ATE117320T1 - Amide der ge 2270-antibiotika. - Google Patents

Amide der ge 2270-antibiotika.

Info

Publication number
ATE117320T1
ATE117320T1 AT92901892T AT92901892T ATE117320T1 AT E117320 T1 ATE117320 T1 AT E117320T1 AT 92901892 T AT92901892 T AT 92901892T AT 92901892 T AT92901892 T AT 92901892T AT E117320 T1 ATE117320 T1 AT E117320T1
Authority
AT
Austria
Prior art keywords
antibiotics
amides
amide derivatives
antibiotic
preparing
Prior art date
Application number
AT92901892T
Other languages
English (en)
Inventor
Paolo Tavecchia
Sergio Lociuro
Romeo Ciabatti
Enrico Selva
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Application granted granted Critical
Publication of ATE117320T1 publication Critical patent/ATE117320T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
AT92901892T 1991-01-03 1992-01-02 Amide der ge 2270-antibiotika. ATE117320T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91100123 1991-01-03

Publications (1)

Publication Number Publication Date
ATE117320T1 true ATE117320T1 (de) 1995-02-15

Family

ID=8206281

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92901892T ATE117320T1 (de) 1991-01-03 1992-01-02 Amide der ge 2270-antibiotika.

Country Status (18)

Country Link
US (1) US5599791A (de)
EP (2) EP0494078A1 (de)
JP (1) JP3183508B2 (de)
KR (1) KR100225763B1 (de)
CN (1) CN1063110A (de)
AT (1) ATE117320T1 (de)
AU (1) AU662122B2 (de)
CA (1) CA2093219C (de)
DE (1) DE69201236T2 (de)
ES (1) ES2067325T3 (de)
FI (1) FI932944A7 (de)
HU (1) HU224072B1 (de)
IE (1) IE920005A1 (de)
IL (1) IL100572A (de)
MX (1) MX9200015A (de)
NZ (1) NZ241216A (de)
WO (1) WO1992012172A1 (de)
ZA (1) ZA927B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0451486T3 (da) * 1990-03-08 1995-05-08 Lepetit Spa Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T
ES2113391T3 (es) * 1991-08-30 1998-05-01 Biosearch Italia Spa Factor c2a de antibiotico ge 2270.
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
WO1994014838A1 (en) * 1992-12-22 1994-07-07 Gruppo Lepetit S.P.A. Antibiotics ge 37468 a, b and c
KR100381688B1 (ko) * 1995-02-07 2003-12-11 바이오써치 이탈리아 에스.피.에이. Ge2270및ge2270-유사항생제의염기성프롤린-아미드유도체
KR100394930B1 (ko) * 1995-02-07 2003-12-18 비큐론 파마세티컬스 인코포레이티드 Ge2270및ge2270-유사항생제의염기성옥사졸린-아미드유도체
CA2242067A1 (en) * 1996-02-14 1997-08-21 Versicor Inc. Derivatives of antibiotic ge2270 factors c2a, d2 and e
JPH1059997A (ja) * 1996-08-22 1998-03-03 Microbial Chem Res Found アミチアマイシンアミド誘導体
US20050166498A1 (en) * 1999-12-17 2005-08-04 Oakey David D. Carpet tile with cutout section, method and apparatus for production and method of installation
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
PT1553967E (pt) * 2002-06-17 2011-08-01 Naicons S C A R L Utilização de um derivado amídico do factor a3 do ge 2270 no tratamento da acne
KR101101982B1 (ko) 2003-04-30 2012-01-02 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 옥사졸리디논-퀴놀린 하이브리드 항생제의 탄저병 및 기타감염증의 치료용의 용도
ATE401326T1 (de) 2003-12-18 2008-08-15 Morphochem Ag Komb Chemie Oxazolidinon-chinolon hybrid antibiotika
EP1706501B1 (de) * 2004-01-19 2010-01-13 DSM IP Assets B.V. Biochemische synthese von 6-aminocapronsäure
AR060977A1 (es) 2006-05-31 2008-07-23 Novartis Ag Aminotiazoles y sus usos
ATE500259T1 (de) * 2006-12-20 2011-03-15 Novartis Ag Aminothiazolmakrocyclen, ihre verwendung als antibakterielle verbindungen und verfahren zu ihrer herstellung
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
EA200901613A1 (ru) 2007-06-04 2010-06-30 Новартис Аг Макроциклы и их применение
WO2009045637A2 (en) 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
NZ585788A (en) * 2007-12-12 2011-07-29 Novartis Ag Aminothiazoles and their uses
WO2009094485A1 (en) 2008-01-22 2009-07-30 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
CA2717586C (en) 2008-03-05 2020-08-11 Genomatica, Inc. Primary alcohol producing organisms
CN102066551B (zh) 2008-03-27 2013-10-09 基因组股份公司 用于产生己二酸和其他化合物的微生物
US8241877B2 (en) 2008-05-01 2012-08-14 Genomatica, Inc. Microorganisms for the production of methacrylic acid
BRPI0913901A2 (pt) 2008-06-17 2016-12-13 Genomatica Inc micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato
WO2010071697A1 (en) 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
EP3318626B1 (de) 2009-04-30 2020-01-15 Genomatica, Inc. Organismen zur herstellung von 1,3-butandiol
WO2010127303A1 (en) 2009-04-30 2010-11-04 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
BRPI1011227A8 (pt) 2009-05-07 2019-02-26 Genomatica Inc microorganismos e métodos para a biossíntese de adipato, hexametilenodiamina e ácido 6-aminocapróico.
BRPI1012877A2 (pt) 2009-05-15 2016-04-05 Genomatica Inc organismo para produção de ciclohexanona
EP2440669A4 (de) 2009-06-10 2013-08-28 Genomatica Inc Mikrooganismen und verfahren für die kohlenstoffwirksame biosynthese mek und 2-butanol
EP2462221B1 (de) 2009-08-05 2017-02-22 Genomatica, Inc. Aus muconsäureproduzierenden mikroorganismen gewonnene halbsynthetische terephthalsäure
EP2933338A3 (de) 2009-09-09 2016-01-06 Genomatica, Inc. Mikroorganismen und Verfahren zur gleichzeitigen Herstellung von Isopropanol und primären Alkoholen, Diolen und Säuren
CN105441374A (zh) 2009-10-13 2016-03-30 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
WO2011050326A1 (en) 2009-10-23 2011-04-28 Genomatica, Inc. Microorganisms for the production of aniline
EP2510102A4 (de) 2009-12-10 2014-01-22 Genomatica Inc Verfahren und organismen zur umwandlung eines synthesegases oder anderer gasförmiger kohlenstoffquellen und methanol in 1,3-butandiol
SG182686A1 (en) 2010-01-29 2012-08-30 Genomatica Inc Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
US8580543B2 (en) 2010-05-05 2013-11-12 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
WO2012018624A2 (en) 2010-07-26 2012-02-09 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
EP3628676A1 (de) * 2018-09-28 2020-04-01 Université de Montpellier Modifizierte peptide und deren verwendungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0406745T3 (da) * 1989-07-04 1995-02-27 Lepetit Spa Antibiotiske GE 2270 faktorer A1, A2, A3 og H

Also Published As

Publication number Publication date
WO1992012172A1 (en) 1992-07-23
FI932944A0 (fi) 1993-06-24
EP0565567A1 (de) 1993-10-20
AU662122B2 (en) 1995-08-24
EP0494078A1 (de) 1992-07-08
HUT64085A (en) 1993-11-29
US5599791A (en) 1997-02-04
NZ241216A (en) 1994-04-27
MX9200015A (es) 1992-07-31
DE69201236D1 (de) 1995-03-02
CA2093219C (en) 2002-04-09
CA2093219A1 (en) 1992-07-04
JPH06504768A (ja) 1994-06-02
EP0565567B1 (de) 1995-01-18
ES2067325T3 (es) 1995-03-16
JP3183508B2 (ja) 2001-07-09
HU224072B1 (hu) 2005-05-30
CN1063110A (zh) 1992-07-29
FI932944L (fi) 1993-06-24
IL100572A (en) 1997-01-10
AU1154492A (en) 1992-08-17
FI932944A7 (fi) 1993-06-24
IE920005A1 (en) 1992-07-15
DE69201236T2 (de) 1995-06-01
HU9301941D0 (en) 1993-09-28
KR930703355A (ko) 1993-11-29
ZA927B (en) 1992-09-30
IL100572A0 (en) 1992-09-06
KR100225763B1 (ko) 1999-10-15

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