ATE113943T1 - Bestimmte 3-substituierte 2-alkyl-benzofuran- derivate. - Google Patents

Bestimmte 3-substituierte 2-alkyl-benzofuran- derivate.

Info

Publication number: ATE113943T1
Authority: AT; Austria
Prior art keywords: substituted; alkyl; certain; methyl; hydrogen
Prior art date: 1987-09-30

Application number

AT88910246T

Other languages

English (en)

Inventor

Thomas P Kennedy

George W Kabalka

Original Assignee

Res Corp Technologies Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-30

Filing date

1988-09-28

Publication date

1994-11-15

1988-09-28 Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc

1994-11-15 Application granted granted Critical

1994-11-15 Publication of ATE113943T1 publication Critical patent/ATE113943T1/de

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
-1 piperidino, piperazino Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT88910246T 1987-09-30 1988-09-28 Bestimmte 3-substituierte 2-alkyl-benzofuran- derivate. ATE113943T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/103,484 US4851554A (en)	1987-04-06	1987-09-30	Certain 3-substituted 2-alkyl benzofuran derivatives
CA000585726A CA1327794C (en)	1987-09-30	1988-12-13	Certain 3-substituted 2-alkyl benzofuran derivatives

Publications (1)

Publication Number	Publication Date
ATE113943T1 true ATE113943T1 (de)	1994-11-15

Family

ID=25672297

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88910246T ATE113943T1 (de)	1987-09-30	1988-09-28	Bestimmte 3-substituierte 2-alkyl-benzofuran- derivate.

Country Status (8)

Country	Link
US (1)	US4851554A (de)
EP (1)	EP0380588B1 (de)
JP (1)	JP2509683B2 (de)
AT (1)	ATE113943T1 (de)
AU (1)	AU618303B2 (de)
CA (1)	CA1327794C (de)
DE (1)	DE3852107T2 (de)
WO (1)	WO1989002892A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4975458A (en) *	1989-03-13	1990-12-04	Taro Pharmaceuticals Industries, Ltd.	2-alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
FR2665444B1 (fr) *	1990-08-06	1992-11-27	Sanofi Sa	Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
GB9416219D0 (en) *	1994-08-11	1994-10-05	Karobio Ab	Receptor ligands
US6703407B1 (en) *	1994-09-20	2004-03-09	Eli Lilly And Company	Benzofuran compounds, compositions, and methods
US7501441B1 (en) *	1994-09-20	2009-03-10	Eli Lilly And Company	Naphthyl compounds, intermediates, processes, compositions, and methods
US6399634B1 (en) *	1994-09-20	2002-06-04	Eli Lilly And Company	Benzothiophene compounds, compositions, and methods
US6417199B1 (en) *	1995-03-10	2002-07-09	Eli Lilly And Company	3-benzyl-benzothiophenes
US6395755B1 (en)	1995-03-10	2002-05-28	Eli Lilly And Company	Benzothiophene pharmaceutical compounds
US5705507A (en) *	1995-03-10	1998-01-06	Eli Lilly And Company	Aplha-substituted-3-benzyl-benzofurans
US6391892B1 (en)	1995-03-10	2002-05-21	Eli Lilly And Company	Naphthyl pharmaceutical compounds
US5523309A (en) *	1995-03-10	1996-06-04	Eli Lilly And Company	Benzofuran pharmaceutical compounds
US5622974A (en) *	1995-03-10	1997-04-22	Eli Lilly And Company	α-substituted-3-benzyl-benzofurans
US6444688B1 (en) *	1995-06-07	2002-09-03	Eli Lilly And Company	Compounds and compositions with nitrogen-containing non-basic side chains
FR2764800B1 (fr)	1997-06-23	1999-09-10	Sanofi Sa	Composition pharmaceutique solide contenant des derives de benzofuranne
FR2813308B1 (fr) *	2000-08-23	2005-07-01	Sanofi Synthelabo	Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
FR2813306B1 (fr) *	2000-08-23	2005-10-21	Sanofi Synthelabo	Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2967067A1 (fr)	2010-11-10	2012-05-11	Sanofi Aventis	Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3248401A (en) *		1966-04-26		Diethylaminoe hoxybenzoyl benzofurans
US3929836A (en) *	1965-05-11	1975-12-30	Hoffmann La Roche	2-(2-Lower alkylamino-1-hydroxy-ethyl)-substituted benzofurans
US3627763A (en) *	1969-09-02	1971-12-14	Knut A Jaeggi	Substituted 2-benzyl-benzofuran derivatives
GB1333471A (en) *	1971-01-27	1973-10-10	Labaz	Imidazoline derivatives and process for preparing the same
GB1335403A (en) *	1971-04-29	1973-10-31	Labaz	Pharmaceutical compositions containing benzofuran derivatives
GB1380145A (en) *	1972-05-02	1975-01-08	Labaz	Acetamidine derivatives process for preparing the same and pharma ceutical uses thereof
GB1382602A (en) *	1972-06-01	1975-02-05	Labaz	Benzodioxan compounds and process for preparing the same
GB1382742A (en) *	1972-09-19	1975-02-05	Labaz	Benzofuran derivatives and process for preparing the same
FR2257273B1 (de) *	1974-01-15	1978-01-13	Labaz
GB1456323A (en) *	1974-06-06	1976-11-24	Labaz	Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
GB1472959A (en) *	1974-09-26	1977-05-11	Roche Products Ltd	Benzofuran derivatives and a process for the manufacture thereof
IT1154888B (it) *	1980-11-12	1987-01-21	Menarini Sas	Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione
JPS5973579A (ja) *	1982-10-19	1984-04-25	Kotobuki Seiyaku Kk	ベンゾフラン又はベンゾチオフェン誘導体，この化合物を有効成分とする尿酸排泄剤及びその製造方法
US4806663A (en) *	1987-04-06	1989-02-21	The University Of Tennessee Research Corporation	Certain 3-substituted 2-alkyl benzofuran derivatives

1987
- 1987-09-30 US US07/103,484 patent/US4851554A/en not_active Expired - Fee Related
1988
- 1988-09-28 AT AT88910246T patent/ATE113943T1/de not_active IP Right Cessation
- 1988-09-28 JP JP63509314A patent/JP2509683B2/ja not_active Expired - Lifetime
- 1988-09-28 EP EP88910246A patent/EP0380588B1/de not_active Expired - Lifetime
- 1988-09-28 WO PCT/US1988/003347 patent/WO1989002892A1/en not_active Ceased
- 1988-09-28 DE DE3852107T patent/DE3852107T2/de not_active Expired - Fee Related
- 1988-09-28 AU AU27222/88A patent/AU618303B2/en not_active Ceased
- 1988-12-13 CA CA000585726A patent/CA1327794C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0380588B1 (de)	1994-11-09
DE3852107T2 (de)	1995-03-30
CA1327794C (en)	1994-03-15
DE3852107D1 (de)	1994-12-15
US4851554A (en)	1989-07-25
AU2722288A (en)	1989-04-18
JP2509683B2 (ja)	1996-06-26
WO1989002892A1 (en)	1989-04-06
EP0380588A1 (de)	1990-08-08
EP0380588A4 (en)	1991-04-03
AU618303B2 (en)	1991-12-19
JPH03501606A (ja)	1991-04-11

Legal Events

Date	Code	Title	Description
1995-05-15	UEP	Publication of translation of european patent specification
2001-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE113943T1 (de)	1994-11-15	Bestimmte 3-substituierte 2-alkyl-benzofuran- derivate.
ATE32077T1 (de)	1988-02-15	7-amino-azolo(1,5-a>-pyrimidine und diese enthaltende fungizide.
GB2078720B (en)	1982-08-11	2-(3-oxobutyl)-2-formyl-1-tetralone intermediates
MY117092A (en)	2004-05-31	Chemotherapeutic pyrrolocarbazole derivatives
IL83141A0 (en)	1987-12-31	Solutions of oxazophorins having improved stability and their preparation
IL75273A (en)	1991-06-10	Cephalosporin derivatives,process for their preparation and pharmaceutical compositions containing them
JPS5756470A (en)	1982-04-05	Dibenzodiazepine derivative
NO164351C (no)	1990-09-26	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-alkyl-l-fenyl-2-piperazinoalkylpyrazolin-3-on-forbindelser.
EP0411912A3 (en)	1991-09-11	Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders