ATE103267T1 - 7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ONIC ACID, PROCESS FOR THEIR MANUFACTURE, THEIR USE AS MEDICINAL PRODUCTS, AND INTERMEDIATE PRODUCTS. - Google Patents

7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ONIC ACID, PROCESS FOR THEIR MANUFACTURE, THEIR USE AS MEDICINAL PRODUCTS, AND INTERMEDIATE PRODUCTS.

Info

Publication number
ATE103267T1
ATE103267T1 AT89117266T AT89117266T ATE103267T1 AT E103267 T1 ATE103267 T1 AT E103267T1 AT 89117266 T AT89117266 T AT 89117266T AT 89117266 T AT89117266 T AT 89117266T AT E103267 T1 ATE103267 T1 AT E103267T1
Authority
AT
Austria
Prior art keywords
dihydroxyhept
products
manufacture
substituted derivatives
onic acid
Prior art date
Application number
AT89117266T
Other languages
German (de)
Inventor
Kurt Kesseler
Wilhelm Bartmann
Guenther Wess
Ernold Granzer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of ATE103267T1 publication Critical patent/ATE103267T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486—Polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/48—Aldehydo radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I <IMAGE> I as well as the corresponding lactones of the formula II <IMAGE> II in which R and R DEG have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.
AT89117266T 1988-09-24 1989-09-19 7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ONIC ACID, PROCESS FOR THEIR MANUFACTURE, THEIR USE AS MEDICINAL PRODUCTS, AND INTERMEDIATE PRODUCTS. ATE103267T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3832570A DE3832570A1 (en) 1988-09-24 1988-09-24 7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ACID, METHODS FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND INTERMEDIATE PRODUCTS
EP89117266A EP0361273B1 (en) 1988-09-24 1989-09-19 7-Substituted derivatives of 3,5-dihydroxyhept-6-inoic acid, process for their preparation, their use as medicaments, and intermediates

Publications (1)

Publication Number Publication Date
ATE103267T1 true ATE103267T1 (en) 1994-04-15

Family

ID=6363688

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89117266T ATE103267T1 (en) 1988-09-24 1989-09-19 7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ONIC ACID, PROCESS FOR THEIR MANUFACTURE, THEIR USE AS MEDICINAL PRODUCTS, AND INTERMEDIATE PRODUCTS.

Country Status (17)

Country Link
US (1) US5091386A (en)
EP (1) EP0361273B1 (en)
JP (1) JP2866678B2 (en)
KR (1) KR0142880B1 (en)
AT (1) ATE103267T1 (en)
AU (1) AU617529B2 (en)
CA (1) CA1340047C (en)
DE (2) DE3832570A1 (en)
DK (1) DK175707B1 (en)
ES (1) ES2061858T3 (en)
FI (1) FI90535C (en)
IE (1) IE63500B1 (en)
IL (1) IL91753A0 (en)
NO (1) NO177004C (en)
NZ (1) NZ230751A (en)
PT (1) PT91766B (en)
ZA (1) ZA897233B (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149705A (en) * 1987-03-13 1992-09-22 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and a tetralin group and having retinoid like activity
DE3722809A1 (en) * 1987-07-10 1989-01-19 Hoechst Ag 3-DESMETHYL-4-FLUOR-MEVALONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS, THEIR USE AND INTERMEDIATE PRODUCTS
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
IT1237792B (en) * 1989-12-21 1993-06-17 Zambon Spa ACTIVE COMPOUNDS AS INHIBITORS OF THE HMG-COA REDUCTASE ENZYME
EP0469480A3 (en) * 1990-08-01 1993-03-10 Hoechst Aktiengesellschaft Process for stereoselective preparation of 5-substituted delta-lactones and their use
US5292898A (en) * 1990-08-01 1994-03-08 Hoechst Aktiengesellschaft Process for the stereoselective preparation of 5-substituted delta-lactones and use thereof
EP0554455B1 (en) * 1991-06-19 1997-12-17 Shionogi Seiyaku Kabushiki Kaisha Optically active intermediate and production thereof
US5202327A (en) * 1991-07-10 1993-04-13 E. R. Squibb & Sons, Inc. Phosphorus-containing hmg-coa reductase inhibitors
WO1994006746A1 (en) * 1992-09-21 1994-03-31 Nissan Chemical Industries Ltd. 6-heptynoic and heptenoic acid compounds
ATE315033T1 (en) 1998-08-07 2006-02-15 Chiron Corp SUBTITUTED ISOXAZOLE DERIVATIVES AS ESTROGEN RECEPTOR MODULATORS
SK288117B6 (en) * 1998-11-20 2013-09-03 Skyepharma Canada Inc. Rapidly dispersing solid dry therapeutic dosage form
JP2003509478A (en) * 1999-09-21 2003-03-11 エモリー・ユニバーシティ Methods and compositions for treating platelet-related disorders
DE60138535D1 (en) * 2000-02-04 2009-06-10 Children S Hospital Res Founda USE OF LYSOSOMAL ACID LIPASE FOR THE TREATMENT OF ATHEROSCLEROSIS AND SIMILAR DISEASES
TWI354568B (en) * 2000-09-20 2011-12-21 Jagotec Ag Insoluble drug particle compositions with improved
US8586094B2 (en) * 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
ES2375181T3 (en) 2002-05-09 2012-02-27 The Brigham And Women's Hospital, Inc. 1L 1RL-1 AS A MARKER OF CARDIOVASCULAR DISEASES.
CA2510319A1 (en) * 2002-12-20 2004-07-15 Thomas J. Smith High pressure compaction for pharmaceutical formulations
US7250444B2 (en) * 2003-08-11 2007-07-31 Pfizer Inc. Pyrrole-based HMG-CoA reductase inhibitors
EP1510208A1 (en) 2003-08-22 2005-03-02 Fournier Laboratories Ireland Limited Pharmaceutical composition comprising a combination of metformin and statin
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
ES2439229T3 (en) 2004-10-06 2014-01-22 The Brigham And Women's Hospital, Inc. Relevance of achieved levels of systemic inflammation markers after treatment
US8329703B2 (en) * 2005-02-15 2012-12-11 Xtl Biopharmaceuticals Ltd. Pyrazole compounds
NZ563759A (en) 2005-05-31 2010-06-25 Mylan Lab Inc Compositions comprising nebivolol, a hydralazine compound and an isosorbide nitrate
US20090297496A1 (en) * 2005-09-08 2009-12-03 Childrens Hospital Medical Center Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
US8119358B2 (en) * 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
CA2659082A1 (en) 2006-06-07 2007-12-21 Tethys Bioscience, Inc. Markers associated with arteriovascular events and methods of use thereof
WO2008026702A1 (en) 2006-08-30 2008-03-06 Kyushu University, National University Corporation Pharmaceutical composition containing statin-encapsulated nanoparticle
CA2680507A1 (en) * 2006-10-13 2008-04-24 Xtl Biopharmaceuticals Ltd. Compounds and methods for treatment of hcv
TW200849035A (en) 2007-04-18 2008-12-16 Tethys Bioscience Inc Diabetes-related biomarkers and methods of use thereof
WO2010012740A1 (en) 2008-07-29 2010-02-04 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines
US8618111B2 (en) 2010-01-26 2013-12-31 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines
US8633183B2 (en) 2010-01-26 2014-01-21 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines
KR20120139723A (en) 2010-02-01 2012-12-27 더 호스피탈 포 식 칠드런 Remote ischemic conditioning for treatment and prevention of restenosis
SG184353A1 (en) 2010-03-31 2012-11-29 Hospital For Sick Children Use of remote ischemic conditioning to improve outcome after myocardial infarction
JP2013523349A (en) 2010-04-08 2013-06-17 ザ・ホスピタル・フォー・シック・チルドレン Using remote ischemic conditioning for traumatic injury
WO2014022195A1 (en) 2012-08-01 2014-02-06 Tavakoli Zahra Free flowing, frozen compositions comprising a therapeutic agent
CN110575445B (en) 2013-03-21 2023-08-18 优普顺药物公司美国分部 Injectable sustained release compositions and methods for treating joint inflammation and related pain
KR101675983B1 (en) * 2014-10-06 2016-11-14 한양대학교 에리카산학협력단 Method for producing difluoroalkylated organics
AU2016343952A1 (en) 2015-10-27 2018-05-10 Eupraxia Pharmaceuticals Inc. Sustained release formulations of local anesthetics

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2964790D1 (en) * 1978-06-23 1983-03-24 Dow Chemical Co Hypoglycemic phenylpropynylamino benzoic acids, their salts, pharmaceutical compositions containing said compounds and their application
EP0068038B1 (en) * 1981-06-29 1985-09-25 Merck & Co. Inc. (+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
AU598775B2 (en) * 1985-10-25 1990-07-05 Sandoz Ag Heterocyclic analogs of mevalonolactone
US4851427A (en) * 1985-10-25 1989-07-25 Sandoz Pharm. Corp. Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use
DE3621372A1 (en) * 1986-06-26 1988-01-07 Thomae Gmbh Dr K Heterocyclically substituted 3,5-dihydroxyhept-6-enecarboxylic acids, their derivatives, processes for the preparation of these compounds and medicaments containing them
DE3722807A1 (en) * 1987-07-10 1989-01-19 Hoechst Ag NEW 3,5-DIHYDROXYCARBONIC ACIDS AND THEIR DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS
PT87929B (en) * 1987-07-10 1995-03-01 Hoechst Ag METHOD FOR PREPARING DERIVATIVES OF 3-DESMETIL-MEVALONIC ACID AND OF PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
US4761419A (en) * 1987-12-07 1988-08-02 Warner-Lambert Company 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
DE3800785A1 (en) * 1988-01-09 1989-07-20 Hoechst Ag SUBSTITUTED 7- (PYRIDAZIN-5-YL) -3,5-DIHYDROXYHEPTANE (EN) - ACID, YOUR CORRESPONDING (DELTA) -LACTONE OR. DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS
NO890521L (en) * 1988-02-25 1989-08-28 Bayer Ag SUBSTITUTED PYRIMIDINES.
WO1990003973A1 (en) * 1988-10-06 1990-04-19 Sandoz Ag Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NO177004C (en) 1995-07-05
JPH02243650A (en) 1990-09-27
AU4161589A (en) 1990-03-29
DK469589D0 (en) 1989-09-22
KR0142880B1 (en) 1998-07-15
FI90535C (en) 1994-02-25
IL91753A0 (en) 1990-06-10
NO893777D0 (en) 1989-09-22
EP0361273A2 (en) 1990-04-04
ES2061858T3 (en) 1994-12-16
KR900004724A (en) 1990-04-12
US5091386A (en) 1992-02-25
CA1340047C (en) 1998-09-15
PT91766B (en) 1995-05-31
PT91766A (en) 1990-03-30
DE3832570A1 (en) 1990-03-29
FI90535B (en) 1993-11-15
FI894477A0 (en) 1989-09-21
NO893777L (en) 1990-03-26
DK469589A (en) 1990-03-25
IE63500B1 (en) 1995-05-03
DE58907280D1 (en) 1994-04-28
JP2866678B2 (en) 1999-03-08
IE893043L (en) 1990-03-24
NO177004B (en) 1995-03-27
AU617529B2 (en) 1991-11-28
EP0361273B1 (en) 1994-03-23
DK175707B1 (en) 2005-01-24
NZ230751A (en) 1997-04-24
FI894477A7 (en) 1990-03-25
EP0361273A3 (en) 1991-07-24
ZA897233B (en) 1990-06-27

Similar Documents

Publication Publication Date Title
DE58907280D1 (en) 7-Substituted derivatives of 3,5-dihydroxyhept-6-acid, process for their preparation, their use as medicines, and intermediates.
AU609149B2 (en) 3-demthylmevalonic acid derivatives, a process for their preparation pharmaceutical products based on these compounds, their use and intermediates
ATE163938T1 (en) TETRAZOLE DERIVATIVES OF GALLEBIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND USE OF THESE COMPOUNDS AS MEDICINAL PRODUCTS
ATE151764T1 (en) NEW BENZOPYRAN DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AND PREPARATIONS CONTAINING THE COMPOUNDS
ATE150749T1 (en) SUBSTITUTED HETEROCYCLIC CARBOXYLIC AMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
AU612665B2 (en) 3-demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on compounds, the use thereof, and intermediates
ATE19870T1 (en) 2-NITRO-1,1-ETHENEDIAMINE, PROCESS FOR THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT.
ATE105838T1 (en) 6-FLUORO-3,5-DIHYDROXYCARBONIC ACIDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS.
DE3770726D1 (en) DECAHYDROCHINOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND INTERMEDIATE PRODUCTS THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND THEIR PHARMACEUTICAL COMPOSITIONS.
ATE121396T1 (en) DIBENZO(1,5)DIOXOCIN-5-ONE DERIVATIVES, THEIR USE IN MEDICINAL PRODUCTS AND METHOD FOR THEIR PRODUCTION.
DE3678470D1 (en) NEW 3-PYRIDYLMETHYLNAPHTHYL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS.
ATE13669T1 (en) 4-ARYLOXY-3-PHENYLPIPERIDINE DERIVATIVES, INTERMEDIATE PRODUCTS, PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND THEIR USE AS MEDICINAL PRODUCTS.
ATE85324T1 (en) 7-(1H-PYRROL-3-YL&gt;-SUBSTITUTED 3,5-DIHYDROXYHEPTANIC URES, THEIR CORRESPONDING DELTA-LACTONES AND SALTS, PROCESSES FOR THEIR PRODUCTION, THEIR USE AS PHARMACEUTICALS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS.
ATE77379T1 (en) NEW IMIDAZO- AND TRIAZOLOTHIADIAZINS, PROCESSES FOR THEIR PRODUCTION, THE MEDICATIONS CONTAINING THEM AND THEIR USE, AND SOME INTERMEDIATE PRODUCTS FORMED IN THE PREPARATION OF THE NAMED COMPOUNDS.
ATE66220T1 (en) SUBSTITUTED QUINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL PREPARATIONS.
ATE139227T1 (en) ACYLSULFONAMIDO AND SULFONAMIDOPYRIDINE-2- CARBOXYLIC ACID ESTERS AND THEIR PYRIDINE-N-OXIDES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
ATE12390T1 (en) BASIC SUBSTITUTED ANTHRANILIC ACIDS, PROCESS FOR THEIR PRODUCTION AND THEIR USE.
ATE33642T1 (en) N-BICYCLOHEPTYL AND N-BICYCLOHEPTENYL IMIDAZOLE, PROCESS FOR THEIR PRODUCTION, THEIR USE AND PHARMACEUTICAL PREPARATIONS.
ATE134617T1 (en) SUBSTITUTED 3-THIA OR 3-OXA-ALKYL FLAVONES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME, MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS AND INTERMEDIATE PRODUCTS
DE3862404D1 (en) BENZYLAMINOARYL DIHYDROPYRIDINELACTONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS.

Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time