ATE102250T1 - Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion. - Google Patents
Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion.Info
- Publication number
- ATE102250T1 ATE102250T1 AT85105405T AT85105405T ATE102250T1 AT E102250 T1 ATE102250 T1 AT E102250T1 AT 85105405 T AT85105405 T AT 85105405T AT 85105405 T AT85105405 T AT 85105405T AT E102250 T1 ATE102250 T1 AT E102250T1
- Authority
- AT
- Austria
- Prior art keywords
- yeast
- promoter region
- pcl
- deposited
- sub
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60954084A | 1984-05-11 | 1984-05-11 | |
| EP85105405A EP0164556B1 (de) | 1984-05-11 | 1985-05-03 | Erhöhte Hefetranskription unter Verwendung einer Hybridkonstruktion der Promotorregion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE102250T1 true ATE102250T1 (de) | 1994-03-15 |
Family
ID=24441222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85105405T ATE102250T1 (de) | 1984-05-11 | 1985-05-03 | Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion. |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP0480480A3 (de) |
| AT (1) | ATE102250T1 (de) |
| CA (1) | CA1281671C (de) |
| DE (1) | DE3587759T2 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523215A (en) * | 1985-03-28 | 1996-06-04 | Chiron Corporation | Enhanced purification and expression of insoluble recombinant proteins |
| US5342921A (en) * | 1985-03-28 | 1994-08-30 | Chiron Corporation | Superoxide dismutase fusion polypeptides for expression of mammalian proteins |
| EP0225887B1 (de) * | 1985-04-08 | 1994-06-08 | Amgen Inc. | Verfahren und hybridpromotor zur steuerung der exogenen gentranskription |
| GB8521496D0 (en) * | 1985-08-29 | 1985-10-02 | Ciba Geigy Ag | Repressible yeast promoters |
| DE3683821D1 (de) * | 1985-10-03 | 1992-03-19 | Green Cross Corp | Hefepromotor und verfahren zur herstellung eines heterologen proteins. |
| EP0237913A1 (de) * | 1986-03-21 | 1987-09-23 | Miles Inc. | Transkriptions-Effektor-Sequenzen |
| JPS62236496A (ja) * | 1986-04-07 | 1987-10-16 | Green Cross Corp:The | ＨＢｓＡｇの製造方法 |
| CA1310602C (en) * | 1986-06-03 | 1992-11-24 | Hajime Horii | Yeast promoter and process for preparing heterologous protein |
| GB8620926D0 (en) * | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
| ATE121776T1 (de) * | 1986-09-19 | 1995-05-15 | Zymogenetics Inc | Expression des biologisch aktiven faktors xiii. |
| US5013652A (en) * | 1986-10-14 | 1991-05-07 | Genex Corporation | Composite yeast vectors |
| CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| NO177065C (no) * | 1988-09-26 | 1995-07-12 | Labofina Sa | Framgangsmåte for framstilling av enzymatisk aktivt humant lysozym |
| JPH03155791A (ja) * | 1989-11-14 | 1991-07-03 | Green Cross Corp:The | 雑種プロモーター |
| FR2656531B1 (fr) * | 1989-12-29 | 1992-04-24 | Sanofi Sa | Promoteur artificiel pour l'expression de proteines dans le levure. |
| US6194140B1 (en) | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
| JPH04108389A (ja) * | 1990-08-30 | 1992-04-09 | Tonen Corp | 酵母において機能する大腸菌由来上流制御配列 |
| EP0785273A1 (de) | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Gepaarte basische Aminosäuren konvertierendes Enzym und dafür kodierende DNA Sequenz |
| US5407822A (en) * | 1991-10-02 | 1995-04-18 | Sanofi | Artificial promoter for the expression of proteins in yeast |
| LT3988B (en) | 1992-02-17 | 1996-06-25 | Fermentas Biotech Inst | Recombinant plasmides pfs19, pfps2-48 and pjlfds1 codingsynthesis of human hepatite b of surfice virus antigenes, methods fof producing thereof |
| RU2115730C1 (ru) * | 1992-03-03 | 1998-07-20 | Акционерное общество "Биофа" | Рекомбинантная плазмида pfs 19, определяющая синтез поверхностного антигена s вируса гепатита b человека |
| DE69433160T2 (de) | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
| US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| US6329141B1 (en) | 1995-12-22 | 2001-12-11 | Dsm N.V. | Methods for transforming Phaffia strains, transformed Phaffia strains so obtained and recombinant DNA in said methods |
| GB2318732A (en) | 1996-11-01 | 1998-05-06 | Johnson & Johnson Medical | Wound healing compositions containing alpha-1-antitrypsin |
| US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
| EP1900818A3 (de) | 1997-11-06 | 2008-06-11 | Novartis Vaccines and Diagnostics S.r.l. | Neissersche Antigene |
| WO1999036544A2 (en) | 1998-01-14 | 1999-07-22 | Chiron S.P.A. | Neisseria meningitidis antigens |
| US6087128A (en) * | 1998-02-12 | 2000-07-11 | Ndsu Research Foundation | DNA encoding an avian E. coli iss |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| EP2261347A3 (de) | 1998-05-01 | 2012-01-11 | Novartis Vaccines and Diagnostics, Inc. | Antigene und Zusammensetzungen gegen Neisseria meningitidis |
| CA2372235A1 (en) | 1999-04-30 | 2000-11-09 | Rino Rappuoli | Conserved neisserial antigens |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| US6297013B1 (en) * | 1999-06-24 | 2001-10-02 | Dnab Diagnostics Inc. | Compositions and methods for determining the activity of DNA-binding proteins and of initiation of transcription |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| EP1226253A2 (de) | 1999-10-29 | 2002-07-31 | Chiron S.P.A. | Antigene peptide aus neisseria |
| US6709863B2 (en) | 1999-12-08 | 2004-03-23 | Iowa State University Research Foundation | Nucleic acid molecules encoding multiple start codons and histidine tags |
| CA2871789C (en) | 2000-01-17 | 2017-04-04 | Novartis Vaccines And Diagnostics S.R.L. | Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins |
| ATE439372T1 (de) | 2000-10-27 | 2009-08-15 | Novartis Vaccines & Diagnostic | Nukleinsäuren und proteine von gruppen a und b- streptokokken |
| RU2200196C2 (ru) * | 2000-11-22 | 2003-03-10 | Государственный научно-исследовательский институт особо чистых биопрепаратов | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pPHO-SOD23, КОДИРУЮЩАЯ СИНТЕЗ СУПЕРОКСИДДИСМУТАЗЫ ЧЕЛОВЕКА, И ШТАММ Saccharomyces cerevisiae № Д-11 ВНИИСХМ-ПРОДУЦЕНТ СУПЕРОКСИДДИСМУТАЗЫ ЧЕЛОВЕКА |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| EP2168596B1 (de) | 2001-12-12 | 2012-05-23 | Novartis Vaccines and Diagnostics S.r.l. | Immunisierung gegen Chlamydia trachomatis |
| WO2003099854A2 (en) | 2002-05-24 | 2003-12-04 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
| WO2004046177A2 (en) | 2002-11-15 | 2004-06-03 | Chiron Srl | Unexpected surface proteins in neisseria meningitidis |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| HRP20120315T1 (hr) | 2003-11-21 | 2012-05-31 | Nps Pharmaceuticals | Proizvodnja peptida 2 nalik glukagonu i analoga |
| AU2005319099B2 (en) | 2004-02-02 | 2010-09-16 | Ambrx, Inc. | Modified human growth hormone |
| CN103755800B (zh) | 2004-02-02 | 2016-02-24 | Ambrx公司 | 经修饰的人类生长激素多肽与其用途 |
| BRPI0509743A (pt) | 2004-04-09 | 2007-09-25 | Monsanto Technology Llc | composições e métodos para controle de infestações de inseto em plantas |
| CN102532321B (zh) | 2004-06-18 | 2018-10-12 | Ambrx公司 | 新颖抗原结合多肽和其用途 |
| US7638299B2 (en) | 2004-07-21 | 2009-12-29 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
| US7385028B2 (en) | 2004-12-22 | 2008-06-10 | Ambrx, Inc | Derivatization of non-natural amino acids and polypeptides |
| EP1951890A4 (de) | 2005-11-16 | 2009-06-24 | Ambrx Inc | Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren |
| KR101423898B1 (ko) | 2005-12-14 | 2014-07-28 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도 |
| ATE522541T1 (de) | 2006-06-09 | 2011-09-15 | Novartis Ag | Bakterielle adhäsine konformere |
| WO2008030558A2 (en) | 2006-09-08 | 2008-03-13 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and their uses |
| KR101476472B1 (ko) | 2007-03-30 | 2015-01-05 | 암브룩스, 인코포레이티드 | 변형된 ｆｇｆ-21 폴리펩티드 및 그 용도 |
| ES2632504T3 (es) | 2007-11-20 | 2017-09-13 | Ambrx, Inc. | Polipéptidos de insulina modificados y sus usos |
| NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| MX2011000859A (es) | 2008-07-23 | 2011-02-24 | Ambrx Inc | Polipeptidos g-csf bovinos modificados y sus usos. |
| NO2337846T3 (de) | 2008-09-26 | 2018-06-16 | ||
| PL2342223T3 (pl) | 2008-09-26 | 2017-09-29 | Ambrx, Inc. | Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania |
| NZ600361A (en) | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
| EP2516455A4 (de) | 2009-12-21 | 2013-05-22 | Ambrx Inc | Modifizierte schweine-somatotropin-polypeptide und deren verwendungen |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| SMT201900495T1 (it) | 2010-08-17 | 2019-11-13 | Ambrx Inc | Polipeptidi di relaxina modificati e loro usi |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| BR112017008157A2 (pt) | 2014-10-24 | 2017-12-19 | Bristol Myers Squibb Co | polipeptídeos de fgf-21 modificados e usos dos mesmos |
| US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR76274B (de) * | 1981-08-04 | 1984-08-04 | Univ California | |
| NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| GB8314961D0 (en) * | 1983-05-31 | 1983-07-06 | Kingsman A J | Dna sequence |
| DE3486452T2 (de) * | 1983-10-03 | 1997-11-06 | Chiron Corp., Emeryville, Calif. | Superoxiddismutase und deren Expression in Mikroorganismen |
| DE3585969D1 (de) * | 1984-06-14 | 1992-06-11 | Chiron Corp | Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung. |
| CA1341423C (en) * | 1984-10-31 | 2003-03-04 | Paul A. Luciw | Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome |
| CA1260858A (en) * | 1985-03-28 | 1989-09-26 | Lawrence S. Cousens | Expression using fused genes providing for protein product |
-
1985
- 1985-05-03 DE DE3587759T patent/DE3587759T2/de not_active Expired - Lifetime
- 1985-05-03 AT AT85105405T patent/ATE102250T1/de not_active IP Right Cessation
- 1985-05-03 EP EP19910121606 patent/EP0480480A3/en not_active Withdrawn
- 1985-05-03 EP EP85105405A patent/EP0164556B1/de not_active Expired - Lifetime
- 1985-05-13 CA CA000481401A patent/CA1281671C/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0164556A2 (de) | 1985-12-18 |
| EP0164556A3 (en) | 1987-01-14 |
| CA1281671C (en) | 1991-03-19 |
| EP0164556B1 (de) | 1994-03-02 |
| DE3587759T2 (de) | 1994-07-07 |
| EP0480480A2 (de) | 1992-04-15 |
| EP0480480A3 (en) | 1992-06-10 |
| DE3587759D1 (de) | 1994-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |