ATE114311T1 - Bivalente liganden, wirksam für die blockierung des enzyms acat. - Google Patents

Bivalente liganden, wirksam für die blockierung des enzyms acat.

Info

Publication number: ATE114311T1
Authority: AT; Austria
Prior art keywords: blocking; bivalent ligands; acat; ligands effective; enzyme acat
Prior art date: 1988-08-16

Application number

AT89907579T

Other languages

English (en)

Inventor

Ronald B Gammill

Frank P Bell

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-16

Filing date

1989-06-16

Publication date

1994-12-15

1989-06-16 Application filed by Upjohn Co filed Critical Upjohn Co

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE114311T1 publication Critical patent/ATE114311T1/de

Links

102000004190 Enzymes Human genes 0.000 title abstract 2
108090000790 Enzymes Proteins 0.000 title abstract 2
230000000903 blocking effect Effects 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT89907579T 1988-08-16 1989-06-16 Bivalente liganden, wirksam für die blockierung des enzyms acat. ATE114311T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23293188A	1988-08-16	1988-08-16

Publications (1)

Publication Number	Publication Date
ATE114311T1 true ATE114311T1 (de)	1994-12-15

Family

ID=22875168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89907579T ATE114311T1 (de)	1988-08-16	1989-06-16	Bivalente liganden, wirksam für die blockierung des enzyms acat.

Country Status (7)

Country	Link
EP (1)	EP0429464B1 (de)
JP (1)	JPH04500506A (de)
KR (1)	KR900701792A (de)
AT (1)	ATE114311T1 (de)
DE (1)	DE68919475T2 (de)
DK (1)	DK25691D0 (de)
WO (1)	WO1990002129A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5304548A (en) *	1988-08-16	1994-04-19	The Upjohn Company	Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol
US5180717A (en) *	1988-08-16	1993-01-19	The Upjohn Company	Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol
WO1995027964A1 (en) *	1994-04-12	1995-10-19	Qualcomm Incorporated	Method and apparatus for freight transportation using a satellite navigation system
JPWO2009038064A1 (ja) *	2007-09-19	2011-01-06	株式会社医薬分子設計研究所	Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する複素環誘導体
BRPI0909105A2 (pt) *	2008-03-05	2015-08-25	Boehringer Ingelheim Int	Derivados de piridina tricíclicos, composição farmacêutica e uso dos mesmos, bem como processos para preparar os ditos compostos e a dita composição farmacêutica
UY33229A (es)	2010-02-19	2011-09-30	Boehringer Ingelheim Int	Derivados de piridina tricíclicos, medicamentos que contienen tales compuestos, su uso y proceso pa ra su preparación
EP2760868B1 (de)	2011-08-17	2018-04-25	Boehringer Ingelheim International GmbH	Furo[3,4-c]chinolinderivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür
CN107021940A (zh) *	2017-05-03	2017-08-08	天津国际生物医药联合研究院	一种双哌嗪类化合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU529561B2 (en) *	1979-02-13	1983-06-09	Upjohn Company, The	Antiatherogenic 6-halofurochromones
US4412071A (en) *	1982-05-17	1983-10-25	The Upjohn Company	Antiatherosclerotic compositions

1989
- 1989-06-16 JP JP1507138A patent/JPH04500506A/ja active Pending
- 1989-06-16 KR KR1019900700773A patent/KR900701792A/ko not_active Withdrawn
- 1989-06-16 EP EP89907579A patent/EP0429464B1/de not_active Expired - Lifetime
- 1989-06-16 WO PCT/US1989/002572 patent/WO1990002129A1/en not_active Ceased
- 1989-06-16 DE DE68919475T patent/DE68919475T2/de not_active Expired - Fee Related
- 1989-06-16 AT AT89907579T patent/ATE114311T1/de not_active IP Right Cessation
1991
- 1991-02-14 DK DK025691A patent/DK25691D0/da unknown

Also Published As

Publication number	Publication date
EP0429464B1 (de)	1994-11-23
AU631801B2 (en)	1992-12-10
JPH04500506A (ja)	1992-01-30
DK25691A (da)	1991-02-14
EP0429464A1 (de)	1991-06-05
KR900701792A (ko)	1990-12-04
WO1990002129A1 (en)	1990-03-08
DE68919475T2 (de)	1995-05-11
AU3835889A (en)	1990-03-23
DE68919475D1 (de)	1995-01-05
DK25691D0 (da)	1991-02-14

Similar Documents

Publication	Publication Date	Title
ATE104380T1 (de)	1994-04-15	Sauerstoffdelignifizierung und enzymatische behandlung.
TR199501643A2 (tr)	1996-07-21	Yünün enzimlerle tedavisi icin yöntem.
NO881697D0 (no)	1988-04-20	Verktoeyenhet, verktoeydeler og fremgangsmaate for sammensetting av delene.
NO910923L (no)	1991-09-10	Trifunksjonell antistofflignende forbindelse som et kombinert diagnostisk og terapeutisk middel.
DE68924026D1 (de)	1995-10-05	Biosensor und dessen herstellung.
DE3783626D1 (de)	1993-03-04	Detergens-bleichmittelzusammensetzungen, bleichmittelzusammensetzungen und bleichmittelaktivatoren.
WO1996021730A3 (en)	1996-10-10	Ribozymes with rna protein binding site
ITVI940016A0 (it)	1994-02-09	Chiusura per bracciali, collane e simili.
DE3788691D1 (de)	1994-02-17	Verhütung von Fusariumkrankheiten und Mikroorganismen dafür.
DE3873992D1 (de)	1992-10-01	Blutfetterniedrigende und antiatherosclerotische harnstoff-verbindungen.
NO900607L (no)	1990-02-08	Enzymatisk oppvaskmiddel.
ATE114311T1 (de)	1994-12-15	Bivalente liganden, wirksam für die blockierung des enzyms acat.
NO865080L (no)	1987-07-24	Belegging av naeringsmidler.
DE69613329D1 (de)	2001-07-19	Enzym enthaltendes Granulat, Herstellungsmethode und das Granulat enthaltende Zusammensetzungen
ES8609468A1 (es)	1986-09-01	Un procedimiento para preparar un derivado de una enzima fibronolitica
NO871844D0 (no)	1987-05-04	Strikkede stoffer og fremgangsmaate for fremstilling av disse.
NO994858L (no)	1999-12-06	Forbindelser og preparater til behandling av sykdommer assosiert med serinprotease, spesielt tryptase aktivitet
DE3763814D1 (de)	1990-08-23	Enzyme enthaltendes geschirrwaschmittel.
NO871883L (no)	1987-11-09	Fremgangsmaate for rensing av enkelt- og dobbeltkjedet vevplasminogenaktivator.
NO892505L (no)	1989-12-21	Behandling av vandige dispersjoner.
FI873060A7 (fi)	1988-01-12	Modifioitu kudosplasmiiniaktivaattori.
LV12149A (lv)	1998-10-20	5-Aizvietoti mikofenolskabes 4-aminoatvasinajumi
NO168055C (no)	1992-01-08	Fremgangsmaate for fremstilling av human vevplasminogenaktivator og urokinase-type plasminogenaktivator.
IT8921592A0 (it)	1989-08-31	Stabilizzazione in forma liquida dell'enzima glucosio ossidasi.
NO903056L (no)	1990-08-17	Fremgangsmaate ved glukoseoksydasebehandling av matvarer.

Legal Events

Date	Code	Title	Description
1996-09-15	REN	Ceased due to non-payment of the annual fee