ATE115958T1 - Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile. - Google Patents

Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile.

Info

Publication number: ATE115958T1
Authority: AT; Austria
Prior art keywords: formula; nucleosides; ingredients; preparation; pharmaceutical compositions
Prior art date: 1987-04-16

Application number

AT88903972T

Other languages

English (en)

Inventor

Roelf Datema

Zsuzanna Maria Ilona Kovacs

Karl Nils Gunnar Johansson

Bjoern Gunnar Lindborg

Goeran Bertil Stening

Bo Fredrik Oeberg

Original Assignee

Medivir Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-16

Filing date

1988-04-06

Publication date

1995-01-15

1988-04-06 Application filed by Medivir Ab filed Critical Medivir Ab

1995-01-15 Application granted granted Critical

1995-01-15 Publication of ATE115958T1 publication Critical patent/ATE115958T1/de

Links

239000004615 ingredient Substances 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
229940127073 nucleoside analogue Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 2
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000006238 prop-1-en-1-yl group Chemical group [H]\C(*)=C(/[H])C([H])([H])[H] 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT88903972T 1987-04-16 1988-04-06 Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile. ATE115958T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8701605A SE8701605D0 (sv)	1987-04-16	1987-04-16	Novel medicinal compounds
CA000580141A CA1336088C (en)	1987-04-16	1988-10-14	1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and uracil

Publications (1)

Publication Number	Publication Date
ATE115958T1 true ATE115958T1 (de)	1995-01-15

Family

ID=25672174

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88903972T ATE115958T1 (de)	1987-04-16	1988-04-06	Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile.

Country Status (9)

Country	Link
JP (1)	JPH01503069A (de)
AT (1)	ATE115958T1 (de)
AU (1)	AU614082B2 (de)
CA (1)	CA1336088C (de)
DE (1)	DE3852531T2 (de)
DK (3)	DK168443B1 (de)
HU (1)	HU211547A9 (de)
SE (1)	SE8701605D0 (de)
WO (1)	WO1988008001A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8629892D0 (en) *	1986-12-15	1987-01-28	Wellcome Found	Antiviral compounds
US5175292A (en) *	1988-01-20	1992-12-29	Regents Of The University Of Minnesota	Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5631370A (en) *	1988-01-20	1997-05-20	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
US4950758A (en) *	1988-01-20	1990-08-21	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
DE68917479D1 (de) *	1988-02-24	1994-09-15	Inst Rech Chim Biolog	Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha-amino-gruppen, verfahren zur herstellung und arzneimittel daraus.
US7119202B1 (en)	1989-02-08	2006-10-10	Glaxo Wellcome Inc.	Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
US5157114A (en) *	1988-08-19	1992-10-20	Burroughs Wellcome Co.	2',3'-dideoxy-3'-fluoro-5-ethyngluridine
US5198539A (en) *	1988-08-19	1993-03-30	Burroughs Wellcome Co.	5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
FI95384C (fi) *	1989-04-06	1996-01-25	Squibb Bristol Myers Co	Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
FR2648045B1 (fr) *	1989-06-13	1991-09-27	Centre Nat Rech Scient	Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus
IE902574A1 (en) *	1989-07-17	1991-02-27	Univ Birmingham	Antiviral pyrimidine nucleosides
US5591722A (en) *	1989-09-15	1997-01-07	Southern Research Institute	2'-deoxy-4'-thioribonucleosides and their antiviral activity
AU6401490A (en) *	1989-09-15	1991-04-18	Southern Research Institute	2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents
US5728575A (en)	1990-02-01	1998-03-17	Emory University	Method of resolution of 1,3-oxathiolane nucleoside enantiomers
GB9008696D0 (en) *	1990-04-18	1990-06-13	Wellcome Found	Anti-viral compounds
US5521163A (en) *	1990-07-13	1996-05-28	University Of Birmingham	Antiviral pyrimidine nucleosides and methods for using same
SE9003151D0 (sv) *	1990-10-02	1990-10-02	Medivir Ab	Nucleoside derivatives
US6369066B1 (en)	1990-11-13	2002-04-09	Biochem Pharma, Inc.	Substituted 1,3-oxathiolanes with antiviral properties
US5587480A (en) *	1990-11-13	1996-12-24	Biochem Pharma, Inc.	Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US6228860B1 (en)	1990-11-13	2001-05-08	Biochem Pharma Inc.	Substituted 1,3-oxathiolanes with antiviral properties
EP0560794B1 (de) *	1990-11-13	1996-09-18	Biochem Pharma Inc	Substituierte 1,3-oxathiolane mit antiviralen eigenschaften
AU3222793A (en) *	1991-11-26	1993-06-28	Gilead Sciences, Inc.	Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US6235887B1 (en)	1991-11-26	2001-05-22	Isis Pharmaceuticals, Inc.	Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
TW393513B (en) *	1991-11-26	2000-06-11	Isis Pharmaceuticals Inc	Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US20020120130A1 (en)	1993-09-10	2002-08-29	Gilles Gosselin	2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) *	1994-01-28	1996-12-24	Univ. Of Ga Research Foundation	L-nucleosides
EP0763048A1 (de) *	1994-05-31	1997-03-19	Medivir Aktiebolag	Hiv-infektionsverhütung nach kontakt mit dem virus
US5612319A (en) *	1994-05-31	1997-03-18	Medivir Ab	Postexposure prevention of HIV infection or seroconversion
US5703058A (en) *	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en)	1995-01-27	2002-05-21	Emory University	[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) *	1995-01-30	1998-09-15	Yale University	L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
CA2219132C (en)	1995-06-07	2007-03-06	Emory University	Nucleosides with anti-hepatitis b virus activity
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US5753789A (en) *	1996-07-26	1998-05-19	Yale University	Oligonucleotides containing L-nucleosides
EP2392580A1 (de)	1998-02-25	2011-12-07	Emory University	2'-Fluornucleoside
CN101862345B (zh)	2000-10-18	2014-06-04	吉利德制药有限责任公司	用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
CN101573370B (zh)	2006-10-10	2013-09-11	美迪维尔公司	Hcv核苷类抑制剂
JP6270742B2 (ja) *	2013-01-10	2018-01-31	塩野義製薬株式会社	架橋型核酸誘導体の製造方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD75084A (de) *
US3116282A (en) *	1960-04-27	1963-12-31	Upjohn Co	Pyrimidine nucleosides and process
FR2040177A1 (en) *	1969-01-31	1971-01-22	Robugen Gmbh	2-deoxyribosyl-uracil derivs
US3817982A (en) *	1971-12-29	1974-06-18	Syntex Inc	2{40 ,3{40 -unsaturated nucleosides and method of making
DE2918260A1 (de) *	1979-05-07	1980-11-27	Robugen Gmbh	Anwendung von 5-alkyl-2'-desoxyuridinen
US4247544A (en) *	1979-07-02	1981-01-27	The Regents Of The University Of California	C-5 Substituted uracil nucleosides
US4267171A (en) *	1979-07-02	1981-05-12	The Regents Of The University Of California	C-5 Substituted cytosine nucleosides
DE2930904A1 (de) *	1979-07-30	1981-02-19	Kailash Kumar Dr Gauri	Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs
DE3002197A1 (de) *	1980-01-22	1981-07-23	Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen	5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel
DE3045375A1 (de) *	1980-12-02	1982-07-01	Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen	Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen
DE3229169A1 (de) *	1982-08-05	1984-02-09	Robugen GmbH Pharmazeutische Fabrik, 7300 Esslingen	Verwendung von 5-alkylpyrimidinnukleosiden und deren derivate als zytostatika
ATE135011T1 (de) *	1985-03-16	1996-03-15	Wellcome Found	Therapeutische nukleoside
DK164392C (da) *	1985-03-16	1992-11-09	Wellcome Found	Anvendelse af 3'-azido-3'-desoxythymidin til fremstilling af et laegemiddel til behandling af eller profylakse for en human retrovirusinfektion
US4724232A (en) *	1985-03-16	1988-02-09	Burroughs Wellcome Co.	Treatment of human viral infections
DE3689976T2 (de) *	1985-05-15	1995-03-16	Wellcome Found	Therapeutische Nucleoside und deren Herstellung.
ATE190064T1 (de) *	1985-09-17	2000-03-15	Wellcome Found	Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.

1987
- 1987-04-16 SE SE8701605A patent/SE8701605D0/xx unknown
1988
- 1988-04-06 AU AU16899/88A patent/AU614082B2/en not_active Ceased
- 1988-04-06 AT AT88903972T patent/ATE115958T1/de not_active IP Right Cessation
- 1988-04-06 WO PCT/SE1988/000169 patent/WO1988008001A1/en not_active Ceased
- 1988-04-06 JP JP63503532A patent/JPH01503069A/ja active Pending
- 1988-04-06 DE DE3852531T patent/DE3852531T2/de not_active Expired - Fee Related
- 1988-10-14 CA CA000580141A patent/CA1336088C/en not_active Expired - Fee Related
- 1988-12-15 DK DK696988A patent/DK168443B1/da not_active IP Right Cessation
1991
- 1991-06-07 DK DK911084A patent/DK108491D0/da not_active Application Discontinuation
1994
- 1994-09-13 DK DK104994A patent/DK104994A/da not_active Application Discontinuation
1995
- 1995-05-12 HU HU95P/P00134P patent/HU211547A9/hu unknown

Also Published As

Publication number	Publication date
DE3852531T2 (de)	1995-08-10
CA1336088C (en)	1995-06-27
JPH01503069A (ja)	1989-10-19
WO1988008001A1 (en)	1988-10-20
AU1689988A (en)	1988-11-04
DK108491A (da)	1991-06-07
DK696988D0 (da)	1988-12-15
DK168443B1 (da)	1994-03-28
DK108491D0 (da)	1991-06-07
DK696988A (da)	1989-01-31
HU211547A9 (en)	1995-12-28
AU614082B2 (en)	1991-08-22
DK104994A (da)	1994-09-13
SE8701605D0 (sv)	1987-04-16
DE3852531D1 (de)	1995-02-02

Legal Events

Date	Code	Title	Description
1995-07-15	UEP	Publication of translation of european patent specification
2001-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE115958T1 (de)	1995-01-15	Nukleoside und nukleosid-analoge, pharmazeutische zusammensetzung und verfahren für die herstellung der bestandteile.
KR900701815A (ko)	1990-12-04	피리미딘 유도체
EE02995B1 (et)	1997-06-16	1,3-oksatiolaannukleosiidi analoogide kasutamine hepatiit B ravimpreparaatide valmistamiseks
SE8802687D0 (sv)	1988-07-20	Nucleoside derivatives
BR0114323A (pt)	2003-07-01	Composto ou um seu sal ou solvato farmaceuticamente aceitável, composição farmacêutica, uso do composto ou de um seu sal ou solvato farmaceuticamente aceitável, método de tratamento ou profilaxia de doenças inflamatórias, e, processo para preparar o composto
DE69025834D1 (de)	1996-04-18	Antivirale Verbindungen
KR930702371A (ko)	1993-09-08	뉴클레오시드 유도체
ATE74603T1 (de)	1992-04-15	Derivate von purin, verfahren zu ihrer herstellung und pharmazeutische zubereitung.
ATE152352T1 (de)	1997-05-15	Pharmazeutische zusammensetzungen zur hemmung der maillardreaktion
OA09454A (fr)	1992-10-15	Nouveaux dérivés peptidiques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
DE69031340D1 (de)	1997-10-02	3'-azido-2',3'-dideoxy-5-methylcytidin enthaltende antivirale zusammensetzungen
IL65328A (en)	1985-06-30	Pharmaceutical compositions comprising a calcium-antagonistic gallopamil or verapamil and their preparation
KR950701638A (ko)	1995-04-28	푸린 동족체의 항비루스성 포스폰산 유도체(Antiviral phosphonic acid derivatives of purine analogues)
DK527186D0 (da)	1986-11-05	Bronchodilaterende farmaceutisk praeparat
ES2038600T3 (es)	1993-08-01	Composiciones para uso terapeutico comprendiendo compuestos organo-siliceos.
GB2122197B (en)	1985-10-16	Antiviral guanine derivatives
EP0294069A3 (de)	1990-08-22	Purinverbindungen, Verfahren zu ihrer Herstellung, Zwischenverbindungen und pharmazeutische Präparate
KR880013963A (ko)	1988-12-22	글루코피라노즈 유도체
KR890005107A (ko)	1989-05-11	약제 제조를 위한 특정 6-머캅토푸린의 용도 및 이 약제의 제조방법
ES2105599T3 (es)	1997-10-16	Composiciones que contienen compuestos analogos al aciclovir y analogos nucleosidicos sustituidos por vinilo en la posicion 2' utilizados en el tratamiento de infecciones virales.
MX9202634A (es)	1994-01-31	Uso de analogos de nucleosido de 1,3-oxatiolano en el tratamiento de hepatitis b.
KR970070015A (ko)	1997-11-07	아시클릭 뉴클레오시드의 인지질유도체 및 이의 제조방법