ATE115160T1 - Biologisch abbaubare polyphosphoester. - Google Patents

Biologisch abbaubare polyphosphoester.

Info

Publication number
ATE115160T1
ATE115160T1 AT90104441T AT90104441T ATE115160T1 AT E115160 T1 ATE115160 T1 AT E115160T1 AT 90104441 T AT90104441 T AT 90104441T AT 90104441 T AT90104441 T AT 90104441T AT E115160 T1 ATE115160 T1 AT E115160T1
Authority
AT
Austria
Prior art keywords
polyphosphoesters
biodegradable
biodegradable polyphosphoesters
poly
phosphate esters
Prior art date
Application number
AT90104441T
Other languages
English (en)
Inventor
Kam W Leong
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of ATE115160T1 publication Critical patent/ATE115160T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
    • C08G79/04—Phosphorus linked to oxygen or to oxygen and carbon

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Polymers & Plastics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT90104441T 1989-03-09 1990-03-08 Biologisch abbaubare polyphosphoester. ATE115160T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/321,360 US5194581A (en) 1989-03-09 1989-03-09 Biodegradable poly(phosphoesters)

Publications (1)

Publication Number Publication Date
ATE115160T1 true ATE115160T1 (de) 1994-12-15

Family

ID=23250286

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90104441T ATE115160T1 (de) 1989-03-09 1990-03-08 Biologisch abbaubare polyphosphoester.

Country Status (6)

Country Link
US (1) US5194581A (de)
EP (1) EP0386757B1 (de)
JP (2) JPH03128938A (de)
AT (1) ATE115160T1 (de)
CA (1) CA2011171C (de)
DE (1) DE69014684D1 (de)

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US5767168A (en) 1995-03-30 1998-06-16 The Proctor & Gamble Company Biodegradable and/or compostable polymers made from conjugated dienes such as isoprene and 2,3-dimethyl-1, 3-butadiene
US5759569A (en) * 1995-01-10 1998-06-02 The Procter & Gamble Company Biodegradable articles made from certain trans-polymers and blends thereof with other biodegradable components
HUP0001256A3 (en) 1997-04-03 2002-12-28 Univ Johns Hopkins Med Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, method for making the same and using them
UA54505C2 (uk) * 1997-04-03 2003-03-17 Гілфорд Фармасьютікалз Інк. Полімери, що біологічно розкладаються, зшиті фосфатами, композиції, вироби і способи для їх виготовлення і використання
US5912225A (en) * 1997-04-14 1999-06-15 Johns Hopkins Univ. School Of Medicine Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same
NZ501184A (en) * 1997-04-30 2002-08-28 Guilford Pharm Inc Biodegradable poly (phosphodiester) compositions that degrade in vivo into non-toxic residues
ATE216712T1 (de) * 1997-06-18 2002-05-15 Guilford Pharm Inc Zweistufige lösungspolymerisation von hochmolekularen poly(phosphorestern)
US6028163A (en) * 1997-06-27 2000-02-22 Guilford Pharmaceuticals Inc. Solution polymerization of high molecular weight poly(phosphoesters) in toluene
US6548302B1 (en) 1998-06-18 2003-04-15 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
JP2002524108A (ja) 1998-07-28 2002-08-06 インナーダイン， インコーポレイテッド 吸収性近接照射療法および化学療法送達デバイスならびに方法
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6153212A (en) * 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6350464B1 (en) 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
US8614291B2 (en) 1999-08-10 2013-12-24 Poly-Med, Inc. Phosphorylated polymers and conjugates thereof
AU2001247346A1 (en) * 2000-03-10 2001-09-24 Johns Hopkins University Phosphate based biodegradable polymers
AU2001265252A1 (en) * 2000-05-31 2001-12-11 The Johns-Hopkins University Biologically useful polyphosphates
AU2001269961A1 (en) 2000-07-06 2002-01-21 Guilford Pharmaceuticals Improved polymers and polymerization processes
GB0100624D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds VII
WO2002058670A1 (en) * 2001-01-25 2002-08-01 Euroceltique S.A. Local anesthetic, and method of use
US20040022853A1 (en) * 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
EP1383504A1 (de) * 2001-04-26 2004-01-28 Control Delivery Systems, Inc. Retardformulierung mit kombinierten wirkstoffen
WO2002092667A1 (en) * 2001-05-14 2002-11-21 Johns Hopkins Singapore Pte Ltd. Biodegradable polyphosphates for controlled release of bioactive substances
WO2003000776A1 (en) * 2001-05-14 2003-01-03 Johns Hopkins Singapore Pte Ltd Biodegradable polyphosphoramidates for controlled release of bioactive substances
IN2014DN10834A (de) * 2001-09-17 2015-09-04 Psivida Inc
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
US7479535B2 (en) 2002-02-25 2009-01-20 Guilford Pharmaceuticals, Inc. Phosphorous-containing compounds with polymeric chains, and methods of making and using the same
US20090004741A1 (en) * 2002-05-14 2009-01-01 Jun Wang Biodegradable polyphosphoramidates for controlled release of bioactive substances
US6781011B2 (en) 2002-12-13 2004-08-24 Texas Christian University Bis-H-phosphinic acid derivatives as precursors to therapeutic bisphosphonates and uses thereof
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
JP2006520392A (ja) * 2003-03-13 2006-09-07 コントロールド・ケミカルズ・インコーポレーテッド 薬物の乱用可能性を低下させ且つ作用持続時間を延長する化合物および方法
US20050025797A1 (en) * 2003-04-08 2005-02-03 Xingwu Wang Medical device with low magnetic susceptibility
US20050155779A1 (en) * 2003-04-08 2005-07-21 Xingwu Wang Coated substrate assembly
WO2004108072A2 (en) * 2003-04-10 2004-12-16 3M Innovative Properties Company Delivery of immune response modifier compounds using metal-containing particulate support materials
AU2004252409A1 (en) * 2003-04-10 2005-01-06 3M Innovative Properties Company Methods and compositions for enhancing immune response
WO2006020616A1 (en) * 2004-08-13 2006-02-23 Reva Medical, Inc. Inherently radiopaque bioresorbable polymers for multiple uses
US20060240059A1 (en) 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious eluting polymer blend and coating made from the same
US20060240060A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious compound and medical device made of the same
US20060240253A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Guidewire and tube with lubricious coating
US20060241000A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious compound and medical device made of the same
AU2007221315B2 (en) * 2006-02-22 2013-03-14 Covidien Lp Biodegradable phosphoester polyamines
JP5554889B2 (ja) * 2007-03-29 2014-07-23 富士フイルム株式会社 有機無機複合組成物および光学部品
MX2009011785A (es) * 2007-05-02 2010-03-04 Tyrx Pharma Inc Polimeros de dihidroxibenzoato y usos de los mismos.
US8303650B2 (en) 2008-01-10 2012-11-06 Telesis Research, Llc Biodegradable self-expanding drug-eluting prosthesis
US8317857B2 (en) * 2008-01-10 2012-11-27 Telesis Research, Llc Biodegradable self-expanding prosthesis
DE102008043277A1 (de) * 2008-10-29 2010-05-06 Biotronik Vi Patent Ag Implantat aus einer biokorrodierbaren Eisen- oder Magnesiumlegierung
US8366763B2 (en) 2009-07-02 2013-02-05 Tryton Medical, Inc. Ostium support for treating vascular bifurcations
CN102725401A (zh) 2009-07-10 2012-10-10 哈佛大学校长及研究员协会 作为抗炎药的永久带电荷的钠和钙通道阻断剂
JP5692839B2 (ja) * 2009-12-21 2015-04-01 学校法人東京理科大学 可溶化剤、分散剤、およびリン酸化アルキレングリコールポリマー誘導体の製造方法
CN108348774A (zh) 2015-08-03 2018-07-31 哈佛大学校长及研究员协会 带电离子通道阻断剂及其应用
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN113811305A (zh) 2019-03-11 2021-12-17 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
SG11202109713PA (en) 2019-03-11 2021-10-28 Nocion Therapeutics Inc Ester substituted ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN119874561A (zh) 2019-03-11 2025-04-25 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
AU2020380118A1 (en) 2019-11-06 2022-05-19 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7513713B2 (ja) 2019-11-06 2024-07-09 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US11332446B2 (en) 2020-03-11 2022-05-17 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use

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GB753319A (en) * 1952-06-17 1956-07-25 Leo Ab High molecular, phosphorus-containing anti-enzymatic substances and the production thereof
GB757800A (en) * 1952-06-21 1956-09-26 Leo Ab High molecular weight phosphorus containing anti-enzymatic substances and a method for the production thereof
US2964552A (en) * 1956-08-31 1960-12-13 Leo Ab Adrenocorticotropic action-retarding and anti-enzymatic substances
US3251828A (en) * 1962-10-23 1966-05-17 Fmc Corp Polyphosphoric acid esters of polyether polyols
US3285863A (en) * 1964-10-21 1966-11-15 Eastman Kodak Co Polymers from phosphonites and diols
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JPS59202240A (ja) * 1983-05-02 1984-11-16 Daihachi Kagaku Kogyosho:Kk 難燃性熱可塑性樹脂組成物
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Also Published As

Publication number Publication date
EP0386757B1 (de) 1994-12-07
CA2011171A1 (en) 1990-09-09
JP2002161140A (ja) 2002-06-04
DE69014684D1 (de) 1995-01-19
US5194581A (en) 1993-03-16
JPH03128938A (ja) 1991-05-31
EP0386757A3 (en) 1990-12-27
CA2011171C (en) 2001-01-30
EP0386757A2 (de) 1990-09-12

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