ATE116373T1 - Monoklonaler antikörper, hybridomen, ihre herstellung und ihre verwendung. - Google Patents

Monoklonaler antikörper, hybridomen, ihre herstellung und ihre verwendung.

Info

Publication number
ATE116373T1
ATE116373T1 AT88103047T AT88103047T ATE116373T1 AT E116373 T1 ATE116373 T1 AT E116373T1 AT 88103047 T AT88103047 T AT 88103047T AT 88103047 T AT88103047 T AT 88103047T AT E116373 T1 ATE116373 T1 AT E116373T1
Authority
AT
Austria
Prior art keywords
hybridomas
production
monoclonal antibodies
bfgf
monoclonal antibody
Prior art date
Application number
AT88103047T
Other languages
English (en)
Inventor
Makoto Iwane
Tsutomu Kurokawa
Koichi Igarashi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP63016260A external-priority patent/JP2526965B2/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE116373T1 publication Critical patent/ATE116373T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT88103047T 1987-03-03 1988-03-01 Monoklonaler antikörper, hybridomen, ihre herstellung und ihre verwendung. ATE116373T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4975987 1987-03-03
JP21159987 1987-08-26
JP63016260A JP2526965B2 (ja) 1987-02-24 1988-01-26 ムテイン，ｄｎａおよびその用途

Publications (1)

Publication Number Publication Date
ATE116373T1 true ATE116373T1 (de) 1995-01-15

Family

ID=27281323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88103047T ATE116373T1 (de) 1987-03-03 1988-03-01 Monoklonaler antikörper, hybridomen, ihre herstellung und ihre verwendung.

Country Status (4)

Country Link
US (2) US5478740A (de)
EP (1) EP0288687B1 (de)
AT (1) ATE116373T1 (de)
DE (1) DE3852561T2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
US5981197A (en) * 1987-02-24 1999-11-09 Takeda Chemical Industries, Ltd. Monoclonal antibody, hybridoma, their production and use thereof
JPH03500529A (ja) * 1987-06-18 1991-02-07 モナシュ ユニバーシティ 増殖因子
EP0387777A3 (de) * 1989-03-15 1992-01-02 Takeda Chemical Industries, Ltd. Verfahren zum Nachweis von FGF und zur Diagnose von Tumoren
EP0420081A1 (de) * 1989-09-26 1991-04-03 Takeda Chemical Industries, Ltd. Monoklonaler Antikörper gegen sauren FGF, seine Herstellung und Verwendung
WO1991006668A1 (en) * 1989-10-27 1991-05-16 The Du Pont Merck Pharmaceutical Company Monoclonal antibodies to basic fibroblast growth factor that inhibit its biological activity
JPH05503842A (ja) 1989-12-27 1993-06-24 武田薬品工業株式会社 モノクローナル抗体、ハイブリドーマおよびそれらの用途
ATE164521T1 (de) * 1991-01-17 1998-04-15 Univ Washington Anti-wachstumsfaktor antikörper in der behandlung von gefässstenose
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
AU3141495A (en) * 1994-08-01 1996-03-04 Board Of Regents, The University Of Texas System Methods and compositions for the expression of a bone and prostate derived growth factor
WO2003087318A2 (en) * 2002-04-08 2003-10-23 Eugene Levin Truncated 24 kda basic fibroblast growth factor
JP2005071556A (ja) * 2003-08-28 2005-03-17 Renesas Technology Corp 半導体記憶装置および半導体集積回路装置
EP2136211B1 (de) * 2007-03-12 2013-08-07 The University of Tokushima Bestimmungsverfahren für eine allergische erkrankung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3689845T3 (de) * 1985-09-12 2001-11-15 Scios Inc., Sunnyvale Rekombinanter fibroblast-wachstumsfaktor.

Also Published As

Publication number Publication date
EP0288687B1 (de) 1994-12-28
US5858779A (en) 1999-01-12
EP0288687A2 (de) 1988-11-02
DE3852561T2 (de) 1995-07-13
DE3852561D1 (de) 1995-02-09
US5478740A (en) 1995-12-26
EP0288687A3 (en) 1989-05-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time