ATE11781T1 - Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten. - Google Patents

Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten.

Info

Publication number
ATE11781T1
ATE11781T1 AT82302334T AT82302334T ATE11781T1 AT E11781 T1 ATE11781 T1 AT E11781T1 AT 82302334 T AT82302334 T AT 82302334T AT 82302334 T AT82302334 T AT 82302334T AT E11781 T1 ATE11781 T1 AT E11781T1
Authority
AT
Austria
Prior art keywords
spirosuccinimide
derivatives
alkyl
hydrogen
formula
Prior art date
Application number
AT82302334T
Other languages
English (en)
Inventor
David Robert Brittain
Robin Wood
Original Assignee
Imperial Chemical Industries Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Plc filed Critical Imperial Chemical Industries Plc
Application granted granted Critical
Publication of ATE11781T1 publication Critical patent/ATE11781T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT82302334T 1981-05-13 1982-05-07 Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten. ATE11781T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8114625 1981-05-13
EP82302334A EP0065392B1 (de) 1981-05-13 1982-05-07 Pharmazeutische Zubereitungen, die Spirosuccinimidderivate enthalten

Publications (1)

Publication Number Publication Date
ATE11781T1 true ATE11781T1 (de) 1985-02-15

Family

ID=10521769

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82302334T ATE11781T1 (de) 1981-05-13 1982-05-07 Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten.

Country Status (5)

Country Link
US (1) US4503066A (de)
EP (1) EP0065392B1 (de)
JP (1) JPS57197217A (de)
AT (1) ATE11781T1 (de)
DE (1) DE3262294D1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4841078A (en) * 1982-03-16 1989-06-20 Pfizer Inc. Benzopyrans
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds
US4863934A (en) * 1982-03-16 1989-09-05 Pfizer Inc. Bicyclic benzo fused pyran compounds used for producing analgesia
US4870084A (en) * 1982-03-16 1989-09-26 Pfizer Inc. Bicyclic benzo fused pyran compounds used for nausea treatment and prevention
US5070100A (en) * 1983-09-14 1991-12-03 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
US5153211A (en) * 1983-09-14 1992-10-06 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4537892A (en) * 1983-09-14 1985-08-27 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4864028A (en) * 1983-09-14 1989-09-05 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
ATE30585T1 (de) * 1983-09-23 1987-11-15 Pfizer Spirosuccinimide und ihre anwendung in der behandlung von zuckerkrankheitskomplikationen.
US4766141A (en) * 1983-09-23 1988-08-23 Pfizer Inc. Spiro-succinimides for treatment of diabetes complications
JPS60142984A (ja) * 1983-12-28 1985-07-29 Kyorin Pharmaceut Co Ltd 新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法
WO1986000807A1 (en) * 1984-07-20 1986-02-13 Pfizer Inc. Spiro-imidazolones for treatment of diabetes complications
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
US4551542A (en) * 1984-09-26 1985-11-05 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
HU206618B (en) * 1986-01-17 1992-12-28 Pfizer Process for producing hydroxyacetic acid derivatives for treating complications of diabetes and pharmaceutical compositions containing them
FI901087A0 (fi) * 1987-09-04 1990-03-02 Pfizer Azolidindionderivat.
US5039672A (en) * 1990-04-05 1991-08-13 Pfizer Inc. Heterocyclic compounds as aldose reductase inhibitors
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
US5106978A (en) * 1991-05-22 1992-04-21 American Home Products Corporation Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US5407897A (en) * 1993-03-03 1995-04-18 American Cyanamid Company Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
US6593337B1 (en) 1999-10-19 2003-07-15 Bristol-Myers Squibb Pharma Company Tricyclic compounds useful as HIV reverse transcriptase inhibitors
WO2002085365A1 (en) 2001-04-19 2002-10-31 Bristol-Myers Squibb Company Tricyclic compounds useful as hiv reverse transcriptase inhibitors
US7014925B2 (en) 2003-04-29 2006-03-21 Canon Kabushiki Kaisha Heterogeneous spiro compounds in organic light emitting device elements

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3185696A (en) * 1959-03-12 1965-05-25 Jack M Tien 3', 6'-diaminofluoran derivatives of gamma-lactam
SE305216B (de) * 1965-09-17 1968-10-21 Astra Apotekarnes Kem Fab
US3652558A (en) * 1969-04-21 1972-03-28 Robins Co Inc A H Spiro condensed aromatic compounds
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4307108A (en) * 1979-12-26 1981-12-22 Pfizer Inc. Method for lowering sorbitol levels using spiro-imides

Also Published As

Publication number Publication date
EP0065392A1 (de) 1982-11-24
EP0065392B1 (de) 1985-02-13
DE3262294D1 (en) 1985-03-28
US4503066A (en) 1985-03-05
JPS57197217A (en) 1982-12-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee