ATE106893T1 - Verfahren zur herstellung von aktiviertem protein c. - Google Patents

Verfahren zur herstellung von aktiviertem protein c.

Info

Publication number: ATE106893T1
Authority: AT; Austria
Prior art keywords: activated protein; pct; sec; production; aprotinin
Prior art date: 1989-04-12

Application number

AT90907093T

Other languages

English (en)

Inventor

Marion Steinbuch

Jacques Chabbat

Olivier Taby

Original Assignee

Fond Nat Transfusion Sanguine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-12

Filing date

1990-04-10

Publication date

1994-06-15

1989-04-12 Priority claimed from FR8904814A external-priority patent/FR2645865B1/fr

1990-04-10 Application filed by Fond Nat Transfusion Sanguine filed Critical Fond Nat Transfusion Sanguine

1994-06-15 Application granted granted Critical

1994-06-15 Publication of ATE106893T1 publication Critical patent/ATE106893T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
101800004937 Protein C Proteins 0.000 abstract 6
102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 6
101800001700 Saposin-D Proteins 0.000 abstract 6
229960000856 protein c Drugs 0.000 abstract 6
108010039627 Aprotinin Proteins 0.000 abstract 2
229960004405 aprotinin Drugs 0.000 abstract 2
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000007975 buffered saline Substances 0.000 abstract 1
230000003196 chaotropic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000010828 elution Methods 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
238000005406 washing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT90907093T 1989-04-12 1990-04-10 Verfahren zur herstellung von aktiviertem protein c. ATE106893T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8904814A FR2645865B1 (fr)	1989-04-12	1989-04-12	Procede de preparation de la proteine c activee et solution de proteine c activee ainsi obtenue
FR909002028A FR2658517B2 (fr)	1989-04-12	1990-02-20	Preparation de la proteine c activee et solution de proteine c activee ainsi obtenue.

Publications (1)

Publication Number	Publication Date
ATE106893T1 true ATE106893T1 (de)	1994-06-15

Family

ID=26227270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90907093T ATE106893T1 (de)	1989-04-12	1990-04-10	Verfahren zur herstellung von aktiviertem protein c.

Country Status (13)

Country	Link
US (1)	US5198534A (de)
EP (1)	EP0424498B1 (de)
JP (1)	JPH03505531A (de)
KR (1)	KR920700220A (de)
AT (1)	ATE106893T1 (de)
CA (1)	CA2030783A1 (de)
DE (1)	DE69009668T2 (de)
DK (1)	DK0424498T3 (de)
ES (1)	ES2054355T3 (de)
FR (1)	FR2658517B2 (de)
MA (1)	MA21807A1 (de)
PL (1)	PL284757A1 (de)
WO (1)	WO1990012028A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT397615B (de) *	1991-05-14	1994-05-25	Immuno Ag	Arzneimittel enthaltend protein c
AT402262B (de) *	1991-06-20	1997-03-25	Immuno Ag	Arzneimittel enthaltend aktiviertes protein c
DE4320294A1 (de) *	1993-06-18	1994-12-22	Immuno Ag	Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US6867045B1 (en) *	1994-11-14	2005-03-15	The Scripps Research Institute	Method for diagnosis of thrombotic disorders
JP3745805B2 (ja) *	1995-10-24	2006-02-15	日本ケミカルリサーチ株式会社	トロンボモジュリンの精製方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8319538D0 (en) *	1983-07-20	1983-08-24	Beecham Group Plc	Compounds
US4849403A (en) *	1985-05-29	1989-07-18	Pentapharm Ag	Protein C activator, methods of preparation and use thereof
DE3882411T2 (de) *	1987-04-17	1993-12-16	Teijin Ltd	Verfahren zur Trennung von aktiviertem menschlichem Protein C.

1990
- 1990-02-20 FR FR909002028A patent/FR2658517B2/fr not_active Expired - Lifetime
- 1990-04-10 ES ES90907093T patent/ES2054355T3/es not_active Expired - Lifetime
- 1990-04-10 US US07/613,843 patent/US5198534A/en not_active Expired - Fee Related
- 1990-04-10 WO PCT/FR1990/000258 patent/WO1990012028A1/fr not_active Ceased
- 1990-04-10 DK DK90907093.0T patent/DK0424498T3/da active
- 1990-04-10 EP EP90907093A patent/EP0424498B1/de not_active Expired - Lifetime
- 1990-04-10 CA CA002030783A patent/CA2030783A1/fr not_active Abandoned
- 1990-04-10 AT AT90907093T patent/ATE106893T1/de not_active IP Right Cessation
- 1990-04-10 KR KR1019900702600A patent/KR920700220A/ko not_active Ceased
- 1990-04-10 DE DE69009668T patent/DE69009668T2/de not_active Expired - Fee Related
- 1990-04-10 JP JP2506627A patent/JPH03505531A/ja active Pending
- 1990-04-12 PL PL28475790A patent/PL284757A1/xx unknown
- 1990-04-12 MA MA22067A patent/MA21807A1/fr unknown

Also Published As

Publication number	Publication date
EP0424498B1 (de)	1994-06-08
DE69009668T2 (de)	1994-10-06
ES2054355T3 (es)	1994-08-01
JPH03505531A (ja)	1991-12-05
FR2658517A2 (fr)	1991-08-23
US5198534A (en)	1993-03-30
PL284757A1 (en)	1991-01-14
WO1990012028A1 (fr)	1990-10-18
CA2030783A1 (fr)	1990-10-13
EP0424498A1 (de)	1991-05-02
DK0424498T3 (da)	1994-07-04
MA21807A1 (fr)	1990-12-31
DE69009668D1 (de)	1994-07-14
KR920700220A (ko)	1992-02-19
FR2658517B2 (fr)	1992-06-19

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Legal Events

Date	Code	Title	Description
1995-01-15	UEP	Publication of translation of european patent specification
1999-01-15	REN	Ceased due to non-payment of the annual fee