ATE119547T1 - Oligosaccharide mit antiatherosclerotischer wirkung. - Google Patents

Oligosaccharide mit antiatherosclerotischer wirkung.

Info

Publication number: ATE119547T1
Authority: AT; Austria
Prior art keywords: oligosaccharides; mucopolysaccharides; antiatherosclerotic; antiatherosclerotic effect; antithrombotic
Prior art date: 1988-10-21

Application number

AT90900186T

Other languages

English (en)

Inventor

Giuseppe Mascellani

Pietro Bianchini

Original Assignee

Opocrin Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-21

Filing date

1989-10-13

Publication date

1995-03-15

1989-10-13 Application filed by Opocrin Spa filed Critical Opocrin Spa

1995-03-15 Application granted granted Critical

1995-03-15 Publication of ATE119547T1 publication Critical patent/ATE119547T1/de

Links

229920001542 oligosaccharide Polymers 0.000 title abstract 4
150000002482 oligosaccharides Chemical class 0.000 title abstract 4
230000000879 anti-atherosclerotic effect Effects 0.000 title abstract 2
229920002683 Glycosaminoglycan Polymers 0.000 abstract 2
239000003146 anticoagulant agent Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000000702 anti-platelet effect Effects 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Polymers & Plastics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Materials Engineering (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)

AT90900186T 1988-10-21 1989-10-13 Oligosaccharide mit antiatherosclerotischer wirkung. ATE119547T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8822386A IT1230582B (it)	1988-10-21	1988-10-21	Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica

Publications (1)

Publication Number	Publication Date
ATE119547T1 true ATE119547T1 (de)	1995-03-15

Family

ID=11195576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90900186T ATE119547T1 (de)	1988-10-21	1989-10-13	Oligosaccharide mit antiatherosclerotischer wirkung.

Country Status (9)

Country	Link
EP (1)	EP0439555B1 (de)
JP (1)	JP2960158B2 (de)
KR (1)	KR0148799B1 (de)
AT (1)	ATE119547T1 (de)
AU (1)	AU639427B2 (de)
DE (1)	DE68921633T2 (de)
ES (1)	ES2021905A6 (de)
IT (1)	IT1230582B (de)
WO (1)	WO1990004607A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5707973A (en) *	1991-04-23	1998-01-13	Rhone-Poulenc Rorer S.A.	Sulfated polysaccharids for treatment or prevention of thromboses
IT1251182B (it) *	1991-08-28	1995-05-04	Opocrin Spa	Oligosaccaridi di dermatan solfato, processo per la loro produzione e relative composizioni farmaceutiche.
US5849721A (en) *	1992-02-07	1998-12-15	Rhone-Poulenc Rorer S.A.	Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
IT1264709B1 (it) *	1993-07-12	1996-10-04	Italfarmaco Spa	Derivati eparinici ad attivita' antimetastatica
WO1995033468A1 (en) *	1994-06-06	1995-12-14	Oestergaard Per Bjoern	A pharmaceutical composition comprising oligosaccharides binding to lipoprotein lipase
US5744457A (en) *	1995-03-31	1998-04-28	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US6001820A (en) *	1995-03-31	1999-12-14	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5763427A (en) *	1995-03-31	1998-06-09	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5821020A (en) *	1995-07-14	1998-10-13	Nhh Biologics	Vitamin D assay
US5980865A (en) *	1995-08-18	1999-11-09	Baker Norton Pharmaceuticals, Inc.	Method for treating late phase allergic reactions and inflammatory diseases
US5767269A (en) *	1996-10-01	1998-06-16	Hamilton Civic Hospitals Research Development Inc.	Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
GB9711443D0 (en)	1997-06-03	1997-07-30	Leo Pharm Prod Ltd	Chemical suppositions
AUPO888497A0 (en) *	1997-09-01	1997-09-25	Australian National University, The	Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
EP1344781A1 (de) *	2002-03-12	2003-09-17	Laboratori Derivati Organici S.P.A.	Verfahren zur Depolymerisierung von Glykosaminoglykanen und so hergestellte Produkte
ITMI20021372A1 (it)	2002-06-21	2003-12-22	Derivati Organici Lab	Processo per la depolimerizzazione fisica dei glicosamminogliacani e prodotti da esso ottenuti
EP1475391A1 (de) *	2003-05-09	2004-11-10	Laboratori Derivati Organici S.P.A.	Verfahren zur physikalischen Depolymerisation von Glykosaminoglykanen und dadurch erhaltene Produkte
GB0509433D0 (en) *	2005-05-09	2005-06-15	Uni For Milj Og Biovitenskap	Method
EP1792621B1 (de)	2005-11-30	2012-04-04	Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni"	Oral verabreichbare Heparinderivate
WO2009007224A1 (en) *	2007-07-10	2009-01-15	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Low molecular weight heparin derivatives having neuroprotective activity
DE102011077393A1 (de) *	2011-06-10	2012-12-13	Johannes Reinmüller	Antiinfektives Mittel
ITLO20130005A1 (it) *	2013-10-31	2015-05-01	He E Biochimiche G Ronzonr S R	Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci
ITLO20130006A1 (it)	2013-11-06	2015-05-07	He E Biochimiche G Ronzoni S R	Derivati carbossilati di glucosamminoglicani e loro uso come farmaci

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2478646A2 (fr)	1980-03-20	1981-09-25	Choay Sa	Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4500519A (en)	1978-11-06	1985-02-19	Choay S.A.	Mucopolysaccharides having biological properties, preparation and method of use
CA1136620A (en)	1979-01-08	1982-11-30	Ulf P.F. Lindahl	Heparin fragments having selective anticoagulation activity
IL61201A (en)	1979-10-05	1984-09-30	Choay Sa	Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
DE2945212A1 (de)	1979-11-09	1981-05-27	C.H. Boehringer Sohn, 6507 Ingelheim	Vorrichtung und verfahren zur abfuellung kleinster pulvermengen
US4281108A (en)	1980-01-28	1981-07-28	Hepar Industries, Inc.	Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
FR2482611B1 (fr)	1980-05-14	1986-03-07	Pharmindustrie	Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
FR2482603A1 (fr)	1980-05-14	1981-11-20	Pharmindustrie	Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation
US4351938A (en)	1980-05-19	1982-09-28	Riker Laboratories, Inc.	Anticoagulant substance
CA1171375A (en)	1980-09-15	1984-07-24	Ulf P.F. Lindahl	Oligosaccharides having selective anticoagulation activity
US4687765A (en)	1983-07-25	1987-08-18	Choay S.A.	Method and composition for thrombolytic treatment
IT1214609B (it) *	1985-05-17	1990-01-18	Opocrin Spa	Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.

1988
- 1988-10-21 IT IT8822386A patent/IT1230582B/it active
1989
- 1989-10-13 EP EP90900186A patent/EP0439555B1/de not_active Expired - Lifetime
- 1989-10-13 DE DE68921633T patent/DE68921633T2/de not_active Expired - Fee Related
- 1989-10-13 AT AT90900186T patent/ATE119547T1/de not_active IP Right Cessation
- 1989-10-13 WO PCT/EP1989/001214 patent/WO1990004607A2/en not_active Ceased
- 1989-10-13 JP JP2500512A patent/JP2960158B2/ja not_active Expired - Lifetime
- 1989-10-13 AU AU48012/90A patent/AU639427B2/en not_active Ceased
- 1989-10-20 ES ES8903550A patent/ES2021905A6/es not_active Expired - Fee Related
- 1989-10-21 KR KR1019900701324A patent/KR0148799B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU639427B2 (en)	1993-07-29
KR900701851A (ko)	1990-12-04
DE68921633D1 (de)	1995-04-13
IT1230582B (it)	1991-10-28
EP0439555A1 (de)	1991-08-07
DE68921633T2 (de)	1995-10-19
WO1990004607A2 (en)	1990-05-03
JPH04502928A (ja)	1992-05-28
WO1990004607A3 (en)	1990-05-31
KR0148799B1 (ko)	1998-08-17
ES2021905A6 (es)	1991-11-16
JP2960158B2 (ja)	1999-10-06
IT8822386A0 (it)	1988-10-21
EP0439555B1 (de)	1995-03-08
AU4801290A (en)	1990-05-14

Legal Events

Date	Code	Title	Description
1995-08-15	UEP	Publication of translation of european patent specification
2009-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE119547T1 (de)	1995-03-15	Oligosaccharide mit antiatherosclerotischer wirkung.
US4933326A (en)	1990-06-12	Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity
Shanmugam et al.	2000	Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant agents
DE69023957D1 (de)	1996-01-18	Sulfatierte Polysaccharide, Antikoagulierungs- und Antikomplementärmittel, hergestellt aus Fukanen aus braunen Algen, und Verfahren zu deren Herstellung.
US5280016A (en)	1994-01-18	Non-anticoagulant heparin derivatives
ZA839652B (en)	1984-08-29	Process for the depolymerisation and sulfation of polysaccharides
ES8206555A1 (es)	1982-08-16	Procedimiento de preparacion de mezclas de polisacaridos sulfatados.
DE69012154D1 (de)	1994-10-13	Heparinderivate und Verfahren zu ihrer Herstellung.
US6197943B1 (en)	2001-03-06	Glycosaminoglycans having high antithrombotic activity
NO305992B1 (no)	1999-08-30	Halvsyntetiske glykosaminglykosaner med heparin- eller heparanstruktur og fremgangsmåte til fremstilling derav
FI863213A0 (fi)	1986-08-06	Xanthomonas-bakteerin valmistama polysakkaridipolymeeri
AU550317B2 (en)	1986-03-20	Polysaccharide anti-thromboticum
CA2283990A1 (en)	1998-09-17	Sulfated oligosaccharides having anticoagulant/antithrombotic activity
DE69813216T2 (de)	2004-01-29	Oligosaccharidemischungen mit antithrombotischer wirkung
ATE150468T1 (de)	1997-04-15	Dermatansulfatoligosaccharide, verfahren zu ihrer herstellung und diese enthaltende phamazeutische zusammensetzungen
RU2000100374A (ru)	2001-11-20	Смеси олигосахаридов, обладающие антитромботической активностью
DE69313826D1 (de)	1997-10-16	Sulfatierte polysaccharide, verfahren zu deren herstellung, pharmazeutische zusammensetzung und ihre verwendung
ATE138938T1 (de)	1996-06-15	Sulfatiertes polysaccharid, dessen pharmazeutisch verträgliche salze, dessen herstellung und medikament, das dieses als wirksstoff enthält
NO903283D0 (no)	1990-07-24	Xanthan-baserte polysakkaridpolymerer og fremgangsmaate til deres fremstilling.
Conrad et al.	1992	Structural analysis of periodate-oxidized heparin
NO934044D0 (no)	1993-11-08	Genetisk kontroll av acetylering op pyruvylering av xantanbaserte polysakkaridpolymerer
PT95511A (pt)	1991-08-14	Processo de producao de glicosaminoglicuronano sulfato e de composicoes farmaceuticas
Raake et al.	1989	Anticoagulant and antithrombotic properties of synthetic sulfated bis-lactobionic acid amides
Franz et al.	1995	Novel pharmaceutical applications of polysaccharides