ATE11416T1 - 4-o-substituierte 2-deoxystreptamin-aminoglucosid-derivate, ihre herstellung und die sie enthaltenden zusammensetzungen. - Google Patents

4-o-substituierte 2-deoxystreptamin-aminoglucosid-derivate, ihre herstellung und die sie enthaltenden zusammensetzungen.

Info

Publication number: ATE11416T1
Authority: AT; Austria
Prior art keywords: alpha; protected; beta; amino; aprosaminide
Prior art date: 1980-09-22

Application number

AT81304323T

Other languages

English (en)

Inventor

Herbert Andrew Kirst

Brenda Alethia Truedell

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-22

Filing date

1981-09-21

Publication date

1985-02-15

1981-09-21 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

1985-02-15 Application granted granted Critical

1985-02-15 Publication of ATE11416T1 publication Critical patent/ATE11416T1/de

Links

DTFAJAKTSMLKAT-JDCCYXBGSA-N 2-deoxystreptamine Chemical class N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O)[C@@H]1O DTFAJAKTSMLKAT-JDCCYXBGSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
-1 amino- alpha -hydroxybutyryl Chemical group 0.000 abstract 12
239000002253 acid Substances 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004103 aminoalkyl group Chemical group 0.000 abstract 2
229940126575 aminoglycoside Drugs 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
SYJXFKPQNSDJLI-HKEUSBCWSA-N neamine Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](N)C[C@@H]1N SYJXFKPQNSDJLI-HKEUSBCWSA-N 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
KSRLKDYACUXDFK-MIRCGDSDSA-N (1s,2r,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]oxycyclohexane-1,2-diol Chemical compound O1[C@H](CN)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](N)C[C@@H]1N KSRLKDYACUXDFK-MIRCGDSDSA-N 0.000 abstract 1
125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
208000035143 Bacterial infection Diseases 0.000 abstract 1
WFYNQZAEUGGNRH-RROBTUQGSA-N Lividamine Chemical class O[C@@H]1[C@@H](O)[C@H](N)C[C@H](N)[C@H]1O[C@@H]1[C@H](N)C[C@H](O)[C@@H](CO)O1 WFYNQZAEUGGNRH-RROBTUQGSA-N 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
QBWLTQZEVUXXSR-RROBTUQGSA-N Nebramine Chemical class N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](N)C[C@@H]1N QBWLTQZEVUXXSR-RROBTUQGSA-N 0.000 abstract 1
JGSMDVGTXBPWIM-UHFFFAOYSA-N Paromamine Chemical class OC1C(O)C(N)CC(N)C1OC1C(N)C(O)C(O)C(CO)O1 JGSMDVGTXBPWIM-UHFFFAOYSA-N 0.000 abstract 1
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical compound O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 abstract 1
229950006334 apramycin Drugs 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000007942 carboxylates Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000007865 diluting Methods 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 1
150000002815 nickel Chemical class 0.000 abstract 1
JGSMDVGTXBPWIM-HKEUSBCWSA-N paromamine Chemical class O[C@@H]1[C@@H](O)[C@H](N)C[C@H](N)[C@H]1O[C@@H]1[C@H](N)[C@@H](O)[C@H](O)[C@@H](CO)O1 JGSMDVGTXBPWIM-HKEUSBCWSA-N 0.000 abstract 1
239000003495 polar organic solvent Substances 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT81304323T 1980-09-22 1981-09-21 4-o-substituierte 2-deoxystreptamin-aminoglucosid-derivate, ihre herstellung und die sie enthaltenden zusammensetzungen. ATE11416T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18944080A	1980-09-22	1980-09-22
EP81304323A EP0048613B1 (de)	1980-09-22	1981-09-21	4-O-Substituierte 2-Deoxystreptamin-aminoglucosid-Derivate, ihre Herstellung und die sie enthaltenden Zusammensetzungen

Publications (1)

Publication Number	Publication Date
ATE11416T1 true ATE11416T1 (de)	1985-02-15

Family

ID=22697337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT81304323T ATE11416T1 (de)	1980-09-22	1981-09-21	4-o-substituierte 2-deoxystreptamin-aminoglucosid-derivate, ihre herstellung und die sie enthaltenden zusammensetzungen.

Country Status (5)

Country	Link
EP (1)	EP0048613B1 (de)
JP (1)	JPS5782399A (de)
AT (1)	ATE11416T1 (de)
DE (1)	DE3168509D1 (de)
GB (1)	GB2084149B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4468513A (en) *	1980-09-22	1984-08-28	Eli Lilly And Company	2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
CH656622A5 (de) *	1981-12-08	1986-07-15	Toyo Jozo Kk	Aminoglycosid-antibiotika saccharocine und deren herstellung.
IT1200774B (it) *	1985-10-10	1989-01-27	Pierrel Spa	Procedimento di sentisi dell'amikacina
CN108026133B (zh)	2015-07-30	2021-05-07	公益财团法人微生物化学研究会	有效对抗多药耐药细菌的新的氨基糖苷抗生素

1981
- 1981-09-19 JP JP56148681A patent/JPS5782399A/ja active Pending
- 1981-09-21 DE DE8181304323T patent/DE3168509D1/de not_active Expired
- 1981-09-21 GB GB8128464A patent/GB2084149B/en not_active Expired
- 1981-09-21 AT AT81304323T patent/ATE11416T1/de not_active IP Right Cessation
- 1981-09-21 EP EP81304323A patent/EP0048613B1/de not_active Expired

Also Published As

Publication number	Publication date
EP0048613A1 (de)	1982-03-31
JPS5782399A (en)	1982-05-22
DE3168509D1 (en)	1985-03-07
EP0048613B1 (de)	1985-01-23
GB2084149A (en)	1982-04-07
GB2084149B (en)	1984-08-15

Legal Events

Date	Code	Title	Description
1985-06-15	UEP	Publication of translation of european patent specification
1987-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
WO1996040665A1 (en)	1996-12-19	N-substituted piperazine nonoates
RU95122661A (ru)	1998-03-10	Производные 1-n-этилгентамицина и способы их получения
GB1438188A (en)	1976-06-03	Gentamicin derivatives and a process for the preparation thereof
KR870002078A (ko)	1987-03-30	에틸렌디아민 모노아미드유도체의 제조방법
PT74087B (en)	1983-05-23	2-oxoazetidine derivatives their production and use
ATE11416T1 (de)	1985-02-15	4-o-substituierte 2-deoxystreptamin-aminoglucosid-derivate, ihre herstellung und die sie enthaltenden zusammensetzungen.
GB1413068A (en)	1975-11-05	Bromoergolines
JPS5782398A (en)	1982-05-22	2-deoxystreptamine aminoglycoside derivative
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KR950014094A (ko)	1995-06-15	에스큘레틴 유도체, 그의 제조 방법, 그의 용도 및 약학 조성물
JPS5488242A (en)	1979-07-13	Novel derivative of fortimicin b and its preparation
ES412207A1 (es)	1976-01-01	Un procedimiento para preparar compuestos antibacterianos de cefalosporinas.
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GB1536320A (en)	1978-12-20	Process for the mono-diazotization of aromatic diamines
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ES307471A1 (es)	1965-09-01	Procedimiento para la preparacion de derivados de fenilalanina.
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