ATE119667T1 - Apparat und methode zur analyse von in einer flüssigkeit suspendierten teilchen. - Google Patents

Apparat und methode zur analyse von in einer flüssigkeit suspendierten teilchen.

Info

Publication number
ATE119667T1
ATE119667T1 AT91909082T AT91909082T ATE119667T1 AT E119667 T1 ATE119667 T1 AT E119667T1 AT 91909082 T AT91909082 T AT 91909082T AT 91909082 T AT91909082 T AT 91909082T AT E119667 T1 ATE119667 T1 AT E119667T1
Authority
AT
Austria
Prior art keywords
particles
liquid
pct
body members
flow area
Prior art date
Application number
AT91909082T
Other languages
English (en)
Inventor
Max Spinell
Original Assignee
Biometic Aps C O Dansk Udvikli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biometic Aps C O Dansk Udvikli filed Critical Biometic Aps C O Dansk Udvikli
Application granted granted Critical
Publication of ATE119667T1 publication Critical patent/ATE119667T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N15/1409—Handling samples, e.g. injecting samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N2015/135—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1418—Eliminating clogging of debris
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Optical Measuring Cells (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT91909082T 1990-05-04 1991-05-06 Apparat und methode zur analyse von in einer flüssigkeit suspendierten teilchen. ATE119667T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK111990A DK111990D0 (da) 1990-05-04 1990-05-04 Apparat og fremgangsmaade til analyse af en vaeskesuspension

Publications (1)

Publication Number Publication Date
ATE119667T1 true ATE119667T1 (de) 1995-03-15

Family

ID=8101226

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91909082T ATE119667T1 (de) 1990-05-04 1991-05-06 Apparat und methode zur analyse von in einer flüssigkeit suspendierten teilchen.

Country Status (10)

Country Link
US (1) US5351118A (de)
EP (1) EP0528877B1 (de)
JP (1) JPH05508910A (de)
AT (1) ATE119667T1 (de)
AU (1) AU655181B2 (de)
CA (1) CA2082043A1 (de)
DE (1) DE69108027T2 (de)
DK (2) DK111990D0 (de)
ES (1) ES2072610T3 (de)
WO (1) WO1991017422A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5501113A (en) * 1993-11-08 1996-03-26 Pacific Scientific Company Particle measuring system with sonically measured flow rate
US5537336A (en) * 1994-03-30 1996-07-16 On-Site Analysis, Inc. On-site oil analyzer
JP3347495B2 (ja) * 1994-11-14 2002-11-20 シスメックス株式会社 粒子分析装置
US5675517A (en) * 1995-04-25 1997-10-07 Systemix Fluorescence spectral overlap compensation for high speed flow cytometry systems
US5786894A (en) * 1996-10-25 1998-07-28 International Paper Company Measurement of paper pulp and fiber visual characteristics
GB9701457D0 (en) * 1997-01-24 1997-03-12 Pa Consulting Services Method and apparatus for counting and/or sizing particles in suspension
ATE514072T1 (de) * 1997-05-05 2011-07-15 Chemometec As Verfahren zur bestimmung von teilchen in einer flüssigen probe
US6710871B1 (en) * 1997-06-09 2004-03-23 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
EP0988523B1 (de) * 1997-06-09 2013-08-14 EMD Millipore Corporation Verfahren und vorrichtung zum nachweis von mikropartikeln in flüssigkeitsproben
US6211956B1 (en) * 1998-10-15 2001-04-03 Particle Sizing Systems, Inc. Automatic dilution system for high-resolution particle size analysis
SE9803557D0 (sv) * 1998-10-19 1998-10-19 Fibertracker Ab Förfarande och anordning för mätning av fiberegenskaper
JP3817091B2 (ja) * 1999-07-02 2006-08-30 テルモ株式会社 細胞数測定装置
JP2002062248A (ja) * 2000-07-01 2002-02-28 Malvern Instruments Ltd 粒子サイズの分布を特定するための装置及び方法
DE10111833C1 (de) * 2001-03-13 2002-07-04 Parsum Ges Fuer Partikel Stroe Messsonde zur Bestimmung der Grösse von bewegten Partikeln in transparenten Medien
US7328889B2 (en) * 2002-11-21 2008-02-12 Sysmex Corporation Measuring unit, partition member, mold for molding the partition member, and production method for the partition member
DE10320870A1 (de) * 2003-05-09 2004-12-09 Evotec Technologies Gmbh Partikelinjektor für einen Zellsortierer
ES2243141B1 (es) * 2004-05-07 2007-02-01 Institut D'investigacions Biomediques August Pi I Sunyer. Unidad de filtracion de celulas ensamblable.
US7625761B2 (en) * 2004-07-30 2009-12-01 Beckman Coulter, Inc. Flexible reactor
US7110192B2 (en) * 2005-01-12 2006-09-19 Dako Denmark A/S System and method for a composite lens for a flow cytometer
US7439855B1 (en) * 2005-05-13 2008-10-21 Yufa Aleksandr L Method and wireless communicating apparatus for analysis of environment
GB2432660A (en) * 2005-11-29 2007-05-30 Bacterioscan Ltd System for counting bacteria and determining their susceptibility to antibiotics
JP5162177B2 (ja) * 2007-07-31 2013-03-13 シスメックス株式会社 粒子分析装置及び粒子分析方法
US20100231904A1 (en) * 2009-03-12 2010-09-16 Tyrie Colin C Method and Device for Measuring Hydrocarbons in Aqueous Solutions
WO2010132053A1 (en) 2009-05-13 2010-11-18 Indevr, Inc. Flow measurement and control for improved quantification of particles in flow cytometry
DE102010008446B4 (de) * 2010-02-18 2015-09-03 Hydac Filter Systems Gmbh Vorrichtung zur Bestimmung der Partikeldichte in einem Fluid
FR2970334A1 (fr) 2011-01-07 2012-07-13 Horiba Abx Sas Dispositif d'inspection d'un fluide biologique
DE102012108989B3 (de) 2012-09-24 2014-01-23 Eads Deutschland Gmbh Detektionsvorrichtung sowie Verfahren zur automatischen Detektion von Partikeln
JP6479037B2 (ja) 2013-12-06 2019-03-06 バクテリオスキャン エルティーディー 試料チャンバを有する光学測定キュベット
EP3077796B1 (de) 2013-12-06 2024-09-18 IP Specialists Ltd. Optische messungen von flüssigkeiten mit freier oberfläche
US10233481B2 (en) 2014-12-05 2019-03-19 Bacterioscan Ltd Multi-sample laser-scatter measurement instrument with incubation feature and systems for using the same
US20160161404A1 (en) 2014-12-05 2016-06-09 Bacterioscan Ltd System Using Laser-Scatter Measurement Instrument For Organism Identification And Related Network
US10065184B2 (en) 2014-12-30 2018-09-04 Bacterioscan Ltd. Pipette having integrated filtration assembly
JP2018503842A (ja) 2015-01-26 2018-02-08 バクテリオスキャン エルティーディー 回転木馬式流体サンプル配置を呈するレーザ散乱計測器具
WO2020028639A1 (en) 2018-08-01 2020-02-06 Essen Instruments, Inc. D/B/A Essen Bioscience, Inc. Methods, kits and stain compositions for flow cytometry evaluation of unassociated virus-size particles using multiple fluorogenic dyes
US11137337B2 (en) 2019-01-21 2021-10-05 Essen Instruments, Inc. Flow cytometry with data analysis for optimized dilution of fluid samples for flow cytometry investigation
US11099121B2 (en) 2019-02-05 2021-08-24 BacterioScan Inc. Cuvette device for determining antibacterial susceptibility
EP3948279B1 (de) 2019-03-26 2025-06-18 Sartorius BioAnalytical Instruments, Inc. Durchflusszytometrieauswertung für nicht-zusammenhängende, nicht umhüllte viruspartikel
US11709116B2 (en) 2020-02-04 2023-07-25 Sartorius Bioanalytical Instruments, Inc. Liquid flourescent dye concentrate for flow cytometry evaluation of virus-size particles and related products and methods
US11353392B2 (en) * 2020-09-21 2022-06-07 The United States Of America As Represented By The Secretary Of The Army Contact-free holographic imaging of aerosol particles from mobile platforms
CN116569021A (zh) * 2020-12-17 2023-08-08 拜奥特股份公司 测试液体样品的方法
DE102021134368B4 (de) 2021-12-22 2023-09-21 Hochschule Reutlingen Körperschaft des öffentlichen Rechts Vorrichtung und Verfahren zur Detektion von markierten Tumorzellen eines Gewebes in einer strömenden Flüssigkeit

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656508A (en) * 1949-08-27 1953-10-20 Wallace H Coulter Means for counting particles suspended in a fluid
DE1673279C3 (de) * 1967-07-18 1975-04-17 Veb Transformatoren- Und Roentgenwerk Dresden, X 8030 Dresden Einrichtung zur Größenbestimmung und Zählung von in einer Suspension enthaltenen Teilchen
DE1932866C3 (de) * 1969-06-28 1974-11-14 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Verfahren zur Herstellung von Homo- oder Copolymerisaten des Trioxans oder Tetroxans
US3714565A (en) * 1971-03-26 1973-01-30 Coulter Electronics Electronic particle analyzing apparatus with improved aperture tube
DE2344427A1 (de) * 1973-09-04 1975-04-03 Wolfgang Dr Goehde Anordnung zum automatischen zaehlen und messen von suspendierten teilchen
DE2462063A1 (de) * 1974-05-08 1975-11-20 Max Planck Gesellschaft Vorrichtung zur messung bestimmter eigenschaften in einer partikelsuspension suspendierter partikel
US3975104A (en) * 1974-07-22 1976-08-17 Varian Associates Convergent light illuminated flow cell for liquid chromatography
US4006990A (en) * 1974-07-22 1977-02-08 Varian Associates Convergent light illuminated flow cell for liquid chromatography
US3946239A (en) * 1975-01-24 1976-03-23 The United States Of America As Represented By The United Energy Research And Development Administration Ellipsoidal cell flow system
US3989381A (en) * 1975-05-05 1976-11-02 Coulter Electronics, Inc. Optical chamber with spherical reflective portion and apparatus employing same
DE2721676A1 (de) * 1977-05-13 1978-11-23 Hans T Noeller Lichtblitzphotometer
FR2408117B1 (fr) * 1977-11-07 1982-04-16 Agronomique Inst Nat Rech Procede et appareil de mesure des dimensions de fibres de bois
DE2750447C2 (de) * 1977-11-11 1986-04-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Vorrichtung zur Messung bestimmter Eigenschaften in einer Partikelsuspension suspendierter Partikel
US4265538A (en) * 1979-10-18 1981-05-05 Leeds & Northrup Company Optical sample cell for analysis of particles in liquid suspension
DE2943116C2 (de) * 1979-10-25 1986-06-19 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Einrichtung zur durchflußcytometrischen Reaktions- und/oder Diffusionsmessung
EP0068404B1 (de) * 1981-06-24 1985-10-02 Becton Dickinson and Company Analysator zur gleichzeitigen Bestimmung des Volumens und der Lichtemissionseigenschaften von Partikeln
US4510438A (en) * 1982-02-16 1985-04-09 Coulter Electronics, Inc. Coincidence correction in particle analysis system
GB2116707A (en) * 1982-03-01 1983-09-28 Varian Associates Optical system for a liquid flow absorption cell
DE3215719C2 (de) * 1982-04-28 1984-01-26 Holger Dr. 5100 Aachen Kiesewetter Meßeinrichtung zur Messung des Verformungsvermögens von roten Blutkörperchen
SE429479B (sv) * 1982-09-03 1983-09-05 Coulter Electronics Flodescell
US4565446A (en) * 1982-09-29 1986-01-21 The Research Foundation Of State University Of New York Scattering cells
US4571078A (en) * 1983-03-10 1986-02-18 Capps Ii Rodney D Quick disassembly flowcell
US4565448A (en) * 1983-03-11 1986-01-21 E. I. Du Pont De Nemours And Company Particle counting apparatus
FI831936A0 (fi) * 1983-05-30 1983-05-30 Labsystems Oy Anordning foer maetning av fluorescens, turbiditet, luminescens eller absorption
DE3414260A1 (de) * 1984-04-14 1985-10-24 Fa. Carl Zeiss, 7920 Heidenheim Durchflusskuevette mit nl-volumen
DE3442910A1 (de) * 1984-11-24 1986-05-28 Desaga GmbH, 6900 Heidelberg Zerlegbare kuevette
NO156916C (no) * 1985-07-10 1987-12-16 Harald B Steen Stroemningskammer for vaeskestroemsfotometer.
DE3530689A1 (de) * 1985-08-28 1987-03-12 Siegfried Dipl Phys Stiller Methode zur kontinuierlichen messung der haemoglobinkonzentration im extrakorporalen kreislauf
US4901024A (en) * 1986-05-28 1990-02-13 Sumitomo Electric Industries Ltd. Apparatus for analyzing and separating particles and a system using the same
JPH073419B2 (ja) * 1986-10-07 1995-01-18 東亜医用電子株式会社 流体中の細胞分析方法および装置
JPS63241337A (ja) * 1986-11-07 1988-10-06 Hitachi Ltd 光度計用フローセル
DD256897A1 (de) * 1987-01-02 1988-05-25 Zeiss Jena Veb Carl Pulsationsarme schlauchpumpe
ATE91789T1 (de) * 1987-02-17 1993-08-15 Ratcom Inc Durchflusszytometrie.
JPS63262565A (ja) * 1987-04-20 1988-10-28 Hitachi Ltd フロ−セル
US4927265A (en) * 1988-04-29 1990-05-22 501 Microphoretic Systems, Inc. Detector for fluorescence and absorption spectroscopy
CA1324894C (en) * 1989-03-31 1993-12-07 Maritime Scientific Services Ltd. Method and apparatus for the identification of particles
US5030002A (en) * 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube

Also Published As

Publication number Publication date
ES2072610T3 (es) 1995-07-16
AU7856491A (en) 1991-11-27
EP0528877A1 (de) 1993-03-03
CA2082043A1 (en) 1991-11-05
DE69108027T2 (de) 1995-09-14
US5351118A (en) 1994-09-27
DK0528877T3 (da) 1995-07-31
WO1991017422A1 (en) 1991-11-14
AU655181B2 (en) 1994-12-08
DE69108027D1 (de) 1995-04-13
EP0528877B1 (de) 1995-03-08
DK111990D0 (da) 1990-05-04
JPH05508910A (ja) 1993-12-09

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