ATE109787T1 - Latente alkylierungsubstituenten enthaltende anthracycline-analoge. - Google Patents

Latente alkylierungsubstituenten enthaltende anthracycline-analoge.

Info

Publication number: ATE109787T1
Authority: AT; Austria
Prior art keywords: alkyl; substituents; alkylation; present; analogues containing
Prior art date: 1990-11-01

Application number

AT91920574T

Other languages

English (en)

Inventor

David Farquhar

Abdallah Charif

Original Assignee

Univ Texas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-01

Filing date

1991-10-16

Publication date

1994-08-15

1991-10-16 Application filed by Univ Texas filed Critical Univ Texas

1994-08-15 Application granted granted Critical

1994-08-15 Publication of ATE109787T1 publication Critical patent/ATE109787T1/de

Links

229940045799 anthracyclines and related substance Drugs 0.000 title abstract 2
230000029936 alkylation Effects 0.000 title 1
238000005804 alkylation reaction Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
150000001299 aldehydes Chemical class 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
108090000371 Esterases Proteins 0.000 abstract 1
101100258328 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) crc-2 gene Proteins 0.000 abstract 1
206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
229960000975 daunorubicin Drugs 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
WPJRFCZKZXBUNI-HCWXCVPCSA-N daunosamine Chemical compound C[C@H](O)[C@@H](O)[C@@H](N)CC=O WPJRFCZKZXBUNI-HCWXCVPCSA-N 0.000 abstract 1
230000018044 dehydration Effects 0.000 abstract 1
238000006297 dehydration reaction Methods 0.000 abstract 1
229960004679 doxorubicin Drugs 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000003834 intracellular effect Effects 0.000 abstract 1
229920002521 macromolecule Polymers 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
201000000050 myeloid neoplasm Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000012038 nucleophile Substances 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
230000002269 spontaneous effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT91920574T 1990-11-01 1991-10-16 Latente alkylierungsubstituenten enthaltende anthracycline-analoge. ATE109787T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/608,149 US5196522A (en)	1990-11-01	1990-11-01	Anthracycline analogues bearing latent alkylating substituents

Publications (1)

Publication Number	Publication Date
ATE109787T1 true ATE109787T1 (de)	1994-08-15

Family

ID=24435271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91920574T ATE109787T1 (de)	1990-11-01	1991-10-16	Latente alkylierungsubstituenten enthaltende anthracycline-analoge.

Country Status (9)

Country	Link
US (3)	US5196522A (de)
EP (1)	EP0555358B1 (de)
JP (1)	JP3051170B2 (de)
AT (1)	ATE109787T1 (de)
AU (1)	AU642798B2 (de)
CA (1)	CA2094914C (de)
DE (1)	DE69103428T2 (de)
DK (1)	DK0555358T3 (de)
WO (1)	WO1992007866A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5196522A (en) *	1990-11-01	1993-03-23	Board Of Regents, The University Of Texas System	Anthracycline analogues bearing latent alkylating substituents
US5622929A (en) *	1992-01-23	1997-04-22	Bristol-Myers Squibb Company	Thioether conjugates
US6218519B1 (en)	1996-04-12	2001-04-17	Pro-Neuron, Inc.	Compounds and methods for the selective treatment of cancer and bacterial infections
US6677309B1 (en)	1997-04-11	2004-01-13	University Technology Corporation	Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity compounds, compositions and methods
US20040038904A1 (en) *	2002-05-21	2004-02-26	Angela Ogden	Method of treating multiple sclerosis
US20050208037A1 (en) *	2003-10-21	2005-09-22	Board Of Regents, The University Of Texas System	Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis
WO2005086951A2 (en) *	2004-03-10	2005-09-22	Threshold Pharmaceuticals, Inc.	Hypoxia-activated anti-cancer agents
US20070060534A1 (en) *	2005-06-30	2007-03-15	Threshold Pharmaceuticals, Inc.	Anthracycline analogs
US7470672B2 (en)	2006-07-31	2008-12-30	Savvipharm Inc.	Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
US7750018B2 (en) *	2006-12-06	2010-07-06	Tactical Therapeutics, Inc	Use of carboxiamidotriazole (CAI) orotate in macular degeneration
US8889193B2 (en)	2010-02-25	2014-11-18	The Johns Hopkins University	Sustained delivery of therapeutic agents to an eye compartment
WO2012039979A2 (en)	2010-09-10	2012-03-29	The Johns Hopkins University	Rapid diffusion of large polymeric nanoparticles in the mammalian brain
WO2012109363A2 (en)	2011-02-08	2012-08-16	The Johns Hopkins University	Mucus penetrating gene carriers
US9415020B2 (en)	2012-01-19	2016-08-16	The Johns Hopkins University	Nanoparticle formulations with enhanced mucosal penetration
US8962577B2 (en)	2012-03-16	2015-02-24	The Johns Hopkins University	Controlled release formulations for the delivery of HIF-1 inhibitors
CA2867203C (en)	2012-03-16	2016-09-20	The Johns Hopkins University	Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
CA2872519C (en)	2012-05-04	2017-09-05	The Johns Hopkins University	Lipid-based drug carriers for rapid penetration through mucus linings
US9533068B2 (en)	2012-05-04	2017-01-03	The Johns Hopkins University	Drug loaded microfiber sutures for ophthalmic application
US10568975B2 (en)	2013-02-05	2020-02-25	The Johns Hopkins University	Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
US8877202B2 (en)	2013-02-07	2014-11-04	Immunomedics, Inc.	Pro-drug form (P2PDOX) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer
WO2015035002A1 (en) *	2013-09-06	2015-03-12	Vanda Pharmaceuticals Inc.	Treatment of cyr61- and vegf-mediated conditions
WO2015127389A1 (en)	2014-02-23	2015-08-27	The Johns Hopkins University	Hypotonic enema formulations and methods of use
PL3204018T3 (pl)	2014-10-07	2022-01-03	Immunomedics, Inc.	Neoadiuwantowe zastosowanie koniugatów przeciwciało-lek
JP6846351B2 (ja)	2015-01-27	2021-03-24	ザ・ジョンズ・ホプキンス・ユニバーシティー	粘膜表面における活性薬剤の増強された輸送のための低張ヒドロゲル製剤
WO2020210805A1 (en)	2019-04-11	2020-10-15	The Johns Hopkins University	Nanoparticles for drug delivery to brain

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4035566A (en) *	1975-09-25	1977-07-12	Sidney Farber Cancer Institute, Inc.	N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
US4109076A (en) *	1977-09-08	1978-08-22	Sri International	5-iminodaunomycin
US4301277A (en) *	1980-10-20	1981-11-17	Sri International	3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4950738A (en) *	1984-09-13	1990-08-21	Cytogen Corporation	Amine derivatives of anthracycline antibiotics
US4826964A (en) *	1982-07-20	1989-05-02	Sri International	Bridged oxygen analogs of daunorubcin and doxorubicin
US4464529A (en) *	1982-07-20	1984-08-07	Sri International	Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
US4585859A (en) *	1983-05-24	1986-04-29	Sri International	Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
GB8508508D0 (en) *	1985-04-01	1985-05-09	Creighton A M	Pharmaceutical compositions
FR2591599B1 (fr)	1985-12-17	1988-08-05	Hoechst Lab	Nouvelles anthracyclines et medicaments les contenant
US5091552A (en)	1986-06-30	1992-02-25	Board Of Regents, The University Of Texas System	Novel antitumor aldophosphamide analogs
US4841085A (en) *	1986-06-30	1989-06-20	Board Of Regents, University Of Texas System	Aldophosphamides
US5196522A (en) *	1990-11-01	1993-03-23	Board Of Regents, The University Of Texas System	Anthracycline analogues bearing latent alkylating substituents

1990
- 1990-11-01 US US07/608,149 patent/US5196522A/en not_active Expired - Lifetime
1991
- 1991-10-16 JP JP3518598A patent/JP3051170B2/ja not_active Expired - Fee Related
- 1991-10-16 DK DK91920574.0T patent/DK0555358T3/da active
- 1991-10-16 WO PCT/US1991/007687 patent/WO1992007866A1/en not_active Ceased
- 1991-10-16 CA CA002094914A patent/CA2094914C/en not_active Expired - Fee Related
- 1991-10-16 EP EP91920574A patent/EP0555358B1/de not_active Expired - Lifetime
- 1991-10-16 AT AT91920574T patent/ATE109787T1/de not_active IP Right Cessation
- 1991-10-16 DE DE69103428T patent/DE69103428T2/de not_active Expired - Fee Related
- 1991-10-16 AU AU90292/91A patent/AU642798B2/en not_active Ceased
1995
- 1995-05-15 US US08/441,240 patent/US6284737B1/en not_active Expired - Fee Related
2001
- 2001-03-02 US US09/796,606 patent/US6433150B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1992007866A1 (en)	1992-05-14
US20010053845A1 (en)	2001-12-20
DK0555358T3 (da)	1994-12-05
AU642798B2 (en)	1993-10-28
AU9029291A (en)	1992-05-26
EP0555358B1 (de)	1994-08-10
EP0555358A1 (de)	1993-08-18
US6433150B2 (en)	2002-08-13
DE69103428T2 (de)	1995-03-30
CA2094914C (en)	1998-02-10
US5196522A (en)	1993-03-23
DE69103428D1 (de)	1994-09-15
US6284737B1 (en)	2001-09-04
CA2094914A1 (en)	1992-05-02
JP3051170B2 (ja)	2000-06-12
JPH06502417A (ja)	1994-03-17

Legal Events

Date	Code	Title	Description
2007-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69103428D1 (de)	1994-09-15	Latente alkylierungsubstituenten enthaltende anthracycline-analoge.
EA199900937A1 (ru)	2000-08-28	Фармацевтические композиции, содержащие вориконазол
ES2142798T3 (es)	2000-05-01	Derivados de 3-amido pirazol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
CA2301093A1 (en)	1999-02-25	Fluoropyrazole-biphenylamide fungicides
ZW19380A1 (en)	1980-11-12	Pesticidal compounds compositions and methods
DK0757677T3 (da)	2003-10-13	Benzocyclohexylimidazolthionderivater
SE8801514D0 (sv)	1988-04-22	Farmaceutisk komposition
AU554476B2 (en)	1986-08-21	Triazole derivatives
UA27108A1 (uk)	2000-02-28	Аhтрацикліhові глікозиди та їх фармацевтичhо прийhятhі кислотhо-адитивhі солі, спосіб їх одержаhhя, похідhі 1,6-дийод-3-оксапеhтаhу та спосіб їх одержаhhя
PT98464A (pt)	1992-05-29	Processo para a preparacao de derivados de ciclopentano e de composicoes farmaceuticas que os contem
IE790311L (en)	1979-08-17	2-phenylimino-imidazolidines
DK0536197T3 (da)	1995-11-13	Ren, krystallinsk form af rifapentine
ES549298A0 (es)	1986-05-16	Un procedimiento para la preparacion de derivados de triazol
FR2360578A1 (fr)	1978-03-03	Diacrylates de derives de l'hydantoine et leurs applications comme resines et adhesifs
PT94078A (pt)	1991-01-08	Processo para a preparacao de derivados de acido butenoico e de composicoes farmaceuticas que os contem
PT837677E (pt)	2006-08-31	Derivados hexa-hidroxibifenilo bromados
BR9912885A (pt)	2001-05-08	Derivado de 3-azabiciclo-[3.2.0]- heptano n-substituìdo
SE8702422D0 (sv)	1987-06-10	Improvements in or relating to fungicides
ES8707193A1 (es)	1987-07-16	Un metodo para producir derivados de bromodicloroimidazol
JPS53124267A (en)	1978-10-30	1-alkoxyacyl-3-(3,5-dihalogenophenyl)hydantoin derivatives, their preparation and bactericides for agricultural and horticultural uses containing the same as active agent
BR8301990A (pt)	1983-12-20	Derivados de 2,2-dihalogenio-3,3-dimetilciclopropano,processo para sua preparacao,composicao funcida,utilizacao de derivados e processos para o combate a fungos e para a preparacao de composicoes
BR9100666A (pt)	1991-10-29	Amidas de acido clorofluormetil-tiadiazoliloxiacetico,processo para sua preparacao,composicoes herbicidas,processo para o combate de ervas daninhas,aplicacao,processo para a preparacao de composicoes e 2-metil-sulfinil-e 2-metil-sulfonil-5-cloro-fluor-metil-1,3,4-tiadiazol
FR2418229A1 (fr)	1979-09-21	Nouveaux sels de 5-phenyl-2-oxazolecarboximidamides, utiles notamment comme antidepressifs
MX9203255A (es)	1992-07-01	Compuestos para inhibir la biosintesis de metabolitos derivados de la lipoxigenasa del acido araquidonico.
BE878842A (nl)	1980-01-16	Hygiene-stuk