ATE103333T1 - Hohe proteinsyntheserate in hefe. - Google Patents
Hohe proteinsyntheserate in hefe.Info
- Publication number
- ATE103333T1 ATE103333T1 AT88104649T AT88104649T ATE103333T1 AT E103333 T1 ATE103333 T1 AT E103333T1 AT 88104649 T AT88104649 T AT 88104649T AT 88104649 T AT88104649 T AT 88104649T AT E103333 T1 ATE103333 T1 AT E103333T1
- Authority
- AT
- Austria
- Prior art keywords
- yeast
- protein synthesis
- yeast host
- high protein
- synthesis rate
- Prior art date
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 5
- 238000001243 protein synthesis Methods 0.000 title 1
- 230000014616 translation Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000002299 complementary DNA Substances 0.000 abstract 2
- 230000002950 deficient Effects 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 230000009395 genetic defect Effects 0.000 abstract 2
- 239000003550 marker Substances 0.000 abstract 2
- 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 abstract 1
- 101710193111 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 abstract 1
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 abstract 1
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 abstract 1
- 229940024142 alpha 1-antitrypsin Drugs 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
- C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2986787A | 1987-03-23 | 1987-03-23 | |
| EP88104649A EP0284044B1 (de) | 1987-03-23 | 1988-03-23 | Hohe Proteinsyntheserate in Hefe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE103333T1 true ATE103333T1 (de) | 1994-04-15 |
Family
ID=21851327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88104649T ATE103333T1 (de) | 1987-03-23 | 1988-03-23 | Hohe proteinsyntheserate in hefe. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0284044B1 (de) |
| JP (1) | JP2795850B2 (de) |
| AT (1) | ATE103333T1 (de) |
| CA (1) | CA1304020C (de) |
| DE (1) | DE3888561T2 (de) |
| DK (1) | DK175243B1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3906540A1 (de) * | 1989-03-02 | 1990-09-13 | Behringwerke Ag | Expressionsvektoren zur synthese von proteinen in der spalthefe schizosaccharomyces pombe |
| FR2656531B1 (fr) * | 1989-12-29 | 1992-04-24 | Sanofi Sa | Promoteur artificiel pour l'expression de proteines dans le levure. |
| US5225537A (en) * | 1989-12-29 | 1993-07-06 | Zymogenetics, Inc. | Methods for producing hybrid phospholipid-binding proteins |
| EP0785273A1 (de) | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Gepaarte basische Aminosäuren konvertierendes Enzym und dafür kodierende DNA Sequenz |
| US5407822A (en) * | 1991-10-02 | 1995-04-18 | Sanofi | Artificial promoter for the expression of proteins in yeast |
| FI924494A0 (fi) * | 1992-10-06 | 1992-10-06 | Valtion Teknillinen | Oekad produktion av avsoendrarde proteiner i eukaryotiska rekombinantceller |
| WO1995009914A1 (en) * | 1993-10-05 | 1995-04-13 | Asahi Glass Company Ltd. | Multicloning vector, expression vector, and production of foreign protein with expression vector |
| US5629167A (en) * | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| EP0952010B1 (de) | 1995-01-27 | 2009-03-18 | The Yokohama Rubber Co., Ltd. | Luftreifen und Verfahren zur Herstellung |
| GB2318732A (en) | 1996-11-01 | 1998-05-06 | Johnson & Johnson Medical | Wound healing compositions containing alpha-1-antitrypsin |
| FI972909A0 (fi) | 1997-07-09 | 1997-07-09 | Valtion Teknillinen | Oekad produktion av avsoendrade proteiner genom rekombinatjaestceller |
| DE19736343B4 (de) | 1997-08-21 | 2006-02-09 | Forschungszentrum Jülich GmbH | Verfahren zur Erhöhung der Genexpression von Saccharose Synthase |
| EP1009836A1 (de) | 1997-09-05 | 2000-06-21 | Pentapharm A.G. | Expressionsvektor für verbesserte herstellung von polypeptide in hefe |
| FR2768743B1 (fr) | 1997-09-23 | 2001-09-14 | Bio Merieux | Procede de lyse de micro-organisme |
| BR9813930A (pt) | 1997-11-06 | 2006-12-19 | Chiron Spa | antìgeno neisserial |
| ATE446368T1 (de) | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| MX343752B (es) | 1998-05-01 | 2016-11-22 | Novartis Vaccines & Diagnostics Inc | Antigenos de neisseria meningitidis y composiciones que los contienen. |
| US6358705B1 (en) | 1998-07-16 | 2002-03-19 | Novo Nordisk A/S | Method of making proteins in transformed yeast cells |
| FR2781500B1 (fr) * | 1998-07-23 | 2000-09-08 | Bio Merieux | Dispositif perfectionne et procede de lyse de micro-organismes |
| NZ571167A (en) | 1999-04-30 | 2010-05-28 | Novartis Vaccines & Diagnostic | Fragments from Neisseria protein ORF 953 and their use in medicaments and diagnostic reagents |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| PT2275551E (pt) | 1999-10-29 | 2015-06-29 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| US6709863B2 (en) | 1999-12-08 | 2004-03-23 | Iowa State University Research Foundation | Nucleic acid molecules encoding multiple start codons and histidine tags |
| ES2588917T3 (es) | 2000-01-17 | 2016-11-07 | Glaxosmithkline Biologicals Sa | Vacuna de VME suplementada contra meningococo |
| US7939087B2 (en) | 2000-10-27 | 2011-05-10 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from Streptococcus groups A & B |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| EP2292273A3 (de) | 2001-10-10 | 2011-11-23 | BioGeneriX AG | Remodellierung und Glycokonjugation von Peptiden |
| ES2386386T3 (es) | 2001-12-12 | 2012-08-20 | Novartis Vaccines And Diagnostics S.R.L. | Inmunización contra Chlamydia trachomatis |
| AU2003243316A1 (en) | 2002-05-24 | 2003-12-12 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
| CA2506318C (en) | 2002-11-15 | 2011-07-12 | Chiron Srl | Unexpected surface proteins in neisseria meningitidis |
| CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| AU2004263900A1 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| US7829307B2 (en) | 2003-11-21 | 2010-11-09 | Nps Pharmaceuticals, Inc. | Production of glucagon-like peptide 2 |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| ES2547381T3 (es) | 2004-04-09 | 2015-10-05 | Monsanto Technology, Llc | Composiciones y procedimientos de control de infestaciones de insectos en plantas |
| EP1771205B1 (de) | 2004-06-18 | 2016-10-26 | Ambrx, Inc. | Neuartige antigen-bindende polypeptide und ihre verwendungen |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| JP4990792B2 (ja) | 2004-12-22 | 2012-08-01 | アンブレツクス・インコーポレイテツド | アミノアシル−ｔＲＮＡシンテターゼの組成物およびこの使用 |
| CA2594557C (en) | 2004-12-22 | 2016-04-26 | Ambrx, Inc. | Modified human growth hormone |
| NZ555308A (en) | 2004-12-22 | 2010-10-29 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| WO2007021297A1 (en) | 2005-08-18 | 2007-02-22 | Ambrx, Inc. | COMPOSITIONS OF tRNA AND USES THEREOF |
| BRPI0616181B1 (pt) | 2005-09-16 | 2024-03-05 | Monsanto Technology Llc | Construção de polinucleotídeo isolada, sequência de ribonucleotídeo de fita dupla, microrganismo transgênico, seu método de produção, e métodos para controle de infestação por coleóptero praga, para melhorar o rendimento e a tolerância a estiagem de um cultivo, e para produção de um produto comercial, alimento ou ração |
| BRPI0615792A2 (pt) | 2005-09-16 | 2009-06-16 | Devgen Nv | métodos de controle de pestes com base no uso de rnai |
| EP1951890A4 (de) | 2005-11-16 | 2009-06-24 | Ambrx Inc | Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren |
| KR101423898B1 (ko) | 2005-12-14 | 2014-07-28 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도 |
| AU2007214547B2 (en) | 2006-02-13 | 2012-09-20 | Monsanto Technology Llc | Selecting and stabilizing dsRNA constructs |
| DK2054431T3 (da) | 2006-06-09 | 2012-01-02 | Novartis Ag | Konformere af bakterielle adhæsiner |
| KR20090060294A (ko) | 2006-09-08 | 2009-06-11 | 암브룩스, 인코포레이티드 | 변형된 인간 혈장 폴리펩티드 또는 Ｆｃ 스캐폴드 및 그의 용도 |
| CA2682147C (en) | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| CA2703830A1 (en) | 2007-11-20 | 2009-05-28 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
| SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| EP2318029B1 (de) | 2008-07-23 | 2017-11-01 | Ambrx, Inc. | Modifizierte bovine g-csf-polypeptide und ihre verwendung |
| PE20110480A1 (es) | 2008-09-26 | 2011-07-01 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales |
| US8278418B2 (en) | 2008-09-26 | 2012-10-02 | Ambrx, Inc. | Modified animal erythropoietin polypeptides and their uses |
| EA201290541A1 (ru) | 2009-12-21 | 2013-05-30 | Амбркс, Инк. | Модифицированные бычьи соматотропиновые полипептиды и их применение |
| JP2013515081A (ja) | 2009-12-21 | 2013-05-02 | アンブルックス，インコーポレイテッド | 修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用 |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| PE20140160A1 (es) | 2010-08-17 | 2014-02-08 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| MX2017004947A (es) | 2014-10-24 | 2017-06-29 | Bristol Myers Squibb Co | Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos. |
| SG10201912034UA (en) | 2017-02-08 | 2020-02-27 | Bristol Myers Squibb Co | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU600885B2 (en) * | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
| EP0245479B1 (de) * | 1985-11-13 | 1993-02-17 | Xoma Corporation | Verkürzter phosphoglycerat-kinase-promotor |
-
1988
- 1988-03-23 EP EP88104649A patent/EP0284044B1/de not_active Expired - Lifetime
- 1988-03-23 DE DE3888561T patent/DE3888561T2/de not_active Expired - Lifetime
- 1988-03-23 CA CA000562260A patent/CA1304020C/en not_active Expired - Lifetime
- 1988-03-23 JP JP63069222A patent/JP2795850B2/ja not_active Expired - Lifetime
- 1988-03-23 AT AT88104649T patent/ATE103333T1/de not_active IP Right Cessation
- 1988-03-23 DK DK198801591A patent/DK175243B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK159188A (da) | 1988-12-14 |
| JPS6416587A (en) | 1989-01-20 |
| DE3888561T2 (de) | 1994-09-01 |
| DK175243B1 (da) | 2004-07-19 |
| JP2795850B2 (ja) | 1998-09-10 |
| EP0284044B1 (de) | 1994-03-23 |
| DK159188D0 (da) | 1988-03-23 |
| DE3888561D1 (de) | 1994-04-28 |
| EP0284044A1 (de) | 1988-09-28 |
| CA1304020C (en) | 1992-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |