ATE113606T1 - Peptide und diese peptide enthaltende wirkstoffe gegen dementia. - Google Patents

Peptide und diese peptide enthaltende wirkstoffe gegen dementia.

Info

Publication number: ATE113606T1
Authority: AT; Austria
Prior art keywords: pro; arg; asn; peptides; gly
Prior art date: 1989-04-15

Application number

AT90303987T

Other languages

English (en)

Inventor

Mitsuo Masaki

Masaki Uehara

Kenji Hirate

Yoshikazu Isowa

Yoshiaki Sato

Yoshiharu Nakashima

Shimoochiai

Original Assignee

Nippon Chemiphar Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-15

Filing date

1990-04-12

Publication date

1994-11-15

1989-04-15 Priority claimed from JP1095920A external-priority patent/JPH0826067B2/ja

1989-04-15 Priority claimed from JP1095918A external-priority patent/JP2542254B2/ja

1989-04-15 Priority claimed from JP1095922A external-priority patent/JPH0826070B2/ja

1989-04-15 Priority claimed from JP1095919A external-priority patent/JPH0832722B2/ja

1989-04-15 Priority claimed from JP1095921A external-priority patent/JPH0826069B2/ja

1989-04-15 Priority claimed from JP1095917A external-priority patent/JP2640778B2/ja

1990-04-12 Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co

1994-11-15 Application granted granted Critical

1994-11-15 Publication of ATE113606T1 publication Critical patent/ATE113606T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title 2
206010012289 Dementia Diseases 0.000 title 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 3
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 2
229940124280 l-arginine Drugs 0.000 abstract 2
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Chemical group CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
125000002038 D-arginyl group Chemical group N[C@@H](C(=O)*)CCCNC(=N)N 0.000 abstract 1
125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
229940024606 amino acid Drugs 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical group NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 1
125000006638 cyclopentyl carbonyl group Chemical group 0.000 abstract 1
VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT90303987T 1989-04-15 1990-04-12 Peptide und diese peptide enthaltende wirkstoffe gegen dementia. ATE113606T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP1095920A JPH0826067B2 (ja)	1989-04-15	1989-04-15	ペプチド誘導体、およびこれを含有する抗痴呆剤
JP1095918A JP2542254B2 (ja)	1989-04-15	1989-04-15	ペプチドおよびこれを含有する抗痴呆剤
JP1095922A JPH0826070B2 (ja)	1989-04-15	1989-04-15	ペプチドおよびこれを含有する抗痴呆剤
JP1095919A JPH0832722B2 (ja)	1989-04-15	1989-04-15	ペプチドおよびこれを含有する抗痴呆剤
JP1095921A JPH0826069B2 (ja)	1989-04-15	1989-04-15	ペプチドおよびこれを含有する抗痴呆剤
JP1095917A JP2640778B2 (ja)	1989-04-15	1989-04-15	ペプチドおよびこれを含有する抗痴呆剤

Publications (1)

Publication Number	Publication Date
ATE113606T1 true ATE113606T1 (de)	1994-11-15

Family

ID=27551968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90303987T ATE113606T1 (de)	1989-04-15	1990-04-12	Peptide und diese peptide enthaltende wirkstoffe gegen dementia.

Country Status (8)

Country	Link
US (2)	US5112947A (de)
EP (2)	EP0620230A1 (de)
KR (2)	KR0155559B1 (de)
AT (1)	ATE113606T1 (de)
AU (1)	AU642644B2 (de)
CA (1)	CA2014590C (de)
DE (1)	DE69013742T2 (de)
DK (1)	DK0393934T3 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0393934T3 (da) *	1989-04-15	1994-11-21	Nippon Chemiphar Co	Nye peptider samt antidemensmidler indeholdende disse peptider
GB2269821B (en) *	1992-08-08	1996-06-05	Shanghai Inst Biochemistry	Memory enhancing peptides and pharmaceutical compositions containing them
CN1036010C (zh) *	1992-08-08	1997-10-01	中国科学院上海生物化学研究所	记忆增强肽及其应用
DE69707690T2 (de)	1996-04-15	2002-05-08	Kabushiki Kaisha Yakult Honsha, Tokio/Tokyo	Neue peptide und nootroper wirkstoff
JP2001072602A (ja) *	1999-09-09	2001-03-21	Nippon Chemiphar Co Ltd	神経疾患治療剤
CN1154656C (zh) *	2000-06-30	2004-06-23	上海中科英泰生物技术有限公司	一类记忆增强肽和它们的用途
US9428845B1 (en)	2010-12-28	2016-08-30	Warp Drive Bio, Inc.	Identifying new therapeutic agents
EP4289950A3 (de)	2015-01-09	2024-01-24	Revolution Medicines, Inc.	Makrozyklische verbindungen mit beteiligung an einer kooperativen bindung und medizinische verwendungen davon
EP3355930A4 (de)	2015-10-01	2019-03-06	Warp Drive Bio, Inc.	Verfahren und reagenzien zur analyse von protein-protein-schnittstellen
KR102359972B1 (ko)	2016-04-12	2022-02-10	징코 바이오웍스, 인크.	화합물의 제조를 위한 조성물 및 방법
WO2018081592A2 (en)	2016-10-28	2018-05-03	Warp Drive Bio, Inc.	Compositions and methods for the production of compounds
CN114867735A (zh)	2019-11-04	2022-08-05	锐新医药公司	Ras抑制剂
CN114786777A (zh)	2019-11-04	2022-07-22	锐新医药公司	Ras抑制剂
PE20221277A1 (es)	2019-11-04	2022-09-05	Revolution Medicines Inc	Inhibidores de ras
AU2021345111B2 (en)	2020-09-15	2025-11-27	Revolution Medicines, Inc.	Indole derivatives as Ras inhibitors in the treatment of cancer
CR20230558A (es)	2021-05-05	2024-01-24	Revolution Medicines Inc	Inhibidores de ras para el tratamiento del cáncer
AR127308A1 (es)	2021-10-08	2024-01-10	Revolution Medicines Inc	Inhibidores ras

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE56021B1 (en) *	1982-10-13	1991-03-27	Akzo Nv	Peptides
US4504469A (en) *	1982-12-21	1985-03-12	Ferring Ab	Vasotocin derivatives
IE58407B1 (en) *	1984-04-13	1993-09-22	Akzo Nv	Peptides
US4748154A (en) *	1985-12-24	1988-05-31	Takeda Chemical Industries, Ltd.	Peptide derivatives, their production and use
KR0141693B1 (ko) *	1988-08-12	1998-06-15	나까무라 하루후미	펩티드 유도체 및 항치매제
KR0144005B1 (ko) *	1988-08-12	1998-07-01	나까무라 하루후미	펩티드 및 항치매제
JPH0253734A (ja) *	1988-08-12	1990-02-22	Nippon Chemiphar Co Ltd	抗痴呆剤
DK0393934T3 (da) *	1989-04-15	1994-11-21	Nippon Chemiphar Co	Nye peptider samt antidemensmidler indeholdende disse peptider

1990
- 1990-04-12 DK DK90303987.3T patent/DK0393934T3/da active
- 1990-04-12 CA CA002014590A patent/CA2014590C/en not_active Expired - Fee Related
- 1990-04-12 EP EP94100233A patent/EP0620230A1/de not_active Ceased
- 1990-04-12 DE DE69013742T patent/DE69013742T2/de not_active Expired - Fee Related
- 1990-04-12 AT AT90303987T patent/ATE113606T1/de not_active IP Right Cessation
- 1990-04-12 EP EP90303987A patent/EP0393934B1/de not_active Expired - Lifetime
- 1990-04-14 KR KR1019900005215A patent/KR0155559B1/ko not_active Expired - Fee Related
- 1990-04-16 US US07/509,950 patent/US5112947A/en not_active Expired - Lifetime
- 1990-04-17 AU AU53621/90A patent/AU642644B2/en not_active Ceased
1992
- 1992-02-18 US US07/838,140 patent/US5349050A/en not_active Expired - Fee Related
1998
- 1998-04-27 KR KR1019980014948A patent/KR0161652B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69013742D1 (de)	1994-12-08
AU5362190A (en)	1990-10-18
CA2014590C (en)	1999-12-14
KR0161652B1 (ko)	1999-10-01
US5349050A (en)	1994-09-20
US5112947A (en)	1992-05-12
CA2014590A1 (en)	1990-10-15
KR900016259A (ko)	1990-11-13
DE69013742T2 (de)	1995-03-23
EP0393934A1 (de)	1990-10-24
AU642644B2 (en)	1993-10-28
DK0393934T3 (da)	1994-11-21
EP0393934B1 (de)	1994-11-02
EP0620230A1 (de)	1994-10-19
KR0155559B1 (ko)	1998-10-15

Legal Events

Date	Code	Title	Description
1995-04-15	UEP	Publication of translation of european patent specification
2007-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69013742D1 (de)	1994-12-08	Peptide und diese Peptide enthaltende Wirkstoffe gegen Dementia.
US5192746A (en)	1993-03-09	Cyclic cell adhesion modulation compounds
DE69017138T2 (de)	1995-09-28	Fibrinogen-Rezeptor-Antagonisten.
US6147051A (en)	2000-11-14	Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
US6232468B1 (en)	2001-05-15	Dipeptides with neurokinin-antagonistic activity
CA2120303C (en)	2007-05-01	Cyclic adhesion inhibitors
FI71567C (fi)	1987-01-19	Foerfarande foer framstaellning av gonadoliberinderivat.
CA2140543C (en)	2001-04-10	Thrombin receptor antagonists
EP0490667B1 (de)	1999-06-09	HIV-Proteaseinhibitoren
JP4116062B2 (ja)	2008-07-09	環状接着阻害剤
CA2079253A1 (en)	1993-03-31	Inhibitors of farnesyl protein transferase
US4003884A (en)	1977-01-18	Peptides having LH-RH/FSH-RH activity
DK0695757T3 (da)	2002-08-19	Peptidamider til inhibering af human cancer
WO1996040752A1 (en)	1996-12-19	Novel dolastatin derivatives, their preparation and use
JPH03118332A (ja)	1991-05-20	フイブリノーゲン受容体拮抗薬
US5698516A (en)	1997-12-16	Biologically active vasopressin analogues
DE10107707A1 (de)	2002-08-29	Antagonisten für alpha¶4¶beta¶7¶-Integrin
US5502035A (en)	1996-03-26	N-terminus modified analogs of LHRH
DE69217763D1 (de)	1997-04-10	Hexapeptide
AU682638B2 (en)	1997-10-09	Peptide, bronchodilator and blood flow ameliorant
DK0918795T3 (da)	2005-03-14	Antiangiogene lægemidler til behandling af cancer, arthritis og retinopati
US5516759A (en)	1996-05-14	LHRH antagonists having lactam groups at the N-terminus
CA2102447C (en)	2007-04-10	Cyclopeptides
GB1489326A (en)	1977-10-19	Pharmaceutically active polypeptides
AU718320B2 (en)	2000-04-13	Peptide derivatives