ATE108788T1 - Phenylalkanolsäureester. - Google Patents

Phenylalkanolsäureester.

Info

Publication number: ATE108788T1
Authority: AT; Austria
Prior art keywords: nitrogen; alkyl; hydrogen; taken together; attached
Prior art date: 1989-05-12

Application number

AT90108375T

Other languages

English (en)

Inventor

Sadahiko C O Minase Res Iguchi

Co Ltd - Sakura Pharmaceutical

Masanori C O Minase R Kawamura

Tsumoru C O Minase Re Miyamoto

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-12

Filing date

1990-05-03

Publication date

1994-08-15

1990-05-03 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

1994-08-15 Application granted granted Critical

1994-08-15 Publication of ATE108788T1 publication Critical patent/ATE108788T1/de

Links

239000002253 acid Substances 0.000 title abstract 3
150000002148 esters Chemical class 0.000 title abstract 2
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 10
229910052757 nitrogen Inorganic materials 0.000 abstract 6
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000005842 heteroatom Chemical group 0.000 abstract 3
RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
239000011593 sulfur Substances 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
206010002383 Angina Pectoris Diseases 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
230000006793 arrhythmia Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
102000016967 beta-1 Adrenergic Receptors Human genes 0.000 abstract 1
108010014494 beta-1 Adrenergic Receptors Proteins 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
-1 nitroxy Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000004953 trihalomethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

AT90108375T 1989-05-12 1990-05-03 Phenylalkanolsäureester. ATE108788T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP11987389		1989-05-12

Publications (1)

Publication Number	Publication Date
ATE108788T1 true ATE108788T1 (de)	1994-08-15

Family

ID=14772367

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90108375T ATE108788T1 (de)	1989-05-12	1990-05-03	Phenylalkanolsäureester.

Country Status (9)

Country	Link
US (1)	US5013734A (de)
EP (1)	EP0397031B1 (de)
JP (2)	JPH0730068B2 (de)
KR (1)	KR970003457B1 (de)
AT (1)	ATE108788T1 (de)
CA (1)	CA2015730C (de)
DE (1)	DE69010757T2 (de)
DK (1)	DK0397031T3 (de)
ES (1)	ES2060853T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6627662B2 (en)	1995-10-10	2003-09-30	William John Louis, Austin And Repatriation Medical Centre	3-amino-propoxyphenyl derivatives (I)
ATE533509T1 (de) *	2003-08-08	2011-12-15	Ono Pharmaceutical Co	Herzverlangsamender arzneistoff mit beta-blockern mit kurzzeitwirkung als wirkstoff
ITMI20110343A1 (it) *	2011-03-04	2012-09-05	Procos Spa	Processo per la sintesi enantioselettiva di landiolol
EP2687521B1 (de)	2012-07-20	2015-01-07	Procos S.p.A.	Verfahren zur enantioselektiven Synthese von Landiolol
CN104003973B (zh) *	2014-06-05	2016-02-24	重庆植恩药业有限公司	一种兰地洛尔草酸盐的制备方法
CN106608863A (zh) *	2015-10-23	2017-05-03	北京创立科创医药技术开发有限公司	一种盐酸兰地洛尔的制备方法
CN106248825B (zh) *	2016-07-21	2017-10-10	山东省分析测试中心	盐酸兰地洛尔原料药物中起始物料a的检测方法
CN118754867A (zh) *	2024-09-05	2024-10-11	伊诺药物研究(南京)有限公司	一种盐酸兰地洛尔的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8004087L (sv) *	1980-06-02	1981-12-03	Haessle Ab	Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ...
ZA827646B (en) *	1981-11-12	1983-08-31	American Hospital Supply Corp	Esters of aryloxypropanolamine derivatives
US4548941A (en) *	1984-07-30	1985-10-22	Merck & Co., Inc.	1,5-Methano-1H-4-benzazonine dicarboxylates, process for preparing and use as calcium blockers
GB2169892B (en) *	1985-01-23	1988-02-03	Ferrer Int	Piperazine derivatives

1990
- 1990-04-30 CA CA002015730A patent/CA2015730C/en not_active Expired - Fee Related
- 1990-05-03 ES ES90108375T patent/ES2060853T3/es not_active Expired - Lifetime
- 1990-05-03 EP EP90108375A patent/EP0397031B1/de not_active Expired - Lifetime
- 1990-05-03 DE DE69010757T patent/DE69010757T2/de not_active Expired - Fee Related
- 1990-05-03 AT AT90108375T patent/ATE108788T1/de not_active IP Right Cessation
- 1990-05-03 DK DK90108375.8T patent/DK0397031T3/da active
- 1990-05-08 JP JP2116947A patent/JPH0730068B2/ja not_active Expired - Lifetime
- 1990-05-09 KR KR1019900006517A patent/KR970003457B1/ko not_active Expired - Fee Related
- 1990-05-11 US US07/521,962 patent/US5013734A/en not_active Expired - Lifetime
1993
- 1993-04-07 JP JP5104985A patent/JP2539734B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2060853T3 (es)	1994-12-01
EP0397031A1 (de)	1990-11-14
JP2539734B2 (ja)	1996-10-02
CA2015730A1 (en)	1990-11-12
DE69010757T2 (de)	1994-12-15
KR900018082A (ko)	1990-12-20
KR970003457B1 (ko)	1997-03-18
JPH0730068B2 (ja)	1995-04-05
US5013734A (en)	1991-05-07
DK0397031T3 (da)	1994-10-31
EP0397031B1 (de)	1994-07-20
CA2015730C (en)	1997-10-07
JPH0673044A (ja)	1994-03-15
JPH0372475A (ja)	1991-03-27
DE69010757D1 (de)	1994-08-25

Legal Events

Date	Code	Title	Description
2007-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
KR101136434B1 (ko)	2012-04-19	향상된 항염증성, 항혈전성 및 항혈소판 활성을 가진콜레스테롤을 낮추는 물질로서의 플루바스타틴,프라바스타틴, 세리바스타틴, 아토르바스타틴 및로수바스타틴의 니트록시유도체들
DK658787D0 (da)	1987-12-15	Mycophenolsyrederivater
FR2697524B1 (fr)	1994-12-23	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
NO174296C (no)	1994-04-13	Analogifremgangsmåte til fremstilling av terapeutisk aktive 1-indolylalkyl-4-(substituert-pyridinyl)piperaziner
CA2065644A1 (en)	1992-10-11	Pyrazolopyridine compound and processes for preparation thereof
ATE189814T1 (de)	2000-03-15	Hydroxypyridin-derivate, ihre herstellung und ihre pharmazeutische verwendung
KR900018037A (ko)	1990-12-20	치환 (퀴놀린-2-일-메톡시)페닐-아실-술폰아미드 및-시안아미드, 그의 제조 방법 및 약제로서의 용도
DE69010757D1 (de)	1994-08-25	Phenylalkanolsäureester.
NO175310C (no)	1994-09-28	Analogifremgangsmåte til fremstilling av terapeutisk aktive pyrrolo(2,3-b)indolderivater
EP0143123A3 (en)	1986-09-03	Industrial products useful as intermediates in the preparation of 4-hydroxy-3 quinoleine carboxamide derivatives substituted at position 2, and the preparation of these intermediates
GB8809481D0 (en)	1988-05-25	Chemical compounds
MX9202975A (es)	1992-07-01	Nuevos compuestos biciclicos y sus sales farmaceuticamente aceptables y procedimiento para su preparacion.
NO172939C (no)	1993-09-29	Analogifremgangsmaate ved fremstilling av terapeutisk aktive estere av estramustin
NO942568L (no)	1995-01-31	1-aryloksy-3-alkylamino-2-propanolnitratestere, deres anvendelse og tilsvarende farmasöytiske blanding
EA200100816A1 (ru)	2001-12-24	2-аминопиридины, содержащие конденсированные кольца в качестве заместителей
IL96762A0 (en)	1992-05-25	Pyridyl cyclopropane derivatives,process for their preparation and fungicidal compositions containing them
Voorstad et al.	1985	Comparison of the hypolipidemic activity of cyclic vs. acyclic imides
TW372967B (en)	1999-11-01	1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof
ATE69443T1 (de)	1991-11-15	Ester als herbizide.
IE882107L (en)	1989-01-09	Pyrimidones
EA199900836A1 (ru)	2000-04-24	Противосудорожные производные изохинолилбензамида
US4833162A (en)	1989-05-23	Substituted benzeneacetonitriles and their use as calcium channel blockers
SE8800846D0 (sv)	1988-03-09	Optiskt aktiva oxo-isoindolinderivat
ATE35263T1 (de)	1988-07-15	Benzoylsaeure-derivat.
JPS55105619A (en)	1980-08-13	Calcium antagonist