ATE110376T1 - Biphenyl-derivate, verfahren zu deren herstellung und deren zwischenprodukte. - Google Patents
Biphenyl-derivate, verfahren zu deren herstellung und deren zwischenprodukte.Info
- Publication number
- ATE110376T1 ATE110376T1 AT90401483T AT90401483T ATE110376T1 AT E110376 T1 ATE110376 T1 AT E110376T1 AT 90401483 T AT90401483 T AT 90401483T AT 90401483 T AT90401483 T AT 90401483T AT E110376 T1 ATE110376 T1 AT E110376T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- biphenyl derivatives
- chem
- substituted
- formula
- Prior art date
Links
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000004682 aminothiocarbonyl group Chemical group NC(=S)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1141988A JPH0660142B2 (ja) | 1989-06-02 | 1989-06-02 | ビフェニル誘導体、その製法及びその合成中間体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE110376T1 true ATE110376T1 (de) | 1994-09-15 |
Family
ID=15304785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90401483T ATE110376T1 (de) | 1989-06-02 | 1990-06-01 | Biphenyl-derivate, verfahren zu deren herstellung und deren zwischenprodukte. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5103023A (de) |
| EP (1) | EP0401125B1 (de) |
| JP (1) | JPH0660142B2 (de) |
| KR (1) | KR0130757B1 (de) |
| AT (1) | ATE110376T1 (de) |
| CA (1) | CA2017897A1 (de) |
| DE (1) | DE69011748T2 (de) |
| DK (1) | DK0401125T3 (de) |
| ES (1) | ES2063305T3 (de) |
| HK (1) | HK174395A (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530028A (en) * | 1992-11-23 | 1996-06-25 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
| US5344958A (en) * | 1992-11-23 | 1994-09-06 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
| US5612341A (en) * | 1995-06-07 | 1997-03-18 | Biotech Research Laboratories | Brominated hexahydroxybiphenyl derivatives |
| CN102250085B (zh) * | 2010-05-21 | 2014-01-22 | 四川大学 | 联苯双酯衍生物及其在制备自身免疫性疾病药物中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60209582A (ja) * | 1984-04-04 | 1985-10-22 | Isukura Sangyo Kk | Ddbの合成方法 |
| HU202854B (en) * | 1986-05-27 | 1991-04-29 | Tsumura & Co | Process for producing new biphenyl derivatives and pharmaceutical compositions comprising such compounds as active ingredient |
| EP0269754B1 (de) * | 1986-06-13 | 1993-11-03 | TSUMURA & CO. | Biphenylabkömmlinge, verfahren zur herstellung und verwendung |
| JPS63192771A (ja) * | 1987-02-06 | 1988-08-10 | Isukura Sangyo Kk | 2,3,2′,3′−ビス(メチレンジオキシ)ビフエニル化合物、その製造法およびそれを含む肝疾患治療剤 |
-
1989
- 1989-06-02 JP JP1141988A patent/JPH0660142B2/ja not_active Expired - Lifetime
-
1990
- 1990-05-29 US US07/529,792 patent/US5103023A/en not_active Expired - Fee Related
- 1990-05-30 CA CA002017897A patent/CA2017897A1/en not_active Abandoned
- 1990-06-01 AT AT90401483T patent/ATE110376T1/de active
- 1990-06-01 ES ES90401483T patent/ES2063305T3/es not_active Expired - Lifetime
- 1990-06-01 KR KR1019900008081A patent/KR0130757B1/ko not_active Expired - Fee Related
- 1990-06-01 DK DK90401483.4T patent/DK0401125T3/da active
- 1990-06-01 DE DE69011748T patent/DE69011748T2/de not_active Expired - Fee Related
- 1990-06-01 EP EP90401483A patent/EP0401125B1/de not_active Expired - Lifetime
-
1995
- 1995-11-16 HK HK174395A patent/HK174395A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69011748T2 (de) | 1995-01-12 |
| EP0401125B1 (de) | 1994-08-24 |
| JPH0660142B2 (ja) | 1994-08-10 |
| DK0401125T3 (da) | 1994-09-19 |
| ES2063305T3 (es) | 1995-01-01 |
| EP0401125A2 (de) | 1990-12-05 |
| JPH037246A (ja) | 1991-01-14 |
| DE69011748D1 (de) | 1994-09-29 |
| HK174395A (en) | 1995-11-24 |
| KR0130757B1 (ko) | 1998-04-07 |
| EP0401125A3 (de) | 1991-04-24 |
| CA2017897A1 (en) | 1990-12-02 |
| KR910000623A (ko) | 1991-01-29 |
| US5103023A (en) | 1992-04-07 |
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