ATE104699T1 - Hervorrufung physischer veraenderungen in pflanzen durch verwendung von negativstrangigen rnas. - Google Patents
Hervorrufung physischer veraenderungen in pflanzen durch verwendung von negativstrangigen rnas.Info
- Publication number
- ATE104699T1 ATE104699T1 AT8686307850T AT86307850T ATE104699T1 AT E104699 T1 ATE104699 T1 AT E104699T1 AT 8686307850 T AT8686307850 T AT 8686307850T AT 86307850 T AT86307850 T AT 86307850T AT E104699 T1 ATE104699 T1 AT E104699T1
- Authority
- AT
- Austria
- Prior art keywords
- negative
- plants
- stranged
- rnas
- physical changes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
- C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
- C12Y105/01019—D-Nopaline dehydrogenase (1.5.1.19), i.e. D-nopaline synthase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/788,002 US6617496B1 (en) | 1985-10-16 | 1985-10-16 | Effecting virus resistance in plants through the use of negative strand RNAs |
| EP86307850A EP0223399B1 (de) | 1985-10-16 | 1986-10-10 | Hervorrufung physischer Veränderungen in Pflanzen durch Verwendung von negativstrangigen RNAs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE104699T1 true ATE104699T1 (de) | 1994-05-15 |
Family
ID=25143142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT8686307850T ATE104699T1 (de) | 1985-10-16 | 1986-10-10 | Hervorrufung physischer veraenderungen in pflanzen durch verwendung von negativstrangigen rnas. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6617496B1 (de) |
| EP (1) | EP0223399B1 (de) |
| AT (1) | ATE104699T1 (de) |
| AU (1) | AU607122B2 (de) |
| BR (1) | BR8605043A (de) |
| CA (1) | CA1341556C (de) |
| DE (1) | DE3689802T2 (de) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751181A (en) * | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
| EP0477994B1 (de) * | 1985-03-21 | 2001-06-13 | Johnston, Stephen, Ph.D. | Von Parasit gewonnener Widerstand |
| US6608241B1 (en) | 1985-10-29 | 2003-08-19 | Monsanto Technology Llc | Protection of plants against viral infection |
| US5107065A (en) * | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| IL81737A (en) * | 1986-03-28 | 1992-11-15 | Calgene Inc | Regulation of gene expression in plant cells |
| US5453566A (en) * | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| AU612972B2 (en) * | 1986-04-02 | 1991-07-25 | Pioneer Hi-Bred International, Inc. | Virus resistant plants having antisense rna |
| WO1988001645A1 (en) * | 1986-08-26 | 1988-03-10 | Macquarie University | Transformation of an organism using antisense rna or promoter occlusion technique |
| US6198026B1 (en) | 1988-02-03 | 2001-03-06 | Pioneer Hi-Bred International, Inc. | Molecular methods of hybrid seed production |
| US5728926A (en) * | 1988-02-03 | 1998-03-17 | Pioneer Hi-Bred International, Inc. | Antisense gene systems of pollination control for hybrid seed production |
| US6198023B1 (en) | 1988-02-03 | 2001-03-06 | Pioneer Hi-Bred International, Inc. | Molecular methods of hybrid seed production |
| US5356799A (en) | 1988-02-03 | 1994-10-18 | Pioneer Hi-Bred International, Inc. | Antisense gene systems of pollination control for hybrid seed production |
| DE3810286A1 (de) * | 1988-03-25 | 1989-10-12 | Max Planck Gesellschaft | Transgene pflanze mit modifizierter physiologie, morphologie und modifiziertem hormonmetabolismus, gewebekulturen dieser pflanze und verfahren zu ihrer herstellung |
| NL8800756A (nl) * | 1988-03-25 | 1989-10-16 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Genetisch gemanipuleerde plantecellen en planten, alsmede daarvoor bruikbaar recombinant dna. |
| US5260205A (en) * | 1990-11-14 | 1993-11-09 | Philip Morris Incorporated | Method of purifying putrescine N-methyltransferase from tobacco plant extract with a polyamine |
| US6013859A (en) * | 1994-07-14 | 2000-01-11 | Pioneer Hi-Bred International, Inc. | Molecular methods of hybrid seed production |
| US6586661B1 (en) | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
| BRPI9908967B1 (pt) | 1998-03-20 | 2017-05-30 | Benitec Australia Ltd | processos para reprimir, retardar ou de outro modo reduzir a expressão de um gene alvo em uma célula de planta |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| US8598332B1 (en) | 1998-04-08 | 2013-12-03 | Bayer Cropscience N.V. | Methods and means for obtaining modified phenotypes |
| AU760041B2 (en) | 1998-04-08 | 2003-05-08 | Commonwealth Scientific And Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
| US20040214330A1 (en) | 1999-04-07 | 2004-10-28 | Waterhouse Peter Michael | Methods and means for obtaining modified phenotypes |
| US6759574B1 (en) | 1998-11-05 | 2004-07-06 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Plants having enhanced gall resistance and methods and compositions for producing same |
| TR200101342T2 (tr) | 1998-11-12 | 2001-09-21 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften | Patojen enfeksiyonu üzerine bitkilerde gen ekspresyonuna aracılık edebilen şimerik promoterler |
| ATE305718T1 (de) | 1999-07-20 | 2005-10-15 | Gvs Ges Fuer Erwerb Und Verwer | Neues verfahren zur herstellung und auswahl von transgenen flachspflanzen und leinsamen |
| US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| CN1330753C (zh) | 2000-08-30 | 2007-08-08 | 北卡罗莱纳州立大学 | 含有可改变蛋白含量的分子诱导物的转基因植物 |
| WO2002038588A2 (en) | 2000-11-07 | 2002-05-16 | North Carolina State University | Putrescine-n-methyltransferase promoter |
| CN1482856A (zh) | 2000-11-09 | 2004-03-17 | ����Ƽ���ҵ�о���֯ | 降低了ssii活性的大麦和降低了支链淀粉含量的淀粉和淀粉制品 |
| EP1406518A4 (de) | 2001-06-08 | 2006-03-29 | Vector Tobacco Ltd | Modifikation von nicotin- und nitrosaminkonzentrationen in tabak |
| CN1646687A (zh) | 2002-03-14 | 2005-07-27 | 联邦科学和工业研究组织 | 修饰的基因沉默rna及其用途 |
| WO2004090141A2 (en) | 2003-04-11 | 2004-10-21 | Cropdesign N.V. | Method to increase stress tolerance in plants |
| WO2005001098A1 (en) | 2003-06-30 | 2005-01-06 | Commonwealth Scientific And Industrial Research Organisation | Wheat with altered branching enzyme activity and starch and starch containing products derived thereform |
| ATE516295T1 (de) | 2004-01-20 | 2011-07-15 | Monsanto Technology Llc | Chimäre promotoren zur verwendung in pflanzen |
| US7453025B2 (en) | 2004-09-22 | 2008-11-18 | Arborgen, Llc | Reproductive ablation constructs |
| WO2006069422A1 (en) | 2004-12-30 | 2006-07-06 | Commonwealth Scientific And Industrial Research Organisation | Method and means for improving bowel health |
| JP5368097B2 (ja) | 2005-09-20 | 2013-12-18 | ジェイ・アール・シンプロット・カンパニー | 低アクリルアミド食品 |
| US7838729B2 (en) | 2007-02-26 | 2010-11-23 | Monsanto Technology Llc | Chloroplast transit peptides for efficient targeting of DMO and uses thereof |
| US20090123626A1 (en) * | 2007-09-28 | 2009-05-14 | J.R. Simplot Company | Reduced acrylamide plants and foods |
| US8809626B2 (en) | 2007-12-21 | 2014-08-19 | Keygene N.V. | Trichome specific promoters |
| EP2100962A1 (de) | 2008-03-12 | 2009-09-16 | Biogemma | Pflanzen mit verbesserter Widerstandsfähigkeit gegen Pathogene |
| PT2262896E (pt) | 2008-04-07 | 2014-04-28 | Monsanto Technology Llc | Elementos reguladores de plantas e suas utilizações |
| US20120277117A1 (en) | 2009-02-27 | 2012-11-01 | Adel Zayed | Hydroponic apparatus and methods of use |
| ES2879599T3 (es) | 2009-06-08 | 2021-11-22 | Nunhems Bv | Plantas tolerantes a la sequía |
| WO2011050271A1 (en) | 2009-10-23 | 2011-04-28 | Monsanto Technology Llc | Methods and compositions for expression of transgenes in plants |
| BR112012019582B1 (pt) | 2010-01-14 | 2021-09-21 | Monsanto Technology Llc | Molécula de dna compreendendo elementos reguladores de plantas |
| MX344585B (es) | 2010-05-28 | 2016-12-20 | Nunhems Bv | Platas con un tamaño de fruto incrementado. |
| KR20140016865A (ko) | 2010-08-30 | 2014-02-10 | 다우 아그로사이언시즈 엘엘씨 | 사탕수수 간균형 바이러스(scbv) 인핸서 및 식물 기능유전체학에서의 그의 용도 |
| US8648230B2 (en) | 2011-03-18 | 2014-02-11 | Ms Technologies, Llc | Regulatory regions preferentially expressing in non-pollen plant tissue |
| PH12013501978A1 (en) | 2011-03-25 | 2013-11-25 | Monsanto Technology Llc | Plant regulatory elements and uses thereof |
| CA2997731C (en) | 2011-05-13 | 2020-05-26 | Monsanto Technology Llc | Plant regulatory elements and uses thereof |
| IN2014DN06986A (de) | 2012-02-29 | 2015-04-10 | Dow Agrosciences Llc | |
| US9644213B2 (en) | 2012-03-09 | 2017-05-09 | Board Of Trustees Of Michigan State University | Method of enhancing plant drought tolerance by expression of NDR1 |
| US9663793B2 (en) | 2012-04-20 | 2017-05-30 | Monsanto Technology, Llc | Plant regulatory elements and uses thereof |
| AU2013362921B2 (en) | 2012-12-19 | 2018-03-01 | Monsanto Technology Llc | Plant regulatory elements and uses thereof |
| JP6580027B2 (ja) | 2013-03-14 | 2019-09-25 | モンサント テクノロジー エルエルシー | 植物調節エレメントおよびその使用 |
| CR20200120A (es) | 2013-03-14 | 2020-06-05 | Monsanto Technology Llc | Elementos regulatorios de planta y sus usos (divisional 2015-0554) |
| US11519011B2 (en) | 2015-03-26 | 2022-12-06 | The Texas A&M University System | Conversion of lignin into bioplastics and lipid fuels |
| CN108291234B (zh) | 2015-09-04 | 2026-04-21 | 主基因有限公司 | 倍数孢子体形成基因 |
| BR112018001122B1 (pt) | 2016-03-11 | 2021-06-01 | Monsanto Technology Llc | Molécula de dna recombinante compreendendo elementos reguladores de planta e método de expressão de uma molécula de dna passível de transcrição |
| EP3462844B1 (de) | 2016-05-24 | 2024-11-27 | Monsanto Technology LLC | Pflanzenregulierungselemente und verwendungen davon |
| WO2018005589A1 (en) | 2016-06-28 | 2018-01-04 | Cellectis | Altering expression of gene products in plants through targeted insertion of nucleic acid sequences |
| CR20240086A (es) | 2017-01-19 | 2024-09-30 | Monsanto Technology Llc | ELEMENTOS REGULATORIOS DE PLANTAS Y SUS USOS (Divisional 2019-0377) |
| US20200332311A1 (en) | 2018-01-12 | 2020-10-22 | The Texas A&M University System | Increasing plant bioproduct yield |
| MX2021002743A (es) | 2019-01-10 | 2021-05-12 | Monsanto Technology Llc | Elementos reguladores de planta y usos de los mismos. |
| US20240263206A1 (en) | 2021-03-26 | 2024-08-08 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for producing circular polyribonucleotides |
| TW202305130A (zh) | 2021-03-26 | 2023-02-01 | 美商旗艦先鋒創新有限責任(Vii)公司 | 原核系統中環狀多核糖核苷酸之產生 |
| EP4314281A1 (de) | 2021-03-26 | 2024-02-07 | Flagship Pioneering Innovations VII, LLC | Herstellung von zirkulären polyribonukleotiden in einem eukaryotischen system |
| UY39997A (es) | 2021-11-01 | 2023-05-15 | Flagship Pioneering Innovations Vii Llc | Polinucleótidos para modificar organismos |
| AU2023209447A1 (en) | 2022-01-20 | 2024-07-18 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
| AU2023337091A1 (en) | 2022-09-09 | 2025-03-06 | Eidgenössische Technische Hochschule Zürich | Plant regulatory elements and uses thereof |
| WO2024229356A2 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial solemoviridae satellite rnas |
| WO2024229347A1 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial tombusviridae satellite rnas |
| CN121816422A (zh) | 2023-05-03 | 2026-04-07 | 旗舰创业创新第七有限责任公司 | 人工混合病毒属卫星rna |
| CN121712898A (zh) | 2023-05-03 | 2026-03-20 | 旗舰创业创新第七有限责任公司 | 用于植物的内源核糖核酸病毒卫星rna扩增系统 |
| CN121712897A (zh) | 2023-05-03 | 2026-03-20 | 旗舰创业创新第七有限责任公司 | 用于植物的分体病毒卫星rna扩增系统 |
| EP4705478A1 (de) | 2023-05-03 | 2026-03-11 | Flagship Pioneering Innovations VII, LLC | Künstliche morellivirale satelliten-rnas |
| EP4705474A2 (de) | 2023-05-03 | 2026-03-11 | Flagship Pioneering Innovations VII, LLC | Künstliche tymovirale satelliten rnas |
| AR132591A1 (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de secoviridae artificiales |
| WO2024229385A1 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial ghabrivirales satellite rnas |
| US20250075226A1 (en) | 2023-08-29 | 2025-03-06 | University Of Freiburg | Proteins for regulation of symbiotic infection and associated regulatory elements |
| WO2026006779A1 (en) | 2024-06-27 | 2026-01-02 | The Regents Of The University Of California | Transgenic plants expressing fern rapid non-photochemical quenching (npq) proteins |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3480718D1 (de) * | 1983-04-15 | 1990-01-18 | Lubrizol Genetics Inc | Expression von pflanzlichen strukturellen genen. |
| CA1341091C (en) | 1983-10-20 | 2000-09-05 | Masayori Inouye | Regulation of gene expression by employing translational inhibition utilizaing mrna interfering complementary rna |
| US5580716A (en) * | 1985-03-21 | 1996-12-03 | Stephen A. Johnston | Parasite-derived resistance |
| IL81737A (en) * | 1986-03-28 | 1992-11-15 | Calgene Inc | Regulation of gene expression in plant cells |
| AU611859B2 (en) * | 1986-07-25 | 1991-06-27 | Louisiana State University And Agricultural And Mechanical College | Method for introduction of disease and pest resistance into plants and novel genes incorporated into plants which code therefor |
| AU7918387A (en) * | 1986-08-26 | 1988-03-24 | Macquarie University | Transformation of an organism using antisense rna or promoter occlusion technique |
-
1985
- 1985-10-16 US US06/788,002 patent/US6617496B1/en not_active Expired - Lifetime
-
1986
- 1986-10-02 CA CA000519667A patent/CA1341556C/en not_active Expired - Lifetime
- 1986-10-10 EP EP86307850A patent/EP0223399B1/de not_active Revoked
- 1986-10-10 DE DE3689802T patent/DE3689802T2/de not_active Revoked
- 1986-10-10 AT AT8686307850T patent/ATE104699T1/de active
- 1986-10-15 BR BR8605043A patent/BR8605043A/pt not_active Application Discontinuation
- 1986-10-15 AU AU63924/86A patent/AU607122B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| BR8605043A (pt) | 1987-07-14 |
| AU607122B2 (en) | 1991-02-28 |
| US6617496B1 (en) | 2003-09-09 |
| AU6392486A (en) | 1987-04-30 |
| DE3689802T2 (de) | 1994-11-17 |
| DE3689802D1 (de) | 1994-05-26 |
| EP0223399B1 (de) | 1994-04-20 |
| EP0223399A1 (de) | 1987-05-27 |
| CA1341556C (en) | 2007-10-09 |
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