ATE109156T1 - Elastase-inhibierungspolypeptide und verfahren zur herstellung durch genetische rekombination. - Google Patents

Elastase-inhibierungspolypeptide und verfahren zur herstellung durch genetische rekombination.

Info

Publication number: ATE109156T1
Authority: AT; Austria
Prior art keywords: cys; pro; lys; gly; val
Prior art date: 1987-12-28

Application number

AT89900924T

Other languages

English (en)

Inventor

Takashi Sugiyama

Takashi Kamimura

Kenichi Masuda

Masahiro Okada

Eiko Ohtsuka

Original Assignee

Teijin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-28

Filing date

1988-12-28

Publication date

1994-08-15

1988-12-28 Application filed by Teijin Ltd filed Critical Teijin Ltd

1994-08-15 Application granted granted Critical

1994-08-15 Publication of ATE109156T1 publication Critical patent/ATE109156T1/de

Links

102000016387 Pancreatic elastase Human genes 0.000 title abstract 2
108010067372 Pancreatic elastase Proteins 0.000 title abstract 2
230000005764 inhibitory process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
230000006798 recombination Effects 0.000 title 1
239000003602 elastase inhibitor Substances 0.000 abstract 3
102000002265 Human Growth Hormone Human genes 0.000 abstract 2
108010000521 Human Growth Hormone Proteins 0.000 abstract 2
239000000854 Human Growth Hormone Substances 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
239000013612 plasmid Substances 0.000 abstract 2
102100021253 Antileukoproteinase Human genes 0.000 abstract 1
KLKHFFMNGWULBN-VKHMYHEASA-N Asn-Gly Chemical compound NC(=O)C[C@H](N)C(=O)NCC(O)=O KLKHFFMNGWULBN-VKHMYHEASA-N 0.000 abstract 1
229940122858 Elastase inhibitor Drugs 0.000 abstract 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
101000615334 Homo sapiens Antileukoproteinase Proteins 0.000 abstract 1
101000879712 Streptomyces lividans Protease inhibitor Proteins 0.000 abstract 1
YTNGABPUXFEOGU-SRVKXCTJSA-N Val-Pro-Arg Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O YTNGABPUXFEOGU-SRVKXCTJSA-N 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
235000018102 proteins Nutrition 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

AT89900924T 1987-12-28 1988-12-28 Elastase-inhibierungspolypeptide und verfahren zur herstellung durch genetische rekombination. ATE109156T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP33021987		1987-12-28

Publications (1)

Publication Number	Publication Date
ATE109156T1 true ATE109156T1 (de)	1994-08-15

Family

ID=18230182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89900924T ATE109156T1 (de)	1987-12-28	1988-12-28	Elastase-inhibierungspolypeptide und verfahren zur herstellung durch genetische rekombination.

Country Status (8)

Country	Link
EP (1)	EP0346500B1 (de)
JP (1)	JP2574048B2 (de)
KR (1)	KR910007573B1 (de)
AT (1)	ATE109156T1 (de)
CA (1)	CA1340877C (de)
DE (1)	DE3850878T2 (de)
ES (1)	ES2015366A6 (de)
WO (1)	WO1989006239A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5871956A (en) *	1984-12-06	1999-02-16	Amgen Inc.	Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US6132990A (en) *	1984-12-06	2000-10-17	Amgen Boulder Inc.	Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5851983A (en) *	1987-12-28	1998-12-22	Teijin Limited	Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
DE3841873A1 (de) *	1988-12-13	1990-06-21	Gruenenthal Gmbh	Neue serinprotease-inhibitor-proteine, diese enthaltende arzneimittel, dna-sequenzen, die fuer diese proteine codieren und verfahren zur herstellung dieser proteine, arzneimittel und dna-sequenzen
WO1991000912A1 (en) *	1989-07-07	1991-01-24	Massachusetts Institute Of Technology	Production and use of hybrid protease inhibitors
DE3938971A1 (de) *	1989-11-24	1991-05-29	Biotechnolog Forschung Gmbh	Leukozytenelastase und kathepsin g blockierendes peptid, dna, vektor, wirtsorganismus und verfahren zu seiner gewinnung sowie pharmazeutisches praeparat
GB8927722D0 (en) *	1989-12-07	1990-02-07	British Bio Technology	Proteins and nucleic acids
EP0616614A1 (de) *	1991-04-18	1994-09-28	The Uab Research Foundation	Zusammensetzungen und methoden zur inhibition von elastase
UA41338C2 (uk) *	1992-09-09	2001-09-17	Амген Інк.	Спосіб інгібування ретровірусної інфекції, яка викликана вірусом імунодефіциту людини (віл), спосіб інгібування вірусу імунодефіциту людини (віл)
US6869925B1 (en)	1992-09-09	2005-03-22	Amgen Inc.	Inhibition of retrovirus infection
US6017880A (en) *	1994-03-09	2000-01-25	Amgen Inc.	Inhibition of retrovirus infection
WO1995025539A1 (en) *	1994-03-23	1995-09-28	Tokyo Tanabe Company Limited	Novel remedy for respiratory-tract viral disease
US5633227A (en) *	1994-09-12	1997-05-27	Miles, Inc.	Secretory leukocyte protease inhibitor as an inhibitor of tryptase
EP1071955B2 (de)	1998-04-17	2009-02-18	N.V. Innogenetics S.A.	Verbessertes immundiagnostische tests durch verwendung von reduzierende agenzien
WO2001064031A2 (en) *	2000-03-01	2001-09-07	The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Slpi knockout mice and methods for wound treatment

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS427042Y1 (de) *	1966-11-08	1967-04-03
US4455122A (en) *	1981-12-14	1984-06-19	United Technologies Corporation	Blade to blade vibration damper
US4505642A (en) *	1983-10-24	1985-03-19	United Technologies Corporation	Rotor blade interplatform seal
US4669959A (en) *	1984-07-23	1987-06-02	United Technologies Corporation	Breach lock anti-rotation key
KR940011339B1 (ko) *	1984-12-06	1994-12-05	씨네겐 바이오로지칼즈, 인코포레이티드	세린프로테아제억제제의 제조를 위한 dna 재조합 방법
DE3600571A1 (de) *	1986-01-10	1987-08-06	Gruenenthal Gmbh	Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel

1988
- 1988-12-21 CA CA000586637A patent/CA1340877C/en not_active Expired - Fee Related
- 1988-12-27 ES ES8803972A patent/ES2015366A6/es not_active Expired - Lifetime
- 1988-12-28 DE DE3850878T patent/DE3850878T2/de not_active Expired - Lifetime
- 1988-12-28 JP JP1500811A patent/JP2574048B2/ja not_active Expired - Fee Related
- 1988-12-28 EP EP89900924A patent/EP0346500B1/de not_active Expired - Lifetime
- 1988-12-28 WO PCT/JP1988/001342 patent/WO1989006239A1/ja not_active Ceased
- 1988-12-28 KR KR1019890701620A patent/KR910007573B1/ko not_active Expired
- 1988-12-28 AT AT89900924T patent/ATE109156T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR900700500A (ko)	1990-08-13
DE3850878D1 (de)	1994-09-01
EP0346500A1 (de)	1989-12-20
DE3850878T2 (de)	1994-11-10
EP0346500A4 (en)	1991-05-22
CA1340877C (en)	2000-01-18
EP0346500B1 (de)	1994-07-27
KR910007573B1 (ko)	1991-09-28
JP2574048B2 (ja)	1997-01-22
WO1989006239A1 (fr)	1989-07-13
ES2015366A6 (es)	1990-08-16

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Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2009-03-15	EELA	Cancelled due to lapse of time