ATE115862T1 - Tocole als impfstoffadjuvans. - Google Patents

Tocole als impfstoffadjuvans.

Info

Publication number
ATE115862T1
ATE115862T1 AT90200127T AT90200127T ATE115862T1 AT E115862 T1 ATE115862 T1 AT E115862T1 AT 90200127 T AT90200127 T AT 90200127T AT 90200127 T AT90200127 T AT 90200127T AT E115862 T1 ATE115862 T1 AT E115862T1
Authority
AT
Austria
Prior art keywords
vaccines
tocole
vaccine adjuvant
adjuvant
tocols
Prior art date
Application number
AT90200127T
Other languages
English (en)
Inventor
Lammert Cornelius
Eric Onno Rijke
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE115862T1 publication Critical patent/ATE115862T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90200127T 1989-02-04 1990-01-18 Tocole als impfstoffadjuvans. ATE115862T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8900277 1989-02-04

Publications (1)

Publication Number Publication Date
ATE115862T1 true ATE115862T1 (de) 1995-01-15

Family

ID=19854075

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90200127T ATE115862T1 (de) 1989-02-04 1990-01-18 Tocole als impfstoffadjuvans.

Country Status (15)

Country Link
US (2) US5650155A (de)
EP (1) EP0382271B1 (de)
JP (1) JP2892739B2 (de)
KR (1) KR0162646B1 (de)
CN (1) CN1056085C (de)
AT (1) ATE115862T1 (de)
AU (1) AU633043B2 (de)
CA (1) CA2008856C (de)
DE (1) DE69015222T2 (de)
DK (1) DK0382271T3 (de)
ES (1) ES2068989T3 (de)
GR (1) GR3015438T3 (de)
HU (1) HU206989B (de)
NZ (1) NZ232354A (de)
ZA (1) ZA90512B (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014837A1 (en) 1989-05-25 1990-12-13 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
US6197311B1 (en) 1991-07-25 2001-03-06 Idec Pharmaceuticals Corporation Induction of cytotoxic T-lymphocyte responses
US5919466A (en) * 1993-10-01 1999-07-06 Gerbu Biotechnik Gmbh Method for improving the yield of immunoantibodies in the vaccination of animals and humans
GB9326253D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US5744137A (en) * 1995-02-06 1998-04-28 The United States Of America As Represented By The Secretary Of The Agriculture Oil emulsion vaccines prepared with animal, vegetable, and synthetic oils using a mixture of nonionic surfactants
JP5124066B2 (ja) * 1999-03-24 2013-01-23 イギリス国 ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用
GB0025577D0 (en) * 2000-10-18 2000-12-06 Smithkline Beecham Biolog Vaccine
ATE534401T1 (de) 2000-10-18 2011-12-15 Glaxosmithkline Biolog Sa Mage antigen gekoppelt an einem protein d fragment enthaltende impfstoffe
WO2013034682A1 (en) 2011-09-08 2013-03-14 Umc Utrecht Holding B.V. Vaccine based on staphylococcal superantigen- line 3 protein (ssl3)
CA2564180A1 (en) * 2004-04-22 2005-11-03 Dainippon Sumitomo Pharma Co., Ltd. Pharmaceutical preparation containing bacterial cell wall skeleton component
DK1861120T3 (en) 2005-03-23 2016-07-25 Glaxosmithkline Biologicals Sa Use of an influenza virus and an oil-in-water emulsion adjuvant to induce CD 4 T cell and / or enhanced B memory cell response
CN101277717A (zh) * 2005-09-09 2008-10-01 英特威国际有限公司 Pcv-2疫苗
DK179025B1 (da) 2005-09-16 2017-08-28 Intervet Int Bv Fiskevaccine
JP5792920B2 (ja) 2005-12-22 2015-10-14 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
NZ570805A (en) 2006-03-30 2011-10-28 Glaxosmithkline Biolog Sa Vaccine comprising Type 5 and Type 8 capsular polysaccharides from Staphyloccocus aureus
EP2043682B1 (de) 2006-07-17 2014-04-02 GlaxoSmithKline Biologicals S.A. Influenzaimpfstoff
SI2097102T1 (sl) 2006-09-07 2012-09-28 Glaxosmithkline Biolog Sa Kombinirano cepivo, ki ima zmanjšane količine antigena za poliovirus
EP2468300B1 (de) 2006-09-26 2017-12-20 Infectious Disease Research Institute Impfstoffzusammensetzung mit einem synthetischen Adjuvans
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
EP2433648A3 (de) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Impfstoff mit einem Öl-in-wasser-emulsionshilfsstoff
CA2664619C (en) 2006-10-12 2012-12-11 Glaxosmithkline Biologicals S.A. Immunogenic compositions comprising an oil-in-water emulsion adjuvant containing a reduced amount of squalene, tocol and an emulsifying agent
US9452209B2 (en) * 2007-04-20 2016-09-27 Glaxosmithkline Biologicals Sa Influenza vaccine
EA200901578A1 (ru) 2007-06-26 2010-08-30 Глаксосмитклайн Байолоджикалс С.А. Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae
RU2010111725A (ru) 2007-08-28 2011-10-10 Юниверсите Де Льеж (Be) Рекомбинантный герпесвирус кои (khv) или герпесвирус 3 семейства карповых (cyhv-3) и вакцина для профилактики заболевания, вызванного khv/cyhv-3 у cyprinus carpio или cyprinus carpio koi
US7741418B2 (en) * 2007-12-31 2010-06-22 Bridgestone Corporation Process for producing polydienes
KR20110009157A (ko) 2008-04-16 2011-01-27 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
TWI551295B (zh) 2008-04-18 2016-10-01 英特威特國際股份有限公司 防備胞內勞森菌(Lawsonia intracellularis)用疫苗
UA100047C2 (ru) * 2008-04-18 2012-11-12 Интервет Интернешонал Б.В. Вакцина для защиты от lawsonia intracellularis
TWI449533B (zh) * 2008-04-18 2014-08-21 Intervet Int Bv 防備胞內勞森菌(Lawsonia intracellularis)、豬肺炎黴漿菌(Mycoplasma hyopneumoniae)及豬環狀病毒(Porcine circo virus)用疫苗
WO2009133054A1 (en) 2008-04-28 2009-11-05 Intervet International B.V. Novel avian astrovirus
WO2010017330A1 (en) * 2008-08-06 2010-02-11 Novartis Ag Microparticles for use in immunogenic compositions
WO2010079081A1 (en) 2009-01-07 2010-07-15 Glaxosmithkline Biologicals S.A. Methods for recovering a virus or a viral antigen produced by cell culture
WO2010089339A1 (en) 2009-02-06 2010-08-12 Glaxosmithkline Biologicals S.A. Purification of virus or viral antigens by density gradient ultracentrifugation
CA2764374C (en) 2009-06-05 2019-11-19 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
JP5774010B2 (ja) 2009-09-25 2015-09-02 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム インフルエンザウイルスのための免疫拡散アッセイ
GB0918830D0 (en) 2009-10-27 2009-12-09 Glaxosmithkline Biolog Niederl Process
GB0919117D0 (en) 2009-10-30 2009-12-16 Glaxosmithkline Biolog Sa Process
US20110305748A1 (en) 2010-03-11 2011-12-15 Immune Design, Corp. Vaccines for Pandemic Influenza
GB201006324D0 (en) 2010-04-15 2010-06-02 Glaxosmithkline Biolog Sa Vaccine
EP2566958B1 (de) 2010-05-03 2015-12-30 GlaxoSmithKline Biologicals S.A. Verfahren zur inaktivierung des influenza-virus
GB201009676D0 (en) 2010-06-10 2010-07-21 Glaxosmithkline Biolog Sa Novel process
GB201009673D0 (en) 2010-06-10 2010-07-21 Glaxosmithkline Biolog Sa Novel process
MA34802B1 (fr) 2010-10-15 2014-01-02 Glaxosmithkline Biolog Sa Nouvel antigène
CN103370079B (zh) 2010-10-18 2016-08-10 英特维特国际股份有限公司 针对家禽中禽流感的火鸡疱疹病毒作为载体的疫苗
SG190937A1 (en) 2010-12-14 2013-07-31 Glaxosmithkline Biolog Sa Mycobacterium antigenic composition
WO2012089748A1 (en) 2010-12-29 2012-07-05 Intervet International B.V. Canine babesiosis vaccine antigen
NZ616304A (en) 2011-04-08 2016-01-29 Immune Design Corp Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
US20120288515A1 (en) 2011-04-27 2012-11-15 Immune Design Corp. Synthetic long peptide (slp)-based vaccines
IN2014CN04655A (de) 2011-12-30 2015-09-18 Université de Liège
AR089868A1 (es) 2012-02-03 2014-09-24 Animal Health Inst Vacuna vectorial de eimeria para campylobacter jejuni
PL2811981T3 (pl) 2012-02-07 2019-09-30 Infectious Disease Research Institute Ulepszone formulacje adiuwantowe zawierające agonistę TLR4 oraz sposoby ich zastosowania
SMT201800368T1 (it) 2012-05-16 2018-09-13 Immune Design Corp Vaccini per l'infezione da virus-2 herpes simplex
EP2928489B1 (de) 2012-12-05 2019-02-27 GlaxoSmithKline Biologicals S.A. Immunogene zusammensetzung
BR112015024391A2 (pt) 2013-03-26 2017-10-24 The Pirbright Inst mutante de proteína, capsídeo, método para melhorar a estabilidade de um capsídeo, molécula de ácido nucleico isolada, célula hospedeira, micro-organismo recombinante carreador vivo, vacina, uso de um mutante da proteína vp2, e, métodos para preparar uma vacina e um mutante da proteína
US9579369B2 (en) 2013-03-29 2017-02-28 Intervet Inc. Vaccine against Rhipicephalus ticks
CA2909221A1 (en) 2013-04-18 2014-10-23 Immune Design Corp. Gla monotherapy for use in cancer treatment
CN105247043A (zh) 2013-05-31 2016-01-13 英特维特国际股份有限公司 鳞片脱落疾病(sdd)致病病毒及其衍生物
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
BE1022132B1 (fr) 2013-08-30 2016-02-19 Glaxosmithkline Biologicals S.A. Nouvelle methode.
CN104436157A (zh) 2013-09-23 2015-03-25 恩金生物有限公司 流感疫苗和治疗
WO2015112485A1 (en) 2014-01-21 2015-07-30 Immune Design Corp. Compositions for use in the treatment of allergic conditions
CN104013955B (zh) * 2014-06-18 2016-02-24 中国科学院过程工程研究所 一种不含表面活性剂的水包油乳液及其用途
BE1022949B1 (fr) 2014-06-25 2016-10-21 Glaxosmithkline Biologicals S.A. Composition immunogene
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
AR102548A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y uso
JP6719468B2 (ja) 2014-12-16 2020-07-08 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 大規模なウイルス精製方法
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
GB201603625D0 (en) 2016-03-02 2016-04-13 Glaxosmithkline Biolog Sa Novel influenza antigens
WO2017167768A1 (en) 2016-03-28 2017-10-05 Glaxosmithkline Biologicals S.A. Novel vaccine composition
CA3045563C (en) * 2016-12-23 2022-05-03 Intervet International B.V. Combination vaccine for swine
WO2018231706A1 (en) 2017-06-11 2018-12-20 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
AU2018285694B2 (en) 2017-06-15 2025-04-10 Access To Advanced Health Institute Nanostructured lipid carriers and stable emulsions and uses thereof
MY202505A (en) 2017-11-03 2024-05-01 Takeda Vaccines Inc Zika vaccines and immunogenic compositions, and methods of using the same
JP7354106B2 (ja) 2017-12-04 2023-10-02 インターベット インターナショナル ベー. フェー. レプリコン粒子および油性アジュバントによるワクチン接種
EP3581201A1 (de) 2018-06-15 2019-12-18 GlaxoSmithKline Biologicals S.A. Escherichia coli o157:h7 polypeptide und verwendungen davon
US20210340185A1 (en) 2018-08-29 2021-11-04 Centre Hospitalier Universitaire Vaudois Ebola vaccine compositions and methods of using same
EP3662929A1 (de) 2018-12-07 2020-06-10 IDT Biologika GmbH Rekombinantes koi-herpesvirus (khv) und diva-impfstoff zur vorbeugung und/oder behandlung von khv-bedingten erkrankungen
MX2022000879A (es) 2019-07-21 2022-05-02 Glaxosmithkline Biologicals Sa Vacuna viral terapeutica.
EP4004018A1 (de) 2019-07-24 2022-06-01 GlaxoSmithKline Biologicals SA Modifizierte humane cytomegalovirus-proteine
WO2021245611A1 (en) 2020-06-05 2021-12-09 Glaxosmithkline Biologicals Sa Modified betacoronavirus spike proteins
US20230293659A1 (en) 2020-08-03 2023-09-21 Glaxosmithkline Biologicals Sa Truncated fusobacterium nucleatum fusobacterium adhesin a (fada) protein and immunogenic compositions thereof
KR102617710B1 (ko) 2020-08-05 2024-01-25 주식회사 이노헨스 기판 처리장치
JP2023553854A (ja) 2020-12-02 2023-12-26 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ドナー鎖補完性fimh
EP4032547A1 (de) 2021-01-20 2022-07-27 GlaxoSmithKline Biologicals S.A. Hsv1 fce abgeleitete fragemente zur hsv therapie
US20250281597A1 (en) 2021-10-25 2025-09-11 Intervet Inc. A vaccine for the protection of piglets against swine influenza a virus infection
US20250101067A1 (en) 2022-01-28 2025-03-27 Glaxosmithkline Biologicals Sa Modified human cytomegalovirus proteins
US20250161421A1 (en) 2022-02-03 2025-05-22 CeCaVa GmbH & Co. KG Co-vaccination with cd4 and cd8 antigens
CN114984201B (zh) * 2022-04-24 2025-10-17 国药中生生物技术研究院有限公司 类天然脂滴纳米乳佐剂及其制备方法
CN115624619A (zh) * 2022-09-29 2023-01-20 山东博科生物产业有限公司 新冠病毒s蛋白佐剂乳化物、羊抗血清及制备方法、应用
EP4658302A1 (de) 2023-02-02 2025-12-10 GlaxoSmithKline Biologicals S.A. Immunogene zusammensetzung
KR20260052081A (ko) 2023-08-09 2026-04-17 글락소스미스클라인 바이오로지칼즈 에스.에이. 변형된 단백질
KR20260051063A (ko) 2023-08-09 2026-04-15 글락소스미스클라인 바이오로지칼즈 에스.에이. 변형된 단백질
WO2025262124A1 (en) 2024-06-19 2025-12-26 Intervet International B.V. Adjuvanted veterinary vaccines against enteric diseases
WO2025262123A1 (en) 2024-06-19 2025-12-26 Intervet International B.V. Veterinary vaccines against enteric diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919411A (en) * 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant
NL8301996A (nl) * 1983-06-06 1985-01-02 Duphar Int Res Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins.
US4772466A (en) * 1983-08-22 1988-09-20 Syntex (U.S.A.) Inc. Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants
US5023271A (en) * 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
AU596581B2 (en) * 1986-04-15 1990-05-10 Sansho Seiyaku Co., Ltd. Topical agents for inhibiting the melanin generation
ZA872532B (en) * 1986-04-21 1987-11-25 Akzo Nv Combined vaccine
US5151267A (en) * 1988-07-15 1992-09-29 University Of Saskatchewan Bovine herpesvirus type 1 polypeptides and vaccines

Also Published As

Publication number Publication date
EP0382271B1 (de) 1994-12-21
KR0162646B1 (ko) 1998-12-01
JP2892739B2 (ja) 1999-05-17
CA2008856C (en) 2001-06-19
CA2008856A1 (en) 1990-08-04
HU206989B (en) 1993-03-01
DK0382271T3 (da) 1995-05-01
JPH02250835A (ja) 1990-10-08
DE69015222T2 (de) 1995-05-04
US5650155A (en) 1997-07-22
US5667784A (en) 1997-09-16
ZA90512B (en) 1990-11-28
HUT56285A (en) 1991-08-28
AU4897590A (en) 1990-08-09
NZ232354A (en) 1991-09-25
ES2068989T3 (es) 1995-05-01
CN1056085C (zh) 2000-09-06
GR3015438T3 (en) 1995-06-30
HU900653D0 (en) 1990-04-28
CN1044594A (zh) 1990-08-15
AU633043B2 (en) 1993-01-21
EP0382271A1 (de) 1990-08-16
KR900012630A (ko) 1990-09-01
DE69015222D1 (de) 1995-02-02

Similar Documents

Publication Publication Date Title
DE69015222D1 (de) Tocole als Impfstoffadjuvans.
LU91485I2 (fr) Vaccin adjuvant grippal dans lequel l'adjuvant estune émulsion huile-dans-eau comprenant du squalèn e, du DL-a-tocophérol et du polysorbate 80
DE3787663D1 (de) Impfstofformulierung.
ES2092306T3 (es) Adyuvante para vacunas.
ES2176232T3 (es) Vacuna adecuada para ser utilizada en la prevencion y tratamiento de la infeccion por helicobacter.
PT764029E (pt) Adjuvantes proteicos
FI925835A0 (fi) Vacciner innehaollande liposomer
ES2034188T3 (es) Composiciones cosmeticas.
ATE149091T1 (de) Einen tetra-polyol enthaltendes impfstoff- adjuvans
NL300185I1 (nl) Acellulair vaccin.
IT9012431A0 (it) Dispositivo per il collegamento amovibile di due mobili per sedersi disposti affiancati
SU1713152A1 (ru) Адъювант для ящурной вакцины

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time