ATE111228T1 - Verfahren zur überwachung des kollagenabbaus. - Google Patents
Verfahren zur überwachung des kollagenabbaus.Info
- Publication number
- ATE111228T1 ATE111228T1 AT89907782T AT89907782T ATE111228T1 AT E111228 T1 ATE111228 T1 AT E111228T1 AT 89907782 T AT89907782 T AT 89907782T AT 89907782 T AT89907782 T AT 89907782T AT E111228 T1 ATE111228 T1 AT E111228T1
- Authority
- AT
- Austria
- Prior art keywords
- collagen degradation
- monitoring
- collagen
- monitoring collagen
- pyridinoline
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000011382 collagen catabolic process Effects 0.000 title abstract 2
- 238000012544 monitoring process Methods 0.000 title abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 2
- 108010035532 Collagen Proteins 0.000 abstract 2
- 229920001436 collagen Polymers 0.000 abstract 2
- ZAHDXEIQWWLQQL-IHRRRGAJSA-N Deoxypyridinoline Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(O)=C(C[C@H](N)C([O-])=O)C(CC[C@H](N)C(O)=O)=C1 ZAHDXEIQWWLQQL-IHRRRGAJSA-N 0.000 abstract 1
- LCYXYLLJXMAEMT-SAXRGWBVSA-N Pyridinoline Chemical compound OC(=O)[C@@H](N)CCC1=C[N+](C[C@H](O)CC[C@H](N)C([O-])=O)=CC(O)=C1C[C@H](N)C(O)=O LCYXYLLJXMAEMT-SAXRGWBVSA-N 0.000 abstract 1
- 239000013060 biological fluid Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/108—Osteoporosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888815174A GB8815174D0 (en) | 1988-06-25 | 1988-06-25 | Method of monitoring collagen degradation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE111228T1 true ATE111228T1 (de) | 1994-09-15 |
Family
ID=10639370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89907782T ATE111228T1 (de) | 1988-06-25 | 1989-06-26 | Verfahren zur überwachung des kollagenabbaus. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0424428B2 (de) |
| JP (1) | JP2751999B2 (de) |
| AT (1) | ATE111228T1 (de) |
| AU (1) | AU3862189A (de) |
| CA (1) | CA1337179C (de) |
| DE (1) | DE68918103T3 (de) |
| GB (1) | GB8815174D0 (de) |
| WO (1) | WO1989012824A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300434A (en) * | 1987-11-06 | 1994-04-05 | Washington Research Foundation | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
| US5702909A (en) * | 1987-11-06 | 1997-12-30 | Washington Research Foundation | Methods of detecting collagen type II degradation in vivo |
| US5962639A (en) * | 1987-11-06 | 1999-10-05 | Washington Research Foundation | Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites |
| US4973666A (en) * | 1987-11-06 | 1990-11-27 | Washington Research Foundation | Peptide fragments containing HP and LP cross-links |
| US5320970A (en) * | 1987-11-06 | 1994-06-14 | Washington Research Foundation | Detection of collagen degradation in vivo |
| US6153732A (en) * | 1987-11-06 | 2000-11-28 | Washington Research Foundation | Kit for detecting analyte indicative of type II collagen resorption in vivo |
| US6027903A (en) * | 1987-11-06 | 2000-02-22 | Washington Research Foundation | Kit for detecting analyte indicative of type I collagen resorption in vivo |
| GB8929366D0 (en) * | 1989-12-30 | 1990-02-28 | Rowett Research Inst | Method to detect connective tissue disorder in humans and animals |
| US5217903A (en) * | 1990-05-15 | 1993-06-08 | Trustees Of Boston University | Measuring connective tissue breakdown products in body fluids |
| US6121002A (en) * | 1990-12-26 | 2000-09-19 | The Rowett Research Institute | Method to detect bone and other connective tissue disorders in humans and animals |
| GB9105893D0 (en) * | 1991-03-20 | 1991-05-08 | Orion Yhtymae Oy | Bone resorption assay based on a peptide liberated during collagen degradation |
| JP3179163B2 (ja) | 1992-01-31 | 2001-06-25 | 武田薬品工業株式会社 | ピリジノリン類の自動定量方法およびその定量装置 |
| US5620861A (en) * | 1992-07-31 | 1997-04-15 | Metra Biosystems, Inc. | Method and kit for pyridinium crosslink assay |
| ES2191015T3 (es) * | 1992-07-31 | 2003-09-01 | Metra Biosystems Inc | Procedimiento y kit de ensayo de reticulacion de piridinio. |
| AU2481992A (en) * | 1992-08-28 | 1994-03-29 | Rowett Research Institute, The | Method to monitor drug therapy and assess metastasis |
| US5350855A (en) * | 1992-09-30 | 1994-09-27 | Metra Biosystems, Inc. | Derivatized D-acyl pyridinium reagent |
| US5736344A (en) * | 1992-12-17 | 1998-04-07 | Metra Biosystems, Inc. | Serum pyridinium crosslinks assay |
| US6110689A (en) | 1994-01-21 | 2000-08-29 | Osteometer A/S | Method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen |
| GB9506050D0 (en) | 1995-03-24 | 1995-05-10 | Osteometer A S | Assaying collagen fragments in body fluids |
| AU3746295A (en) | 1994-10-17 | 1996-05-06 | Osteometer Biotech As | Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen |
| US6107047A (en) * | 1996-03-21 | 2000-08-22 | Osteometer Biotech A/S | Assaying protein fragments in body fluids |
| GB9617616D0 (en) | 1996-08-22 | 1996-10-02 | Osteometer Biotech As | Assaying protein fragments in body fluids |
| EP0944833B1 (de) | 1996-12-09 | 2001-06-27 | Osteometer Biotech AS | Sandwichtest zum nachweis von kollagenfragmenten |
| US5989925A (en) | 1997-06-27 | 1999-11-23 | Serex, Inc. | Antibody to and assay for peptide linked-pyridinoline as indicator of bone resorption level |
| US5972623A (en) * | 1997-07-31 | 1999-10-26 | Metra Biosystems, Inc. | Collagen-peptide assay method |
| US6117646A (en) * | 1997-09-22 | 2000-09-12 | Osteometer Biotech A/S | Assaying protein fragments in body fluids |
| US6916903B2 (en) | 1998-06-19 | 2005-07-12 | Washington Research Foundation | Collagen type III synthetic peptides for collagen resorption assays |
| DK1088228T3 (da) | 1998-06-19 | 2006-01-02 | Washington Res Found | Bruskresorptionsassays |
| US6602980B1 (en) | 1998-06-19 | 2003-08-05 | Washington Research Foundation | Collagen type III synthetic peptides for collagen resorption assays |
| US6348320B1 (en) | 1998-06-19 | 2002-02-19 | Washington Research Foundation | Cartilage resorption assays measuring type II collagen fragments |
| FR2795823B1 (fr) | 1999-07-01 | 2001-11-23 | Inst Nat Sante Rech Med | Methodes et kits pour le diagnostic ou le suivi d'une pathologie synoviale ou osteoarticulaire comprenant l'utilisation d'un marqueur specifique de la degradation du tissu synovial |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973666A (en) * | 1987-11-06 | 1990-11-27 | Washington Research Foundation | Peptide fragments containing HP and LP cross-links |
-
1988
- 1988-06-25 GB GB888815174A patent/GB8815174D0/en active Pending
-
1989
- 1989-06-26 CA CA000603900A patent/CA1337179C/en not_active Expired - Lifetime
- 1989-06-26 JP JP1507262A patent/JP2751999B2/ja not_active Expired - Lifetime
- 1989-06-26 WO PCT/GB1989/000715 patent/WO1989012824A1/en not_active Ceased
- 1989-06-26 AU AU38621/89A patent/AU3862189A/en not_active Abandoned
- 1989-06-26 AT AT89907782T patent/ATE111228T1/de not_active IP Right Cessation
- 1989-06-26 EP EP89907782A patent/EP0424428B2/de not_active Expired - Lifetime
- 1989-06-26 DE DE68918103T patent/DE68918103T3/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0424428B2 (de) | 1998-10-21 |
| EP0424428B1 (de) | 1994-09-07 |
| GB8815174D0 (en) | 1988-08-03 |
| JP2751999B2 (ja) | 1998-05-18 |
| DE68918103T3 (de) | 1999-08-05 |
| DE68918103T2 (de) | 1995-01-19 |
| EP0424428A1 (de) | 1991-05-02 |
| WO1989012824A1 (en) | 1989-12-28 |
| AU3862189A (en) | 1990-01-12 |
| CA1337179C (en) | 1995-10-03 |
| JPH04501002A (ja) | 1992-02-20 |
| DE68918103D1 (de) | 1994-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |