ATE108788T1 - Phenylalkanolsäureester. - Google Patents
Phenylalkanolsäureester.Info
- Publication number
- ATE108788T1 ATE108788T1 AT90108375T AT90108375T ATE108788T1 AT E108788 T1 ATE108788 T1 AT E108788T1 AT 90108375 T AT90108375 T AT 90108375T AT 90108375 T AT90108375 T AT 90108375T AT E108788 T1 ATE108788 T1 AT E108788T1
- Authority
- AT
- Austria
- Prior art keywords
- nitrogen
- alkyl
- hydrogen
- taken together
- attached
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 10
- 229910052757 nitrogen Inorganic materials 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 102000016967 beta-1 Adrenergic Receptors Human genes 0.000 abstract 1
- 108010014494 beta-1 Adrenergic Receptors Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- -1 nitroxy Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11987389 | 1989-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE108788T1 true ATE108788T1 (de) | 1994-08-15 |
Family
ID=14772367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90108375T ATE108788T1 (de) | 1989-05-12 | 1990-05-03 | Phenylalkanolsäureester. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5013734A (de) |
| EP (1) | EP0397031B1 (de) |
| JP (2) | JPH0730068B2 (de) |
| KR (1) | KR970003457B1 (de) |
| AT (1) | ATE108788T1 (de) |
| CA (1) | CA2015730C (de) |
| DE (1) | DE69010757T2 (de) |
| DK (1) | DK0397031T3 (de) |
| ES (1) | ES2060853T3 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2271026C (en) * | 1995-10-10 | 2007-03-13 | The University Of Melbourne | 3-amino-propoxyphenyl derivatives |
| JP4816083B2 (ja) * | 2003-08-08 | 2011-11-16 | 小野薬品工業株式会社 | 短時間型β遮断薬を有効成分とする心拍数減少剤 |
| ITMI20110343A1 (it) * | 2011-03-04 | 2012-09-05 | Procos Spa | Processo per la sintesi enantioselettiva di landiolol |
| ES2532851T3 (es) | 2012-07-20 | 2015-04-01 | Procos S.P.A. | Proceso para la síntesis enantioselectiva de landiolol |
| CN104003973B (zh) * | 2014-06-05 | 2016-02-24 | 重庆植恩药业有限公司 | 一种兰地洛尔草酸盐的制备方法 |
| CN106608863A (zh) * | 2015-10-23 | 2017-05-03 | 北京创立科创医药技术开发有限公司 | 一种盐酸兰地洛尔的制备方法 |
| CN106248825B (zh) * | 2016-07-21 | 2017-10-10 | 山东省分析测试中心 | 盐酸兰地洛尔原料药物中起始物料a的检测方法 |
| CN118754867A (zh) * | 2024-09-05 | 2024-10-11 | 伊诺药物研究(南京)有限公司 | 一种盐酸兰地洛尔的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8004087L (sv) * | 1980-06-02 | 1981-12-03 | Haessle Ab | Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ... |
| ZA827646B (en) * | 1981-11-12 | 1983-08-31 | American Hospital Supply Corp | Esters of aryloxypropanolamine derivatives |
| US4548941A (en) * | 1984-07-30 | 1985-10-22 | Merck & Co., Inc. | 1,5-Methano-1H-4-benzazonine dicarboxylates, process for preparing and use as calcium blockers |
| GB2169892B (en) * | 1985-01-23 | 1988-02-03 | Ferrer Int | Piperazine derivatives |
-
1990
- 1990-04-30 CA CA002015730A patent/CA2015730C/en not_active Expired - Fee Related
- 1990-05-03 DK DK90108375.8T patent/DK0397031T3/da active
- 1990-05-03 AT AT90108375T patent/ATE108788T1/de not_active IP Right Cessation
- 1990-05-03 ES ES90108375T patent/ES2060853T3/es not_active Expired - Lifetime
- 1990-05-03 EP EP90108375A patent/EP0397031B1/de not_active Expired - Lifetime
- 1990-05-03 DE DE69010757T patent/DE69010757T2/de not_active Expired - Fee Related
- 1990-05-08 JP JP2116947A patent/JPH0730068B2/ja not_active Expired - Lifetime
- 1990-05-09 KR KR1019900006517A patent/KR970003457B1/ko not_active Expired - Fee Related
- 1990-05-11 US US07/521,962 patent/US5013734A/en not_active Expired - Lifetime
-
1993
- 1993-04-07 JP JP5104985A patent/JP2539734B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2015730A1 (en) | 1990-11-12 |
| KR900018082A (ko) | 1990-12-20 |
| KR970003457B1 (ko) | 1997-03-18 |
| US5013734A (en) | 1991-05-07 |
| JP2539734B2 (ja) | 1996-10-02 |
| JPH0673044A (ja) | 1994-03-15 |
| EP0397031B1 (de) | 1994-07-20 |
| EP0397031A1 (de) | 1990-11-14 |
| DE69010757D1 (de) | 1994-08-25 |
| JPH0730068B2 (ja) | 1995-04-05 |
| DE69010757T2 (de) | 1994-12-15 |
| JPH0372475A (ja) | 1991-03-27 |
| CA2015730C (en) | 1997-10-07 |
| ES2060853T3 (es) | 1994-12-01 |
| DK0397031T3 (da) | 1994-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101136434B1 (ko) | 향상된 항염증성, 항혈전성 및 항혈소판 활성을 가진콜레스테롤을 낮추는 물질로서의 플루바스타틴,프라바스타틴, 세리바스타틴, 아토르바스타틴 및로수바스타틴의 니트록시유도체들 | |
| DK658787A (da) | Mycophenolsyrederivater | |
| NO174296C (no) | Analogifremgangsmåte til fremstilling av terapeutisk aktive 1-indolylalkyl-4-(substituert-pyridinyl)piperaziner | |
| CA2065644A1 (en) | Pyrazolopyridine compound and processes for preparation thereof | |
| DE69701298D1 (de) | Hydroxypyridin-Derivate, ihre Herstellung und ihre pharmazeutische Verwendung | |
| KR900018037A (ko) | 치환 (퀴놀린-2-일-메톡시)페닐-아실-술폰아미드 및-시안아미드, 그의 제조 방법 및 약제로서의 용도 | |
| DE69010757D1 (de) | Phenylalkanolsäureester. | |
| DK0430201T3 (de) | ||
| EP0143123A3 (en) | Industrial products useful as intermediates in the preparation of 4-hydroxy-3 quinoleine carboxamide derivatives substituted at position 2, and the preparation of these intermediates | |
| ZA892898B (en) | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them | |
| NO172939C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive estere av estramustin | |
| NO942568D0 (no) | 1-aryloksy-3-alkylamino-2-propanolitratestere, deres anvendelse og tilsvarende farmasöytiske blanding | |
| IL96762A0 (en) | Pyridyl cyclopropane derivatives,process for their preparation and fungicidal compositions containing them | |
| Voorstad et al. | Comparison of the hypolipidemic activity of cyclic vs. acyclic imides | |
| TW372967B (en) | 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof | |
| IE882107L (en) | Pyrimidones | |
| EA199900836A1 (ru) | Противосудорожные производные изохинолилбензамида | |
| IT1205640B (it) | Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono | |
| ES2006361A6 (es) | Un procedimiento para preparar derivados de insoindolinilo opticamente activos. | |
| US4833162A (en) | Substituted benzeneacetonitriles and their use as calcium channel blockers | |
| ATE35263T1 (de) | Benzoylsaeure-derivat. | |
| ES528454A0 (es) | Procedimiento de preparacion de nuevos derivados aminoetoxibencilalcoholicos y de sus sales de adicion acidas y amonicas cuaternarias | |
| EP0284069A3 (en) | Benzopyranopyridineacetic acid ester compounds and their pharmaceutical uses | |
| JPS55105620A (en) | Calcium antagonist | |
| JPS55105619A (en) | Calcium antagonist |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |