ATE114672T1 - Peptidzusammensetzung und verfahren zum nachweis von antikörpern gegen htlv-iii. - Google Patents
Peptidzusammensetzung und verfahren zum nachweis von antikörpern gegen htlv-iii.Info
- Publication number
- ATE114672T1 ATE114672T1 AT87305278T AT87305278T ATE114672T1 AT E114672 T1 ATE114672 T1 AT E114672T1 AT 87305278 T AT87305278 T AT 87305278T AT 87305278 T AT87305278 T AT 87305278T AT E114672 T1 ATE114672 T1 AT E114672T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide composition
- htlv
- iii
- aids
- assay
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/974—Aids related test
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/22—Viral peptide or viral protein
- Y10S930/221—Retrovirus related, or human immunodeficiency virus related, or simian immunodeficiency virus related
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/013,014 US4879212A (en) | 1986-04-02 | 1987-02-10 | Peptide composition and method for the detection of antibodies to HTLV-III |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE114672T1 true ATE114672T1 (de) | 1994-12-15 |
Family
ID=21757877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87305278T ATE114672T1 (de) | 1987-02-10 | 1987-06-15 | Peptidzusammensetzung und verfahren zum nachweis von antikörpern gegen htlv-iii. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4879212A (de) |
| EP (1) | EP0278148B1 (de) |
| JP (1) | JP2675009B2 (de) |
| AT (1) | ATE114672T1 (de) |
| CA (1) | CA1280363C (de) |
| DE (1) | DE3750812T2 (de) |
| DK (1) | DK296087A (de) |
| ES (1) | ES2064316T3 (de) |
| HK (1) | HK155795A (de) |
| IL (1) | IL82847A0 (de) |
| NO (2) | NO175482C (de) |
| ZA (1) | ZA874759B (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4629783A (en) * | 1985-04-29 | 1986-12-16 | Genetic Systems Corporation | Synthetic antigen for the detection of AIDS-related disease |
| KR910002374B1 (ko) | 1985-04-29 | 1991-04-20 | 제네틱 시스템즈 코포레이션 | Aids 관련질병의 검출을 위한 합성항원 |
| US6130314A (en) * | 1986-03-26 | 2000-10-10 | Genetic Systems Corporation | Synthetic antigen for the detection of AIDS-related disease |
| US5681696A (en) * | 1987-01-09 | 1997-10-28 | United Biomedical, Inc. | Synthetic peptide compositions with immunoreactivities to antibodies to HTLV |
| US5476765A (en) * | 1987-01-09 | 1995-12-19 | United Biomedical, Inc. | Synthetic peptide compositions with immunoreactivities to antibodies to HTLV and as vaccines |
| DE3887053D1 (de) * | 1987-04-16 | 1994-02-24 | Johnson & Johnson | Stlv-iii-verwandte polypeptide, diagnosesysteme und testmethoden. |
| JPH0215098A (ja) * | 1987-05-18 | 1990-01-18 | Virovahl Sa | Hiv−1感染検出用合成ペプチド杭原、その組成物およびその使用方法 |
| US20030022826A1 (en) * | 1987-09-08 | 2003-01-30 | Duke University | Use of synthetic peptides to induce tolerance to pathogenic T and B cell epitopes of autoantigens or infectious agents |
| SE8704185L (sv) * | 1987-10-28 | 1989-04-29 | Ferring Ab | Nya peptider, artificiella antigener och immunoanalystestsatser |
| JPH01163198A (ja) * | 1987-12-28 | 1989-06-27 | Birobaaru Sa | Hiv−2感染検出用合成ペプチド抗原、その組成物およびその使用方法 |
| SE8705197D0 (sv) * | 1987-12-30 | 1987-12-30 | Jonas Blomberg | New peptides, two diagnostic methods using the peptides and a medicament based on the peptides |
| US6210874B1 (en) | 1988-01-27 | 2001-04-03 | Biochem Immunosystems, Inc. | Synthetic peptides and mixtures thereof for detecting HIV antibodies |
| US6214537B1 (en) | 1988-01-27 | 2001-04-10 | Biochem Immunosystems, Inc. | Synthetic peptides and mixtures thereof for detecting HIV antibodies |
| US5241047A (en) * | 1988-12-08 | 1993-08-31 | Biochem Pharma Inc. | Synthetic peptides and mixtures thereof for detecting HIV antibodies |
| US6218102B1 (en) * | 1988-01-27 | 2001-04-17 | Biochem Immunosystems, Inc. | Synthetic peptides and mixtures thereof for detecting HIV antibodies |
| AU629528B2 (en) * | 1988-01-27 | 1992-10-08 | Biochem Pharma Inc. | Synthetic peptides and mixtures thereof for detecting hiv antibodies |
| US5516632A (en) * | 1988-02-08 | 1996-05-14 | Duke University | Synthetic peptides |
| CA1335880C (en) * | 1988-07-14 | 1995-06-13 | Thomas P. O'connor | Detection of an antibody and antigen in an immunoassay |
| CA2003300A1 (en) * | 1988-11-21 | 1990-05-21 | Franklin Volvovitz | Skin test and test kit for aids |
| US5260189A (en) * | 1988-12-20 | 1993-11-09 | Immunodiagnostics, Inc. | Synthetic HIV-like peptides their compositions and uses |
| US5439792A (en) * | 1989-06-02 | 1995-08-08 | Genetic Systems Corporation | Cysteine thiol-protected peptides for use in immunoassays |
| US5882853A (en) * | 1989-09-01 | 1999-03-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of evaluating HTLV-I-specific T cell responses |
| US6248574B1 (en) | 1989-12-13 | 2001-06-19 | Avigdor Shaffermann | Polypeptides selectively reactive with antibodies against human immunodeficiency virus and vaccines comprising the polypeptides |
| FR2657017B1 (fr) * | 1990-01-16 | 1995-08-18 | Clonatec Sa | Peptides derivant de la glycoproteine d'enveloppe du virus-hiv-1, leurs applications a la detection d'une infection due a ce virus et a la vaccination contre le sida. |
| ATE164853T1 (de) * | 1990-01-16 | 1998-04-15 | Orgenics Ltd | Peptide, von virus-hiv-hüllen-glycoproteinen abstammend, deren verwendung zum nachweis einer infektion dieser viren und für die impfung gegen aids |
| US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
| US5106726A (en) * | 1990-02-16 | 1992-04-21 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV |
| KR940000755B1 (ko) * | 1990-02-16 | 1994-01-29 | 유나이티드 바이오메디칼 인코오포레이티드 | Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드 |
| US5654401A (en) * | 1990-11-28 | 1997-08-05 | The Johns Hopkins University | Borna disease virus-specific protein and kits |
| ATE185350T1 (de) * | 1990-12-14 | 1999-10-15 | Innogenetics Nv | Synthetische antigene zum nachweis von antikörpern gegen hepatitis c virus |
| US7119182B1 (en) | 1991-02-19 | 2006-10-10 | The Regents Of The University Of California | Recombinant thrombin receptor and related pharmaceuticals |
| US5688768A (en) * | 1991-02-19 | 1997-11-18 | Cor Therapeutics, Inc. | Recombinant thrombin receptor and related pharmaceuticals |
| US6139843A (en) * | 1991-04-02 | 2000-10-31 | Albert Einstein College Of Medicine Of Yeshiva University | Peptide compositions for the treatment of HIV |
| JPH07502493A (ja) * | 1991-10-08 | 1995-03-16 | デューク・ユニバーシテイ | Htlvの抗原決定基に対応するペプチド |
| US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
| US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
| US7094884B2 (en) * | 2001-06-22 | 2006-08-22 | Roche Diagnostics Corporation | Soluble complexes of amylod β peptide and peptidyl prolyl isomerase chaperone and methods of making and using them |
| US6962982B2 (en) * | 2001-06-22 | 2005-11-08 | Roche Diagnostics Corporation | Soluble complexes of target proteins and peptidyl prolyl isomerase chaperones and methods of making and using them |
| KR100702373B1 (ko) | 2001-06-22 | 2007-04-02 | 에프. 호프만-라 로슈 아게 | 레트로바이러스 표면 당단백질을 함유하는 가용성 복합체 |
| US7094757B2 (en) * | 2001-06-22 | 2006-08-22 | Roche Diagnostics Corporation | Complexes comprising a prion protein and a peptidyl prolyl isomerase chaperone, and method for producing and using them |
| ES2327340T3 (es) * | 2003-09-11 | 2009-10-28 | Idexx Laboratories, Inc. | Procedimiento y dispositivo para detectar el virus de la inmunodeficiencia felina. |
| WO2006011919A1 (en) * | 2004-06-30 | 2006-02-02 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
| CA2550264C (en) * | 2003-12-18 | 2011-06-28 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
| JP2007523170A (ja) * | 2004-02-19 | 2007-08-16 | アイデックス ラボラトリーズ インコーポレイテッド | ネコ免疫不全ウイルスの検出のための方法および装置 |
| JP4866848B2 (ja) * | 2004-06-30 | 2012-02-01 | アイデックス ラボラトリーズ インコーポレイテッド | ネコ免疫不全ウイルス(fiv)のenvタンパク質のv3領域に由来するペプチドの使用を含むfivを検出するための方法および装置 |
| FR2874017B1 (fr) * | 2004-08-06 | 2006-11-24 | Bio Rad Pasteur Sa | Peptides vih-1 modifies et leur utilisation en detection d'anticorps anti-vih |
| US7291338B2 (en) * | 2005-03-09 | 2007-11-06 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
| US8663968B2 (en) * | 2007-05-21 | 2014-03-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Simian T-cell lymphotropic virus |
| EP2553452B1 (de) | 2010-04-02 | 2015-03-04 | IDEXX Laboratories, Inc. | Nachweis des felinen immundefizienzvirus |
| CN103134709A (zh) * | 2011-11-30 | 2013-06-05 | 内蒙古蒙牛乳业(集团)股份有限公司 | 检测原料奶中孕酮含量的前处理方法及检测方法 |
| CN103134717B (zh) * | 2011-11-30 | 2015-04-08 | 内蒙古蒙牛乳业(集团)股份有限公司 | 检测乳酸菌饮料中雌二醇含量的前处理方法及检测方法 |
| CN103134716A (zh) * | 2011-11-30 | 2013-06-05 | 内蒙古蒙牛乳业(集团)股份有限公司 | 检测乳酸菌饮料中孕酮含量的前处理方法及检测方法 |
| CN103134715A (zh) * | 2011-11-30 | 2013-06-05 | 内蒙古蒙牛乳业(集团)股份有限公司 | 检测乳酸菌饮料中催乳素含量的前处理方法及检测方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| WO1984004372A1 (en) * | 1983-04-20 | 1984-11-08 | Applied Motion Products Inc | An improved magnetic seal assembly |
| JPS62500452A (ja) * | 1984-09-19 | 1987-02-26 | ザ リ−ジエンツ オブ ザ ユニバ−シテイ オブ カリフオルニア | ヒト細胞形質転換に関連するレトロウイルスポリペプチド |
| DE3587512T2 (de) * | 1984-10-18 | 1993-12-02 | Centre Nat Rech Scient | Hüllenantigene vom menschlichen Immunodefizienz-Virus und deren Verwendungen. |
| US4774175A (en) * | 1985-03-01 | 1988-09-27 | Centocor, Inc. | Immunochemical methods for the detection of antibody against HTLV-III |
| IE64785B1 (en) * | 1985-04-08 | 1995-09-06 | Genetic Systems Corp | Expression of immunologically reactive viral proteins |
| US4629783A (en) * | 1985-04-29 | 1986-12-16 | Genetic Systems Corporation | Synthetic antigen for the detection of AIDS-related disease |
| KR910002374B1 (ko) * | 1985-04-29 | 1991-04-20 | 제네틱 시스템즈 코포레이션 | Aids 관련질병의 검출을 위한 합성항원 |
| JP2702911B2 (ja) * | 1985-09-11 | 1998-01-26 | ユナイテツド・バイオメデイカル・インコ−ポレ−テツド | 合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法 |
| GB8525615D0 (en) * | 1985-10-17 | 1985-11-20 | Hoffmann La Roche | Polypeptides |
| ATE87103T1 (de) * | 1985-12-17 | 1993-04-15 | Akzo Nv | Immunochemisches reagenz. |
| AU7234387A (en) * | 1986-03-24 | 1987-10-20 | Ortho Pharmaceutical Corporation | Synthetic htlv-iii peptides, compositions and uses thereof |
| DE3789633T2 (de) * | 1986-05-27 | 1994-08-04 | Hoffmann La Roche | HTLV-III(LAV)Decke-Peptide. |
| DK169582B1 (da) * | 1986-06-23 | 1994-12-12 | Squibb Bristol Myers Co | Humant monoklonalt antistof, der er i stand til at reagere med en epitop på LAV/HTLV-III kappeglycoproteinet gp41, cellelinier, som producerer sådant antistof, farmaceutisk præparat indeholdende antistoffet samt fremgangsmåde til bestemmelse af nærværelsen af LAV/HTLV-III i en biologisk prøve og fremgangsmåde til separering af specifikke antigendeterminanter af LAV/HTLV-III under anvendelse af ant |
-
1987
- 1987-02-10 US US07/013,014 patent/US4879212A/en not_active Expired - Lifetime
- 1987-06-10 DK DK296087A patent/DK296087A/da not_active Application Discontinuation
- 1987-06-10 IL IL82847A patent/IL82847A0/xx not_active IP Right Cessation
- 1987-06-15 NO NO872473A patent/NO175482C/no unknown
- 1987-06-15 ES ES87305278T patent/ES2064316T3/es not_active Expired - Lifetime
- 1987-06-15 EP EP87305278A patent/EP0278148B1/de not_active Revoked
- 1987-06-15 AT AT87305278T patent/ATE114672T1/de not_active IP Right Cessation
- 1987-06-15 DE DE3750812T patent/DE3750812T2/de not_active Revoked
- 1987-07-01 ZA ZA874759A patent/ZA874759B/xx unknown
- 1987-07-06 JP JP62167117A patent/JP2675009B2/ja not_active Expired - Fee Related
- 1987-08-18 CA CA000544765A patent/CA1280363C/en not_active Expired - Fee Related
-
1992
- 1992-07-10 NO NO922744A patent/NO922744D0/no unknown
-
1995
- 1995-09-28 HK HK155795A patent/HK155795A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO175482B (no) | 1994-07-11 |
| DE3750812D1 (de) | 1995-01-12 |
| NO872473D0 (no) | 1987-06-15 |
| NO922744D0 (no) | 1992-07-10 |
| ZA874759B (en) | 1988-01-05 |
| EP0278148A2 (de) | 1988-08-17 |
| EP0278148A3 (en) | 1990-06-06 |
| US4879212A (en) | 1989-11-07 |
| NO922744L (no) | 1988-08-11 |
| NO175482C (no) | 1994-10-19 |
| DK296087D0 (da) | 1987-06-10 |
| JPS63196856A (ja) | 1988-08-15 |
| IL82847A0 (en) | 1987-12-20 |
| ES2064316T3 (es) | 1995-02-01 |
| JP2675009B2 (ja) | 1997-11-12 |
| HK155795A (en) | 1995-10-06 |
| NO872473L (no) | 1988-08-11 |
| DE3750812T2 (de) | 1995-06-22 |
| CA1280363C (en) | 1991-02-19 |
| DK296087A (da) | 1988-08-11 |
| EP0278148B1 (de) | 1994-11-30 |
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