ATE109004T1 - Toleranzinduktion gegenüber einem fremdantigen. - Google Patents

Toleranzinduktion gegenüber einem fremdantigen.

Info

Publication number
ATE109004T1
ATE109004T1 AT89907436T AT89907436T ATE109004T1 AT E109004 T1 ATE109004 T1 AT E109004T1 AT 89907436 T AT89907436 T AT 89907436T AT 89907436 T AT89907436 T AT 89907436T AT E109004 T1 ATE109004 T1 AT E109004T1
Authority
AT
Austria
Prior art keywords
antigen
foreign antigen
tolerance induction
mammal
receptor
Prior art date
Application number
AT89907436T
Other languages
English (en)
Inventor
Terry B Strom
Vicki E Kelley
Original Assignee
Beth Israel Hospital
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital, Brigham & Womens Hospital filed Critical Beth Israel Hospital
Application granted granted Critical
Publication of ATE109004T1 publication Critical patent/ATE109004T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Steel Electrode Plates (AREA)
AT89907436T 1988-05-19 1989-05-18 Toleranzinduktion gegenüber einem fremdantigen. ATE109004T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19603688A 1988-05-19 1988-05-19

Publications (1)

Publication Number Publication Date
ATE109004T1 true ATE109004T1 (de) 1994-08-15

Family

ID=22723875

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89907436T ATE109004T1 (de) 1988-05-19 1989-05-18 Toleranzinduktion gegenüber einem fremdantigen.

Country Status (6)

Country Link
EP (1) EP0414816B1 (de)
JP (1) JPH03504248A (de)
AT (1) ATE109004T1 (de)
CA (1) CA1340494C (de)
DE (1) DE68917138T2 (de)
WO (1) WO1989011287A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5152980A (en) * 1988-05-19 1992-10-06 The Beth Israel Hospital Association Induction of tolerance to a foreign antigen IL-2 receptor-binding substances
EP0537229A1 (de) * 1990-07-05 1993-04-21 Akzo Nobel N.V. Gegen rezeptoren gerichtete toxin-konjugate
JPH06508821A (ja) * 1991-03-07 1994-10-06 セラジュン　インク ウイルス病治療のための細胞表面受容体を標的とする分子の使用
EP1578397B1 (de) 2002-11-15 2012-12-26 Genmab A/S Humane monoklonale antikörper gegen cd25
US11203626B2 (en) 2016-03-10 2021-12-21 The Johns Hopkins University Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses
US11965009B2 (en) 2016-03-10 2024-04-23 The Johns Hopkins University Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses
KR102430891B1 (ko) 2016-03-10 2022-08-09 더 존스 홉킨스 유니버시티 응집체-비함유 단량체성 디프테리아 독소 융합 단백질의 제조 방법 및 치료적 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES522315A0 (es) * 1982-05-12 1984-08-16 Harvard College Un procedimiento para obtener una proteina hibrida.
US4545985A (en) * 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
US4681760A (en) * 1985-04-17 1987-07-21 The Board Of Trustees Of The Leland Stanford Junior University Method of conferring immunotolerance to a specific antigen
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies

Also Published As

Publication number Publication date
DE68917138D1 (de) 1994-09-01
EP0414816A4 (en) 1991-11-13
WO1989011287A1 (en) 1989-11-30
JPH03504248A (ja) 1991-09-19
CA1340494C (en) 1999-04-13
EP0414816B1 (de) 1994-07-27
EP0414816A1 (de) 1991-03-06
DE68917138T2 (de) 1995-02-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee