ATE108453T1 - Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung. - Google Patents
Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung.Info
- Publication number
- ATE108453T1 ATE108453T1 AT89304169T AT89304169T ATE108453T1 AT E108453 T1 ATE108453 T1 AT E108453T1 AT 89304169 T AT89304169 T AT 89304169T AT 89304169 T AT89304169 T AT 89304169T AT E108453 T1 ATE108453 T1 AT E108453T1
- Authority
- AT
- Austria
- Prior art keywords
- piperidylids
- benzopyridopiperidine
- compositions
- preparation
- methods
- Prior art date
Links
- RIOPPPCBVKCDAC-UHFFFAOYSA-N 1,2,3,4-tetrahydrobenzo[b][1,5]naphthyridine Chemical compound C1=CC=C2N=C(CCCN3)C3=CC2=C1 RIOPPPCBVKCDAC-UHFFFAOYSA-N 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- -1 piperidylidene Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18760488A | 1988-04-28 | 1988-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE108453T1 true ATE108453T1 (de) | 1994-07-15 |
Family
ID=22689668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89304169T ATE108453T1 (de) | 1988-04-28 | 1989-04-26 | Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung. |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP0341860B1 (de) |
| JP (1) | JPH0678315B2 (de) |
| KR (1) | KR950004004B1 (de) |
| AT (1) | ATE108453T1 (de) |
| AU (1) | AU629835B2 (de) |
| CA (1) | CA1341044C (de) |
| DE (1) | DE68916699T2 (de) |
| DK (1) | DK256890A (de) |
| ES (1) | ES2056214T3 (de) |
| FI (1) | FI96690C (de) |
| IE (1) | IE64522B1 (de) |
| IL (1) | IL90101A (de) |
| MY (1) | MY106280A (de) |
| NZ (1) | NZ228888A (de) |
| OA (1) | OA09629A (de) |
| WO (1) | WO1989010369A1 (de) |
| ZA (1) | ZA893104B (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665726A (en) * | 1986-10-31 | 1997-09-09 | Schering Corporation | Benzo[5,6]cycloheptapyridines, compositions and methods of use |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| CA2004211A1 (en) * | 1988-11-30 | 1990-05-31 | Masataka Syoji | Piperidine derivatives and hyportensives containing the same |
| ZA914764B (en) * | 1990-06-22 | 1992-03-25 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene,piperidylidene and piperazine compounds,compositions and methods of use |
| US5393753A (en) * | 1990-10-10 | 1995-02-28 | Schering Corporation | Substituted imidazobenzazepines |
| GB9109557D0 (en) * | 1991-05-02 | 1991-06-26 | Wellcome Found | Chemical compounds |
| EP0586560A1 (de) * | 1991-05-23 | 1994-03-16 | Schering Corporation | Neue benzopyrido-piperidyliden verbindungen, zusammensetzungen, verfahren zur herstellung und verwendung |
| JPH06509341A (ja) * | 1991-07-23 | 1994-10-20 | シェリング・コーポレーション | 新規ベンゾピリドピペリジリデン化合物、組成物、製造方法および使用方法 |
| JP2974529B2 (ja) * | 1992-02-20 | 1999-11-10 | 北陸製薬株式会社 | 両性型三環系化合物 |
| CA2132848A1 (en) * | 1992-03-27 | 1993-10-14 | Richard Friary | Unabridged bis-aryl carbinol derivatives, compositions and methods of use |
| JPH07505394A (ja) * | 1992-03-27 | 1995-06-15 | シェリング・コーポレーション | 橋渡しビスアリールカルビノール誘導体，組成物および使用法 |
| US5464840A (en) * | 1993-12-06 | 1995-11-07 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
| US5538986A (en) * | 1993-12-06 | 1996-07-23 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
| US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
| US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
| US5801175A (en) | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| PE92098A1 (es) * | 1996-07-31 | 1998-12-31 | Schering Corp | N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo |
| CH688412A5 (de) * | 1997-03-11 | 1997-09-15 | Cilag Ag | Verfahren zur Herstellung von 1,4-disubstituierten Piperidinverbindungen. |
| US6051582A (en) * | 1997-06-17 | 2000-04-18 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| AU753533B2 (en) * | 1997-06-17 | 2002-10-17 | Schering Corporation | Benzo(5,6)cyclohepta(1,2B)pyridine derivatives useful for inhibition of farnesyl protein transferase |
| US5925648A (en) * | 1997-07-29 | 1999-07-20 | Schering Corporation | Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase |
| US6632455B2 (en) | 1997-12-22 | 2003-10-14 | Schering Corporation | Molecular dispersion composition with enhanced bioavailability |
| WO1999037619A1 (en) * | 1998-01-21 | 1999-07-29 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| ATE309249T1 (de) | 1998-01-21 | 2005-11-15 | Millennium Pharm Inc | Chemokin rezeptor antagonisten und verwndung |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| WO2000023023A1 (en) * | 1998-10-20 | 2000-04-27 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| US6455554B1 (en) | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
| AU6503900A (en) * | 1999-07-28 | 2001-02-19 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| ATE387439T1 (de) | 2000-09-20 | 2008-03-15 | Schering Corp | Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| EP1448566B3 (de) | 2001-11-21 | 2009-04-08 | Millennium Pharmaceuticals, Inc. | Chemokine rezeptor antagonisten und methoden zu deren anwendung |
| ES2211315B1 (es) | 2002-11-12 | 2005-10-16 | Almirall Prodesfarma, S.A. | Nuevos compuestos triciclicos. |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
| JPS61501205A (ja) * | 1984-02-15 | 1986-06-19 | シェリング・コ−ポレ−ション | ８↓−クロル↓−６，１１↓−ジヒドロ↓−１１↓−（４↓−ピペリジリデン）↓−５Ｈ↓−ベンゾ〔５，６〕シクロヘプタ〔１，２−ｂ〕ピリジンおよびその塩、これらの化合物の製造方法、ならびにこれらの化合物を含有する医薬組成物 |
| DE3677842D1 (de) * | 1985-05-13 | 1991-04-11 | Schering Corp | Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln. |
| US4804666A (en) * | 1985-08-14 | 1989-02-14 | Schering Corporation | Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines |
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
-
1989
- 1989-04-26 CA CA000597849A patent/CA1341044C/en not_active Expired - Fee Related
- 1989-04-26 JP JP1505871A patent/JPH0678315B2/ja not_active Expired - Lifetime
- 1989-04-26 WO PCT/US1989/001688 patent/WO1989010369A1/en not_active Ceased
- 1989-04-26 DE DE68916699T patent/DE68916699T2/de not_active Expired - Fee Related
- 1989-04-26 NZ NZ228888A patent/NZ228888A/en unknown
- 1989-04-26 ES ES89304169T patent/ES2056214T3/es not_active Expired - Lifetime
- 1989-04-26 AT AT89304169T patent/ATE108453T1/de not_active IP Right Cessation
- 1989-04-26 EP EP89304169A patent/EP0341860B1/de not_active Expired - Lifetime
- 1989-04-26 MY MYPI89000537A patent/MY106280A/en unknown
- 1989-04-26 ZA ZA893104A patent/ZA893104B/xx unknown
- 1989-04-26 KR KR1019890702471A patent/KR950004004B1/ko not_active Expired - Fee Related
- 1989-04-26 EP EP89905928A patent/EP0411048A1/de active Pending
- 1989-04-26 AU AU37344/89A patent/AU629835B2/en not_active Ceased
- 1989-04-27 IL IL9010189A patent/IL90101A/en not_active IP Right Cessation
- 1989-04-27 IE IE137989A patent/IE64522B1/en not_active IP Right Cessation
-
1990
- 1990-10-25 DK DK256890A patent/DK256890A/da not_active Application Discontinuation
- 1990-10-26 OA OA59879A patent/OA09629A/en unknown
- 1990-10-26 FI FI905280A patent/FI96690C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2056214T3 (es) | 1994-10-01 |
| FI96690B (fi) | 1996-04-30 |
| DE68916699T2 (de) | 1994-12-01 |
| DK256890A (da) | 1990-12-21 |
| DE68916699D1 (de) | 1994-08-18 |
| IL90101A (en) | 1996-11-14 |
| EP0411048A1 (de) | 1991-02-06 |
| IL90101A0 (en) | 1989-12-15 |
| AU3734489A (en) | 1989-11-24 |
| ZA893104B (en) | 1989-12-27 |
| EP0341860B1 (de) | 1994-07-13 |
| EP0341860A1 (de) | 1989-11-15 |
| KR950004004B1 (ko) | 1995-04-22 |
| OA09629A (en) | 1993-04-30 |
| JPH03504012A (ja) | 1991-09-05 |
| FI905280A0 (fi) | 1990-10-26 |
| IE64522B1 (en) | 1995-08-09 |
| JPH0678315B2 (ja) | 1994-10-05 |
| DK256890D0 (da) | 1990-10-25 |
| KR900700486A (ko) | 1990-08-13 |
| CA1341044C (en) | 2000-07-04 |
| AU629835B2 (en) | 1992-10-15 |
| WO1989010369A1 (en) | 1989-11-02 |
| NZ228888A (en) | 1991-12-23 |
| FI96690C (fi) | 1996-08-12 |
| IE891379L (en) | 1989-10-28 |
| MY106280A (en) | 1995-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |