ATE110279T1 - Verfahren zur herstellung eines pertussis-toxin- toxoides. - Google Patents

Verfahren zur herstellung eines pertussis-toxin- toxoides.

Info

Publication number: ATE110279T1
Authority: AT; Austria
Prior art keywords: pertussis toxin; toxoide; production; toxoid; treatment
Prior art date: 1988-11-29

Application number

AT89122006T

Other languages

English (en)

Inventor

Akihiro Ginnaga

Kazunori Morokuma

Katsutoshi Aihara

Mitsuo Sakoh

Original Assignee

Chemo Sero Therapeut Res Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-29

Filing date

1989-11-29

Publication date

1994-09-15

1989-11-29 Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst

1994-09-15 Application granted granted Critical

1994-09-15 Publication of ATE110279T1 publication Critical patent/ATE110279T1/de

Links

108010081690 Pertussis Toxin Proteins 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
229940066827 pertussis vaccine Drugs 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT89122006T 1988-11-29 1989-11-29 Verfahren zur herstellung eines pertussis-toxin- toxoides. ATE110279T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP63303767A JP2706792B2 (ja)	1988-11-29	1988-11-29	百日咳毒素のトキソイド化法

Publications (1)

Publication Number	Publication Date
ATE110279T1 true ATE110279T1 (de)	1994-09-15

Family

ID=17925036

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89122006T ATE110279T1 (de)	1988-11-29	1989-11-29	Verfahren zur herstellung eines pertussis-toxin- toxoides.

Country Status (6)

Country	Link
US (1)	US4996299A (de)
EP (1)	EP0377114B1 (de)
JP (1)	JP2706792B2 (de)
AT (1)	ATE110279T1 (de)
CA (1)	CA2004206C (de)
DE (1)	DE68917709T2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5165927A (en) *	1986-08-01	1992-11-24	University Of Southern California	Composition with modified pertussis toxin
US5332583A (en) *	1987-11-24	1994-07-26	Connaught Laboratories Limited	Vaccine containing genetically-detoxified pertussis holotoxin
US5578308A (en) *	1990-02-12	1996-11-26	Capiau; Carine	Glutaraldehyde and formalin detoxified bordetella toxin vaccine
GB9021004D0 (en) *	1990-09-27	1990-11-07	Wellcome Found	Acellular vaccines
GB9216351D0 (en) *	1992-07-31	1992-09-16	Wellcome Found	Vaccine production
BRPI0402630B8 (pt) *	2004-07-05	2021-05-25	Fund Butantan	processo de obtenção de vacina pertussis celular menos reatogênica
JP5207380B2 (ja) *	2006-03-27	2013-06-12	北里第一三共ワクチン株式会社	長期保存においても毒性復帰がおこらない特徴を持つ全菌体細菌ワクチンならびにその用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5750925A (en) *	1980-09-12	1982-03-25	Takeda Chem Ind Ltd	Preparation of pertussis toxoid
CA1213234A (en) *	1983-03-30	1986-10-28	Akihiro Ginnaga	Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine
KR890001003B1 (ko) *	1984-07-19	1989-04-18	자이단 호오진 까가꾸 오요비 겟세이 료오호 겐뀨쇼	Lpf-ha의 정제방법
GB8512972D0 (en) *	1985-05-22	1985-06-26	Univ Glasgow	Vaccine production
GB8601279D0 (en) *	1986-01-20	1986-02-26	Public Health Lab Service	Purification of pertussis antigens
FR2597344B1 (fr) *	1986-04-16	1989-06-23	Merieux Inst	Perfectionnement au procede de purification d'antigenes proteiques de bacteries appartenant au genre bordetella, en vue de l'obtention d'un vaccin acellulaire.
US4762710A (en) *	1986-06-16	1988-08-09	The United States Of America As Represented By The Department Of Health And Human Services	Novel method of preparing toxoid by oxidation and metal ions
US4845036A (en) *	1987-02-03	1989-07-04	The United States Of America As Represented By The Department Of Health And Human Services	Process for isolation of the B oligomer of pertussis toxin
CA1337859C (en) *	1987-04-24	1996-01-02	Masashi Chazono	Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine

1988
- 1988-11-29 JP JP63303767A patent/JP2706792B2/ja not_active Expired - Lifetime
1989
- 1989-11-28 US US07/442,148 patent/US4996299A/en not_active Expired - Lifetime
- 1989-11-29 DE DE68917709T patent/DE68917709T2/de not_active Expired - Lifetime
- 1989-11-29 EP EP89122006A patent/EP0377114B1/de not_active Expired - Lifetime
- 1989-11-29 CA CA002004206A patent/CA2004206C/en not_active Expired - Lifetime
- 1989-11-29 AT AT89122006T patent/ATE110279T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2706792B2 (ja)	1998-01-28
JPH02149529A (ja)	1990-06-08
CA2004206C (en)	2000-02-08
EP0377114A1 (de)	1990-07-11
EP0377114B1 (de)	1994-08-24
DE68917709D1 (de)	1994-09-29
CA2004206A1 (en)	1990-05-29
DE68917709T2 (de)	1995-05-04
US4996299A (en)	1991-02-26

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Legal Events

Date	Code	Title	Description
1995-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties