ATE100098T1 - Nukleoside, ihre herstellung und pharmazeutische zusammenstellungen. - Google Patents

Nukleoside, ihre herstellung und pharmazeutische zusammenstellungen.

Info

Publication number
ATE100098T1
ATE100098T1 AT88109952T AT88109952T ATE100098T1 AT E100098 T1 ATE100098 T1 AT E100098T1 AT 88109952 T AT88109952 T AT 88109952T AT 88109952 T AT88109952 T AT 88109952T AT E100098 T1 ATE100098 T1 AT E100098T1
Authority
AT
Austria
Prior art keywords
nucleosides
preparation
pharmaceutical compositions
infections
dideoxynucleosides
Prior art date
Application number
AT88109952T
Other languages
English (en)
Inventor
Samuel Broder
Hiroaki Mitsuya
Steve Tam
Manfred Weigele
Original Assignee
Hoffmann La Roche
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Us Health filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE100098T1 publication Critical patent/ATE100098T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT88109952T 1987-06-22 1988-06-22 Nukleoside, ihre herstellung und pharmazeutische zusammenstellungen. ATE100098T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/064,631 US4837311A (en) 1987-06-22 1987-06-22 Anti-retroviral compounds
EP88109952A EP0296573B1 (de) 1987-06-22 1988-06-22 Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen

Publications (1)

Publication Number Publication Date
ATE100098T1 true ATE100098T1 (de) 1994-01-15

Family

ID=22057259

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88109952T ATE100098T1 (de) 1987-06-22 1988-06-22 Nukleoside, ihre herstellung und pharmazeutische zusammenstellungen.

Country Status (6)

Country Link
US (1) US4837311A (de)
EP (1) EP0296573B1 (de)
JP (1) JPH02262587A (de)
AT (1) ATE100098T1 (de)
DE (1) DE3887014T2 (de)
DK (1) DK336688A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187163A (en) * 1987-03-27 1993-02-16 Baker Norton Pharmaceuticals, Inc. Anti-viral compounds, dosage forms and methods
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
FR2631964B1 (fr) * 1988-05-31 1990-09-07 Pasteur Institut Glucosyl phosphotriesters de derives de thymidine ayant une activite contre les retrovirus
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5824796A (en) * 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
USRE38416E1 (en) 1988-09-28 2004-02-03 Epoch Biosciences, Inc. Cross-linking oligonucleotides
GR1000618B (el) * 1989-03-17 1992-08-31 Oncogen Μεθοδος αναστολης hiv χρησιμοποιωντας συνεργιστικους συνδυασμους νουκλεοσιδικων παραγωγων.
US5585364A (en) * 1989-04-13 1996-12-17 British Technology Group Limited Antiviral compounds
EP0472648A4 (en) * 1989-05-18 1992-09-16 Microprobe Corporation Crosslinking oligonucleotides
EP0537299A1 (de) * 1990-03-29 1993-04-21 Gilead Sciences, Inc. Disulfidkonjugate von oligonukleotid-transportagenten
US5430138A (en) * 1990-07-27 1995-07-04 Chiron Corporation Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable
US5561225A (en) * 1990-09-19 1996-10-01 Southern Research Institute Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
JPH06510020A (ja) * 1991-03-29 1994-11-10 ユニバーシティ・オブ・フロリダ 混成リン酸エステル誘導体を経た標的への薬剤供給
CA2090026C (en) * 1991-06-21 1995-09-19 Bruno Konrad Radatus Anti-viral compounds and processes for production of anti-viral compounds
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
US5693791A (en) * 1995-04-11 1997-12-02 Truett; William L. Antibiotics and process for preparation
WO1999028308A1 (en) * 1997-11-29 1999-06-10 Truett William L Antibiotics and process for preparation
JP4547911B2 (ja) 2002-02-01 2010-09-22 アリアド・ファーマシューティカルズ・インコーポレイテッド リン含有化合物およびその用途
IL149298A0 (en) * 2002-04-23 2002-11-10 Lycored Natural Prod Ind Ltd Tomato product and method for obtaining same
MXPA05006230A (es) * 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199451B1 (de) * 1985-03-16 1996-03-06 The Wellcome Foundation Limited Therapeutische Nukleoside
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
NZ216172A (en) * 1985-05-15 1989-08-29 Wellcome Found Nucleosides and pharmaceutical compositions
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods

Also Published As

Publication number Publication date
EP0296573A2 (de) 1988-12-28
EP0296573B1 (de) 1994-01-12
JPH02262587A (ja) 1990-10-25
EP0296573A3 (en) 1990-07-04
DE3887014D1 (de) 1994-02-24
US4837311A (en) 1989-06-06
DK336688D0 (da) 1988-06-20
DE3887014T2 (de) 1994-05-19
DK336688A (da) 1988-12-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee