ATE113983T1 - Gewebeplasminogenaktivator mit fibrin- spezifischen eigenschaften. - Google Patents

Gewebeplasminogenaktivator mit fibrin- spezifischen eigenschaften.

Info

Publication number
ATE113983T1
ATE113983T1 AT91904945T AT91904945T ATE113983T1 AT E113983 T1 ATE113983 T1 AT E113983T1 AT 91904945 T AT91904945 T AT 91904945T AT 91904945 T AT91904945 T AT 91904945T AT E113983 T1 ATE113983 T1 AT E113983T1
Authority
AT
Austria
Prior art keywords
variant
fibrin
plasminogen activator
tissue plasminogen
specific properties
Prior art date
Application number
AT91904945T
Other languages
English (en)
Inventor
John F Gill
Leonard G Presta
Mark J Zoller
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE113983T1 publication Critical patent/ATE113983T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT91904945T 1990-03-01 1991-02-14 Gewebeplasminogenaktivator mit fibrin- spezifischen eigenschaften. ATE113983T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/486,657 US5156969A (en) 1988-09-02 1990-03-01 Tissue plasminogen activator variant with deletion of amino acids 466-470 having fibrin specific properties

Publications (1)

Publication Number Publication Date
ATE113983T1 true ATE113983T1 (de) 1994-11-15

Family

ID=23932757

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91904945T ATE113983T1 (de) 1990-03-01 1991-02-14 Gewebeplasminogenaktivator mit fibrin- spezifischen eigenschaften.

Country Status (10)

Country Link
US (1) US5156969A (de)
EP (1) EP0517756B1 (de)
JP (1) JP3081238B2 (de)
AT (1) ATE113983T1 (de)
AU (1) AU642984B2 (de)
CA (1) CA2075901C (de)
DE (1) DE69105121T2 (de)
DK (1) DK0517756T3 (de)
ES (1) ES2067221T3 (de)
WO (1) WO1991013149A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272076A (en) * 1991-06-13 1993-12-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA
DE4423574A1 (de) * 1994-07-05 1996-01-11 Boehringer Mannheim Gmbh Nicht-glykosylierte Plasminogenaktivator-Derivate und ihre Verwendung bei erhöhtem Blutungsrisiko
US5837688A (en) * 1996-11-27 1998-11-17 Gelfand; Mathew I. Use of thrombolytic reagents for prevention of vascular disease
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
DE102014112212A1 (de) 2014-08-26 2016-03-03 Akesion Gmbh Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
AU3876789A (en) * 1988-06-20 1990-01-12 Washington University Use of modified tpa to detect blood clots
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
JP3126381B2 (ja) * 1990-07-31 2001-01-22 ジェネンテク，インコーポレイテッド 減少されたクリアランスを有する組織プラスミノーゲンアクチベーター変異体

Also Published As

Publication number Publication date
DE69105121D1 (de) 1994-12-15
CA2075901A1 (en) 1991-09-02
JP3081238B2 (ja) 2000-08-28
EP0517756B1 (de) 1994-11-09
AU7339891A (en) 1991-09-18
WO1991013149A1 (en) 1991-09-05
AU642984B2 (en) 1993-11-04
EP0517756A1 (de) 1992-12-16
ES2067221T3 (es) 1995-03-16
DK0517756T3 (da) 1995-04-24
US5156969A (en) 1992-10-20
CA2075901C (en) 2001-07-03
JPH05504685A (ja) 1993-07-22
DE69105121T2 (de) 1995-05-04

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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time