ATE117212T1 - Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung. - Google Patents

Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung.

Info

Publication number: ATE117212T1
Authority: AT; Austria
Prior art keywords: hirudin; biocompatible; bicompatible; analogues; fragments
Prior art date: 1988-08-03

Application number

AT89307922T

Other languages

English (en)

Inventor

Ralph K Ito

Frank W Logerfo

Original Assignee

New England Deaconess Hospital

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-03

Filing date

1989-08-03

Publication date

1995-02-15

1989-08-03 Application filed by New England Deaconess Hospital filed Critical New England Deaconess Hospital

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117212T1 publication Critical patent/ATE117212T1/de

Links

102000007625 Hirudins Human genes 0.000 title abstract 2
108010007267 Hirudins Proteins 0.000 title abstract 2
239000012634 fragment Substances 0.000 title abstract 2
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 2
229940006607 hirudin Drugs 0.000 title abstract 2
239000000463 material Substances 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 abstract 3
239000000126 substance Substances 0.000 abstract 2
239000000560 biocompatible material Substances 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
- A61L33/128—Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Surgery (AREA)
Materials Engineering (AREA)
Hematology (AREA)
Oral & Maxillofacial Surgery (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
External Artificial Organs (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT89307922T 1988-08-03 1989-08-03 Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung. ATE117212T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/227,700 US5167960A (en)	1988-08-03	1988-08-03	Hirudin-coated biocompatible substance

Publications (1)

Publication Number	Publication Date
ATE117212T1 true ATE117212T1 (de)	1995-02-15

Family

ID=22854125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89307922T ATE117212T1 (de)	1988-08-03	1989-08-03	Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung.

Country Status (17)

Country	Link
US (1)	US5167960A (de)
EP (1)	EP0357242B1 (de)
JP (1)	JPH02147067A (de)
KR (1)	KR900002752A (de)
AT (1)	ATE117212T1 (de)
AU (1)	AU624170B2 (de)
CA (1)	CA1338756C (de)
DD (1)	DD283933A5 (de)
DE (1)	DE68920671T2 (de)
DK (1)	DK379189A (de)
ES (1)	ES2068897T3 (de)
FI (1)	FI893660L (de)
IE (1)	IE892501L (de)
IL (1)	IL91188A (de)
NZ (1)	NZ230180A (de)
PT (1)	PT91345A (de)
ZA (1)	ZA895862B (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5182317A (en) *	1988-06-08	1993-01-26	Cardiopulmonics, Inc.	Multifunctional thrombo-resistant coatings and methods of manufacture
US5262451A (en) *	1988-06-08	1993-11-16	Cardiopulmonics, Inc.	Multifunctional thrombo-resistant coatings and methods of manufacture
US5342693A (en) *	1988-06-08	1994-08-30	Cardiopulmonics, Inc.	Multifunctional thrombo-resistant coating and methods of manufacture
US5338770A (en) *	1988-06-08	1994-08-16	Cardiopulmonics, Inc.	Gas permeable thrombo-resistant coatings and methods of manufacture
US5112615A (en) *	1988-08-03	1992-05-12	New England Deaconess Hospital Corporation	Soluble hirudin conjugates
CA2000887A1 (en) *	1988-11-01	1990-05-01	Cecilia S.L. Ku	Thromboresistant materials and methods for making same
US5053453A (en) *	1988-11-01	1991-10-01	Baxter International Inc.	Thromboresistant materials and methods for making same
US6146358A (en) *	1989-03-14	2000-11-14	Cordis Corporation	Method and apparatus for delivery of therapeutic agent
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
KR920703137A (ko) *	1990-11-22	1992-12-17	마에타 카쯔노수케	이식재
DE69229312T2 (de) *	1991-03-29	1999-11-04	Vascular Graft Research Center Co. Ltd., Tokio/Tokyo	Künstliches blutgefäss aus komposit-material
US5837808A (en) *	1991-08-20	1998-11-17	Baxter International Inc.	Analogs of hirudin
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
EP0559911B1 (de) *	1991-10-01	1997-11-26	Otsuka Pharmaceutical Factory, Inc.	Antithrombotisches harz, röhre, film und beschichtung
DE4136928A1 (de) *	1991-11-11	1993-05-13	Rehau Ag & Co	Verfahren zum blutgerinnungshemmenden ausstatten von medizinischen arbeitsmitteln
US5332398A (en) *	1992-02-01	1994-07-26	Board Of Regents, The University Of Texas System	Intramedullary catheter
US5468505A (en) *	1992-02-28	1995-11-21	Board Of Regents, The University Of Texas System	Local delivery of fibrinolysis enhancing agents
US5376692A (en) *	1992-05-15	1994-12-27	Purdue Research Foundation	Method of binding using irradiation and product with albumin bound to biomaterials
US5350800A (en) *	1993-01-19	1994-09-27	Medtronic, Inc.	Method for improving the biocompatibility of solid surfaces
US6663881B2 (en)	1993-01-28	2003-12-16	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en)	1993-01-28	1999-11-09	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
AU7721594A (en) *	1993-09-07	1995-03-27	Baxter International Inc.	Analogs of hirudin
US5718694A (en) *	1993-11-09	1998-02-17	The Board Of Regents Of The University Of Nebraska	Inhibition of adherence of microorganisms to biomaterial surfaces by treatment with carbohydrates
US5588962A (en) *	1994-03-29	1996-12-31	Boston Scientific Corporation	Drug treatment of diseased sites deep within the body
US5505713A (en) *	1994-04-01	1996-04-09	Minimed Inc.	Indwelling catheter with stable enzyme coating
US5681278A (en) *	1994-06-23	1997-10-28	Cormedics Corp.	Coronary vasculature treatment method
US5660873A (en) *	1994-09-09	1997-08-26	Bioseal, Limited Liability Corporaton	Coating intraluminal stents
ATE244584T1 (de) *	1995-01-16	2003-07-15	Baxter Int	Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen
AT404516B (de) *	1995-06-13	1998-12-28	Immuno Ag	Vorrichtung zur quantifizierung von prothrombin-derivaten
AT404357B (de) *	1995-06-13	1998-11-25	Immuno Ag	Prothrombin-derivate
US5900433A (en) *	1995-06-23	1999-05-04	Cormedics Corp.	Vascular treatment method and apparatus
US7883693B2 (en)	1995-12-18	2011-02-08	Angiodevice International Gmbh	Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
WO1997022371A1 (en)	1995-12-18	1997-06-26	Collagen Corporation	Crosslinked polymer compositions and methods for their use
US6833408B2 (en)	1995-12-18	2004-12-21	Cohesion Technologies, Inc.	Methods for tissue repair using adhesive materials
US6458889B1 (en)	1995-12-18	2002-10-01	Cohesion Technologies, Inc.	Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US5674236A (en) *	1996-04-30	1997-10-07	Medtronic, Inc.	Lancet for capillary puncture blood samples
AR013829A1 (es)	1996-07-12	2001-01-31	Baxter Int	Un dispositivo medico para suministrar cantidades volumetricas de un primer y un segundo fluido, bioquimicamente reactivos, y metodo para suministrarfibrina a una superficie con dicho dispositivo
US6764509B2 (en)	1996-09-06	2004-07-20	Carbomedics Inc.	Prosthetic heart valve with surface modification
US6702851B1 (en)	1996-09-06	2004-03-09	Joseph A. Chinn	Prosthetic heart valve with surface modification
GB9626795D0 (en)	1996-12-23	1997-02-12	Geistlich Soehne Ag	Combating infection in delivery systems
US5891196A (en) *	1997-04-16	1999-04-06	Baxter International Inc.	Method for actively binding heparin to crosslinked biological tissues
US5879697A (en) *	1997-04-30	1999-03-09	Schneider Usa Inc	Drug-releasing coatings for medical devices
US7132413B1 (en) *	1997-07-31	2006-11-07	Ed. Geistlich Soehne Ag Fuer Chemische Industrie	Anticoagulant/sterilizing compositions and methods
US8304390B2 (en) *	1997-07-31	2012-11-06	Ed. Geistlich Soehne Ag Fuer Chemische Industrie	Method of treatment for preventing or reducing tumor growth in the liver of patient
US20050124608A1 (en) *	2001-04-03	2005-06-09	Redmond H. P.	Treatment of cancers
US6221425B1 (en)	1998-01-30	2001-04-24	Advanced Cardiovascular Systems, Inc.	Lubricious hydrophilic coating for an intracorporeal medical device
US8128595B2 (en)	1998-04-21	2012-03-06	Zoll Circulation, Inc.	Method for a central venous line catheter having a temperature control system
US6126684A (en) *	1998-04-21	2000-10-03	The Regents Of The University Of California	Indwelling heat exchange catheter and method of using same
US6419643B1 (en)	1998-04-21	2002-07-16	Alsius Corporation	Central venous catheter with heat exchange properties
US6530946B1 (en)	1998-04-21	2003-03-11	Alsius Corporation	Indwelling heat exchange heat pipe catheter and method of using same
US6248127B1 (en)	1998-08-21	2001-06-19	Medtronic Ave, Inc.	Thromboresistant coated medical device
BE1012536A3 (fr)	1998-11-04	2000-12-05	Baxter Int	Element muni d'une couche de fibrine sa preparation et son utilisation.
US6582398B1 (en) *	1999-02-19	2003-06-24	Alsius Corporation	Method of managing patient temperature with a heat exchange catheter
US7345039B2 (en) *	1999-06-04	2008-03-18	Ed. Geistlich Soehne Ag Fuer Chemische Industrie	Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
US7892530B2 (en) *	1999-06-04	2011-02-22	Ed. Geistlich Soehne Ag Fuer Chemische Industrie	Treatment of tumor metastases and cancer
US8030301B2 (en) *	1999-06-04	2011-10-04	Ed. Geistlich Soehne Ag Fuer Chemische Industrie	Treatment of cancers with methylol-containing compounds and at least one electrolyte
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
US6572640B1 (en)	2001-11-21	2003-06-03	Alsius Corporation	Method and apparatus for cardiopulmonary bypass patient temperature control
PT1549333E (pt) *	2002-09-20	2012-01-03	Univ Pennsylvania	Análogos de compstatina com actividade melhorada
US7135027B2 (en)	2002-10-04	2006-11-14	Baxter International, Inc.	Devices and methods for mixing and extruding medically useful compositions
AU2003300076C1 (en)	2002-12-30	2010-03-04	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
US7278984B2 (en)	2002-12-31	2007-10-09	Alsius Corporation	System and method for controlling rate of heat exchange with patient
CN104174071A (zh)	2004-04-28	2014-12-03	安希奥设备国际有限责任公司	用于形成交联生物材料的组合物和系统及关联的制备方法与用途
US20060009839A1 (en) *	2004-07-12	2006-01-12	Scimed Life Systems, Inc.	Composite vascular graft including bioactive agent coating and biodegradable sheath
EP1796602A4 (de)	2004-09-17	2016-10-19	Angiotech Pharm Inc	Multifunktionelle verbindungen zur erzeugung vernetzter biomaterialien sowie herstellungs- und verwendungsverfahren dafür
CN102977191B (zh)	2005-11-28	2016-08-10	宾夕法尼亚州大学理事会	有效的c3补体抑制素类似物
US20080220042A1 (en) *	2006-01-27	2008-09-11	The Regents Of The University Of California	Biomolecule-linked biomimetic scaffolds
CN101410508B (zh) *	2006-01-27	2013-07-03	加利福尼亚大学董事会	仿生支架
WO2008154608A1 (en) *	2007-06-11	2008-12-18	Nanovasc, Inc.	Stents
CA2847862C (en)	2011-09-07	2021-01-12	The Trustees Of The University Of Pennsylvania	Compstatin analogs with improved pharmacokinetic properties
EP4011905A3 (de)	2018-04-06	2022-06-29	The Trustees Of The University Of Pennsylvania	Compstatinanaloga mit erhöhter löslichkeit und verbesserten pharmakokinetischen eigenschaften

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3432596A (en) *	1967-10-13	1969-03-11	Dresden Arzneimittel	Method for producing highly pure hirudine
US4116898A (en) *	1977-01-31	1978-09-26	Becton, Dickinson And Company	Non-thrombogenic articles
WO1979000638A1 (en) *	1978-02-17	1979-09-06	Thin Conductive Coating Oester	A method of producing thrombosis-resistant surfaces
JPS54157816A (en) *	1978-05-27	1979-12-13	Unitika Ltd	Fixing of bioactive substance to solid surface
US4447562A (en) *	1981-07-15	1984-05-08	Ivani Edward J	Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
US4734097A (en) *	1981-09-25	1988-03-29	Nippon Oil Company, Ltd.	Medical material of polyvinyl alcohol and process of making
NL188622C (nl) *	1981-12-15	1992-08-17	Cordis Europ	Werkwijze ter verbetering van de bloedcompatibiliteit van een materiaaloppervlak door bekleding daarvan met een heparine of heparine-analoga en een eiwit houdende film, alsmede voorwerp, omvattende een oppervlak met verbeterde bloedcompatibiliteit verkregen onder toepassing van een op het oppervlak aangebrachte heparine of heparine-analoga en een eiwit houdende film.
US4680177A (en) *	1982-04-28	1987-07-14	Trustees of the Garfield Weston Trust for Research into Heart Surgery	Processes for the production of blood products
US4594407A (en) *	1983-09-20	1986-06-10	Allied Corporation	Prosthetic devices derived from krebs-cycle dicarboxylic acids and diols
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
US4521564A (en) *	1984-02-10	1985-06-04	Warner-Lambert Company	Covalent bonded antithrombogenic polyurethane material
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
US4563485A (en) *	1984-04-30	1986-01-07	The Trustees Of Columbia University In The City Of New York	Injection-resistant materials and method of making same through use of nalidixic acid derivatives
DE3583361D1 (de) *	1984-06-14	1991-08-08	Ucp Gen Pharma Ag	Verfahren zur herstellung von thrombin-inhibitoren.
GB8418772D0 (en) *	1984-07-24	1984-08-30	Geistlich Soehne Ag	Chemical substances
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US4600652A (en) *	1985-04-01	1986-07-15	Warner-Lambert Company	Permanently bonded antithrombogenic polyurethane surface
US4713446A (en) *	1985-09-06	1987-12-15	Minnesota Mining And Manufacturing Company	Viscoelastic collagen solution for ophthalmic use and method of preparation
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.
US4720512A (en) *	1986-03-24	1988-01-19	Becton, Dickinson And Company	Polymeric articles having enhanced antithrombogenic activity
DE3622642A1 (de) *	1986-07-05	1988-01-14	Behringwerke Ag	Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
MC1834A1 (fr) *	1986-07-10	1988-06-03	Transgene Sa	Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
DE3631413A1 (de) *	1986-09-16	1988-03-24	Knoll Ag	Therapeutisches system zur lokalen applikation von pharmawirkstoffen

1988
- 1988-08-03 US US07/227,700 patent/US5167960A/en not_active Expired - Fee Related
1989
- 1989-08-01 AU AU39188/89A patent/AU624170B2/en not_active Ceased
- 1989-08-01 ZA ZA895862A patent/ZA895862B/xx unknown
- 1989-08-02 PT PT91345A patent/PT91345A/pt unknown
- 1989-08-02 NZ NZ230180A patent/NZ230180A/xx unknown
- 1989-08-02 DK DK379189A patent/DK379189A/da not_active Application Discontinuation
- 1989-08-02 FI FI893660A patent/FI893660L/fi not_active IP Right Cessation
- 1989-08-02 IE IE892501A patent/IE892501L/xx unknown
- 1989-08-02 DD DD89331408A patent/DD283933A5/de not_active IP Right Cessation
- 1989-08-02 IL IL9118889A patent/IL91188A/en not_active IP Right Cessation
- 1989-08-02 JP JP1199518A patent/JPH02147067A/ja active Pending
- 1989-08-03 EP EP89307922A patent/EP0357242B1/de not_active Expired - Lifetime
- 1989-08-03 DE DE68920671T patent/DE68920671T2/de not_active Expired - Fee Related
- 1989-08-03 AT AT89307922T patent/ATE117212T1/de not_active IP Right Cessation
- 1989-08-03 KR KR1019890011108A patent/KR900002752A/ko not_active Withdrawn
- 1989-08-03 ES ES89307922T patent/ES2068897T3/es not_active Expired - Lifetime
- 1989-08-03 CA CA000607503A patent/CA1338756C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE892501L (en)	1990-02-03
CA1338756C (en)	1996-12-03
DE68920671D1 (de)	1995-03-02
DK379189D0 (da)	1989-08-02
EP0357242B1 (de)	1995-01-18
EP0357242A1 (de)	1990-03-07
ES2068897T3 (es)	1995-05-01
JPH02147067A (ja)	1990-06-06
NZ230180A (en)	1991-02-26
AU3918889A (en)	1990-02-08
IL91188A (en)	1994-02-27
DK379189A (da)	1990-02-04
FI893660A7 (fi)	1990-02-04
US5167960A (en)	1992-12-01
FI893660L (fi)	1990-02-04
FI893660A0 (fi)	1989-08-02
DD283933A5 (de)	1990-10-31
ZA895862B (en)	1990-05-30
KR900002752A (ko)	1990-03-23
PT91345A (pt)	1990-03-08
AU624170B2 (en)	1992-06-04
DE68920671T2 (de)	1995-07-06
IL91188A0 (en)	1990-03-19

Legal Events

Date	Code	Title	Description
1995-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE117212T1 (de)	1995-02-15	Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung.
EP0205997A3 (en)	1989-05-24	Implant
EP0269745A4 (de)	1989-06-13	Knochenimplantat.
DE69421799D1 (de)	1999-12-30	Mit einem trockenmittel überzogenes substrat und methode zur dessen herstellung
DE68914868D1 (de)	1994-06-01	Verfahren zur Herstellung einer Polyesterfolie mit einer dünnen gehärteten Polyurethanbeschichtung und Verwendung der Polyesterfolie.
AU8123694A (en)	1995-03-22	Intravascular medical device
EP0403650A4 (en)	1991-01-30	Medical material permitting cells to enter thereinto and artificial skin
AU579852B2 (en)	1988-12-15	Process for the manufacture of collagen tubes in particular small diameter tubes and application of the tubes obtained in the field of vascular prostheses and nerve sutures
CA2188563A1 (en)	1995-11-09	Stent with collagen
DE68922726D1 (de)	1995-06-22	Medizinisches material und verfahren zur herstellung.
ATE116863T1 (de)	1995-01-15	Bioverträglichkeit harter flächen.
CA2003489A1 (fr)	1990-05-25	Film elastomere thermoplastique permeable a la vapeur d'eau a base de polyetheresteramide, son procede de fabrication et articles comprenant un tel film
FI873967A7 (fi)	1988-03-16	Hioma-aineella päällystetty taipuisa kappale ja menetelmä sen valmistamiseksi.
DE69533800D1 (de)	2004-12-30	Thromboseresistente oberflächenbehandlung von biomaterialien
DE3762888D1 (de)	1990-06-28	Substrat mit zirkonnitrid-ueberzug und verfahren zur herstellung dieses ueberzugs.
IT1156484B (it)	1987-02-04	Procedimento per la fabbricazione di un dispositivo protetico provvisto di un rivestimento di materiale carbonioso biocompatibile e dispositivo protetico provvisto di un tale rivestimento
DE3877090D1 (de)	1993-02-11	Artikel mit einer blutkompatiblen oberflaeche und verfahren zu ihrer herstellung.
DE3868665D1 (de)	1992-04-09	Nichtausfransendes substrat zur verwendung bei orthopaedischen bandagen und verfahren zu seiner herstellung.
DE58904063D1 (de)	1993-05-19	Oxidbeschichtete carrier, ein verfahren zur herstellung dieser carrier und deren verwendung.
DE3884241D1 (de)	1993-10-28	Analoge des Porcin-Wachstumshormones.
AU3886389A (en)	1991-01-17	Method of producing shoes and the like with moulded soles
NO175457C (no)	1994-10-19	Gjenstander som har et blodkompatibelt overflatelag og fremgangsmåte for å utstyre gjenstander med slikt overflatelag samt anvendelse av et belagt substratmateriale for fremstilling av en medisinsk gjenstand
DE59209807D1 (de)	2000-03-09	Verfahren zur Herstellung eines biologisch aktiven menschlichen Blutserums
DE3884894D1 (de)	1993-11-18	Verfahren zur Herstellung von mechanischen Teilen mit verschleiss- und/oder korrosionsfester Beschichtung.
DE68903140D1 (de)	1992-11-12	Verfahren zur stoerungsfreien beschichtung von hydrophoben materialien mit polyurethanen.