ATE105188T1 - Reinigung von pertussis-toxinen und herstellung von vakzine. - Google Patents

Reinigung von pertussis-toxinen und herstellung von vakzine.

Info

Publication number
ATE105188T1
ATE105188T1 AT8989303369T AT89303369T ATE105188T1 AT E105188 T1 ATE105188 T1 AT E105188T1 AT 8989303369 T AT8989303369 T AT 8989303369T AT 89303369 T AT89303369 T AT 89303369T AT E105188 T1 ATE105188 T1 AT E105188T1
Authority
AT
Austria
Prior art keywords
fha
lpf
medium
purified
adsorbing
Prior art date
Application number
AT8989303369T
Other languages
English (en)
Inventor
Larry U L Tan
Gail Jackson
Dirk Alkema
Po S Wah
Rafaat Emil Fahmy Fahim
Original Assignee
Connaught Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Connaught Lab filed Critical Connaught Lab
Application granted granted Critical
Publication of ATE105188T1 publication Critical patent/ATE105188T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT8989303369T 1988-04-05 1989-04-05 Reinigung von pertussis-toxinen und herstellung von vakzine. ATE105188T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888807860A GB8807860D0 (en) 1988-04-05 1988-04-05 Pertussis vaccine
EP89303369A EP0336736B1 (de) 1988-04-05 1989-04-05 Reinigung von Pertussis-Toxinen und Herstellung von Vakzine

Publications (1)

Publication Number Publication Date
ATE105188T1 true ATE105188T1 (de) 1994-05-15

Family

ID=10634535

Family Applications (1)

Application Number Title Priority Date Filing Date
AT8989303369T ATE105188T1 (de) 1988-04-05 1989-04-05 Reinigung von pertussis-toxinen und herstellung von vakzine.

Country Status (8)

Country Link
US (1) US4997915A (de)
EP (1) EP0336736B1 (de)
JP (1) JPH0789949B2 (de)
AT (1) ATE105188T1 (de)
CA (1) CA1331134C (de)
DE (1) DE68915045T2 (de)
ES (1) ES2052909T3 (de)
GB (1) GB8807860D0 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8412207D0 (en) 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
US5191197A (en) * 1988-05-11 1993-03-02 Symbol Technologies, Inc. Arm mounted scanner actuatable by hand movement
GB8910570D0 (en) 1989-05-08 1989-06-21 Wellcome Found Acellular vaccine
US5391715A (en) * 1989-11-06 1995-02-21 Smithkline Beecham Biologicals Method for isolating and purifying bordetella pertussis antigenic factors
US5578308A (en) * 1990-02-12 1996-11-26 Capiau; Carine Glutaraldehyde and formalin detoxified bordetella toxin vaccine
US6197548B1 (en) 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
IL97985A0 (en) * 1990-05-07 1992-06-21 North American Vaccine Inc Improved vaccine compositions
NZ239643A (en) * 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
GB9021004D0 (en) * 1990-09-27 1990-11-07 Wellcome Found Acellular vaccines
US6444211B2 (en) 1991-04-03 2002-09-03 Connaught Laboratories, Inc. Purification of a pertussis outer membrane protein
US5932217A (en) * 1991-05-03 1999-08-03 The Rockefeller University Peptides which inhibit adhesion between leukocytes and endothelial cells
GB9115332D0 (en) * 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
AU2352595A (en) * 1994-04-28 1995-11-29 Takeda Chemical Industries Ltd. Method of separating protective components of bordetella pertussis
US6764682B1 (en) * 1994-06-16 2004-07-20 Aventis Pasteur Limited Adjuvant compositions containing more than one adjuvant
CA2433502A1 (en) 1995-05-04 1996-11-07 Aventis Pasteur Limited Acellular pertussis vaccines and methods of preparation thereof
US6696065B1 (en) * 1995-05-04 2004-02-24 Aventis Pastuer Limited Acellular pertussis vaccines and methods of preparation thereof
US6290971B1 (en) 1995-06-15 2001-09-18 Aventis Pasteur Limited Adjuvant compositions comprising a mineral salt and another immunostimulating compound
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
BR9710460A (pt) 1996-07-02 1999-08-17 Connaught Lab Composi-Æo imunolÄgica multi-valente e seu uso em vacinas
AU2232399A (en) * 1998-01-16 1999-08-02 Maxim Pharmaceuticals, Inc. Recombinant ctb-based vaccines
MXPA05003057A (es) 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
PT1601689E (pt) * 2003-03-13 2008-01-04 Glaxosmithkline Biolog Sa Processo de purificação para citolisina bacteriana
AU2004279209A1 (en) * 2003-10-14 2005-04-21 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Filamentous haemagglutinin in the treatment and/or prophylaxis of immune-mediated disorders
JP4885729B2 (ja) * 2003-11-20 2012-02-29 サノフィ パストゥール インコーポレイテッド 百日咳毒素を精製する方法およびそれに有用なペプチド
WO2005117965A1 (en) 2004-06-04 2005-12-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for preparing immunogenic conjugates
AU2008217189B2 (en) * 2007-02-22 2013-06-13 Baxalta GmbH Method of purification of hydrophobic proteins
US20080306610A1 (en) * 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
EP2430040A1 (de) 2009-05-11 2012-03-21 Novartis AG Antigenaufreinigungs­verfahren für pertactinantigen
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
WO2013049535A2 (en) 2011-09-30 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Influenza vaccine
EP2863943B1 (de) 2013-03-08 2016-07-13 Crucell Holland B.V. Nicht zellulärer pertussis-impfstoff
EP3518968B1 (de) 2016-10-03 2022-01-05 The U.S.A. as represented by the Secretary, Department of Health and Human Services Hiv-1-env-fusionspeptid-immunogene und deren verwendung
US11202824B2 (en) 2016-10-31 2021-12-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptide fragments from filoviruses and their uses
EP3600405B1 (de) 2017-03-24 2025-08-20 The United States of America, as represented by the Secretary, Department of Health and Human Services Glycanmaskierte manipulierte äussere domänen von hiv-1 gp120 und deren verwendung
EP3697440A1 (de) 2017-10-16 2020-08-26 The United States of America, as represented by the Secretary, Department of Health and Human Services Rekombinante hiv-1-hüllproteine und deren verwendung
WO2020061564A1 (en) 2018-09-23 2020-03-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use
EP3870703A1 (de) 2018-10-22 2021-09-01 The United States of America, as represented by the Secretary, Department of Health and Human Services Rekombinantes gp120-protein mit v1-schleifendeletion
US12210017B2 (en) 2020-01-08 2025-01-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptides representing epitopes from filoviruses
AU2022323509A1 (en) 2021-08-03 2024-02-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection
US20250197455A1 (en) 2022-03-27 2025-06-19 TThe United States of America, as represented by the Secretary, Department of Health and Human Servi Base-covered hiv-1 envelope ectodomains and their use
WO2024249626A1 (en) 2023-05-30 2024-12-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv-1 envelope triple tandem trimers and their use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
CA1213234A (en) * 1983-03-30 1986-10-28 Akihiro Ginnaga Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine
AU571078B2 (en) * 1984-04-14 1988-03-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Purification of filamentous hemagglutinin
JPS6176422A (ja) * 1984-09-22 1986-04-18 Chemo Sero Therapeut Res Inst 百日ぜきコンポ−ネントワクチンおよび百日ぜき・ジフテリア・破傷風混合ワクチンの製造方法
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
US4705686A (en) * 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
FR2601250B1 (fr) * 1986-07-08 1989-12-01 Pasteur Institut Procede de preparation de fractions antigeniques exocellulaires de bordetella pertussis et vaccin contre la coqueluche contenant de telles fractions.

Also Published As

Publication number Publication date
EP0336736B1 (de) 1994-05-04
DE68915045T2 (de) 1994-08-25
EP0336736A1 (de) 1989-10-11
JPH0789949B2 (ja) 1995-10-04
ES2052909T3 (es) 1994-07-16
CA1331134C (en) 1994-08-02
DE68915045D1 (de) 1994-06-09
US4997915A (en) 1991-03-05
JPH0231689A (ja) 1990-02-01
GB8807860D0 (en) 1988-05-05

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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time