ATE112689T1 - Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung. - Google Patents

Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung.

Info

Publication number: ATE112689T1
Authority: AT; Austria
Prior art keywords: macrocylic; formulations; manufacture; methods; acid complexes
Prior art date: 1988-12-19

Application number

AT90901464T

Other languages

English (en)

Inventor

Jaime Simon

David A Wilson

Joseph R Garlich

David E Troutner

Original Assignee

Dow Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-19

Filing date

1989-12-15

Publication date

1994-10-15

1989-12-15 Application filed by Dow Chemical Co filed Critical Dow Chemical Co

1994-10-15 Application granted granted Critical

1994-10-15 Publication of ATE112689T1 publication Critical patent/ATE112689T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/06—Chelate

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT90901464T 1988-12-19 1989-12-15 Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung. ATE112689T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/284,876 US5059412A (en)	1984-06-04	1988-12-19	Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors

Publications (1)

Publication Number	Publication Date
ATE112689T1 true ATE112689T1 (de)	1994-10-15

Family

ID=23091854

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90901464T ATE112689T1 (de)	1988-12-19	1989-12-15	Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung.

Country Status (26)

Country	Link
US (1)	US5059412A (de)
EP (2)	EP0408701B1 (de)
JP (1)	JP2515929B2 (de)
KR (1)	KR0178966B1 (de)
CN (1)	CN1025983C (de)
AR (1)	AR248140A1 (de)
AT (1)	ATE112689T1 (de)
AU (3)	AU639899B2 (de)
BR (1)	BR8907255A (de)
CA (1)	CA2005880C (de)
CY (1)	CY1902A (de)
DE (1)	DE68918852T2 (de)
DK (1)	DK175479B1 (de)
ES (1)	ES2061010T3 (de)
FI (1)	FI101857B1 (de)
HK (1)	HK146795A (de)
HU (1)	HU207454B (de)
IE (2)	IE66391B1 (de)
IL (1)	IL92784A (de)
MX (1)	MX18786A (de)
NO (1)	NO180434C (de)
NZ (1)	NZ231818A (de)
PT (1)	PT92619B (de)
SA (1)	SA91120234B1 (de)
WO (1)	WO1990006776A1 (de)
ZA (1)	ZA899734B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5059412A (en) *	1984-06-04	1991-10-22	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5645818A (en) *	1989-03-24	1997-07-08	Guerbet S.A.	Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions
DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1991016075A1 (en) *	1990-04-20	1991-10-31	Australian Nuclear Science & Technology Organisation	Bone marrow treatments
AU648315B2 (en) *	1990-06-18	1994-04-21	Dow Chemical Company, The	The use of macrocyclic aminophosphonic acid complexes as imaging agents
MC2260A1 (fr) *	1990-06-18	1993-04-26	Dow Chemical Co	Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
DE4035760A1 (de) *	1990-11-08	1992-05-14	Schering Ag	Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5739294A (en) *	1991-12-10	1998-04-14	The Dow Chemical Company	Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
US5320829A (en) *	1991-12-10	1994-06-14	The Dow Chemical Company	Oral compositions for inhibiting plaque formation
US5428139A (en) *	1991-12-10	1995-06-27	The Dow Chemical Company	Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
JP3356289B2 (ja) *	1995-06-26	2002-12-16	コンキャットリミティド	第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用
US5834456A (en) *	1996-02-23	1998-11-10	The Dow Chemical Company	Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US6005083A (en)	1997-03-28	1999-12-21	Neorx Corporation	Bridged aromatic substituted amine ligands with donor atoms
JP2003501488A (ja) *	1999-06-11	2003-01-14	ネオルックスコーポレイション	骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en)	1999-07-11	2006-08-22	Neorx Corporation	Skeletal-targeted radiation to treat bone-associated pathologies
US6565828B2 (en) *	2000-04-07	2003-05-20	Bristol-Myers Squibb Company	Macrocyclic chelants for metallopharmaceuticals
EP1390081A2 (de)	2001-01-08	2004-02-25	Neorx Corporation	Therapeutische und diagnostische verbindungen, zusammenstellungen und methoden
US20020094316A1 (en) *	2001-01-09	2002-07-18	Shuang Liu	Polypodal chelants for metallopharmaceuticals
WO2003051403A1 (en) *	2001-12-13	2003-06-26	Dow Global Technologies Inc.	Treatment of osteomyelitis with radiopharmaceuticals
US20030228256A1 (en) *	2002-06-11	2003-12-11	Inverardi Luca A.	Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations
WO2007008232A2 (en)	2004-09-03	2007-01-18	Board Of Regents, The University Of Texas System	Locoregional internal radionuclide ablation of abnormal tissues.
WO2011149844A1 (en) *	2010-05-24	2011-12-01	Iso Therapeutics Group Llc	Delivery of high dose therapeutic radioisotopes to bone
US10172965B2 (en)	2013-10-07	2019-01-08	Igl Pharma, Inc.	High purity therapeutic bone agents
US11369700B2 (en)	2015-05-25	2022-06-28	IGL Pharma Inc.	DOTMP kit formulations for radioisotopes
WO2016191413A1 (en)	2015-05-25	2016-12-01	Iso Therapeutics Group, Llc	Dotmp kit formulations for radioisotopes
HRP20200922T1 (hr)	2016-09-27	2020-09-18	Bayer Pharma Aktiengesellschaft	Postupak za proizvodnju kristalnog oblika modifikacije a kalkobutrola
WO2018148209A1 (en)	2017-02-08	2018-08-16	Iso Therapeutics Group, Llc	Method of use for therapeutic bone agents

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3965254A (en) *	1973-05-23	1976-06-22	The Procter & Gamble Company	Compositions for the treatment of calcific tumors
US4017595A (en) *	1975-08-28	1977-04-12	Research Corporation	Bone-seeking indium-113m or indium-111 organic phosphonate complexes
CA1078731A (en) *	1976-12-16	1980-06-03	Charles E. Frosst And Co.	Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid)
US4957939A (en) *	1981-07-24	1990-09-18	Schering Aktiengesellschaft	Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US5064633A (en) *	1984-06-04	1991-11-12	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes, their formulations and use
US4898724A (en) *	1984-06-04	1990-02-06	The Dow Chemical Company	Organis amine phosphonic acid complexes for the treatment of calcific tumors
US5059412A (en) *	1984-06-04	1991-10-22	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
DE164843T1 (de) *	1984-06-04	1989-12-07	The Dow Chemical Co., Midland, Mich.	Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.
US4885363A (en) *	1987-04-24	1989-12-05	E. R. Squibb & Sons, Inc.	1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2614020B1 (fr) *	1987-04-14	1989-07-28	Guerbet Sa	Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US4853209A (en) *	1987-05-18	1989-08-01	The Dow Chemical Company	Bone marrow suppressing agents
US4882142A (en) *	1988-12-19	1989-11-21	The Dow Chemical Company	Bone marrow suppressing agents
US4976950A (en) *	1988-12-19	1990-12-11	The Dow Chemical Company	Bone marrow suppressing agents

1988
- 1988-12-19 US US07/284,876 patent/US5059412A/en not_active Expired - Lifetime
1989
- 1989-12-15 KR KR1019900701800A patent/KR0178966B1/ko not_active Expired - Fee Related
- 1989-12-15 WO PCT/US1989/005782 patent/WO1990006776A1/en not_active Ceased
- 1989-12-15 HU HU901163A patent/HU207454B/hu not_active IP Right Cessation
- 1989-12-15 AT AT90901464T patent/ATE112689T1/de not_active IP Right Cessation
- 1989-12-15 EP EP90901464A patent/EP0408701B1/de not_active Expired - Lifetime
- 1989-12-15 JP JP2501907A patent/JP2515929B2/ja not_active Expired - Fee Related
- 1989-12-15 DE DE68918852T patent/DE68918852T2/de not_active Expired - Lifetime
- 1989-12-15 CY CY190289A patent/CY1902A/xx unknown
- 1989-12-15 ES ES90901464T patent/ES2061010T3/es not_active Expired - Lifetime
- 1989-12-15 AU AU48282/90A patent/AU639899B2/en not_active Expired
- 1989-12-15 BR BR898907255A patent/BR8907255A/pt not_active Application Discontinuation
- 1989-12-18 IL IL9278489A patent/IL92784A/en unknown
- 1989-12-18 NZ NZ231818A patent/NZ231818A/en unknown
- 1989-12-18 CA CA002005880A patent/CA2005880C/en not_active Expired - Lifetime
- 1989-12-18 IE IE406389A patent/IE66391B1/en not_active IP Right Cessation
- 1989-12-18 IE IE940833A patent/IE940833L/xx unknown
- 1989-12-19 EP EP19890313308 patent/EP0375376A3/de not_active Withdrawn
- 1989-12-19 ZA ZA899734A patent/ZA899734B/xx unknown
- 1989-12-19 MX MX1878689A patent/MX18786A/es unknown
- 1989-12-19 AR AR89315722A patent/AR248140A1/es active
- 1989-12-19 PT PT92619A patent/PT92619B/pt not_active IP Right Cessation
- 1989-12-19 CN CN89109819A patent/CN1025983C/zh not_active Expired - Lifetime
- 1989-12-19 AU AU47009/89A patent/AU4700989A/en not_active Abandoned
1990
- 1990-08-16 DK DK199001959A patent/DK175479B1/da not_active IP Right Cessation
- 1990-08-17 NO NO903632A patent/NO180434C/no not_active IP Right Cessation
- 1990-08-17 FI FI904084A patent/FI101857B1/fi not_active IP Right Cessation
1991
- 1991-11-20 SA SA91120234A patent/SA91120234B1/ar unknown
1993
- 1993-11-12 AU AU50685/93A patent/AU657641B2/en not_active Expired
1995
- 1995-09-14 HK HK146795A patent/HK146795A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2005880C (en)	1999-01-05
PT92619A (pt)	1990-06-29
PT92619B (pt)	1995-09-12
HK146795A (en)	1995-09-22
IL92784A (en)	1994-08-26
NO903632D0 (no)	1990-08-17
WO1990006776A1 (en)	1990-06-28
DE68918852T2 (de)	1995-05-11
MX18786A (es)	1993-12-01
NO180434C (no)	1997-04-23
KR0178966B1 (ko)	1999-03-20
DK195990A (da)	1990-08-16
EP0408701A1 (de)	1991-01-23
IE66391B1 (en)	1995-12-27
ZA899734B (en)	1991-08-28
AU657641B2 (en)	1995-03-16
AU639899B2 (en)	1993-08-12
EP0375376A3 (de)	1991-06-12
JPH03502936A (ja)	1991-07-04
DK175479B1 (da)	2004-11-08
EP0375376A2 (de)	1990-06-27
AU4828290A (en)	1990-07-10
CN1025983C (zh)	1994-09-28
FI101857B (fi)	1998-09-15
EP0408701A4 (en)	1991-07-31
DE68918852D1 (de)	1994-11-17
AU5068593A (en)	1994-02-24
AR248140A1 (es)	1995-06-30
HU901163D0 (en)	1991-03-28
ES2061010T3 (es)	1994-12-01
FI101857B1 (fi)	1998-09-15
KR910700073A (ko)	1991-03-13
NO180434B (no)	1997-01-13
CA2005880A1 (en)	1990-06-19
SA91120234B1 (ar)	2004-09-04
AU4700989A (en)	1990-06-21
BR8907255A (pt)	1991-03-12
EP0408701B1 (de)	1994-10-12
HU207454B (en)	1993-04-28
CY1902A (en)	1989-12-15
IL92784A0 (en)	1990-09-17
HUT54897A (en)	1991-04-29
IE940833L (en)	1990-06-19
CN1046739A (zh)	1990-11-07
DK195990D0 (da)	1990-08-16
US5059412A (en)	1991-10-22
JP2515929B2 (ja)	1996-07-10
IE894063L (en)	1990-06-19
FI904084A0 (fi)	1990-08-17
NO903632L (no)	1990-10-17
NZ231818A (en)	1992-05-26

Legal Events

Date	Code	Title	Description
2010-03-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE112689T1 (de)	1994-10-15	Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung.
DE3582754D1 (de)	1991-06-13	Medizinisches werkzeug und verfahren zur herstellung.
DE3879218D1 (de)	1993-04-15	Medizinisches instrument und verfahren zur herstellung.
DE3482943D1 (de)	1990-09-13	Katheter und verfahren zur herstellung.
DE3779199D1 (de)	1992-06-25	Atmungsaktive folie und verfahren zur herstellung derselben.
DE68916233D1 (de)	1994-07-21	Querstromfilteranordnung und verfahren zur herstellung.
DE68923819D1 (de)	1995-09-21	Verwendung von gamma-Hydroxy-Buttersäuresalzen zur Herstellung von pharmazeutischen Zusammensetzungen zur Verwendung bei der Behandlung von Alkoholismus und die hergestellten Zusammensetzungen.
DE3668782D1 (de)	1990-03-15	Kuenstliche lunge des membrantyps und verfahren zu ihrer herstellung.
DE3683869D1 (de)	1992-03-26	Zweistueckige modulsteckdose und verfahren zur herstellung derselben.
ATE108067T1 (de)	1994-07-15	Impfstoff und verfahren zur herstellung.
DE3785329D1 (de)	1993-05-13	Harzzusammensetzung und verfahren zur herstellung.
DE3681946D1 (de)	1991-11-21	Zahnfaeuleschutzpraeparate und verfahren zur herstellung derselben.
DE68918967D1 (de)	1994-12-01	Bipolare Transistorstruktur und Verfahren zu ihrer Herstellung.
DE3778089D1 (de)	1992-05-14	Verfahren zur herstellung und verwendung fester, pflanzenwirksamer zusammensetzungen.
ATA232687A (de)	1991-06-15	Zahnpflegemittel, sowie verfahren zur herstellung des zahnpflegemittels
DE3885387D1 (de)	1993-12-09	Verstärkte Ionenaustauschermembran und Verfahren zur Herstellung derselben.
DE68916092D1 (de)	1994-07-21	Schweisshemmende Mittel und Verfahren zur Herstellung.
DE3677349D1 (de)	1991-03-07	Kuenstliche lunge des membrantyps und verfahren zu ihrer herstellung.
DE3671375D1 (de)	1990-06-28	Hartgewebeprothese und verfahren zu ihrer herstellung.
DE3885304D1 (de)	1993-12-02	Zubereitung für zahnbehandlung und verfahren zur herstellung.
DE3582371D1 (de)	1991-05-08	Oxindolverbindungen, diese enthaltende zusammensetzungen sowie verfahren zur herstellung derselben.
ATA200786A (de)	1989-09-15	Skischuh und verfahren zur herstellung desselben
DE3886211D1 (de)	1994-01-20	Gereinigter Guajakolharz und Verfahren zu seiner Herstellung.
AT388293B (de)	1989-05-26	Stabiles, zahnbelag verhinderndes zahnpflegemittel und verfahren zur herstellung desselben
DE3762733D1 (de)	1990-06-21	Keramischer formkoerper und verfahren zu seiner herstellung.