゼルシヤフト	アリ−ルメチルアゾ−ルおよびそれらの塩ならびにそれらの製法
ZW10287A1 (en) *	1986-07-15	1988-01-13	Hoffmann La Roche	Tetrahydronaphthaline and indane derivatives
US4859691A (en) *	1987-07-08	1989-08-22	Ciba-Geigy Corporation	Certain 1,2-benzisoxazole derivatives
US4957931A (en) *	1987-07-08	1990-09-18	Ciba-Geigy Corporation	Certain 1,2-benzisoxazole and 1,2-benzisothiazole derivatives
JPH03115267A (ja) *	1989-09-28	1991-05-16	Maruho Kk	プロピオフエノン誘導体、その製造方法、それを含む中枢性筋弛緩剤および抗痙攣剤
GB9409882D0 (en) *	1994-05-18	1994-07-06	Sandoz Ltd	Organic compounds
CA2512201A1 (en) *	2003-01-08	2005-02-17	3M Innovative Properties Company	Ceramic fiber composite and method for making the same
AU2011246088B2 (en) *	2010-04-27	2014-09-04	Nippon Paper Industries Co., Ltd.	Cell differentiation promoter and use of same
JP5912946B2 (ja) *	2012-01-11	2016-04-27	株式会社Adeka	感光性樹脂組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3050520A (en) *	1960-03-31	1962-08-21	Air Prod & Chem	Process of preparing 2-olefinic imidazoles
GB1321701A (en) *	1969-10-01	1973-06-27	Continental Pharma	Amino-alcohols their salts and process for prepairing the same
US4104383A (en) *	1973-11-02	1978-08-01	C M Industries	Derivatives of phenylpropenylamine
IE40911B1 (en) *	1974-04-11	1979-09-12	Schering Ag	Imidazole derivatives and process for their manufacture
US3927017A (en) *	1974-06-27	1975-12-16	Janssen Pharmaceutica Nv	1-({62 -Aryl-{62 -R-ethyl)imidazoles
IL48319A0 (en) *	1974-10-26	1975-12-31	Merck Patent Gmbh	Araliphatic nitrogen compounds and a process for their preparation
US4105762A (en) *	1975-02-05	1978-08-08	Rohm And Haas Company	Metal salt complexes of 1-substituted aralkyl imidazoles, and methods and compositions for controlling phytopathogenic fungi using them
US4085209A (en) *	1975-02-05	1978-04-18	Rohm And Haas Company	Preparation and safening effect of 1-substituted imidazole metal salt complexes
GB1569267A (en) *	1975-12-16	1980-06-11	Ici Ltd	Substituted propiophenones and herbicidal and fungicidal compositions containing them
US4067989A (en) *	1976-05-07	1978-01-10	Imperial Chemical Industries Limited	1,3-Diazole heterocyclic compounds and their use as pesticides
DE2628420A1 (de) *	1976-06-24	1978-01-05	Bayer Ag	1-acyloxy-2-imidazolyl-1-phenyl- aethane, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide und nematizide
DE2628421A1 (de) *	1976-06-24	1978-01-05	Bayer Ag	Antimikrobielle mittel
US4150153A (en) *	1977-05-13	1979-04-17	Syntex (U.S.A.) Inc.	1-(Naphthylethyl)imidazole derivatives
DE2750031A1 (de) *	1977-11-09	1979-05-10	Basf Ag	Insektizide mittel
US4159380A (en) *	1978-07-10	1979-06-26	E. R. Squibb & Sons, Inc.	Imidazolylethoxy derivatives of pyrazolo[3,4-b]pyridine-5-methanols

1978
- 1978-07-26 IT IT26094/78A patent/IT1097314B/it active
1979
- 1979-02-07 GB GB7904269A patent/GB2030563B/en not_active Expired
- 1979-06-25 SU SU792790705A patent/SU865125A3/ru active
- 1979-07-10 US US06/056,290 patent/US4275071A/en not_active Expired - Lifetime
- 1979-07-16 HU HU79RE652A patent/HU184669B/hu unknown
- 1979-07-17 PT PT69928A patent/PT69928A/pt unknown
- 1979-07-17 AR AR277345A patent/AR221734A1/es active
- 1979-07-18 NZ NZ191044A patent/NZ191044A/xx unknown
- 1979-07-19 FR FR7918736A patent/FR2434154A1/fr active Granted
- 1979-07-19 AU AU49067/79A patent/AU528564B2/en not_active Ceased
- 1979-07-19 DK DK303079A patent/DK303079A/da not_active Application Discontinuation
- 1979-07-19 NL NL7905630A patent/NL7905630A/nl not_active Application Discontinuation
- 1979-07-20 IL IL57849A patent/IL57849A/xx unknown
- 1979-07-20 NO NO792404A patent/NO155490C/no unknown
- 1979-07-20 GR GR59660A patent/GR69643B/el unknown
- 1979-07-20 YU YU01778/79A patent/YU177879A/xx unknown
- 1979-07-20 CA CA000332278A patent/CA1116611A/en not_active Expired
- 1979-07-21 EG EG434/79A patent/EG14301A/xx active
- 1979-07-23 AT AT0505579A patent/AT374188B/de not_active IP Right Cessation
- 1979-07-23 DE DE19792929777 patent/DE2929777A1/de active Granted
- 1979-07-23 FI FI792302A patent/FI73668C/fi not_active IP Right Cessation
- 1979-07-23 DD DD79214544A patent/DD144408A5/de unknown
- 1979-07-23 JP JP54094177A patent/JPS6036426B2/ja not_active Expired
- 1979-07-24 ES ES482782A patent/ES482782A1/es not_active Expired
- 1979-07-24 PH PH22808A patent/PH19846A/en unknown
- 1979-07-25 SE SE7906357A patent/SE445640B/sv not_active IP Right Cessation
- 1979-07-25 CH CH689579A patent/CH640837A5/fr not_active IP Right Cessation
- 1979-07-25 ZA ZA00793808A patent/ZA793808B/xx unknown
- 1979-08-08 IE IE652/79A patent/IE48368B1/en unknown

Also Published As

Publication number	Publication date
JPS5519294A (en)	1980-02-09
EG14301A (en)	1983-09-30
IL57849A0 (en)	1979-11-30
NO155490B (no)	1986-12-29
GB2030563A (en)	1980-04-10
SU865125A3 (ru)	1981-09-15
IT1097314B (it)	1985-08-31
ZA793808B (en)	1980-08-27
NZ191044A (en)	1982-03-23
HU184669B (en)	1984-09-28
AU528564B2 (en)	1983-05-05
AR221734A1 (es)	1981-03-13
GR69643B (de)	1982-07-06
FI73668B (fi)	1987-07-31
FI792302A7 (fi)	1980-01-27
ES482782A1 (es)	1980-04-16
GB2030563B (en)	1982-12-08
CA1116611A (en)	1982-01-19
NO792404L (no)	1980-01-29
DE2929777A1 (de)	1980-02-07
PT69928A (fr)	1979-08-01
JPS6036426B2 (ja)	1985-08-20
NL7905630A (nl)	1980-01-29
NO155490C (no)	1987-04-08
FR2434154A1 (fr)	1980-03-21
FI73668C (fi)	1987-11-09
DE2929777C2 (de)	1988-07-28
AT374188B (de)	1984-03-26
PH19846A (en)	1986-07-22
CH640837A5 (fr)	1984-01-31
SE7906357L (sv)	1980-01-27
DD144408A5 (de)	1980-10-15
US4275071A (en)	1981-06-23
AU4906779A (en)	1980-02-07
IL57849A (en)	1985-10-31
FR2434154B1 (de)	1983-07-22
IE48368B1 (en)	1984-12-26
IE790652L (en)	1980-01-26
DK303079A (da)	1980-01-27
IT7826094A0 (it)	1978-07-26
SE445640B (sv)	1986-07-07
YU177879A (en)	1983-01-21

Legal Events

Date	Code	Title	Description
1989-05-15	ELJ	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
SE7906357L (sv)	1980-01-27	Imidazolderivat samt forfarande for framstellning av dem
AU3350484A (en)	1985-04-04	Pyranyl (or cyclohexyl) methane sulfamates and their use as anticonvulsants
ES2060413T3 (es)	1994-11-16	Compuestos biaromaticos y su utilizacion en medicina humana y veterinaria y en cosmetica.
JPS5681561A (en)	1981-07-03	Anilide derivative* its manufacture and its use
ES452763A1 (es)	1977-10-01	Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta.
NO923081D0 (no)	1992-08-05	Neurobeskyttende 3-piperidino-4-hydroksykromanderivater og analoger derav
GR3003522T3 (de)	1993-03-16
KR870005986A (ko)	1987-07-08	방향족 티오에테르 및 이의 제조방법
DE3879258D1 (de)	1993-04-22	Praeparat gegen ulcus.
IT1246991B (it)	1994-12-12	Composizione per l'igiene orale.
TW363052B (en)	1999-07-01	Anti-arrhythmic fluorine-containing benzoylguanidines, and preparation process and pharmaceutical composition thereof
CA2031892A1 (en)	1991-06-26	Triazole derivatives
ES8404974A1 (es)	1984-06-01	Un procedimiento para la preparacion de eteres alquil-naftilicos.
ES420643A1 (es)	1976-09-01	Procedimiento para la obtencion de sulfuros organicos.
JPS5772970A (en)	1982-05-07	Azolylalkyl derivatives, manufacture and use as fungicide
GB1417723A (en)	1975-12-17	Phosphorus-containing ester derivatives of hydroxytriazoles
IL72669A (en)	1988-12-30	Antimicrobial compositions containing hydroxyalkyl-(and hydroxyalkoxy)benzoic acid derivatives and their use as disinfectants and preservative agents
GB1550772A (en)	1979-08-22	(1-phenyl-2-triazolyl-ethyl)-thioether derivatives and their use as fungicides and plant growth regulators
IE40909B1 (en)	1979-09-12	Terpeno-phenoxyalkylamines
GR3006371T3 (de)	1993-06-21
ES8200880A1 (es)	1981-11-16	Procedimiento para la obtencion de nuevos tioles
IL64128A0 (en)	1982-01-31	Thiolcarbamate compounds and their use as herbicides
EG17841A (en)	1990-08-30	New-benzotriazoles the preparation thereof and their use as fungicides
ES425830A1 (es)	1976-07-01	Procedimiento para la obtencion de derivados aromaticos de la guanidina.
ES2082090T3 (es)	1996-03-16	Azolilmetilespiro-2.5-octanoles y los fungicidas que los contienen.