ATE11781T1 - Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten. - Google Patents

Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten.

Info

Publication number: ATE11781T1
Authority: AT; Austria
Prior art keywords: spirosuccinimide; derivatives; alkyl; hydrogen; formula
Prior art date: 1981-05-13

Application number

AT82302334T

Other languages

English (en)

Inventor

David Robert Brittain

Robin Wood

Original Assignee

Imperial Chemical Industries Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-05-13

Filing date

1982-05-07

Publication date

1985-02-15

1982-05-07 Application filed by Imperial Chemical Industries Plc filed Critical Imperial Chemical Industries Plc

1985-02-15 Application granted granted Critical

1985-02-15 Publication of ATE11781T1 publication Critical patent/ATE11781T1/de

Links

239000000825 pharmaceutical preparation Substances 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
-1 sulphinyl Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 abstract 2
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
208000027472 Galactosemias Diseases 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
125000005277 alkyl imino group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT82302334T 1981-05-13 1982-05-07 Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten. ATE11781T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8114625		1981-05-13
EP82302334A EP0065392B1 (de)	1981-05-13	1982-05-07	Pharmazeutische Zubereitungen, die Spirosuccinimidderivate enthalten

Publications (1)

Publication Number	Publication Date
ATE11781T1 true ATE11781T1 (de)	1985-02-15

Family

ID=10521769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT82302334T ATE11781T1 (de)	1981-05-13	1982-05-07	Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten.

Country Status (5)

Country	Link
US (1)	US4503066A (de)
EP (1)	EP0065392B1 (de)
JP (1)	JPS57197217A (de)
AT (1)	ATE11781T1 (de)
DE (1)	DE3262294D1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4486428A (en) *	1982-03-16	1984-12-04	Pfizer Inc.	Bicyclic benzo fused compounds
US4870084A (en) *	1982-03-16	1989-09-26	Pfizer Inc.	Bicyclic benzo fused pyran compounds used for nausea treatment and prevention
US4863934A (en) *	1982-03-16	1989-09-05	Pfizer Inc.	Bicyclic benzo fused pyran compounds used for producing analgesia
US4841078A (en) *	1982-03-16	1989-06-20	Pfizer Inc.	Benzopyrans
US5070100A (en) *	1983-09-14	1991-12-03	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives
US5153211A (en) *	1983-09-14	1992-10-06	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4864028A (en) *	1983-09-14	1989-09-05	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives
US4537892A (en) *	1983-09-14	1985-08-27	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
ATE30585T1 (de) *	1983-09-23	1987-11-15	Pfizer	Spirosuccinimide und ihre anwendung in der behandlung von zuckerkrankheitskomplikationen.
US4766141A (en) *	1983-09-23	1988-08-23	Pfizer Inc.	Spiro-succinimides for treatment of diabetes complications
JPS60142984A (ja) *	1983-12-28	1985-07-29	Kyorin Pharmaceut Co Ltd	新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法
WO1986000807A1 (en) *	1984-07-20	1986-02-13	Pfizer Inc.	Spiro-imidazolones for treatment of diabetes complications
US4609663A (en) *	1984-09-11	1986-09-02	Alcon Laboratories, Inc.	Aldose reductase inhibitors useful in glaucoma therapy
US4551542A (en) *	1984-09-26	1985-11-05	Pfizer Inc.	Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
WO1987004344A1 (en) *	1986-01-17	1987-07-30	Pfizer Inc.	Hydroxyacetic acid derivatives for the treatment of diabetic complications
FI901087A0 (fi) *	1987-09-04	1990-03-02	Pfizer	Azolidindionderivat.
US5039672A (en) *	1990-04-05	1991-08-13	Pfizer Inc.	Heterocyclic compounds as aldose reductase inhibitors
US5091409A (en) *	1990-05-17	1992-02-25	Merck & Co., Inc.	4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
US5106978A (en) *	1991-05-22	1992-04-21	American Home Products Corporation	Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US5407897A (en) *	1993-03-03	1995-04-18	American Cyanamid Company	Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds
US5760246A (en)	1996-12-17	1998-06-02	Biller; Scott A.	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
US6593337B1 (en) *	1999-10-19	2003-07-15	Bristol-Myers Squibb Pharma Company	Tricyclic compounds useful as HIV reverse transcriptase inhibitors
US6825210B2 (en)	2001-04-19	2004-11-30	Bristol-Myers Squibb Pharma Company	Tricyclic compounds useful as HIV reverse transcriptase inhibitors
US7014925B2 (en)	2003-04-29	2006-03-21	Canon Kabushiki Kaisha	Heterogeneous spiro compounds in organic light emitting device elements

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3185696A (en) *	1959-03-12	1965-05-25	Jack M Tien	3', 6'-diaminofluoran derivatives of gamma-lactam
SE305216B (de) *	1965-09-17	1968-10-21	Astra Apotekarnes Kem Fab
US3652558A (en) *	1969-04-21	1972-03-28	Robins Co Inc A H	Spiro condensed aromatic compounds
US4117230A (en) *	1976-10-18	1978-09-26	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
CA1088945A (en) *	1976-10-18	1980-11-04	Pfizer Limited	Hydantoin derivatives as therapeutic agents
US4307108A (en) *	1979-12-26	1981-12-22	Pfizer Inc.	Method for lowering sorbitol levels using spiro-imides

1982
- 1982-05-07 AT AT82302334T patent/ATE11781T1/de not_active IP Right Cessation
- 1982-05-07 DE DE8282302334T patent/DE3262294D1/de not_active Expired
- 1982-05-07 EP EP82302334A patent/EP0065392B1/de not_active Expired
- 1982-05-11 US US06/377,132 patent/US4503066A/en not_active Expired - Fee Related
- 1982-05-13 JP JP57079290A patent/JPS57197217A/ja active Pending

Also Published As

Publication number	Publication date
EP0065392A1 (de)	1982-11-24
DE3262294D1 (en)	1985-03-28
US4503066A (en)	1985-03-05
JPS57197217A (en)	1982-12-03
EP0065392B1 (de)	1985-02-13

Legal Events

Date	Code	Title	Description
1985-06-15	UEP	Publication of translation of european patent specification
1990-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3262294D1 (en)	1985-03-28	Pharmaceutical compositions containing spiro succinimide derivatives
RO92607A (ro)	1987-11-30	Procedeu pentru prepararea unor derivati de dihidropiridazinona
NZ511707A (en)	2004-01-30	Substituted bicyclic derivatives useful as anticancer agents
MX9800415A (es)	1998-04-30	Compuestos quimicos.
FI882081A0 (fi)	1988-05-04	2-substituerade e-fusionerade (1,2,4) triazolo(1,5-c) pyrimidiner, farmaceutiska kompositioner och deras anvaendning.
ATE102930T1 (de)	1994-04-15	Heterozyklische verbindungen, deren herstellung und medikamente diese enthaltend.
DK615984D0 (da)	1984-12-20	Spiro-bundne pyrrolidin-2,5-dioner og baseadditionssalte deraf samt fremgangsmaade til fremstilling af saadanne forbindelser
DE3262529D1 (en)	1985-04-18	Pharmaceutical spiro-succinimide derivatives
NO158459C (no)	1988-09-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyl-cyklobutanderivater.
NO161493C (no)	1989-08-23	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1,6-nafthyridinderivater.
NO169442C (no)	1992-06-24	Analogifremgangsmaate ved fremstilling av terapeutisk aktive prolinderivater og lignende forbindelser
FI89594C (fi)	1993-10-25	Foerfarande foer framstaellning av farmakologiskt vaerdefull pyrrolidinfoerening
MY103572A (en)	1993-08-28	3,4-dihydro-2-alkyl-3-oxo-n-aryl-2h-[1] benzothieno [3,2-e]-1,2-thiazine-4-carboxamide-1, 1-dioxides.
JPS57192386A (en)	1982-11-26	Pyrrole derivative, manufacture and drug composition containing same for preventing or treating diabetes or complication of galactosemia
NO165593C (no)	1991-03-06	Analogifremgangsmaate ved fremstilling av nye tetracykliske indolderivater.
DK0784973T3 (da)	2002-03-18	Quinoxalinderivater til behandling af tinnitus
ATE22081T1 (de)	1986-09-15	Substituierte thienobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DK316986A (da)	1987-01-06	Kemiske forbindelser, som er phosphodiesterase type iii inhibitorer
US4371541A (en)	1983-02-01	Antiinflammatory and/or analgesic 3,4-dihydro-(or 1,4-dihydro)-4-aryl-2-((substituted)thio)-(1)-benzopyrano(3,4-d)imidazoles and their corresponding sulfoxides and sulfones
HUP9900916A2 (hu)	1999-09-28	Benzotiofénszármazékok felhasználása az érszövetek kalciumvezetékeit antagonizáló hatású gyógyszerkészítmények előállítására
IE36204B1 (en)	1976-09-15	Penicilloic acid derivatives
ATE241604T1 (de)	2003-06-15	Polyhydroxyalkylpyrazine derivate und deren herstellung und diese enthaltende arzneimittel
TH20908B (th)	2006-11-17	อนุพันธ์คาร์โบไฮเดรต
TH31635A (th)	1999-01-11	อนุพันธ์คาร์โบไฮเดรต