ATE107650T1 - Verfahren zur herstellung von 23-(c1-c6- alkyloxim)ll-f28249-verbindungen. - Google Patents

Verfahren zur herstellung von 23-(c1-c6- alkyloxim)ll-f28249-verbindungen.

Info

Publication number
ATE107650T1
ATE107650T1 AT90114919T AT90114919T ATE107650T1 AT E107650 T1 ATE107650 T1 AT E107650T1 AT 90114919 T AT90114919 T AT 90114919T AT 90114919 T AT90114919 T AT 90114919T AT E107650 T1 ATE107650 T1 AT E107650T1
Authority
AT
Austria
Prior art keywords
compounds
preparation
alkyloxime
nitrobenzoyl
crystalline
Prior art date
Application number
AT90114919T
Other languages
English (en)
Inventor
Donald Roy Maulding
Anil Kumar
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE107650T1 publication Critical patent/ATE107650T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cosmetics (AREA)
  • Liquid Crystal Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Lubricants (AREA)
AT90114919T 1989-09-11 1990-08-03 Verfahren zur herstellung von 23-(c1-c6- alkyloxim)ll-f28249-verbindungen. ATE107650T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/405,793 US4988824A (en) 1989-09-11 1989-09-11 Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds

Publications (1)

Publication Number Publication Date
ATE107650T1 true ATE107650T1 (de) 1994-07-15

Family

ID=23605260

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90114919T ATE107650T1 (de) 1989-09-11 1990-08-03 Verfahren zur herstellung von 23-(c1-c6- alkyloxim)ll-f28249-verbindungen.

Country Status (27)

Country Link
US (1) US4988824A (de)
EP (1) EP0421081B1 (de)
JP (1) JP2939312B2 (de)
KR (1) KR0160977B1 (de)
CN (1) CN1028428C (de)
AT (1) ATE107650T1 (de)
AU (1) AU634579B2 (de)
BG (1) BG60620B1 (de)
BR (1) BR9004493A (de)
CA (1) CA2024919C (de)
DE (1) DE69010129T2 (de)
DK (1) DK0421081T3 (de)
ES (1) ES2057291T3 (de)
GE (1) GEP19981003B (de)
HU (1) HU206721B (de)
IE (1) IE66030B1 (de)
IL (1) IL95303A (de)
LV (1) LV10503B (de)
MD (1) MD425C2 (de)
NZ (1) NZ235151A (de)
PL (1) PL165332B1 (de)
PT (1) PT95242B (de)
RU (1) RU2030416C1 (de)
SI (1) SI9011711A (de)
UA (1) UA26907C2 (de)
YU (1) YU47520B (de)
ZA (1) ZA907186B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU660205B2 (en) 1991-12-23 1995-06-15 Virbac, Inc Systemic control of parasites
US5439924A (en) * 1991-12-23 1995-08-08 Virbac, Inc. Systemic control of parasites
US5478951A (en) * 1994-06-22 1995-12-26 American Cyanamid Company Method for the purification of 23-E isomers of 23-imino derivatives of LL-F28249 compounds
US5994395A (en) * 1995-02-24 1999-11-30 Novartis Animal Health Us, Inc. Composition for controlling parasites
DE69619894T2 (de) * 1995-06-30 2002-11-14 American Cyanamid Co., Madison Stabile Makrolide und Makrolide Imptstoff-Zusammensetzungen
WO1999017760A2 (en) 1997-10-02 1999-04-15 Microcide Pharmaceuticals, Inc. Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug
US6762327B2 (en) * 2002-04-29 2004-07-13 Wyeth Selective oxidation process with enhanced safety
US7348417B2 (en) * 2003-08-07 2008-03-25 Wyeth Method of purifying moxidectin through crystallization
NZ548934A (en) * 2006-05-08 2007-01-26 Wyeth Corp Process for preparing moxidectin
NZ548932A (en) * 2006-05-08 2007-01-26 Wyeth Corp Intermediates and processes using them for preparing moxidectin
NZ548936A (en) * 2006-06-22 2007-02-23 Wyeth Corp Selective oxidation of LL-F28249-alpha using o-iodoxybenzoic acid
BR122020002199B1 (pt) 2011-12-02 2021-01-19 Merial, Inc. formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina
CN104277050B (zh) * 2013-07-04 2016-05-04 北大方正集团有限公司 一种制备莫西克汀的方法
CN104017001B (zh) * 2014-06-18 2016-01-13 大连九信生物化工科技有限公司 一种化学合成莫西克汀的方法
CN104292239A (zh) * 2014-09-30 2015-01-21 大连九信生物化工科技有限公司 一种消除莫西克汀生产过程中副产物二甲基硫醚的方法
CN104628740B (zh) * 2015-02-13 2017-06-16 河北圣雪大成制药有限责任公司 一种化学合成及纯化莫西克汀的方法
CN104860961B (zh) * 2015-04-10 2017-08-04 新宇药业股份有限公司 一种制备5‑氧（对‑硝基苯甲酰）‑尼莫克汀的方法
CN106831811B (zh) * 2015-08-12 2018-10-26 内蒙古佳瑞米精细化工有限公司 一种制备高含量尼莫克汀的方法
CN114591347B (zh) * 2022-03-29 2023-03-24 河北美荷药业有限公司 莫西菌素中间体及制备方法、莫西菌素的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
ES8802229A1 (es) * 1985-04-30 1988-04-16 Glaxo Group Ltd Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
EP0259779B1 (de) * 1986-09-12 1994-08-10 American Cyanamid Company 23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen
US4855317A (en) * 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
GB8721376D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
JP2629047B2 (ja) * 1988-05-10 1997-07-09 アメリカン・サイアナミツド・カンパニー マクロライド化合物
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
US4900758A (en) * 1989-05-11 1990-02-13 Ici Americas Inc. Novel insecticides
ATE130006T1 (de) * 1989-09-11 1995-11-15 American Cyanamid Co 13-alkyl-23-imino und 13-halo-23-imino-derivate von ll-f28249-verbindungen und ihre verwendung als endo- und ectoparasitizide, insektizide, akarizide und nematozide mittel.

Also Published As

Publication number Publication date
DE69010129D1 (de) 1994-07-28
IL95303A0 (en) 1991-06-30
CA2024919A1 (en) 1991-03-12
HK1000095A1 (en) 1997-11-21
ES2057291T3 (es) 1994-10-16
HU206721B (en) 1992-12-28
CN1051043A (zh) 1991-05-01
PL286824A1 (en) 1991-08-12
LV10503A (lv) 1995-02-20
HUT55019A (en) 1991-04-29
EP0421081A1 (de) 1991-04-10
IL95303A (en) 1994-11-28
IE66030B1 (en) 1995-11-29
BG92810A (bg) 1993-12-24
SI9011711A (sl) 1998-02-28
KR0160977B1 (ko) 1998-12-01
UA26907C2 (uk) 1999-12-29
BR9004493A (pt) 1991-09-10
PT95242B (pt) 1997-06-30
YU171190A (sh) 1992-07-20
EP0421081B1 (de) 1994-06-22
YU47520B (sh) 1995-10-03
PL165332B1 (pl) 1994-12-30
KR910006490A (ko) 1991-04-29
LV10503B (en) 1996-04-20
CN1028428C (zh) 1995-05-17
AU6236290A (en) 1991-03-14
MD425C2 (ro) 1997-04-30
GEP19981003B (en) 1998-10-27
CA2024919C (en) 2001-12-11
NZ235151A (en) 1992-11-25
JPH03141283A (ja) 1991-06-17
PT95242A (pt) 1991-05-22
JP2939312B2 (ja) 1999-08-25
IE903273A1 (en) 1991-03-27
RU2030416C1 (ru) 1995-03-10
BG60620B1 (bg) 1995-10-31
DE69010129T2 (de) 1995-01-26
DK0421081T3 (da) 1994-07-25
US4988824A (en) 1991-01-29
HU905842D0 (en) 1991-03-28
ZA907186B (en) 1991-06-26
AU634579B2 (en) 1993-02-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time