ATE118043T1 - HYDROXYLATION OF METHYL GROUPS IN AROMATIC HETEROCYCLES USING MICROORGANISMS. - Google Patents

HYDROXYLATION OF METHYL GROUPS IN AROMATIC HETEROCYCLES USING MICROORGANISMS.

Info

Publication number
ATE118043T1
ATE118043T1 AT91116165T AT91116165T ATE118043T1 AT E118043 T1 ATE118043 T1 AT E118043T1 AT 91116165 T AT91116165 T AT 91116165T AT 91116165 T AT91116165 T AT 91116165T AT E118043 T1 ATE118043 T1 AT E118043T1
Authority
AT
Austria
Prior art keywords
microorganisms
methyl groups
hydroxylation
aromatic heterocycles
aromatic
Prior art date
Application number
AT91116165T
Other languages
German (de)
Inventor
Thomas Dr Zimmermann
Andreas Dr Kiener
Shigeaki Dr Harayama
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of ATE118043T1 publication Critical patent/ATE118043T1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process using microorganisms which contain genes, which form an active xylene monooxygenase, which form no effective, chromosomally or plasmid-coded alcohol hydrogenase, and which are, thus, capable of hydroxylating methyl groups on aromatic 5- or 6-atom heterocycles to the corresponding hydroxymethyl derivatives, for the production of hydroxymethylated 5- or 6-atom heterocycles.
AT91116165T 1990-09-24 1991-09-23 HYDROXYLATION OF METHYL GROUPS IN AROMATIC HETEROCYCLES USING MICROORGANISMS. ATE118043T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH306690 1990-09-24

Publications (1)

Publication Number Publication Date
ATE118043T1 true ATE118043T1 (en) 1995-02-15

Family

ID=4247870

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91116165T ATE118043T1 (en) 1990-09-24 1991-09-23 HYDROXYLATION OF METHYL GROUPS IN AROMATIC HETEROCYCLES USING MICROORGANISMS.

Country Status (9)

Country Link
US (1) US5217884A (en)
EP (1) EP0477828B1 (en)
JP (1) JPH05130875A (en)
AT (1) ATE118043T1 (en)
CZ (1) CZ279464B6 (en)
DE (1) DE59104472D1 (en)
DK (1) DK0477828T3 (en)
HU (1) HUT63200A (en)
RU (1) RU2088667C1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI922125A7 (en) * 1991-06-21 1992-12-22 Lonza Ag Microbiological process for the preparation of 5-hydroxypyrazinecarboxylic acid
RU2099418C1 (en) * 1991-11-21 1997-12-20 Лонца Аг Dna fragment providing the betaine utilization, recombinant plasmid dna having dna fragment providing the betaine utilization, strain of bacterium rhizobium/agrobacterium assigned for stable storage of plasmid having dna fragment, a method of the bacterium strain preparing
CZ282939B6 (en) * 1992-03-04 1997-11-12 Lonza A.G. NITROGENOUS HYDROXY HETEROCYCLIC CARBOXYLIC ACIDS, PROCESS OF THEIR PREPARATION AND MICRO-ORGANISMS Ki101DSN6920
DK0707656T3 (en) * 1993-07-05 1999-02-08 Basf Ag Process for biotechnological preparation of alcohols, aldehydes and carboxylic acids
EP1219446B1 (en) 1993-07-20 2005-03-09 Canon Kabushiki Kaisha Ink jet recording apparatus using recording unit with ink cartridge having ink including element
US6156946A (en) * 1996-04-12 2000-12-05 Exxon Research And Engineering Company Biological activation of aromatics for chemical processing and/or upgrading of aromatic compounds, petroleum, coal, resid, bitumen and other petrochemical streams
DE19951768A1 (en) * 1999-10-27 2001-05-03 Basf Ag Microbiological process for the production of aromatic aldehydes and / or carboxylic acids
US20030077768A1 (en) * 2001-08-10 2003-04-24 Bramucci Michael G. Use of xylene monooxygenase for the oxidation of substituted polycyclic aromatic compounds
DE10225371A1 (en) * 2002-06-06 2003-12-18 Bayer Ag Microbiological process for enantioselective (S) -hydroxylation
ATE444284T1 (en) * 2002-06-17 2009-10-15 Saltigo Gmbh METHOD FOR PRODUCING MONO-N-SULFONYLATED DIAMINES
CN107974428A (en) * 2017-12-13 2018-05-01 迪沙药业集团有限公司 A kind of recombination bacillus coli and the method for converting production 5-Methylpyrazine-2-carboxylic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8700085A (en) * 1987-01-15 1988-08-01 Rijksuniversiteit METHOD FOR PREPARING COMPOUNDS WITH TERMINAL HYDROXYL OR EPOXY GROUP; USEFUL MICROORGANISMS FOR THAT.
GB8807939D0 (en) * 1988-04-05 1988-05-05 Univ Brunel Regulatory cassette for expression vectors

Also Published As

Publication number Publication date
US5217884A (en) 1993-06-08
JPH05130875A (en) 1993-05-28
CS282591A3 (en) 1992-04-15
DE59104472D1 (en) 1995-03-16
EP0477828A3 (en) 1993-03-31
HU913035D0 (en) 1992-01-28
EP0477828A2 (en) 1992-04-01
RU2088667C1 (en) 1997-08-27
DK0477828T3 (en) 1995-04-10
EP0477828B1 (en) 1995-02-01
HUT63200A (en) 1993-07-28
CZ279464B6 (en) 1995-05-17

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee