ATE112687T1 - Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen. - Google Patents

Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen.

Info

Publication number
ATE112687T1
ATE112687T1 AT89909916T AT89909916T ATE112687T1 AT E112687 T1 ATE112687 T1 AT E112687T1 AT 89909916 T AT89909916 T AT 89909916T AT 89909916 T AT89909916 T AT 89909916T AT E112687 T1 ATE112687 T1 AT E112687T1
Authority
AT
Austria
Prior art keywords
hiv
mutants
missing
envelope protein
hypervariable domains
Prior art date
Application number
AT89909916T
Other languages
English (en)
Inventor
Nancy L Haigwood
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE112687T1 publication Critical patent/ATE112687T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT89909916T 1988-09-13 1989-08-21 Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen. ATE112687T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24394488A 1988-09-13 1988-09-13

Publications (1)

Publication Number Publication Date
ATE112687T1 true ATE112687T1 (de) 1994-10-15

Family

ID=22920746

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89909916T ATE112687T1 (de) 1988-09-13 1989-08-21 Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen.

Country Status (6)

Country Link
US (3) US5814458A (de)
EP (1) EP0434713B1 (de)
AT (1) ATE112687T1 (de)
DE (1) DE68918867T2 (de)
HK (1) HK166495A (de)
WO (1) WO1990002568A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP237A (en) * 1990-05-29 1993-04-29 Cedars Sinai Medical Center Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use.
WO1994028929A1 (en) 1993-06-07 1994-12-22 Genentech, Inc. Hiv envelope polypeptides
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
NL9400384A (nl) * 1994-03-11 1995-10-02 Smit Victor Retrovirus-vaccins, vaccinatie en immunotherapie tegen retrovirale infecties.
US6585979B1 (en) * 1996-07-08 2003-07-01 Genentech, Inc. HIV envelope polypeptides and immunogenic composition
FR2777007B1 (fr) * 1998-04-01 2000-05-26 Orstom Mutants de glycoproteines d'enveloppes de retrovirus et leurs applications biologiques
FR2786488B1 (fr) * 1998-11-27 2003-04-25 Orstom Mutants de la gp120 et leurs applications biologiques
JP4776075B2 (ja) 1998-12-31 2011-09-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 改変ｈｉｖｅｎｖポリペプチド
AU2487300A (en) 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
AU2221600A (en) 1998-12-31 2000-07-31 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
AP1674A (en) 1999-11-16 2006-10-30 Geneart Ag The genome of the HIV-1 inter-subtype (C/B') and use thereof.
CA2434546C (en) 2001-01-12 2012-09-11 Chiron Corporation Induction of immune response by a replication-defective venezuelan equine encephalitis-sindbis chimeric virus replicon particle encoding an antigen
RU2221873C2 (ru) * 2001-04-24 2004-01-20 Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" Способ получения каталитических антител (варианты), антигены для иммунизации и нуклеотидная последовательность
EP2280074A3 (de) 2001-07-05 2011-06-22 Novartis Vaccines and Diagnostics, Inc. Antigene typ-b- und/oder typ-c-hiv-polypeptide codierende polynukleotide, polypeptide und deren verwendungen
EP1411770A4 (de) 2001-07-05 2006-05-10 Chiron Corp Polynukleotide, die für antigene hiv-polypeptide des c-typs codieren, polypeptide und ihre verwendung
CA2458995C (en) 2001-08-31 2013-04-30 Chiron Corporation Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
WO2004053100A2 (en) * 2002-12-11 2004-06-24 The Scripps Research Institute Immunogenic mutant human immunodeficiency virus gp120 polypeptides, and methods of using same
US20040247586A1 (en) * 2003-03-05 2004-12-09 Asa Abeliovich Parkin-associated complex for protecting post-mitotic neurons from excitotoxicity and uses thereof
US20070073048A1 (en) * 2003-05-15 2007-03-29 Ying Lian Hiv polynucleotides and polypeptides derived from botswana mj4
CN101072585A (zh) 2004-11-01 2007-11-14 诺华疫苗和诊断公司 产生免疫应答的组合方法
CA2626253A1 (en) 2005-10-18 2007-04-26 Novartis Vaccines And Diagnostics, Inc. Mucosal and systemic immunizations with alphavirus replicon particles
ES2388443T3 (es) * 2006-03-29 2012-10-15 Dana-Farber Cancer Institute, Inc. Métodos y composiciones para inducir una respuesta inmune frente a VIH y modelos para ensayo
EP2382988A1 (de) 2006-03-31 2011-11-02 Novartis AG Kombinierte mukosale und parenterale Immunisierung gegen HIV
WO2008039983A2 (en) * 2006-09-28 2008-04-03 President And Fellows Of Harvard College Methods and compositions using mutant gp120
BR122012024318A2 (pt) 2008-09-26 2019-07-30 Ambrx, Inc. Polipeptídeos modificados de eritropoetina animal e seus usos
CN104271155A (zh) 2011-11-14 2015-01-07 诺华股份有限公司 聚阴离子卡波姆和Env多肽的免疫原性复合物及其制造方法和用途
US11318197B2 (en) 2016-03-03 2022-05-03 Duke University Compositions and methods for inducing HIV-1 antibodies
US11246920B2 (en) 2016-03-03 2022-02-15 Duke University Compositions and methods for inducing HIV-1 antibodies
WO2018067580A1 (en) 2016-10-03 2018-04-12 Duke University Methods to identify immunogens by targeting improbable mutations
TW201922138A (zh) 2017-10-17 2019-06-16 英商Ｈｄ３有限公司 頭髮造型裝置、頭髮造型方法及驅動系統
GB2614463B (en) 2018-06-15 2024-04-10 Japham Group Ltd Hair styling device
EP3860650A4 (de) 2018-10-01 2022-06-29 Duke University Hiv-1-envelope-stabilisierende mutationen
GB201902443D0 (en) 2019-02-22 2019-04-10 Hd3 Ltd Hair styling device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341423C (en) * 1984-10-31 2003-03-04 Paul A. Luciw Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
DE3588134T2 (de) * 1984-12-24 1997-03-20 Genentech Inc Fusionen von AIDS-verwandten Polypeptiden
EP0242216A1 (de) * 1986-04-16 1987-10-21 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Nicht cytopathischer Klon von menschlichem T-Zellen lymphotropen Virus Typ-III
US5128319A (en) * 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome

Also Published As

Publication number Publication date
US5817792A (en) 1998-10-06
EP0434713A1 (de) 1991-07-03
DE68918867T2 (de) 1995-02-16
EP0434713A4 (en) 1992-05-20
WO1990002568A1 (en) 1990-03-22
US5792459A (en) 1998-08-11
DE68918867D1 (de) 1994-11-17
HK166495A (en) 1995-11-03
EP0434713B1 (de) 1994-10-12
US5814458A (en) 1998-09-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time