ATE109154T1 - 2'-methylidenpyrimidin-nukleoside, ihre verwendung und verfahren zu ihrer herstellung. - Google Patents

2'-methylidenpyrimidin-nukleoside, ihre verwendung und verfahren zu ihrer herstellung.

Info

Publication number: ATE109154T1
Authority: AT; Austria
Prior art keywords: stands; compounds; methylidene; preparation; salts
Prior art date: 1988-08-25

Application number

AT89115516T

Other languages

English (en)

Inventor

Tohru Ueda

Takuma Sasaki

Akira Minamishinkawa-K Matsuda

-Jo Kita-Ku Kita

Keiji Yamagami

Akihiro Fujii

Original Assignee

Yoshitomi Pharmaceutical

Yamasa Shoyu Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-25

Filing date

1989-08-23

Publication date

1994-08-15

1989-08-23 Application filed by Yoshitomi Pharmaceutical, Yamasa Shoyu Kk filed Critical Yoshitomi Pharmaceutical

1994-08-15 Application granted granted Critical

1994-08-15 Publication of ATE109154T1 publication Critical patent/ATE109154T1/de

Links

239000002777 nucleoside Substances 0.000 title abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
230000001093 anti-cancer Effects 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
-1 nucleoside compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT89115516T 1988-08-25 1989-08-23 2'-methylidenpyrimidin-nukleoside, ihre verwendung und verfahren zu ihrer herstellung. ATE109154T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP21206188		1988-08-25

Publications (1)

Publication Number	Publication Date
ATE109154T1 true ATE109154T1 (de)	1994-08-15

Family

ID=16616219

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT89115516T ATE109154T1 (de)	1988-08-25	1989-08-23	2'-methylidenpyrimidin-nukleoside, ihre verwendung und verfahren zu ihrer herstellung.
AT93109165T ATE154359T1 (de)	1988-08-25	1989-08-23	2'-methylidenpyrimidinnukleosidverbindungen, ihre verwendung und verfahren zu ihrer herstellung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT93109165T ATE154359T1 (de)	1988-08-25	1989-08-23	2'-methylidenpyrimidinnukleosidverbindungen, ihre verwendung und verfahren zu ihrer herstellung

Country Status (7)

Country	Link
US (1)	US5705630A (de)
EP (2)	EP0566162B1 (de)
KR (1)	KR0136869B1 (de)
AT (2)	ATE109154T1 (de)
CA (1)	CA1319685C (de)
DE (2)	DE68917060T2 (de)
ES (1)	ES2057031T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9020930D0 (en) *	1990-09-26	1990-11-07	Wellcome Found	Pharmaceutical combinations
US5206244A (en) *	1990-10-18	1993-04-27	E. R. Squibb & Sons, Inc.	Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) *	1990-10-18	1994-08-23	E. R. Squibb & Sons, Inc.	Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
US5665711A (en) *	1995-12-12	1997-09-09	Yoshitomi Pharmaceutical Industries, Ltd.	Antitumor composition for oral administration
EP1270008B1 (de) *	2001-05-31	2006-07-12	Yung Shin Pharmaceutical Ind. Co., Ltd.	Kondensierte trizyklische Derivate des Guanosins zur Behandlung von Tumoren
KR100481356B1 (ko) *	2002-10-17	2005-04-07	이수화학 주식회사	2'-ｏ-치환된 뉴클레오시드의 제조 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988007049A1 (fr) *	1987-03-19	1988-09-22	Yamasa Shoyu Kabushiki Kaisha	Derives de nucleosides de 2'-alkylidene pyrimidine, procede de preparation et utilisation de ces composes

1989
- 1989-08-23 AT AT89115516T patent/ATE109154T1/de not_active IP Right Cessation
- 1989-08-23 DE DE68917060T patent/DE68917060T2/de not_active Expired - Fee Related
- 1989-08-23 EP EP93109165A patent/EP0566162B1/de not_active Expired - Lifetime
- 1989-08-23 DE DE68928127T patent/DE68928127T2/de not_active Expired - Fee Related
- 1989-08-23 AT AT93109165T patent/ATE154359T1/de not_active IP Right Cessation
- 1989-08-23 EP EP89115516A patent/EP0360018B1/de not_active Expired - Lifetime
- 1989-08-23 ES ES89115516T patent/ES2057031T3/es not_active Expired - Lifetime
- 1989-08-24 CA CA000609209A patent/CA1319685C/en not_active Expired - Fee Related
- 1989-08-25 KR KR1019890012101A patent/KR0136869B1/ko not_active Expired - Fee Related
1992
- 1992-01-07 US US07/818,656 patent/US5705630A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR900003195A (ko)	1990-03-26
US5705630A (en)	1998-01-06
EP0360018A1 (de)	1990-03-28
EP0566162A1 (de)	1993-10-20
CA1319685C (en)	1993-06-29
DE68928127D1 (de)	1997-07-17
EP0360018B1 (de)	1994-07-27
DE68928127T2 (de)	1997-09-25
EP0566162B1 (de)	1997-06-11
KR0136869B1 (ko)	1998-04-25
ES2057031T3 (es)	1994-10-16
DE68917060T2 (de)	1994-12-08
ATE154359T1 (de)	1997-06-15
DE68917060D1 (de)	1994-09-01

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Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2001-05-15	REN	Ceased due to non-payment of the annual fee