ATE116332T1 - Enzym-inhibierende peptid-derivate. - Google Patents

Enzym-inhibierende peptid-derivate.

Info

Publication number: ATE116332T1
Authority: AT; Austria
Prior art keywords: amino acid; peptide derivatives; derivatives; hydroxy; hydrogen
Prior art date: 1989-06-06

Application number

AT90110321T

Other languages

English (en)

Inventor

Paul Cates Anderson

Yvan Guindon

Christiane Yoakim

Original Assignee

Bio Mega Boehringer Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-06

Filing date

1990-05-31

Publication date

1995-01-15

1990-05-31 Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim

1995-01-15 Application granted granted Critical

1995-01-15 Publication of ATE116332T1 publication Critical patent/ATE116332T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
102000004190 Enzymes Human genes 0.000 title 1
108090000790 Enzymes Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 3
241000725303 Human immunodeficiency virus Species 0.000 abstract 2
108090000783 Renin Proteins 0.000 abstract 2
102100028255 Renin Human genes 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
NNOPDLNHPOLRRE-UHFFFAOYSA-N Nequinate Chemical group CCCCC1=CC(C(C(C(=O)OC)=CN2)=O)=C2C=C1OCC1=CC=CC=C1 NNOPDLNHPOLRRE-UHFFFAOYSA-N 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT90110321T 1989-06-06 1990-05-31 Enzym-inhibierende peptid-derivate. ATE116332T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/361,895 US5126326A (en)	1989-06-06	1989-06-06	Enzyme inhibiting peptide derivatives

Publications (1)

Publication Number	Publication Date
ATE116332T1 true ATE116332T1 (de)	1995-01-15

Family

ID=23423841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90110321T ATE116332T1 (de)	1989-06-06	1990-05-31	Enzym-inhibierende peptid-derivate.

Country Status (7)

Country	Link
US (1)	US5126326A (de)
EP (1)	EP0401675B1 (de)
JP (1)	JPH0341091A (de)
AT (1)	ATE116332T1 (de)
AU (1)	AU645751B2 (de)
CA (1)	CA2016663C (de)
DE (1)	DE69015451T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993002674A1 (en) *	1991-08-02	1993-02-18	Smithkline Beecham Corporation	Hiv protease inhibitors
EP0532466A3 (en) *	1991-09-12	1993-06-16	Ciba-Geigy Ag	Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
US5643878A (en) *	1991-09-12	1997-07-01	Ciba-Geigy Corporation	5-amino-4-hydroxyhexanoic acid derivatives
JPH07504654A (ja) *	1992-03-11	1995-05-25	ナルヘックス　リミテッド	オキソ及びヒドロキシ置換炭化水素のアミン誘導体
DE69333270T2 (de)	1992-03-11	2004-08-05	Narhex Ltd.	Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5888992A (en) *	1992-03-11	1999-03-30	Narhex Limited	Polar substituted hydrocarbons
US6071895A (en) *	1992-03-11	2000-06-06	Narhex Limited	Polar-substituted hydrocarbons
TW217410B (de) *	1992-04-01	1993-12-11	Ciba Geigy
US5559256A (en) *	1992-07-20	1996-09-24	E. R. Squibb & Sons, Inc.	Aminediol protease inhibitors
US5430150A (en) *	1992-12-16	1995-07-04	American Cyanamid Company	Retroviral protease inhibitors
IL110898A0 (en) *	1993-09-10	1994-11-28	Narhex Australia Pty Ltd	Polar-substituted hydrocarbons
US6222043B1 (en)	1995-06-30	2001-04-24	Japan Energy Corporation	Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
US5932550A (en) *	1995-06-30	1999-08-03	Japan Energy Corporation	Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof
US5849691A (en) *	1996-02-20	1998-12-15	The United States Of America As Represented By The Department Of Health And Human Services	Peptidomimetic inhibitors of cathepsin D and plasmepsins I and II
CA2249747A1 (en)	1996-12-27	1998-07-09	Tsutomu Mimoto	Novel tripeptide compounds and anti-aids drugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1258748A (en) *	1981-10-08	1989-08-22	Daniel F. Veber	Renin inhibitory peptides
AU573735B2 (en) *	1983-02-07	1988-06-23	Aktiebolaget Hassle	Peptide analogue enzyme inhibitors
EP0245361A1 (de) *	1985-11-15	1987-11-19	The Upjohn Company	Polypeptid-analoge, die renin inhibieren und s-aryl-d- oder -l- oder-d,l-cysteinyl,3-(arylthio)-milchsäure oder 3-(arylthio)alkyl-reste enthalten
DE3627877A1 (de) *	1986-07-30	1988-02-04	Hoechst Ag	Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
FR2614533A1 (fr) *	1987-04-23	1988-11-04	Sandoz Sa	Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments

1989
- 1989-06-06 US US07/361,895 patent/US5126326A/en not_active Expired - Lifetime
1990
- 1990-05-14 CA CA002016663A patent/CA2016663C/en not_active Expired - Fee Related
- 1990-05-31 AT AT90110321T patent/ATE116332T1/de not_active IP Right Cessation
- 1990-05-31 EP EP90110321A patent/EP0401675B1/de not_active Expired - Lifetime
- 1990-05-31 DE DE69015451T patent/DE69015451T2/de not_active Expired - Fee Related
- 1990-06-05 JP JP2147158A patent/JPH0341091A/ja active Pending
- 1990-06-05 AU AU56288/90A patent/AU645751B2/en not_active Ceased

Also Published As

Publication number	Publication date
JPH0341091A (ja)	1991-02-21
US5126326A (en)	1992-06-30
AU645751B2 (en)	1994-01-27
DE69015451D1 (de)	1995-02-09
AU5628890A (en)	1990-12-13
EP0401675B1 (de)	1994-12-28
CA2016663A1 (en)	1990-12-06
CA2016663C (en)	2000-04-11
EP0401675A1 (de)	1990-12-12
DE69015451T2 (de)	1995-05-24

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Legal Events

Date	Code	Title	Description
1995-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties