ATE111073T1 - Neue zwischenprodukte, ihre herstellung und verwendung. - Google Patents
Neue zwischenprodukte, ihre herstellung und verwendung.Info
- Publication number
- ATE111073T1 ATE111073T1 AT90917427T AT90917427T ATE111073T1 AT E111073 T1 ATE111073 T1 AT E111073T1 AT 90917427 T AT90917427 T AT 90917427T AT 90917427 T AT90917427 T AT 90917427T AT E111073 T1 ATE111073 T1 AT E111073T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- stands
- sec
- aryl
- hydrogen
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
- C07C329/04—Esters of monothiocarbonic acids
- C07C329/06—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909001405A GB9001405D0 (en) | 1990-01-22 | 1990-01-22 | New intermediates,their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE111073T1 true ATE111073T1 (de) | 1994-09-15 |
Family
ID=10669692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90917427T ATE111073T1 (de) | 1990-01-22 | 1990-11-28 | Neue zwischenprodukte, ihre herstellung und verwendung. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5401868A (de) |
| EP (1) | EP0541550B1 (de) |
| JP (1) | JP3025532B2 (de) |
| AT (1) | ATE111073T1 (de) |
| AU (1) | AU6883191A (de) |
| CA (1) | CA2064872C (de) |
| DE (1) | DE69012351T2 (de) |
| DK (1) | DK0541550T3 (de) |
| ES (1) | ES2061077T3 (de) |
| GB (1) | GB9001405D0 (de) |
| HU (1) | HUT60459A (de) |
| IE (1) | IE64470B1 (de) |
| WO (1) | WO1991010639A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020063837A (ko) | 1999-07-19 | 2002-08-05 | 시오노기세이야쿠가부시키가이샤 | 아실옥시메톡시카르보닐 측쇄를 갖는 삼환 화합물 |
| JP2004501067A (ja) * | 2000-01-28 | 2004-01-15 | ローム アンド ハース カンパニー | 高められた特性をもつ医薬 |
| US6376548B1 (en) | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) * | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| AU2002310409C1 (en) * | 2001-06-11 | 2008-04-17 | Xenoport, Inc. | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
| US6927036B2 (en) * | 2002-02-19 | 2005-08-09 | Xero Port, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| PA8579701A1 (es) * | 2002-08-23 | 2005-05-24 | Pfizer Prod Inc | Profarmaco inhibidor de beta-lactamasa |
| JP2006526612A (ja) * | 2003-06-05 | 2006-11-24 | ファイザー・プロダクツ・インク | ベータ−ラクタマーゼ阻害剤・プロドラッグ |
| WO2005010011A2 (en) * | 2003-07-15 | 2005-02-03 | Xenoport, Inc. | Methods of synthesis of acyloxyalkyl compounds |
| AU2004267100B2 (en) * | 2003-08-20 | 2010-10-07 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| CN101486668B (zh) * | 2003-12-30 | 2014-07-02 | 什诺波特有限公司 | 酰氧基烃基氨基甲酸酯前药及其中间体的合成 |
| CA2551859C (en) | 2003-12-30 | 2011-10-04 | Xenoport, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
| EP1919859B1 (de) | 2005-06-20 | 2010-06-02 | Xenoport, Inc. | Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung |
| TW200820963A (en) * | 2006-07-28 | 2008-05-16 | Xenoport Inc | Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use |
| WO2010008886A2 (en) * | 2008-06-24 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Processes for preparing prodrugs of gabapentin and intermediates thereof |
| WO2011028234A1 (en) * | 2009-09-04 | 2011-03-10 | Xenoport, Inc. | Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid |
| JP6105207B2 (ja) * | 2012-03-30 | 2017-03-29 | 美津濃株式会社 | ラケットフレーム |
| US20140024621A1 (en) | 2012-07-23 | 2014-01-23 | Ms Therapeutics Limited | Aminopyridine compounds and their uses |
| WO2022033202A1 (zh) * | 2020-08-13 | 2022-02-17 | 南京海融医药科技股份有限公司 | 布洛芬酯类前药、药物组合物以及制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3479328A (en) * | 1966-11-18 | 1969-11-18 | Ashland Oil Inc | Novel monomers and polymers |
| US3769271A (en) * | 1971-04-15 | 1973-10-30 | Lilly Co Eli | N-protected amino acids and peptides |
| FR2363546A1 (fr) * | 1976-09-07 | 1978-03-31 | Poudres & Explosifs Ste Nale | Monomeres mixtes allyliques-acryliques, leur preparation et polymeres en derivant |
| DE2939660A1 (de) * | 1979-09-29 | 1981-04-16 | Basf Ag, 6700 Ludwigshafen | Neue carbamate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
| JPS58189186A (ja) * | 1982-04-30 | 1983-11-04 | Takeda Chem Ind Ltd | セフアロスポリン誘導体 |
| IL67445A (en) * | 1982-12-09 | 1985-11-29 | Teva Pharma | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
| DE3301670A1 (de) * | 1983-01-20 | 1984-07-26 | Bayer Ag, 5090 Leverkusen | Leimungsmittel |
| US5221754A (en) * | 1989-06-09 | 1993-06-22 | Research Corporation Technologies, Inc. | Reagents for rapid peptide synthesis |
-
1990
- 1990-01-22 GB GB909001405A patent/GB9001405D0/en active Pending
- 1990-11-28 ES ES90917427T patent/ES2061077T3/es not_active Expired - Lifetime
- 1990-11-28 CA CA002064872A patent/CA2064872C/en not_active Expired - Fee Related
- 1990-11-28 WO PCT/DK1990/000308 patent/WO1991010639A1/en not_active Ceased
- 1990-11-28 EP EP90917427A patent/EP0541550B1/de not_active Expired - Lifetime
- 1990-11-28 DK DK90917427.8T patent/DK0541550T3/da active
- 1990-11-28 AU AU68831/91A patent/AU6883191A/en not_active Abandoned
- 1990-11-28 AT AT90917427T patent/ATE111073T1/de not_active IP Right Cessation
- 1990-11-28 JP JP3501196A patent/JP3025532B2/ja not_active Expired - Lifetime
- 1990-11-28 US US07/835,444 patent/US5401868A/en not_active Expired - Lifetime
- 1990-11-28 DE DE69012351T patent/DE69012351T2/de not_active Expired - Fee Related
- 1990-11-28 HU HU9200477A patent/HUT60459A/hu unknown
- 1990-11-29 IE IE430990A patent/IE64470B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05503925A (ja) | 1993-06-24 |
| DE69012351T2 (de) | 1995-02-09 |
| WO1991010639A1 (en) | 1991-07-25 |
| ES2061077T3 (es) | 1994-12-01 |
| CA2064872C (en) | 2002-01-22 |
| HU9200477D0 (en) | 1992-08-28 |
| JP3025532B2 (ja) | 2000-03-27 |
| HUT60459A (en) | 1992-09-28 |
| EP0541550A1 (de) | 1993-05-19 |
| GB9001405D0 (en) | 1990-03-21 |
| DE69012351D1 (de) | 1994-10-13 |
| AU6883191A (en) | 1991-08-05 |
| DK0541550T3 (da) | 1994-10-17 |
| US5401868A (en) | 1995-03-28 |
| EP0541550B1 (de) | 1994-09-07 |
| CA2064872A1 (en) | 1991-07-23 |
| IE904309A1 (en) | 1991-07-31 |
| IE64470B1 (en) | 1995-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |